Molecular insights into polyubiquitin chain assembly: Crystal structure of the Mms2/Ubc13 heterodimer

Cell

Volumn 105, Issue 6, 2001, Pages 711-720

  VanDemark, Andrew P ^a   Hofmann, Roseanne M ^b   Tsui, Colleen ^b   Pickart, Cecile M ^b   Wolberger, Cynthia ^a,c  

^a Institute for Cell Engineering   (United States)

^b Dept of Environ Health Sciences   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; LYSINE; PHOSPHOTRANSFERASE; POLYUBIQUITIN; PROTEIN; PROTEIN MMS2; PROTEIN UBC13; UBIQUITIN; UBIQUITIN E2 VARIANT; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA REPAIR; DNA REPLICATION; ENZYME ACTIVATION; HUMAN; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; ULTRAVIOLET RADIATION;

EID: 0035875079     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(01)00387-7     Document Type: Article

References (49)

1. A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains
2. Surface hydrophobic residues of multiubiquitin chains essential for proteolytic targeting
3. MMS2, encoding a ubiquitin-conjugating-enzyme-like protein, is a member of the yeast error-free postreplication repair pathway
4. Crystallography & NMR system: A new software suite for macromolecular structure determination
5. UBC13, a DNA-damage-inducible gene, is a member of the error-free postreplication repair pathway in Saccharomyces cerevisiae
6. SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53
7. A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein
8. 25K) and overexpression of the functional enzyme in Escherichia coli
9. Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity
10. Three-dimensional structure of a ubiquitin-conjugating enzyme (E2)
11. Tertiary structures of class I ubiquitin-conjugating enzymes are highly conserved: Crystal structure of yeast Ubc4
12. Activation of the IκB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
13. Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant
14. Modelling protein docking using shape complementarity, electrostatics and biochemical information
15. Ubiquitin Lys63 is involved in ubiquitination of a yeast plasma membrane protein
16. The ubiquitin system
17. Gettin' down with ubiquitin: Turning off cell-surface receptors, transporters and channels
18. Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair
19. Structure of an E6AP-UbcH7 complex: Insights into ubiquitination by the E2-E3 enzyme cascade
20. VMD - Visual molecular dynamics
21. The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme
22. Crystal structure of the cyclin-specific ubiquitin-conjugating enzyme from clam, E2-C, at 2.0 Å resolution
23. RING finger proteins: Mediators of ubiquitin ligase activity
24. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase
25. Saccharomyces cerevisiae RAD5-encoded DNA repair protein contains DNA helicase and zinc-binding sequence motifs and affects the stability of simple repetitive sequences in the genome
26. Regulation of transcription by ubiquitination without proteolysis: Cdc34/SCF(Met30)-mediated inactivation of the transcription factor Met4
27. A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly
28. How the cyclin became a cyclin: Regulated proteolysis in the cell cycle
29. TSG101 may be the prototype of a class of dominant negative ubiquitin regulators
30. Automated refinement of protein models
31. XtalView/Xfit - A versatile program for manipulating atomic coordinates and electron density
32. Raster3D: Photorealistic molecular graphics
33. Characterization of the binding interface between ubiquitin and class I human ubiquitin-conjugating enzyme 2b by multidimensional heteronuclear NMR spectroscopy in solution
34. Processing of X-ray diffraction data collected in oscillation mode
35. Ubiquitin in chains
36. Inhibition of the 26 S proteasome by polyubiquitin chains synthesized to have defined lengths
37. Degradation of cell proteins and the generation of MHC class I-presented peptides
38. Role of UEV-1, an inactive variant of the E2 ubiquitin-conjugating enzymes, in vitro differentiation and cell cycle behavior of HT-29-M6 intestinal mucosecretory cells
39. Cell cycle-regulated modification of the ribosome by a variant multiubiquitin chain
40. A ubiquitin mutant with specific defects in DNA repair and multiubiquitination
41. Role of UEV-1A, a homologue of the tumor suppressor protein TSG101, in protection from DNA damage
42. Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair
43. MOLREP: An automated program for molecular replacement
44. Crystal structure of the Saccharomyces cerevisiae ubiquitin-conjugating enzyme Rad6 at 2.6 A resolution
45. The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family
46. The Saccharomyces cerevisiae RAD6 group is composed of an error-prone and two error-free postreplication repair pathways
47. Construct for high-level expression and low misincorporation of lysine for arginine during expression of pET-encoded eukaryotic proteins in Escherichia coli
48. Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases