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Volumn 208, Issue 2, 2006, Pages 233-248

Helicobacter infection and gastric neoplasia

Author keywords

Cag pathogenicity island; Cytokine gene polymorphisms; Gastric neoplasia; Helicobacter pylori; Inflammation; VacA

Indexed keywords

CAGA PROTEIN; CYTOTOXIN; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

EID: 31144461664     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.1868     Document Type: Review
Times cited : (497)

References (206)
  • 1
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens LM, Werb Z. Inflammation and cancer. Nature 2002;420:860-867.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 2
    • 0036370334 scopus 로고    scopus 로고
    • Helicobacter pylori and gastrointestinal tract adenocarcinomas
    • Peek RM Jr, Blaser MJ. Helicobacter pylori and gastrointestinal tract adenocarcinomas. Nature Rev Cancer 2002;2:28-37.
    • (2002) Nature Rev Cancer , vol.2 , pp. 28-37
    • Peek Jr., R.M.1    Blaser, M.J.2
  • 3
    • 4344704061 scopus 로고    scopus 로고
    • Is gastric cancer preventable?
    • Correa P. Is gastric cancer preventable? Gut 2004;53:1217-1219.
    • (2004) Gut , vol.53 , pp. 1217-1219
    • Correa, P.1
  • 5
    • 0029956022 scopus 로고    scopus 로고
    • Helicobacter pylori and gastric cancer: State of the art
    • Correa P. Helicobacter pylori and gastric cancer: state of the art. Cancer Epidemiol Biomarkers Prev 1996;5:477-481.
    • (1996) Cancer Epidemiol Biomarkers Prev , vol.5 , pp. 477-481
    • Correa, P.1
  • 6
    • 13644269831 scopus 로고    scopus 로고
    • Gastrointestinal lymphoma: Where morphology meets molecular biology
    • Isaacson PG, Du MQ. Gastrointestinal lymphoma: where morphology meets molecular biology. J Pathol 2005;205:255-274.
    • (2005) J Pathol , vol.205 , pp. 255-274
    • Isaacson, P.G.1    Du, M.Q.2
  • 7
    • 0025740015 scopus 로고
    • Positive serum antibody and negative tissue staining for Helicobacter pylori in subjects with atrophic body gastritis
    • Karnes WE Jr, Samloff IM, Siurala M, Kekki M, Sipponen P, Kim SW, et al. Positive serum antibody and negative tissue staining for Helicobacter pylori in subjects with atrophic body gastritis. Gastroenterology 1991;101:167-174.
    • (1991) Gastroenterology , vol.101 , pp. 167-174
    • Karnes Jr., W.E.1    Samloff, I.M.2    Siurala, M.3    Kekki, M.4    Sipponen, P.5    Kim, S.W.6
  • 8
    • 0025871037 scopus 로고
    • Association between infection with Helicobacter pylori and risk of gastric cancer: Evidence from a prospective investigation
    • Forman D, Newell DG, Fullerton F, Yarnell JW, Stacey AR, Wald N, et al. Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. Br Med J 1991;302:1302-1305.
    • (1991) Br Med J , vol.302 , pp. 1302-1305
    • Forman, D.1    Newell, D.G.2    Fullerton, F.3    Yarnell, J.W.4    Stacey, A.R.5    Wald, N.6
  • 11
    • 0030839749 scopus 로고    scopus 로고
    • Helicobacter pylori infection and gastric cancer. A nested case-control study in a rural area of Japan
    • Watanabe Y, Kurata JH, Mizuno S, Mukai M, Inokuchi H, Miki K, et al. Helicobacter pylori infection and gastric cancer. A nested case-control study in a rural area of Japan. Dig Dis Sci 1997;42:1383-1387.
    • (1997) Dig Dis Sci , vol.42 , pp. 1383-1387
    • Watanabe, Y.1    Kurata, J.H.2    Mizuno, S.3    Mukai, M.4    Inokuchi, H.5    Miki, K.6
  • 12
    • 0031465972 scopus 로고    scopus 로고
    • Association between Helicobacter pylori and gastric carcinoma in the city of Malmo, Sweden. A prospective study
    • Siman JH, Forsgren A, Berglund G, Floren CH. Association between Helicobacter pylori and gastric carcinoma in the city of Malmo, Sweden. A prospective study. Scand J Gastroenterol 1997;32:1215-1221.
    • (1997) Scand J Gastroenterol , vol.32 , pp. 1215-1221
    • Siman, J.H.1    Forsgren, A.2    Berglund, G.3    Floren, C.H.4
  • 15
    • 0028037438 scopus 로고
    • Association of Helicobacter pylori with gastric cancer and observations on the detection of this bacterium in gastric cancer cases
    • Hu PJ, Mitchell HM, Li YY, Zhou MH, Hazell SL. Association of Helicobacter pylori with gastric cancer and observations on the detection of this bacterium in gastric cancer cases. Am J Gastroenterol 1994;89:1806-1810.
