Signaling through monoubiquitination

Current Topics in Microbiology and Immunology

Volumn 286, Issue , 2004, Pages 149-185

  Sigismund, S ^a   Polo, S ^b   Di Fiore, P P ^a,b,c  

^a FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CBL PROTEIN; GROWTH FACTOR; HISTONE; I KAPPA B KINASE; PROTEIN TYROSINE KINASE; UBIQUITIN;

DNA DAMAGE; DNA REPAIR; DNA REPLICATION; ENDOCYTOSIS; ENDOSOME; FANCONI ANEMIA; MEMBRANE TRANSPORT; METHYLATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; RECEPTOR DOWN REGULATION; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION; UBIQUITINATION;

EID: 3242685293     PISSN: 0070217X     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-3-540-69494-6_6     Document Type: Review

References (163)

1. Ahn, S. et al. Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. J Biol Chem 277, 26642-51 (2002)
2. Andoniou, C. E., Thien, C. B., Langdon, W. Y. Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene. Embo J 13, 4515-23 (1994)
3. Andoniou, C. E. et al. The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation. Mol Cell Biol 20, 851-67 (2000)
4. Babst, M., Katzmann, D. J., Estepa-Sabal, E. J., Meerloo, T., Emr, S. D. Escrt-III: an endosome-associated heterooligomeric protein complex required for mvb sorting. Dev Cell 3, 271-82 (2002)
5. Babst, M., Katzmann, D. J., Snyder, W. B., Wendland, B., Emr, S. D. Endosome-associated complex, ESCRT-II, recruits transport machinery for protein sorting at the multivesicular body. Dev Cell 3, 283-9 (2002)
6. Bach, I., Ostendorff, H. P. Orchestrating nuclear functions: ubiquitin sets the rhythm. Trends Biochem Sci 28, 189-95 (2003)
7. Bache, K. G., Raiborg, C., Mehlum, A., Stenmark, H. STAM and Hrs are subunits of a multivalent Ubiquitin-binding complex on early endosomes. J Biol Chem (2003)
8. Baker, D., Hicke, L., Rexach, M., Schleyer, M., Schekman, R. Reconstitution of SEC gene product-dependent intercompartmental protein transport. Cell 54, 335-44 (1988)
9. Barbieri, M. A. et al. Epidermal growth factor and membrane trafficking. EGF receptor activation of endocytosis requires Rab5a. J Cell Biol 151, 539-50 (2000)
10. Bilodeau, P. S., Urbanowski, J. L., Winistorfer, S. C., Piper, R. C. The Vps27p Hselp complex binds ubiquitin and mediates endosomal protein sorting. Nat Cell Biol 4, 534-9 (2002)
11. Bishop, N., Horman, A., Woodman, P. Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates. J Cell Biol 157, 91-101 (2002)
12. Brett, T. J., Traub, L. M., Fremont, D. H. Accessory protein recruitment motifs in clathrin-mediated endocytosis. Structure (Camb) 10, 797-809 (2002)
13. Briggs, S. D. et al. Gene silencing: trans-histone regulatory pathway in chromatin. Nature 418, 498 (2002)
14. Buchberger, A. From UBA to UBX: new words in the ubiquitin vocabulary. Trends Cell Biol 12, 216-21 (2002)
15. Burnett, B., Li, F., Pittman, R. N. The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity. Hum Mol Genet (2003)
16. Carter, R. S., Geyer, B. C., Xie, M., Acevedo-Suarez, C. A., Ballard, D. W. Persistent activation of NF-kappa B by the tax transforming protein involves chronic phosphorylation of IkappaB kinase subunits IKKbeta and IKKgamma. J Biol Chem 276, 24445-8 (2001)
17. Carter, R. S., Pennington, K. N., Ungurait, B. J., Arrate, P., Ballard, D. W. Signal-induced ubiquitination of Ikappa B kinase-beta. J Biol Chem (2003)
18. Chen, H. et al. Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis. Nature 394, 793-7 (1998)
19. Courbard, J. R. et al. Interaction between two E3 ubiquitin ligases of different classes, CBLC and AIP4/ITCH. J Biol Chem 10, 10 (2002)
