Rab5-dependent Trafficking of the m4 Muscarinic Acetylcholine Receptor to the Plasma Membrane, Early Endosomes, and Multivesicular Bodies

Journal of Biological Chemistry

Volumn 276, Issue 50, 2001, Pages 47590-47598

  Volpicelli, Laura A ^a   Lah, James J ^a   Levey, Allan I ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; BIOMARKERS; DEGRADATION; ELECTRON MICROSCOPY; PROTEINS;

INTRACELLULAR TRAFFICKING;

BIOLOGICAL MEMBRANES;

CARBACHOL; CELL MARKER; CYCLOHEXIMIDE; G PROTEIN COUPLED RECEPTOR; MEMBRANE RECEPTOR; MUSCARINIC M4 RECEPTOR; PROTEIN; PROTEIN EEA1; PROTEIN RAB5Q79L; PROTEIN RAB5S34N; RAB PROTEIN; RECEPTOR SUBTYPE; TRANSFERRIN; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ATROPINE; CHOLINERGIC RECEPTOR STIMULATING AGENT; LIGAND; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; NA(+) K(+) EXCHANGING ATPASE; PROTEIN SYNTHESIS INHIBITOR; RAB5 GTP BINDING PROTEINS;

ANIMAL CELL; ANTIBODY SPECIFICITY; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; ENDOCYTOSIS; ENDOSOME; IMMUNOCYTOCHEMISTRY; INTRACELLULAR TRANSPORT; LIGAND BINDING; MEMBRANE BINDING; MEMBRANE VESICLE; MENTAL DISEASE; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUANTITATIVE DIAGNOSIS; RECEPTOR BINDING; RECYCLING; ANIMAL; BIOSYNTHESIS; CELL MEMBRANE; CELL STRAIN; DOMINANT GENE; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MUTATION; PLASMID; PROTEIN BINDING; PROTEIN TRANSPORT; RAT; SITE DIRECTED MUTAGENESIS; TIME; ULTRASTRUCTURE;

ANIMALIA;

ANIMAL; ATROPINE; CARBACHOL; CELL MEMBRANE; CHOLINERGIC AGONISTS; CYCLOHEXIMIDE; ENDOCYTOSIS; ENDOSOMES; GENES, DOMINANT; IMMUNOHISTOCHEMISTRY; LIGANDS; MICROSCOPY, ELECTRON; MUSCARINIC ANTAGONISTS; MUTAGENESIS, SITE-DIRECTED; MUTATION; NA(+)-K(+)-EXCHANGING ATPASE; PC12 CELLS; PLASMIDS; PROTEIN BINDING; PROTEIN SYNTHESIS INHIBITORS; PROTEIN TRANSPORT; RAB5 GTP-BINDING PROTEINS; RATS; RECEPTORS, MUSCARINIC; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS; TRANSFECTION; TRANSFERRIN; VACUOLES;

EID: 0035861729     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M106535200     Document Type: Article

References (31)

1. Koenig, J. A., and Edwardson, J. M. (1997) Trends Pharmacol. Sci. 18, 276-287
2. Ghosh, R. N., Gelman, D. L., and Maxfield, F. R. (1994) J. Cell Sci. 107, 2177-2189
3. Sonnichsen, B., De Renzis, S., Nielsen, E., Rietdorf, J., and Zerial, M. (2000) J. Cell Biol. 149, 901-914
4. Ullrich, O., Reinsch, S., Urbe, S., Zerial, M., and Parton, R. G. (1996) J. Cell Biol. 135, 913-924
5. Somsel Rodman, J., and Wandinger-Ness, A. (2000) J. Cell Sci. 113, 183-192
6. Stenmark, H., Parton, R. G., Steele-Mortimer, O., Lutcke, A., Gruenberg, J., and Zerial, M. (1994) EMBO J. 13, 1287-1296
7. Gomeza, J., Zhang, L., Kostenis, E., Felder, C., Bymaster, F., Brodkin, J., Shannon, H., Xia, B., Deng, C., and Wess, J. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 10483-10488
8. Flynn, D. D., Ferrari-DiLeo, G., Mash, D. C., and Levey, A. I. (1995) J. Neurochem. 64, 1888-1891
9. Felder, C. C., Porter, A. C., Skillman, T. L., Zhang, L., Bymaster, F. P., Nathanson, N. M., Hamilton, S. E., Gomeza, J., Wess, J., and McKinzie, D. L. (2001) Life Sci. 68, 2605-2613
10. Caulfield, M. P. (1993) Pharmacol. Ther. 58, 319-379
11. Krudewig, R., Langer, B., Vogler, O., Markschies, N., Erl, M., Jakobs, K. H., and van Koppen, C. J. (2000) J. Neurochem. 74, 1721-1730
12. Bernheim, L., Mathie, A., and Hille, B. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 9544-9548
13. Koenig, J. A., and Edwardson, J. M. (1996) Mol. Pharmacol. 49, 351-359
14. Berkeley, J. L., and Levey, A. I. (2000) J. Neurochem. 75, 487-493
15. Burry, B. W., and Perrone-Bizzozero, N. I. (1993) J. Neurosci. Res. 36, 241-251
16. Szekeres, P. G., Koenig, J. A., and Edwardson, J. M. (1998) J. Neurochem. 70, 1694-1703
17. Bernard, V., Levey, A. I., and Bloch, B. (1999) J. Neurosci. 19, 10237-10249
18. Levey, A. I., Kitt, C. A., Simonds, W. F., Price, D. L., Brann, M. R. (1991) J. Neurosci. 11, 3218-3226
19. Tsao, P. I., and von Zastrow, M. (2000) J. Biol. Chem. 275, 11130-11140
20. Vogler, O., Bogatkewitsch, G. S., Wriske, C., Krummenerl, P., Jakobs, K. H., and van Koppen, C. J. (1998) J. Biol. Chem. 273, 12155-12160
21. Rubino, M., Miaczynska, M., Lippe, R., and Zerial, M. (2000) J. Biol. Chem. 275, 3745-3748
22. Simonsen, A., Lippe, R., Christoforidis, S., Gaullier, J. M., Brech, A., Callaghan, J., Toh, B. H., Murphy, C., Zerial, M., and Stenmark, H. (1998) Nature 394, 494-498
23. Iwata, K., Ito, K., Fukuzaki, A., Inaki, K., and Haga, T. (1999) Eur. J. Biochem. 263, 596-602
24. Seachrist, J. L., Anborgh, P. H., and Ferguson, S. S. (2000) J. Biol. Chem. 275, 27221-27228
25. Ullrich, O., Horiuchi, H., Bucci, C., and Zerial, M. (1994) Nature 368, 157-160
26. Greene, L. A., and Rein, G. (1977) Nature 268, 349-351
27. Schubert, D., and Klier, F. G. (1977) Proc. Natl. Acad. Sci. U. S. A. 74, 5184-5188
28. Futter, C. E., Pearse, A., Hewlett, L. J., and Hopkins, C. R. (1996) J. Cell Biol. 132, 1011-1023
29. Hopkins, C. R., Gibson, A., Shipman, M., and Miller, K. (1990) Nature 346, 335-339
30. Felder, S., Miller, K., Moehren, G., Ullrich, A., Schlessinger, J., and Hopkins, C. R. (1990) Cell 61, 623-634
31. Tsao, P., Cao, T., and von Zastrow, M. (2001) Trends Pharmacol. Sci. 22, 91-96