    • (1994) Am J Gastroenterol , vol.89 , pp. 1806-1810
    • Hu, P.J.1    Mitchell, H.M.2    Li, Y.Y.3    Zhou, M.H.4    Hazell, S.L.5
  • 16
    • 0029019917 scopus 로고
    • Serum anti-Helicobacter pylori antibody and gastric carcinoma among young adults
    • Research Group on Prevention of Gastric Carcinoma among Young Adults
    • Kikuchi S, Wada O, Nakajima T, Nishi T, Kobayashi O, Konishi T, et al. Serum anti-Helicobacter pylori antibody and gastric carcinoma among young adults. Research Group on Prevention of Gastric Carcinoma among Young Adults. Cancer 1995;75:2789-2793.
    • (1995) Cancer , vol.75 , pp. 2789-2793
    • Kikuchi, S.1    Wada, O.2    Nakajima, T.3    Nishi, T.4    Kobayashi, O.5    Konishi, T.6
  • 18
    • 0030983167 scopus 로고    scopus 로고
    • Significance of Helicobacter pylori infection as a risk factor in gastric cancer: Serological and histological studies
    • Barreto-Zuniga R, Maruyama M, Kato Y, Aizu K, Ohta H, Takekoshi T, et al. Significance of Helicobacter pylori infection as a risk factor in gastric cancer: serological and histological studies. J Gastroenterol 1997;32:289-294.
    • (1997) J Gastroenterol , vol.32 , pp. 289-294
    • Barreto-Zuniga, R.1    Maruyama, M.2    Kato, Y.3    Aizu, K.4    Ohta, H.5    Takekoshi, T.6
  • 19
    • 0031564161 scopus 로고    scopus 로고
    • Histological diagnosis of Helicobacter pylori gastritis is predictive of a high risk of gastric carcinoma
    • Miehlke S, Hackelsberger A, Meining A, von Arnim U, Muller P, Ochsenkuhn T, et al. Histological diagnosis of Helicobacter pylori gastritis is predictive of a high risk of gastric carcinoma. Int J Cancer 1997;73:837-839.
    • (1997) Int J Cancer , vol.73 , pp. 837-839
    • Miehlke, S.1    Hackelsberger, A.2    Meining, A.3    von Arnim, U.4    Muller, P.5    Ochsenkuhn, T.6
  • 20
    • 0034878894 scopus 로고    scopus 로고
    • Gastric cancer and Helicobacter pylori: A combined analysis of 12 case control studies nested within prospective cohorts
    • Helicobacter and Cancer Collaborative Group
    • Helicobacter and Cancer Collaborative Group. Gastric cancer and Helicobacter pylori:a combined analysis of 12 case control studies nested within prospective cohorts. Gut 2001;49:347-353.
    • (2001) Gut , vol.49 , pp. 347-353
  • 22
    • 0037352558 scopus 로고    scopus 로고
    • Role of Helicobacter pylori CagA+ strains and risk of adenocarcinoma of the stomach and esophagus
    • Wu AH, Crabtree JE, Bernstein L, Hawtin P, Cockburn M, Tseng CC, et al. Role of Helicobacter pylori CagA+ strains and risk of adenocarcinoma of the stomach and esophagus. Int J Cancer 2003;103:815-821.
    • (2003) Int J Cancer , vol.103 , pp. 815-821
    • Wu, A.H.1    Crabtree, J.E.2    Bernstein, L.3    Hawtin, P.4    Cockburn, M.5    Tseng, C.C.6
  • 24
    • 0033552961 scopus 로고    scopus 로고
    • Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori
    • Alm RA, Ling LS, Moir DT, King BL, Brown ED, Doig PC, et al. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature 1999;397:176-180.
    • (1999) Nature , vol.397 , pp. 176-180
    • Alm, R.A.1    Ling, L.S.2    Moir, D.T.3    King, B.L.4    Brown, E.D.5    Doig, P.C.6
  • 25
    • 0029935007 scopus 로고    scopus 로고
    • Population genetic analysis of Helicobacter pylori by multilocus enzyme electrophoresis: Extensive allelic diversity and recombinational population structure
    • Go MF, Kapur V, Graham DY, Musser JM. Population genetic analysis of Helicobacter pylori by multilocus enzyme electrophoresis: extensive allelic diversity and recombinational population structure. J Bacteriol 1996;178:3934-3938.