20. D'Andrea, A. D. The Fanconi road to cancer. Genes Dev 17, 1933-6 (2003)
21. D'Andrea, A. D., Grompe, M. The Fanconi anaemia/BRCA pathway. Nat Rev Cancer 3, 23-34 (2003)
22. Debonneville, C. et al. Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression. Embo J 20, 7052-9 (2001)
23. Delhase, M., Hayakawa, M., Chen, Y., Karin, M. Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science 284, 309-13 (1999)
24. de Melker, A. A., van der Horst, G., Calafat, J., Jansen, H., Borst, J. c-Cbl ubiquitinates the EGF receptor at the plasma membrane and remains receptor associated throughout the endocytic route. J Cell Sci 114, 2167-78. (2001)
25. de Winter, J. P. et al. The Fanconi anaemia group G gene FANCG is identical with XRCC9. Nat Genet 20, 281-3 (1998)
26. de Winter, J. P. et al. Isolation of a cDNA representing the Fanconi anemia complementation group E gene. Am J Hum Genet 67, 1306-8 (2000)
27. de Winter, J. P. et al. The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG. Hum Mol Genet 9, 2665-74 (2000)
28. Dieckmann, T. et al. Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr. Nat Struct Biol 5, 1042-7 (1998)
29. Di Fiore, P. P., Polo, S., Hofmann, K. When ubiquitin meets ubiquitin receptors: a signalling connection. Nat Rev Mol Cell Biol 4, 491-7 (2003)
30. Dikic, I. CIN85/CMS family of adaptor molecules. FEBS Lett 529, 110-5 (2002)
31. Dikic, I., Szymkiewicz, I., Soubeyran, P. Cbl signaling networks in the regulation of cell function. Cell Mol Life Sci 60, 1805-27 (2003)
32. Donaldson, K. M. et al. Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates. Proc Natl Acad Sci U S A 100, 8892-7 (2003)
33. Donaldson, K. M., Yin, H., Gekakis, N., Supek, F., Joazeiro, C. A. Ubiquitin Signals Protein Trafficking via Interaction with a Novel Ubiquitin Binding Domain in the Membrane Fusion Regulator, Vps9p. Curr Biol 13, 258-62 (2003)
34. Dover, J. et al. Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6. J Biol Chem 277, 28368-71 (2002)
35. Drake, M. T., Downs, M. A., Traub, L. M. Epsin binds to clathrin by associating directly with the clathrin-terminal domain. Evidence for cooperative binding through two discrete sites. J Biol Chem 275, 6479-89 (2000)
36. Duan, L. et al. Cbl-mediated ubiquitinylation is required for lysosomal sorting of epidermal growth factor receptor but is dispensable for endocytosis. J Biol Chem 278, 28950-60 (2003)
37. Dunn, R., Hicke, L. Multiple roles for Rsp5p-dependent ubiquitination at the internalization step of endocytosis. J Biol Chem 276, 25974-81 (2001)
38. Ekstrand, A. J., Sugawa, N., James, C. D., Collins, V. P. Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails. Proc Natl Acad Sci U S A 89, 4309-13 (1992)
39. Farsad, K. et al. Generation of high curvature membranes mediated by direct endophilin bilayer interactions. J Cell Biol 155, 193-200 (2001)
40. Fisher, R. D. et al. Structure and ubiquitin binding of the ubiquitin interacting motif. J Biol Chem 278, 28976-84 (2003)
41. Garcia-Higuera, I., Kuang, Y., D'Andrea, A. D. The molecular and cellular biology of Fanconi anemia. Curr Opin Hematol 6, 83-8 (1999)
42. Garrus, J. E. et al. Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. Cell 107, 55-65 (2001)
43. Giasson, B. I., Lee, V. M. Are ubiquitination pathways central to Parkinson's disease? Cell 114, 1-8 (2003)
44. Grossman, S. R. et al. Polyubiquitination of p53 by a ubiquitin ligase activity of p300. Science 300, 342-4 (2003)
45. Gregory, R. C., Taniguchi, T., D'Andrea, A. D. Regulation of the Fanconi anemia pathway by monoubiquitination. Semin Cancer Biol 13, 77-82 (2003)
