Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4

EMBO Journal

Volumn 21, Issue 21, 2002, Pages 5645-5652

  Meyer, Hemmo H ^a   Wang, Yanzhuang ^a   Warren, Graham ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CDC48; NZF; TAB2; UBA; VPS36

Indexed keywords

ADAPTOR PROTEIN; POLYUBIQUITIN; PROTEIN P47; PROTEIN UFD1 NPL4; UBIQUITIN; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ARTICLE; CELL NUCLEUS MEMBRANE; COMPLEX FORMATION; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HUMAN; HUMAN CELL; MOLECULAR MODEL; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN DOMAIN; PROTEIN FUNCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL CYCLE PROTEINS; GOLGI APPARATUS; MAMMALS; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; UBIQUITIN; ZINC FINGERS;

MAMMALIA; METAZOA;

EID: 0036845476     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf579     Document Type: Article

References (45)

1. Acharya, U., Jacobs, R., Peters, J.-U., Watson, N., Farquhar, M.G. and Malhotra, V. (1995) The formation of Golgi stacks from vesiculated Golgi membranes requires two distinct fusion events. Cell, 82, 895-904.
2. Bays, N.W. and Hampton, R.Y. (2002) Cdc48-ufd1-npl4: Stuck in the middle with ub. Curr. Biol., 12, R366-R371.
3. Bays, N.W., Wilhovsky, S.K., Goradia, A., Hodgkiss-Harlow, K. and Hampton, R.Y. (2001) HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins. Mol. Biol. Cell, 12, 4114-4128.
4. Bertolaet, B.L., Clarke, D.J., Wolff, M., Watson, M.H., Henze, M., Divita, G. and Reed, S.I. (2001) UBA domains of DNA damage-inducible proteins interact with ubiquitin. Nat. Struct. Biol., 8, 417-422.
5. Braun, S., Matuschewski, K., Rape, M., Thorns, S. and Jentsch, S. (2002) Role of the ubiquitin-selective CDC48(UFD1/NPL4) chaperone (segregase) in ERAD of OLE1 and other substrates. EMBO J., 21, 615-621.
6. Buchberger, A. (2002) From UBA to UBX: New words in the ubiquitin vocabulary. Trends Cell Biol., 12, 216-221.
7. Burke, B. (2001) The nuclear envelope: Filling in gaps. Nat. Cell Biol., 3, 273-274.
8. Dai, R.M. and Li, C.C. (2001) Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation. Nat. Cell Biol., 3, 740-744.
9. Garrus, J.E. et al. (2001) Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding. Cell, 107, 55-65.
10. Ghislain, M., Dohmen, R., Levy, F. and Varshavsky, A. (1996) Cdc48p interacts with Ufd3p, a WD repeat protein required for ubiquitin-mediated proteolysis in Saccharomyces cerevisiae. EMBO J., 15, 4884-4899.
11. Golbik, R., Lupas, A., Koretke, K., Baumeister, W. and Peters, J. (1999) The Janus face of the archaeal Cdc48/p97 homologue VAT: Protein folding versus unfolding. Biol. Chem., 380, 1049-1062.
12. Hetzer, M., Meyer, H.H., Walther, T.C., Bilbao-Cortes, D., Warren, G. and Mattaj, I.W. (2001) Distinct AAA-ATPase p97 complexes function in discrete steps of nuclear assembly, Nat. Cell Biol., 3, 1086-1091.
13. Hicke, L. (2001) Protein regulation by monoubiquitin. Nat. Rev. Mol. Cell. Biol., 2, 195-201.
14. Hitchcock, A.L., Krebber, H., Frietze, S., Lim, A., Latterich, M. and Silver, P.A. (2001) The conserved npl4 protein complex mediates proteasome-dependent membrane-bound transcription factor activation. Mol. Biol. Cell, 12, 3226-3241.
15. Hofmann, K. and Bucher. P. (1996) The UBA domain: A sequence motif present in multiple enzyme classes of the ubiquitination pathway. Trends Biochem. Sci., 21, 172-173.
16. Jarosch, E., Taxis, C., Volkwein, C., Bordallo, J., Finley, D., Wolf, D.H. and Sommer, T. (2002) Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48. Nat. Cell Biol., 4, 134-139.
17. Johnson, E.S., Ma, P.C., Ota, I.M. and Varshavsky, A. (1995) A proteolytic pathway that recognizes ubiquitin as a degradation signal. J. Biol. Chem., 270, 17442-17456.
18. Katzmann, D.J., Babst, M. and Emr, S.D. (2001) Ubiquitin-dependent sorting into the multivesicular body pathway requires the function of a conserved endosomal protein sorting complex, ESCRT-I. Cell, 106, 145-155.
19. Koegl, M., Hoppe, T., Schlenker, S., Ulrich, H., Mayer, T. and Jentsch, S. (1999) A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. Cell, 96, 635-644.
20. Kondo, H., Rabouille, C., Newman, R., Levine, T.P., Pappin, D., Freemont, P. and Warren, G. (1997) p47 is a cofactor for p97-mediated membrane fusion. Nature, 388, 75-78.
21. Latterich, M., Fröhlich, K.-U. and Schekman, R. (1995) Membrane fusion and the cell cycle: cdc48p participates in the fusion of ER membranes. Cell, 82, 885-893.