    • (1996) J Bacteriol , vol.178 , pp. 3934-3938
    • Go, M.F.1    Kapur, V.2    Graham, D.Y.3    Musser, J.M.4
  • 28
    • 0029963677 scopus 로고    scopus 로고
    • Cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors
    • Censini S, Lange C, Xiang Z, Crabtree JE, Ghiara P, Borodovsky M, et al. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc Natl Acad Sci U S A 1996;93:14648-14653.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 14648-14653
    • Censini, S.1    Lange, C.2    Xiang, Z.3    Crabtree, J.E.4    Ghiara, P.5    Borodovsky, M.6
  • 30
    • 0025101087 scopus 로고
    • Characterization of and human serologic response to proteins in Helicobacter pylori broth culture supernatants with vacuolizing cytotoxin activity
    • Cover TL, Dooley CP, Blaser MJ. Characterization of and human serologic response to proteins in Helicobacter pylori broth culture supernatants with vacuolizing cytotoxin activity. Infect Immun 1990;58:603-610.
    • (1990) Infect Immun , vol.58 , pp. 603-610
    • Cover, T.L.1    Dooley, C.P.2    Blaser, M.J.3
  • 31
    • 0025807183 scopus 로고
    • Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology
    • Crabtree JE, Taylor JD, Wyatt JI, Heatley RV, Shallcross TM, Tompkins DS, et al. Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulceration, and gastric pathology. Lancet 1991;338:332-335.
    • (1991) Lancet , vol.338 , pp. 332-335
    • Crabtree, J.E.1    Taylor, J.D.2    Wyatt, J.I.3    Heatley, R.V.4    Shallcross, T.M.5    Tompkins, D.S.6
  • 32
    • 0029561158 scopus 로고
    • Heightened inflammatory response and cytokine expression in vivo to cagA+ Helicobacter pylori strains
    • Peek RM Jr, Miller GG, Tham KT, Perez-Perez GI, Zhao XM, Atherton JC, et al. Heightened inflammatory response and cytokine expression in vivo to cagA+ Helicobacter pylori strains. Lab Invest 1995;73:760-770.
    • (1995) Lab Invest , vol.73 , pp. 760-770
    • Peek Jr., R.M.1    Miller, G.G.2    Tham, K.T.3    Perez-Perez, G.I.4    Zhao, X.M.5    Atherton, J.C.6
  • 35
    • 0029899369 scopus 로고    scopus 로고
    • Antibodies to CagA protein are associated with gastric atrophy in Helicobacter pylori infection
    • Beales IL, Crabtree JE, Scunes D, Covacci A, Calam J. Antibodies to CagA protein are associated with gastric atrophy in Helicobacter pylori infection. Eur J Gastroenterol Hepatol 1996;8:645-649.
    • (1996) Eur J Gastroenterol Hepatol , vol.8 , pp. 645-649
    • Beales, I.L.1    Crabtree, J.E.2    Scunes, D.3    Covacci, A.4    Calam, J.5
  • 37
    • 0029043658 scopus 로고
    • Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach
    • Blaser MJ, Perez-Perez GI, Kleanthous H, Cover TL, Peek RM, Chyou PH, et al. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res 1995;55:2111-2115.
    • (1995) Cancer Res , vol.55 , pp. 2111-2115
    • Blaser, M.J.1    Perez-Perez, G.I.2    Kleanthous, H.3    Cover, T.L.4    Peek, R.M.5    Chyou, P.H.6
  • 38
    • 0030975595 scopus 로고    scopus 로고
    • Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection
    • Parsonnet J, Friedman GD, Orentreich N, Vogelman H. Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut 1997;40:297-301.
    • (1997) Gut , vol.40 , pp. 297-301
    • Parsonnet, J.1    Friedman, G.D.2    Orentreich, N.3    Vogelman, H.4
  • 39
    • 0030764244 scopus 로고    scopus 로고
    • Serum antibodies against Helicobacter pylori proteins VacA and CagA are associated with increased risk for gastric adenocarcinoma
    • Rudi J, Kolb C, Maiwald M, Zuna I, von Herbay A, Galle PR, et al. Serum antibodies against Helicobacter pylori proteins VacA and CagA are associated with increased risk for gastric adenocarcinoma. Dig Dis Sci 1997;42:1652-1659.
    • (1997) Dig Dis Sci , vol.42 , pp. 1652-1659
    • Rudi, J.1    Kolb, C.2    Maiwald, M.3    Zuna, I.4    von Herbay, A.5    Galle, P.R.6
  • 41
    • 0032578692 scopus 로고    scopus 로고
    • Infection with CagA+ Helicobacter pylori strains as a possible predictor of risk in the development of gastric adenocarcinoma in Mexico
    • Torres J, Perez-Perez GI, Leal-Herrera Y, Munoz O. Infection with CagA+ Helicobacter pylori strains as a possible predictor of risk in the development of gastric adenocarcinoma in Mexico. Int J Cancer 1998;78:298-300.
    • (1998) Int J Cancer , vol.78 , pp. 298-300
    • Torres, J.1    Perez-Perez, G.I.2    Leal-Herrera, Y.3    Munoz, O.4
  • 43
    • 0031978227 scopus 로고    scopus 로고
    • CagA seropositivity associated with development of gastric cancer in a Japanese population
    • Shimoyama T, Fukuda S, Tanaka M, Mikami T, Munakata A, Crabtree JE. CagA seropositivity associated with development of gastric cancer in a Japanese population. J Clin Pathol 1998;51:225-228.