46. Haglund, K. et al. Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation. Nat Cell Biol 5, 461-6 (2003)
47. Haglund, K., Shimokawa, N., Szymkiewicz, I., Dikic, I. Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors. Proc Natl Acad Sci U S A 99, 12191-6 (2002)
48. Hama, H., Tall, G. G., Horazdovsky, B. F. Vps9p is a guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport. J Biol Chem 274, 15284-91 (1999)
49. Hershko, A., Ciechanover, A. The ubiquitin system. Annu Rev Biochem 67, 425-79 (1998)
50. Kicke, L. A new ticket for entry into budding vesicles-ubiquitin. Cell 106, 527-30 (2001)
51. Hicke, L. Protein regulation by monoubiquitin. Nat Rev Mol Cell Biol 2, 195-201 (2001)
52. Hinrichsen, L., Harborth, J., Andrees, L., Weber, K., Ungewickell, E. J. Effect of clathrin heavy chain- and alpha -adaptin specific small interfering RNAs on endocytic accessory proteins and receptor trafficking in HeLa cells. J Biol Chem (2003)
53. Hitchcock, A. L., Auld, K., Gygi, S. P., Silver, P. A. A subset of membrane-associated proteins is ubiquitinated in response to mutations in the endoplasmic reticulum degradation machinery. Proc Natl Acad Sci U S A 100, 12735-40 (2003)
54. Hoege, C., Pfander, B., Moldovan, G. L., Pyrowolakis, G., Jentsch, S. RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO. Nature 419, 135-41 (2002)
55. Hofmann, K., Bucher, P. The UBA domain: a sequence motif present in multiple enzyme classes of the ubiquitination pathway. Trends Biochem Sci 21, 172-3 (1996)
56. Hofmann, K., Falquet, L. A ubiquitin-interacting motif conserved in components of the proteasomal and lysosomal protein degradation systems. Trends Biochem Sci 26, 347-50 (2001)
57. Hofmann, R. M., Pickart, C. M. Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. Cell 96, 645-53 (1999)
58. Hook, S. S., Orian, A., Cowley, S. M., Eisenman, R. N. Histone deacetylase 6 binds polyubiquitin through its zinc finger (PAZ domain) and copurifies with deubiquitinating enzymes. Proc Natl Acad Sci U S A 99, 13425-30 (2002)
59. Horiuchi, H. et al. A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell 90, 1149-59 (1997)
60. Howlett, N. G. et al. Biallelic inactivation of BRCA2 in Fanconi anemia. Science 297, 606-9 (2002)
61. Hutchings, N. J., Clarkson, N., Chalkley, R., Barclay, A. N., Brown, M. H. Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85. J Biol Chem 278, 22396-403 (2003)
62. Hwang, W. W. et al. A Conserved RING Finger Protein Required for Histone H2B Monoubiquitination and Cell Size Control. Mol Cell 11, 261-6 (2003)
63. Jiang, X., Huang, F., Marusyk, A., Sorkin, A. Grb2 Regulates Internalization of EGF Receptors through Clathrin-coated Pits. Mol Biol Cell 14, 858-70 (2003)
64. Jiang, X., Sorkin, A. Epidermal growth factor receptor internalization through clathrin-coated pits requires Cbl RING finger and proline-rich domains but not receptor polyubiquitylation. Traffic 4, 529-43 (2003)
65. Kang, R. S. et al. Solution structure of a CUE-ubiquitin complex reveals a conserved mode of ubiquitin binding. Cell 113, 621-30 (2003)
66. Katz, M. et al. Ligand-independent degradation of epidermal growth factor receptor involves receptor ubiquitylation and Hgs, an adaptor whose ubiquitin-interacting motif targets ubiquitylation by Nedd4. Traffic 3, 740-51 (2002)
67. Katzmann, D. J., Babst, M., Emr, S. D. Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell 106, 145-55 (2001)
68. Katzmann, D. J., Odorizzi, G., Emr, S. D. Receptor downregulation and multivesicular-body sorting. Nat Rev Mol Cell Biol 3, 893-905 (2002)
69. Kirsch, K. H. et al. The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction. J Biol Chem 276, 4957-63 (2001)
70. Klapisz, E. et al. A ubiquitin-interacting motif (UIM) is essential for Eps15 and Eps15R ubiquitination. J Biol Chem 277, 30746-53 (2002)
71. Komada, M., Soriano, P. Hrs, a FYVE finger protein localized to early endosomes, is implicated in vesicular traffic and required for ventral folding morphogenesis. Genes Dev 13, 1475-85 (1999)
72. Kowanetz, K. et al. Identification of a novel proline-arginine motif involved in CIN85-dependent clustering of Cbl and down-regulation of epidermal growth factor receptors. J Biol Chem 278, 39735-46 (2003)
73. Lafont, F., Simons, K. Raft-partitioning of the ubiquitin ligases Cbl and Nedd4 upon IgE- triggered cell signaling. Proc Natl Acad Sci U S A 98, 3180-4. (2001)
74. Lai, Z. et al. Human mdm2 mediates multiple mono-ubiquitination of p53 by a mechanism requiring enzyme isomerization. J Biol Chem 276, 31357-67 (2001)
75. Lee, P. S. et al. The Cbl protooncoprotein stimulates CSF-1 receptor multiubiquitination and endocytosis, and attenuates macrophage proliferation. Embo J 18, 3616-28 (1999)
76. Levkowitz, G. et al. c-Cbl/Sli-1 regulates endocytic sorting and ubiquitination of the epidermal growth factor receptor. Genes Dev 12, 3663-74. (1998)
77. Levkowitz, G. et al. Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol Cell 4, 1029-40 (1999)
78. Li, L., Cohen, S. N. Tsg101: a novel tumor susceptibility gene isolated by controlled homozygous functional knockout of allelic loci in mammalian cells. Cell 85, 319-29 (1996)
79. Li, Q., Verma, I. M. NF-kappaB regulation in the immune system. Nat Rev Immunol 2, 725-34 (2002)
80. Lo Ten Foe, J. R. et al. Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA. Nat Genet 14, 320-3 (1996)
81. Magnifico, A. et al. WW Domain HECT E3 s Target Cbl RING Finger E3 s for Proteasomal Degradation. J Biol Chem 278, 43169-77 (2003)
82. Mancini, A., Koch, A., Wilms, R., Tamura, T. c-Cbl associates directly with the C-terminal tail of the receptor for the macrophage colony-stimulating factor, c-Fms, and down-modulates this receptor but not the viral oncogene v-Fms. J Biol Chem 277, 14635-40. (2002)
83. McKenna, S. et al. Energetics and specificity of interactions within Ub.Uev.Ubc13 human ubiquitin conjugation complexes. Biochemistry 42, 7922-30 (2003)
84. Meetei, A. R. et al. A novel ubiquitin ligase is deficient in Fanconi anemia. Nat Genet 35, 165-70 (2003)
85. Melchior, F. SUMO-nonclassical ubiquitin. Annu Rev Cell Dev Biol 16, 591-626 (2000)
86. Meyer, H. H., Wang, Y., Warren, G. Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4. Embo J 21, 5645-52 (2002)
87. Miyake, S., Lupher, M. L., Jr., Druker, B., Band, H. The tyrosine kinase regulator Cbl enhances the ubiquitination and degradation of the platelet-derived growth factor receptor alpha. Proc Natl Acad Sci U S A 95, 7927-32 (1998)
88. Mochida, J., Yamamoto, T., Fujimura-Kamada, K., Tanaka, K. The novel adaptor protein, Mti1p, and Vrp1p, a homolog of Wiskott-Aldrich syndrome protein-interacting protein (WIP), may antagonistically regulate type I myosins in Saccharomyces cerevisiae. Genetics 160, 923-34 (2002)
89. Mosesson, Y. et al. Endocytosis of receptor tyrosine kinases is driven by monoubiquitylation, not polyubiquitylation. J Biol Chem 278, 21323-6 (2003)
90. Mori, S., Heldin, C. H., Claesson-Welsh, L. Ligand-induced ubiquitination of the platelet-derived growth factor beta-receptor plays a negative regulatory role in its mitogenic signaling. J Biol Chem 268, 577-83 (1993)
