Solution structures of UBA domains reveal a conserved hydrophobic surface for protein-protein interactions

Journal of Molecular Biology

Volumn 319, Issue 5, 2002, Pages 1243-1255

  Mueller, Thomas D ^a   Feigon, Juli ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

HHR23A; NMR; Proteasome; Ubiquitin; Vpr

Indexed keywords

FUNGAL PROTEIN; PROTEIN; PROTEIN KINASE; PROTEIN RAD23A; UBIQUITIN ASSOCIATED PROTEIN; UNCLASSIFIED DRUG; VPR PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; BETA SHEET; BINDING SITE; CARBOXY TERMINAL SEQUENCE; EXCISION REPAIR; HYDROPHOBICITY; MUTAGENESIS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PREDICTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0036300780     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)00302-9     Document Type: Article

References (40)

1. The Saccharomyces cerevisiae DNA repair gene RAD23 encodes a nuclear protein containing a ubiquitin-like domain required for biological function
2. Purification and cloning of a nucleotide excision repair complex involving the xeroderma pigmentosum group C protein and a human homologue of yeast RAD23
3. XPC and human homologs of RAD23: Intracellular localization and relationship to other nucleotide excision repair complexes
4. Identification and characterization of XPC-binding domain of hHR23B
5. Two human homologs of Rad23 are functionally interchangeable in complex formation and stimulation of XPC repair activity
6. Rad23 links DNA repair to the ubiquitin/proteasome pathway
7. Interaction of hHR23 with S5a. The ubiquitin-like domain of hHR23 mediates interaction with S5a subunit of 26 S proteasome
8. The UBA domain: A sequence motif present in multiple enzyme classes of the ubiquitination pathway
9. p62, A phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins
10. UBA domains of DNA damage-inducible proteins interact with ubiquitin
11. Ubiquitin-associated (UBA) domains in Rad23 bind ubiquitin and promote inhibition of multi-ubiquitin chain assembly
12. Proteins containing the UBA domain are able to bind to multi-ubiquitin chains
13. Human immunodeficiency virus type 1 Vpr interacts with HHR23A, a cellular protein implicated in nucleotide excision DNA repair
14. 3-Methyladenine-DNA glycosylase (MPG protein) interacts with human RAD23 proteins
15. Rad23 provides a link between the Png1 deglycosylating enzyme and the 26 S proteasome in yeast
16. Human homologue of yeast Rad23 protein A interacts with p300/cyclic AMP-responsive element binding (CREB)-binding protein to down-regulate transcriptional activity of p53
17. Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination
18. Structure of a human DNA repair protein UBA domain that interacts with HIV-1 Vpr
19. Biochemical and structural analysis of the interaction between the UBA(2) domain of the DNA repair protein HHR23A and HIV-1 Vpr
20. Amino acid preferences for specific locations at the ends of alpha helices
21. The DNA repair protein rad23 is a negative regulator of multi-ubiquitin chain assembly
22. Structure of a diubiquitin conjugate and a model for interaction with ubiquitin conjugating enzyme (E2)
23. Structure of tetraubiquitin shows how multiubiquitin chains can be formed
24. An NMR analysis of ubiquitin recognition by yeast ubiquitin hydrolase: Evidence for novel substrate recognition by a cysteine protease
25. Ubiquitin binding interface mapping on yeast ubiquitin hydrolase by NMR chemical shift perturbation
26. The binding interface between an E2 (UBC9) and a ubiquitin homologue (UBL1)
27. Characterization of the binding interface between ubiquitin and class I human ubiquitin-conjugating enzyme 2b by multidimensional heteronuclear NMR spectroscopy in solution
28. Identification of the ubiquitin interfacial residues in a ubiquitin-E2 covalent complex
29. The hydrophobic effect contributes to polyubiquitin chain recognition
30. Dosage suppressors of pds1 implicate ubiquitin-associated domains in checkpoint control
31. 1H, 13C and 15N chemical shift referencing in biomolecular NMR
32. Determination of three-dimensional structures of proteins from interproton distance data by dynamical simulated annealing from a random array of atoms. Circumventing problems associated with folding
33. Determination of three-dimensional structures of proteins by simulated annealing with interproton distance restraints. Application to crambin, potato carboxypeptidase inhibitor and barley serine proteinase inhibitor 2
34. CHARMM: A program for macromolecular energy, minimization, and dynamics calculations
35. PROCHECK: A program to check the stereochemical quality of protein structures
36. PROMOTIF - A program to identify and analyze structural motifs in proteins
37. Residual colours: A proposal for aminochromography