    • (1998) J Clin Pathol , vol.51 , pp. 225-228
    • Shimoyama, T.1    Fukuda, S.2    Tanaka, M.3    Mikami, T.4    Munakata, A.5    Crabtree, J.E.6
  • 44
    • 0032926290 scopus 로고    scopus 로고
    • Gastric cancer, cytotoxin associated gene A positive Helicobacter pylori and serum pepsinogens: An international study
    • Webb PM, Crabtree JE, Forman D. Gastric cancer, cytotoxin associated gene A positive Helicobacter pylori and serum pepsinogens: an international study. Gastroenterology 1999;116:269-276.
    • (1999) Gastroenterology , vol.116 , pp. 269-276
    • Webb, P.M.1    Crabtree, J.E.2    Forman, D.3
  • 45
    • 0033456273 scopus 로고    scopus 로고
    • Altered states: Involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori
    • Segal ED, Cha J, Lo J, Falkow S, Tompkins LS. Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori. Proc Natl Acad Sci U S A 1999;96:14559-14564.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 14559-14564
    • Segal, E.D.1    Cha, J.2    Lo, J.3    Falkow, S.4    Tompkins, L.S.5
  • 46
    • 17344379177 scopus 로고    scopus 로고
    • Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion
    • Odenbreit S, Puls J, Sedlmaier B, Gerland E, Fischer W, Haas R. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science 2000;287:1497-1500.
    • (2000) Science , vol.287 , pp. 1497-1500
    • Odenbreit, S.1    Puls, J.2    Sedlmaier, B.3    Gerland, E.4    Fischer, W.5    Haas, R.6
  • 47
    • 0033953359 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation
    • Stein M, Rappuoli R, Covacci A. Tyrosine phosphorylation of the Helicobacter pylori CagA antigen after cag-driven host cell translocation. Proc Natl Acad Sci USA 2000;97:1263-1268.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1263-1268
    • Stein, M.1    Rappuoli, R.2    Covacci, A.3
  • 48
    • 0034695875 scopus 로고    scopus 로고
    • Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells
    • Asahi M, Azuma T, Ito S, Ito Y, Suto H, Nagai Y, et al. Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells. J Exp Med 2000;191:593-602.
    • (2000) J Exp Med , vol.191 , pp. 593-602
    • Asahi, M.1    Azuma, T.2    Ito, S.3    Ito, Y.4    Suto, H.5    Nagai, Y.6
  • 49
    • 0034042694 scopus 로고    scopus 로고
    • Translocation of the Helicobacter pylori CagA protein in gastric epithelial cells by a type IV secretion apparatus
    • Backert S, Ziska E, Brinkmann V, Zimny-Arndt U, Fauconnier A, Jungblut PR, et al. Translocation of the Helicobacter pylori CagA protein in gastric epithelial cells by a type IV secretion apparatus. Cell Microbiol 2000;2:155-164.
    • (2000) Cell Microbiol , vol.2 , pp. 155-164
    • Backert, S.1    Ziska, E.2    Brinkmann, V.3    Zimny-Arndt, U.4    Fauconnier, A.5    Jungblut, P.R.6
  • 50
    • 0036510363 scopus 로고    scopus 로고
    • Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo
    • Selbach M, Moese S, Hauck CR, Meyer TF, Backert S. Src is the kinase of the Helicobacter pylori CagA protein in vitro and in vivo. J Biol Chem 2002;277:6775-6778.
    • (2002) J Biol Chem , vol.277 , pp. 6775-6778
    • Selbach, M.1    Moese, S.2    Hauck, C.R.3    Meyer, T.F.4    Backert, S.5
  • 51
    • 0036227053 scopus 로고    scopus 로고
    • c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs
    • Stein M, Bagnoli F, Halenbeck R, Rappuoli R, Fantl WJ, Covacci A. c-Src/Lyn kinases activate Helicobacter pylori CagA through tyrosine phosphorylation of the EPIYA motifs. Mol Microbiol 2002;43:971-980.
    • (2002) Mol Microbiol , vol.43 , pp. 971-980
    • Stein, M.1    Bagnoli, F.2    Halenbeck, R.3    Rappuoli, R.4    Fantl, W.J.5    Covacci, A.6
  • 52
    • 0037169076 scopus 로고    scopus 로고
    • SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein
    • Higashi H, Tsutsumi R, Muto S, Sugiyama T, Azuma T, Asaka M, et al. SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science 2002;295:683-686.