91. Motley, A., Bright, N. A., Seaman, M. N., Robinson, M. S. Clathrin-mediated endocytosis in AP-2-depleted cells. J Cell Biol 162, 909-18 (2003)
92. Mueller, T. D., Feigon, J. Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions. J Mol Biol 319, 1243-55 (2002)
93. Muller, S., Hoege, C., Pyrowolakis, G., Jentsch, S. SUMO, ubiquitin's mysterious cousin. Nat Rev Mol Cell Biol 2, 202-10 (2001)
94. Naar, A. M., Lemon, B. D., Tjian, R. Transcriptional coactivator complexes. Annu Rev Biochem 70, 475-501 (2001)
95. Nakatsu, F. et al. A Di-leucine signal in the ubiquitin moiety. Possible involvement in ubiquitination-mediated endocytosis. J Biol Chem 275, 26213-9 (2000)
96. Nyberg, K. A., Michelson, R. J., Putnam, C. W., Weinert, T. A. Toward maintaining the genome: DNA damage and replication checkpoints. Annu Rev Genet 36, 617-56 (2002)
97. Oldham, C. E., Mohney, R. P., Miller, S. L., Hanes, R. N., O'Bryan, J. P. The ubiquitin-interacting motifs target the endocytic adaptor protein epsin for ubiquitination. Curr Biol 12, 1112-6 (2002)
98. Ortolan, T. G. et al. The DNA repair protein rad23 is a negative regulator of multiubiquitin chain assembly. Nat Cell Biol 2, 601-8 (2000)
99. Peng, J. et al. A proteomics approach to understanding protein ubiquitination. Nat Biotechnol 21, 921-926 (2003)
100. Peschard, P. et al. Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein. Mol Cell 8, 995-1004. (2001)
101. Petrelli, A. et al. The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met. Nature 416, 187-90. (2002)
102. Pham, A. D., Sauer, F. Ubiquitin-activating/conjugating activity of TAFII250, a mediator of activation of gene expression in Drosophila. Science 289, 2357-60 (2000)
103. Pickart, C. M. Ubiquitin in chains. Trends Biochem Sci 25, 544-8 (2000)
104. Pickart, C. M. Mechanisms underlying ubiquitination. Annu Rev Biochem 70, 503-33 (2001)
105. Piper, R. C., Cooper, A. A., Yang, H., Stevens, T. H. VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae. J Cell Biol 131, 603-17 (1995)
106. Polo, S. et al. A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins. Nature 416, 451-5 (2002)
107. Ponting, C. P. Proteins of the endoplasmic-reticulum-associated degradation pathway: domain detection and function prediction. Biochem J 351 Pt 2, 527-35 (2000)
108. Pornillos, O. et al. Structure and functional interactions of the Tsg101 UEV domain. Embo J 21, 2397-406 (2002)
109. Prag, G. et al. Mechanism of ubiquitin recognition by the CUE domain of Vps9p. Cell 113, 609-20 (2003)
110. Raiborg, C. et al. Hrs sorts ubiquitinated proteins into clathrin-coated microdomains of early endosomes. Nat Cell Biol 4, 394-8 (2002)
111. Rao, H., Sastry, A. Recognition of specific ubiquitin conjugates is important for the proteolytic functions of the ubiquitin-associated domain proteins Dsk2 and Rad23. J Biol Chem 277, 11691-5 (2002)
112. Ridge, S. A., Worwood, M., Oscier, D., Jacobs, A., Padua, R. A. FMS mutations in myelodysplastic, leukemic, and normal subjects. Proc Natl Acad Sci U S A 87, 1377-80 (1990)
113. Ringstad, N. et al. Endophilin/SH3p4 is required for the transition from early to late stages in clathrin-mediated synaptic vesicle endocytosis. Neuron 24, 143-54 (1999)
114. Robzyk, K., Recht, J., Osley, M. A. Rad6-dependent ubiquitination of histone H2B in yeast. Science 287, 501-4 (2000)
115. Rubin, C. et al. Sprouty fine-tunes EGF signaling through interlinked positive and negative feedback loops. Curr Biol 13, 297-307 (2003)
116. Russell, C. S., Ben-Yehuda, S., Dix, I., Kupiec, M., Beggs, J. D. Functional analyses of interacting factors involved in both pre-mRNA splicing and cell cycle progression in Saccharomyces cerevisiae. Rna 6, 1565-72 (2000)
117. Salcini, A. E., Chen, H., Iannolo, G., De Camilli, P., Di Fiore, P. P. Epidermal growth factor pathway substrate 15, Eps15. Int J Biochem Cell Biol 31, 805-9 (1999)
118. Sanjay, A., Horne, W. C., Baron, R. The Cbl family: ubiquitin ligases regulating signaling by tyrosine kinases. Sci STKE 2001, E40. (2001)
119. Schmidt, A. et al. Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid. Nature 401, 133-41 (1999)
120. Schnell, J. D., Hicke, L. Non-traditional Functions of Ubiquitin and Ubiquitin-binding proteins. J Biol Chem (2003)
121. Seachrist, J. L. et al. Rab5 association with the angiotensin II type 1A receptor promotes Rab5 GTP binding and vesicular fusion. J Biol Chem 277, 679-85 (2002)
122. Seigneurin-Berny, D. et al. Identification of components of the murine histone deacetylase 6 complex: link between acetylation and ubiquitination signaling pathways. Mol Cell Biol 21, 8035-44 (2001)
123. Shekhtman, A., Cowburn, D. A ubiquitin-interacting motif from Hrs binds to and occludes the ubiquitin surface necessary for polyubiquitination in monoubiquitinated proteins. Biochem Biophys Res Commun 296, 1222-7 (2002)
124. Shih, S. C., Sloper-Mould, K. E., Hicke, L. Monoubiquitin carries a novel internalization signal that is appended to activated receptors. Embo J 19, 187-98 (2000)
125. Shih, S. C. et al. Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis. Nat Cell Biol 4, 389-93 (2002)
126. Shih, S. C. et al. A ubiquitin-binding motif required for intramolecular monoubiquitylation, the CUE domain. Embo J 22, 1273-81 (2003)
127. Shu, H. K., Pelley, R. J., Kung, H. J. Dissecting the activating mutations in v-erbB of avian erythroblastosis virus strain R. J Virol 65, 6173-80 (1991)
128. Snyder, P. M., Olson, D. R., Thomas, B. C. Serum and glucocorticoid- regulated kinase modulates Nedd4-2-mediated inhibition of the epithelial Na+ channel. J Biol Chem 277, 5-8 (2002)
129. Sorkin, A. Internalization of the epidermal growth factor receptor: role in signalling. Biochem Soc Trans 29, 480-4 (2001)
130. Soubeyran, P., Kowanetz, K., Szymkiewicz, I., Langdon, W. Y., Dikic, I. Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors. Nature 416, 183-7. (2002)
131. Stang, E., Johannessen, L. E., Knardal, S. L., Madshus, I. H. Polyubiquitination of the epidermal growth factor receptor occurs at the plasma membrane upon ligand-induced activation. J Biol Chem 275, 13940-7 (2000)
132. Stelter, P., Ulrich, H. D. Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation. Nature 425, 188-91 (2003)
133. Strathdee, C. A., Gavish, H., Shannon, W. R., Buchwald, M. Cloning of cDNAs for Fanconi's anaemia by functional complementation. Nature 358, 434 (1992)
134. Strous, G. J., Gent, J. Dimerization, ubiquitylation and endocytosis go together in growth hormone receptor function. FEBS Lett 529, 102-9 (2002)
135. Strous, G. J., van Kerkhof, P., Govers, R., Ciechanover, A., Schwartz, A. L. The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor. Embo J 15, 3806-12. (1996)
136. Sun, S. C., Ballard, D. W. Persistent activation of NF-kappaB by the tax transforming protein of HTLV-1: hijacking cellular IkappaB kinases. Oncogene 18, 6948-58 (1999)
137. Sun, Z. W., Allis, C. D. Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Nature 418, 104-8 (2002)
138. Swanson, K. A., Kang, R. S., Stamenova, S. D., Hicke, L., Radhakrishnan, I. Solution structure of Vps27 UIM-ubiquitin complex important for endosomal sorting and receptor downregulation. Embo J 22, 4597-606 (2003)