22. Madeo, F., Frohlich, E., Ligr, M., Grey, M., Sigrist, S.J., Wolf, D.H. and Frohlich, K.U. (1999) Oxygen stress: A regulator of apoptosis in yeast. J. Cell Biol., 145, 757-767.
23. Meyer, H.H., Shorter, J.G., Seemann, J., Pappin, D. and Warren, G. (2000) A complex of mammalian Ufd1 and Npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways. EMBO J., 19, 2181-2192.
24. Moir, D., Stewart, S., Osmond, B. and Botstein, D. (1982) Cold-sensitive cell-division-cycle mutants of yeast: Isolation, properties and pseudoreversion studies. Genetics, 100, 547-563.
25. Nakielny, S., Shaikh, S., Burke, B. and Dreyfuss, G. (1999) Nup153 is an M9-containing mobile nucleoporin with a novel Ran-binding domain. EMBO J., 18, 1982-1995.
26. Ogura,T. and Wilkinson,A.J. (2001) AAA+ superfamily ATPases: Common structure - Diverse function. Genes Cells, 6, 575-597
27. Ortolan, T.G., Tongaonkar, P., Lambertson, D., Chen, L., Schauber, C. and Madura, K. (2000) The DNA repair protein rad23 is a negative regulator of multi-ubiquitin chain assembly. Nat. Cell Biol., 2, 601-608.
28. Patel, S. and Latterich, M. (1998) The AAA team: Related ATPases with diverse functions. Trends Cell Biol., 8. 65-71.
29. Rabinovich, E., Kerem, A., Frohlich, K.U., Diamant, N. and Bar-Nun, S. (2002) AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation. Mol. Cell. Biol., 22, 626-634.
30. Rabouille, C., Levine, T.P., Peters, J.M. and Warren, G. (1995) An NSF-like ATPase, p97 and NSF mediate cisternal regrowth from mitotic Golgi fragments. Cell, 82, 905-914.
31. Rabouille, C., Kondo, H., Newman, R., Hui, N., Freemont, P. and Warren, G. (1998) Syntaxin 5 is a common component of the NSF-and p97-mediated reassembly pathways of Golgi cistemae from mitotic Golgi fragments in vitro. Cell, 92. 603-610.
32. Rape, M., Hoppe, T., Gorr, I., Kalocay, M., Richly, H. and Jentsch, S. (2001) Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone. Cell, 107, 667-677.
33. Roy, L. et al. (2000) Role of p97 and syntaxin 5 in the assembly of transitional endoplasmic reticulum. Mol. Biol. Cell, 11, 2529-2542.
34. Seigneurin-Berny, D., Verdel, A., Curtet, S., Lemercier, C., Garin, J., Rousseaux, S. and Khochbin, S. (2001) Identification of components of the murine histone deacetylase 6 complex: Link between acetylation and ubiquitination signaling pathways. Mol. Cell. Biol., 21, 8035-8044.
35. Shih, S.C., Katzmann, D.J., Schnell, J.D., Sutanto, M., Emr, S.D. and Hicke, L. (2002) Epsins and Vps27p/Hrs contain ubiquitin-binding domains that function in receptor endocytosis. Nat. Cell Biol., 4, 389-393.
36. Shirogane, T., Fukada, T., Muller, J.M., Shima, D.T., Hibi, M. and Hirano, T. (1999) Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis. Immunity, 11, 709-719.
37. Söllner, T., Bennett, M.K., Whiteheart, S.W., Scheller, R.H. and Rothman, J.E. (1993) A protein assembly-disassembly pathway in-vitro that may correspond to sequential steps of synaptic vesicle docking, activation and fusion. Cell, 75, 409-418.
38. Suyama, M., Doerks, T., Braun, I.C., Sattler, M., Izaurralde, E. and Bork, P. (2000) Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins. EMBO Rep., 1, 53-58.
39. Tsai, B., Ye, Y. and Rapoport, T.A. (2002) Retro-translocation of proteins from the endoplasmic reticulum into the cytosol. Nat. Rev. Mol. Cell. Biol., 3, 246-255.
40. Wang, C., Deng, L., Hong, M., Akkaraju, G.R., Inoue, J. and Chen, Z.J. (2001) TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature, 412, 346-351.
41. Wilkinson, C.R., Seeger, M., Hartmann-Petersen, R., Stone, M., Wallace, M., Semple, C. and Gordon, C. (2001) Proteins containing the UBA domain are able to bind to multi-ubiquitin chains. Nat. Cell Biol., 3, 939-943.
42. Withers-Ward, E.S. et al. (1997) Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair. J. Virol., 71, 9732-9742.
43. Yaseen, N.R. and Blobel, G. (1999) Two distinct classes of Ran-binding sites on the nucleoporin Nup-358. Proc. Natl. Acad. Sci. USA, 96, 5516-5521.
44. Ye, Y., Meyer, H.H. and Rapoport, T.A. (2001) The AAA ATPase Cdc48/ p97 and its partners transport proteins from the ER into the cytosol. Nature, 414, 652-656.
45. Yuan, X., Shaw, A., Zhang, X., Kondo, H., Lally, J., Freemont, P.S. and Matthews, S. (2001) Solution structure and interaction surface of the C-terminal domain from p47: A major p97-cofactor involved in SNARE disassembly. J. Mol. Biol., 311, 255-263.