    • (2002) Science , vol.295 , pp. 683-686
    • Higashi, H.1    Tsutsumi, R.2    Muto, S.3    Sugiyama, T.4    Azuma, T.5    Asaka, M.6
  • 53
    • 0037195107 scopus 로고    scopus 로고
    • Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites
    • Higashi H, Tsutsumi R, Fujita A, Yamazaki S, Asaka M, Azuma T, et al. Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites. Proc Natl Acad Sci U S A 2002;99:14428-14433.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 14428-14433
    • Higashi, H.1    Tsutsumi, R.2    Fujita, A.3    Yamazaki, S.4    Asaka, M.5    Azuma, T.6
  • 54
    • 0037423309 scopus 로고    scopus 로고
    • Attenuation of Helicobacter pylori CagA-SHP-2 signaling by interaction between CagA and C-terminal Src kinase
    • Tsutsumi R, Higashi H, Higuchi M, Okada M, Hatakeyama M. Attenuation of Helicobacter pylori CagA-SHP-2 signaling by interaction between CagA and C-terminal Src kinase. J Biol Chem 2003;2778:3664-3670.
    • (2003) J Biol Chem , vol.2778 , pp. 3664-3670
    • Tsutsumi, R.1    Higashi, H.2    Higuchi, M.3    Okada, M.4    Hatakeyama, M.5
  • 55
    • 2342429370 scopus 로고    scopus 로고
    • Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation
    • Higashi H, Nakaya A, Tsutsumi R, Yokoyama K, Fujii Y, Ishikawa S, et al. Helicobacter pylori CagA induces Ras-independent morphogenetic response through SHP-2 recruitment and activation. J Biol Chem 2004;279:17205-17216.
    • (2004) J Biol Chem , vol.279 , pp. 17205-17216
    • Higashi, H.1    Nakaya, A.2    Tsutsumi, R.3    Yokoyama, K.4    Fujii, Y.5    Ishikawa, S.6
  • 56
    • 0035930508 scopus 로고    scopus 로고
    • Cag+ Helicobacter pylori induce transactivation of the epidermal growth factor receptor in AGS gastric epithelial cells
    • Keates S, Sougioultzis S, Keates AC, Zhao D, Peek RM, Shaw LM,et al. cag+ Helicobacter pylori induce transactivation of the epidermal growth factor receptor in AGS gastric epithelial cells. J Biol Chem 2001;276:48127-48134.
    • (2001) J Biol Chem , vol.276 , pp. 48127-48134
    • Keates, S.1    Sougioultzis, S.2    Keates, A.C.3    Zhao, D.4    Peek, R.M.5    Shaw, L.M.6
  • 57
    • 25444506882 scopus 로고    scopus 로고
    • Transactivation of the EGFR by cag+ Helicobacter pylori induces upregulation of the early growth response gene Egr-1 in gastric epithelial cells
    • Keates S, Keates AC, Nath S, Peek RM, Kelly CP. Transactivation of the EGFR by cag+ Helicobacter pylori induces upregulation of the early growth response gene Egr-1 in gastric epithelial cells. Gut 2005;54:1363-1369.
    • (2005) Gut , vol.54 , pp. 1363-1369
    • Keates, S.1    Keates, A.C.2    Nath, S.3    Peek, R.M.4    Kelly, C.P.5
  • 59
    • 0040187860 scopus 로고    scopus 로고
    • Helicobacter pylori activates the histidine decarboxylase promoter through a mitogen-activated protein kinase pathway independent of pathogenicity island-encoded virulence factors
    • Wessler S, Hocker M, Fischer W, Meyer TF, Schoneberg T, Hocker M, et al. Helicobacter pylori activates the histidine decarboxylase promoter through a mitogen-activated protein kinase pathway independent of pathogenicity island-encoded virulence factors. J Biol Chem 2000;275:3629-3636.
    • (2000) J Biol Chem , vol.275 , pp. 3629-3636
    • Wessler, S.1    Hocker, M.2    Fischer, W.3    Meyer, T.F.4    Schoneberg, T.5    Hocker, M.6
  • 60
    • 0346729816 scopus 로고    scopus 로고
    • Helicobacter pylori-induced epithelial cell signalling in gastric carcinogenesis
    • Naumann M, Crabtree JE. Helicobacter pylori-induced epithelial cell signalling in gastric carcinogenesis. Trends Microbiol 2004;12:29-36.
    • (2004) Trends Microbiol , vol.12 , pp. 29-36
    • Naumann, M.1    Crabtree, J.E.2
  • 61
    • 0033571334 scopus 로고    scopus 로고
    • Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag-Helicobacter pylori
    • Keates S, Keates AC, Warny M, Peek RM Jr, Murray PG, Kelly CP. Differential activation of mitogen-activated protein kinases in AGS gastric epithelial cells by cag+ and cag-Helicobacter pylori. J Immunol 1999;163:5552-5559.