139. Szymkiewicz, I. et al. CIN85 Participates in Cbl-b-mediated Down-regulation of Receptor Tyrosine Kinases. J Biol Chem 277, 39666-72. (2002)
140. Taher, T. E. et al. c-Cbl Is Involved in Met Signaling in B Cells and Mediates Hepatocyte Growth Factor-Induced Receptor Ubiquitination. J Immunol 169, 3793-800. (2002)
141. Taniguchi, T., Dandrea, A. D. Molecular pathogenesis of fanconi anemia. Int J Hematol 75, 123-8 (2002)
142. Taniguchi, T. et al. S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood 100, 2414-20 (2002)
143. Taniguchi, T. et al. Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways. Cell 109, 459-72 (2002)
144. Terrell, J., Shih, S., Dunn, R., Hicke, L. A function for monoubiquitination in the internalization of a G protein-coupled receptor. Mol Cell 1, 193-202 (1998)
145. Thien, C. B., Walker, F., Langdon, W. Y. RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation. Mol Cell 7, 355-65. (2001)
146. van Delft, S., Govers, R., Strous, G. J., Verkleij, A. J., van Bergen en Henegouwen, P. M. Epidermal growth factor induces ubiquitination of Eps15. J Biol Chem 272, 14013-6 (1997)
147. VanDemark, A. P., Hofmann, R. M., Tsui, C., Pickart, C. M., Wolberger, C. Molecular insights into polyubiquitin chain assembly: crystal structure of the Mms2/Ubc13 heterodimer. Cell 105, 711-20 (2001)
148. Vandenberg, C. J. et al. BRCA1-independent ubiquitination of FANCD2. Mol Cell 12, 247-54 (2003)
149. Volpicelli, L. A., Lah, J. J., Levey, A. I. Rab5-dependent trafficking of the m4 muscarinic acetylcholine receptor to the plasma membrane, early endosomes, and multivesicular bodies. J Biol Chem 276, 47590-8 (2001)
150. Vu, P. K., Sakamoto, K. M. Ubiquitin-mediated proteolysis and human disease. Mol Genet Metab 71, 261-6 (2000)
151. Wang, B. et al. Structure and ubiquitin interactions of the conserved zinc finger domain of Npl4. J Biol Chem 278, 20225-34 (2003)
152. Wang, Y., Yeung, Y. G., Stanley, E. R. CSF-1 stimulated multiubiquitination of the CSF-1 receptor and of Cbl follows their tyrosine phosphorylation and association with other signaling proteins. J Cell Biochem 72, 119-34 (1999)
153. Wang, Y. et al. Negative regulation of EphA2 receptor by Cbl. Biochem Biophys Res Commun 296, 214-20. (2002)
154. Watanabe, S. et al. Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes. Biochem Biophys Res Commun 278, 167-74 (2000)
155. Waterman, H. et al. A mutant EGF-receptor defective in ubiquitylation and endocytosis unveils a role for Grb2 in negative signaling. Embo J 21, 303-13 (2002)
156. Wilde, A. et al. EGF receptor signaling stimulates SRC kinase phosphorylation of clathrin, influencing clathrin redistribution and EGF uptake. Cell 96, 677-87 (1999)
157. Wilkinson, C. R. et al. Proteins containing the UBA domain are able to bind to multi-ubiquitin chains. Nat Cell Biol 3, 939-43 (2001)
158. Wilkinson, K. D. Ubiquitination and deubiquitination: targeting of proteins for degradation by the proteasome. Semin Cell Dev Biol 11, 141-8. (2000)
159. Wong, A. et al. FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl. Proc Natl Acad Sci U S A 99, 6684-9. (2002)
160. Wood, A. et al. Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter. Mol Cell 11, 267-74 (2003)
161. Yokouchi, M. et al. Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7. J Biol Chem 274, 31707-12. (1999)
162. Yokouchi, M. et al. Src-catalyzed phosphorylation of c-Cbl leads to the interdependent ubiquitination of both proteins. J Biol Chem 276, 35185-93. (2001)
163. Zandi, E., Karin, M. Bridging the gap: composition, regulation, and physiological function of the IkappaB kinase complex. Mol Cell Biol 19, 4547-51 (1999)