The polyglutamine neurodegenerative protein ataxin-3 binds polyubiquitylated proteins and has ubiquitin protease activity

Human Molecular Genetics

Volumn 12, Issue 23, 2003, Pages 3195-3205

  Burnett, Barrington ^a   Li, Fusheng ^a   Pittman, Randall N ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DERIVATIVE; ATAXIN 3; BINDING PROTEIN; CYSTEINE; LEUCINE; POLYGLUTAMINE; POLYUBIQUITIN; PROTEASOME; PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SUBSTRATE; GENE MUTATION; GENETIC CONSERVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN INTERACTION;

ANIMALS; BINDING SITES; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; CYSTEINE ENDOPEPTIDASES; ESCHERICHIA COLI; MULTIENZYME COMPLEXES; MURAMIDASE; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; UBIQUITIN;

EID: 0345099501     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddg344     Document Type: Article

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