    • (1999) J Immunol , vol.163 , pp. 5552-5559
    • Keates, S.1    Keates, A.C.2    Warny, M.3    Peek Jr., R.M.4    Murray, P.G.5    Kelly, C.P.6
  • 62
    • 1342347651 scopus 로고    scopus 로고
    • Helicobacter pylori gamma-glutamyltranspeptidase upregulates COX-2 and EGF-related peptide expression in human gastric cells
    • Busiello I, Acquaviva R, Di Popolo A, Blanchard TG, Ricci V, Romano M, et al. Helicobacter pylori gamma-glutamyltranspeptidase upregulates COX-2 and EGF-related peptide expression in human gastric cells. Cell Microbiol 2004;6:255-267.
    • (2004) Cell Microbiol , vol.6 , pp. 255-267
    • Busiello, I.1    Acquaviva, R.2    Di Popolo, A.3    Blanchard, T.G.4    Ricci, V.5    Romano, M.6
  • 63
    • 0037415684 scopus 로고    scopus 로고
    • The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation
    • Selbach M, Moese S, Hurwitz R, Hauck CR, Meyer TF, Backert S. The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation. EMBO J 2003;22:515-528.
    • (2003) EMBO J , vol.22 , pp. 515-528
    • Selbach, M.1    Moese, S.2    Hurwitz, R.3    Hauck, C.R.4    Meyer, T.F.5    Backert, S.6
  • 64
  • 65
    • 0037732638 scopus 로고    scopus 로고
    • Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response
    • Churin Y, Al-Ghoul L, Kepp O, Meyer TF, Birchmeier W, Naumann M. Helicobacter pylori CagA protein targets the c-Met receptor and enhances the motogenic response. J Cell Biol 2003;161:249-255.
    • (2003) J Cell Biol , vol.161 , pp. 249-255
    • Churin, Y.1    Al-Ghoul, L.2    Kepp, O.3    Meyer, T.F.4    Birchmeier, W.5    Naumann, M.6
  • 66
    • 0028802245 scopus 로고
    • Induction of interleukin-8 secretion from gastric epithelial cells by cagA negative isogenic mutant of Helicobacter pylori
    • Crabtree JE, Xiang Z, Lindley IJD, Tompkins DS, Rappuoli R, Covacci A. Induction of interleukin-8 secretion from gastric epithelial cells by cagA negative isogenic mutant of Helicobacter pylori. J Clin Pathol 1995;48:967-969.
    • (1995) J Clin Pathol , vol.48 , pp. 967-969
    • Crabtree, J.E.1    Xiang, Z.2    Lindley, I.J.D.3    Tompkins, D.S.4    Rappuoli, R.5    Covacci, A.6
  • 67
    • 0031899363 scopus 로고    scopus 로고
    • Proteins encoded by the cag pathogenicity island of Helicobacter pylori are required for NF-kappaB activation
    • Glocker E, Lange C, Covacci A, Bereswill S, Kist M, Pahl HL. Proteins encoded by the cag pathogenicity island of Helicobacter pylori are required for NF-kappaB activation. Infect Immun 1998;66:2346-2348.
    • (1998) Infect Immun , vol.66 , pp. 2346-2348
    • Glocker, E.1    Lange, C.2    Covacci, A.3    Bereswill, S.4    Kist, M.5    Pahl, H.L.6
  • 68
    • 0032769215 scopus 로고    scopus 로고
    • Multiple genes in the left half of the cag pathogenicity island of Helicobacter pylori are required for tyrosine kinase-dependent transcription of interleukin-8 in gastric epithelial cells
    • Li SD, Kersulyte D, Lindley IJ, Neelam B, Berg DE, Crabtree JE. Multiple genes in the left half of the cag pathogenicity island of Helicobacter pylori are required for tyrosine kinase-dependent transcription of interleukin-8 in gastric epithelial cells. Infect Immun 1999;67:3893-3899.
    • (1999) Infect Immun , vol.67 , pp. 3893-3899
    • Li, S.D.1    Kersulyte, D.2    Lindley, I.J.3    Neelam, B.4    Berg, D.E.5    Crabtree, J.E.6
  • 69
    • 0033615661 scopus 로고    scopus 로고
    • Activation of activator protein 1 and stress response kinases in epithelial cells colonized by Helicobacter pylori encoding the cag pathogenicity island
    • Naumann M, Wessler S, Bartsch C, Wieland B, Covacci A, Haas R, et al. Activation of activator protein 1 and stress response kinases in epithelial cells colonized by Helicobacter pylori encoding the cag pathogenicity island. J Biol Chem 1999;274:31655-31662.
    • (1999) J Biol Chem , vol.274 , pp. 31655-31662
    • Naumann, M.1    Wessler, S.2    Bartsch, C.3    Wieland, B.4    Covacci, A.5    Haas, R.6
  • 70
    • 0032831644 scopus 로고    scopus 로고
    • Modulation of Helicobacter pylori induced interleukin-8 synthesis in gastric epithelial cells mediated by cag PAI encoded VirD4 homologue
    • Crabtree JE, Kersulyte D, Li SD, Lindley IJ, Berg DE. Modulation of Helicobacter pylori induced interleukin-8 synthesis in gastric epithelial cells mediated by cag PAI encoded VirD4 homologue. J Clin Pathol 1999;52:653-657.
