Aminophosphinic inhibitors as transition state analogues of enkephalin-degrading enzymes: A class of central analgesics

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 20, 1998, Pages 12028-12033

  Chen, Huixiong ^a   Noble, Florence ^a   Coric, Pascale ^a   Fournie Zaluski, Marie Claude ^a   Roques, Bernard P ^a  

^a Laboratoire de Pharmacochimie   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANALGESIC AGENT; ENKEPHALIN; MEMBRANE METALLOENDOPEPTIDASE; MICROSOMAL AMINOPEPTIDASE; MORPHINE; PHOSPHINE DERIVATIVE;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG DETERMINATION; DRUG SYNTHESIS; ENZYME INHIBITION; HOT PLATE TEST; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PAIN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; WRITHING TEST;

ANALGESICS, NON-NARCOTIC; ANIMALS; ANTIGENS, CD13; BINDING SITES; BRAIN; DRUG DESIGN; ENKEPHALINS; ENZYME INHIBITORS; MALE; MICE; NEPRILYSIN; NOCICEPTORS; PAIN; PHOSPHINIC ACIDS; RABBITS; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE;

EID: 0032578513     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.20.12028     Document Type: Article

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