    • (1999) J Clin Pathol , vol.52 , pp. 653-657
    • Crabtree, J.E.1    Kersulyte, D.2    Li, S.D.3    Lindley, I.J.4    Berg, D.E.5
  • 71
    • 0034717029 scopus 로고    scopus 로고
    • Helicobacter pylori activates mitogen-activated protein kinase cascades and induces expression of the proto-oncogenes c-fos and c-jun
    • Meyer-Ter-Vehn T, Covacci A, Kist M, Pahl HL. Helicobacter pylori activates mitogen-activated protein kinase cascades and induces expression of the proto-oncogenes c-fos and c-jun. J Biol Chem 2000;275:16064-16072.
    • (2000) J Biol Chem , vol.275 , pp. 16064-16072
    • Meyer-Ter-Vehn, T.1    Covacci, A.2    Kist, M.3    Pahl, H.L.4
  • 72
    • 0035725211 scopus 로고    scopus 로고
    • Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: Essential genes for CagA translocation in host cells and induction of interleukin-8
    • Fischer W, Puls J, Buhrdorf R, Gebert B, Odenbreit S, Haas R. Systematic mutagenesis of the Helicobacter pylori cag pathogenicity island: essential genes for CagA translocation in host cells and induction of interleukin-8. Mol Microbiol 2001;42:1337-1348.
    • (2001) Mol Microbiol , vol.42 , pp. 1337-1348
    • Fischer, W.1    Puls, J.2    Buhrdorf, R.3    Gebert, B.4    Odenbreit, S.5    Haas, R.6
  • 74
    • 0028898495 scopus 로고
    • Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype
    • Crabtree JE, Covacci A, Farmery S, Xiang Z, Tompkins DS, Perry S, et al. Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype. J Clin Pathol 1995;48:41-45.
    • (1995) J Clin Pathol , vol.48 , pp. 41-45
    • Crabtree, J.E.1    Covacci, A.2    Farmery, S.3    Xiang, Z.4    Tompkins, D.S.5    Perry, S.6
  • 75
    • 0028961743 scopus 로고
    • Interleukin-8 response of gastric epithelial cell lines to Helicobacter pylori stimulation in vitro
    • Sharma SA, Tummuru MK, Miller GG, Blaser MJ. Interleukin-8 response of gastric epithelial cell lines to Helicobacter pylori stimulation in vitro. Infect Immun 1995;63:1681-1687.
    • (1995) Infect Immun , vol.63 , pp. 1681-1687
    • Sharma, S.A.1    Tummuru, M.K.2    Miller, G.G.3    Blaser, M.J.4
  • 76
    • 0028814039 scopus 로고
    • Expression of interleukin 8 and CD54 by human gastric epithelium after Helicobacter pylori infection in vitro
    • Crowe SE, Alvarez L, Dytoc M, Hunt RH, Muller M, Sherman P, et al. Expression of interleukin 8 and CD54 by human gastric epithelium after Helicobacter pylori infection in vitro. Gastroenterology 1995;108:65-74.
    • (1995) Gastroenterology , vol.108 , pp. 65-74
    • Crowe, S.E.1    Alvarez, L.2    Dytoc, M.3    Hunt, R.H.4    Muller, M.5    Sherman, P.6
  • 77
    • 0029891126 scopus 로고    scopus 로고
    • Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa
    • Yamaoka Y, Kita M, Kodama T, Sawai N, Imanishi J. Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa. Gastroenterology 1996;110:1744-1752.
    • (1996) Gastroenterology , vol.110 , pp. 1744-1752
    • Yamaoka, Y.1    Kita, M.2    Kodama, T.3    Sawai, N.4    Imanishi, J.5
  • 78
    • 0031724633 scopus 로고    scopus 로고
    • Chemokine mRNA expression in gastric mucosa is associated with Helicobacter pylori cagA positivity and severity of gastritis
    • Shimoyama T, Everett SM, Dixon MF, Axon ATR, Crabtree JE. Chemokine mRNA expression in gastric mucosa is associated with Helicobacter pylori cagA positivity and severity of gastritis. J Clin Pathol 1998;51:765-770.
    • (1998) J Clin Pathol , vol.51 , pp. 765-770
    • Shimoyama, T.1    Everett, S.M.2    Dixon, M.F.3    Axon, A.T.R.4    Crabtree, J.E.5
  • 79
    • 9244245293 scopus 로고    scopus 로고
    • Nodl responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
    • Viala J, Chaput C, Boneca IG, Cardona A, Girardin SE, Moran AP, et al. Nodl responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nature Immunol 2004;5:1166-1174.
    • (2004) Nature Immunol , vol.5 , pp. 1166-1174
    • Viala, J.1    Chaput, C.2    Boneca, I.G.3    Cardona, A.4    Girardin, S.E.5    Moran, A.P.6
  • 80
    • 0037069449 scopus 로고    scopus 로고
    • Cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection
    • Guillemin K, Salama NR, Tompkins LS, Falkow S. cag pathogenicity island-specific responses of gastric epithelial cells to Helicobacter pylori infection. Proc Natl Acad Sci U S A 2002;99:15136-15141.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 15136-15141
    • Guillemin, K.1    Salama, N.R.2    Tompkins, L.S.3    Falkow, S.4
  • 81
    • 0034773557 scopus 로고    scopus 로고
    • cDNA array analysis of cag pathogenicity island-associated Helicobacter pylori epithelial cell response genes
    • Cox JM, Clayton CL, Tomita T, Wallace DM, Robinson PA, Crabtree JE. cDNA array analysis of cag pathogenicity island-associated Helicobacter pylori epithelial cell response genes. Infect Immun 2001;69:6970-6980.
    • (2001) Infect Immun , vol.69 , pp. 6970-6980
    • Cox, J.M.1    Clayton, C.L.2    Tomita, T.3    Wallace, D.M.4    Robinson, P.A.5    Crabtree, J.E.6
  • 82
    • 4944245876 scopus 로고    scopus 로고
    • Phosphorylation-independent effects of CagA during interaction between Helicobacter pylori and T84 polarized monolayers
    • El-Etr SH, Mueller A, Tompkins LS, Falkow S, Merrell DS. Phosphorylation-independent effects of CagA during interaction between Helicobacter pylori and T84 polarized monolayers. J Infect Dis 2004;190:1516-1523.
    • (2004) J Infect Dis , vol.190 , pp. 1516-1523
    • El-Etr, S.H.1    Mueller, A.2    Tompkins, L.S.3    Falkow, S.4    Merrell, D.S.5
  • 83
    • 0026739795 scopus 로고
    • Purification and characterization of the vacuolating toxin from Helicobacter pylori
    • Cover TL, Blaser MJ. Purification and characterization of the vacuolating toxin from Helicobacter pylori. J Biol Chem 1992;267:10570-10575.
    • (1992) J Biol Chem , vol.267 , pp. 10570-10575
    • Cover, T.L.1    Blaser, M.J.2
  • 84
    • 0028308711 scopus 로고
    • Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains
    • Cover TL, Tummum MK, Cao P, Thompson SA, Blaser MJ. Divergence of genetic sequences for the vacuolating cytotoxin among Helicobacter pylori strains. J Biol Chem 1994;269:10566-10573.
    • (1994) J Biol Chem , vol.269 , pp. 10566-10573
    • Cover, T.L.1    Tummum, M.K.2    Cao, P.3    Thompson, S.A.4    Blaser, M.J.5
  • 85
    • 0028355422 scopus 로고
    • Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease
    • Telford JL, Ghiara P, Dell'Orco M, Comanducci M, Burroni D, Bugnoli M, et al. Gene structure of the Helicobacter pylori cytotoxin and evidence of its key role in gastric disease. J Exp Med 1994;179:1653-1658.
    • (1994) J Exp Med , vol.179 , pp. 1653-1658
    • Telford, J.L.1    Ghiara, P.2    Dell'Orco, M.3    Comanducci, M.4    Burroni, D.5    Bugnoli, M.6
  • 86
    • 0028365481 scopus 로고
    • Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: Structural similarities with the IgA protease type of exported protein
    • Schmitt W, Haas R. Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: structural similarities with the IgA protease type of exported protein. Mol Microbiol 1994;12:307-319.
    • (1994) Mol Microbiol , vol.12 , pp. 307-319
    • Schmitt, W.1    Haas, R.2
  • 87
    • 0028280638 scopus 로고
    • Pathological significance and molecular characterization of the vacuolating toxin gene of Helicobacter pylori
    • Phadnis SH, Ilver D, Janzon L, Normark S, Westblom TU. Pathological significance and molecular characterization of the vacuolating toxin gene of Helicobacter pylori. Infect Immun 1994;62:1557-1565.
    • (1994) Infect Immun , vol.62 , pp. 1557-1565
    • Phadnis, S.H.1    Ilver, D.2    Janzon, L.3    Normark, S.4    Westblom, T.U.5
  • 89
    • 0029059733 scopus 로고
    • Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration
    • Atherton JC, Cao P, Peek RM Jr, Tummuru MK, Blaser MJ, Cover TL. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J Biol Chem 1995;270:17771-17777.
    • (1995) J Biol Chem , vol.270 , pp. 17771-17777
    • Atherton, J.C.1    Cao, P.2    Peek Jr., R.M.3    Tummuru, M.K.4    Blaser, M.J.5    Cover, T.L.6
  • 92
    • 0033607258 scopus 로고    scopus 로고
    • Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin
    • Gerhard M, Lehn N, Neumayer N, Boren T, Rad R, Schepp W, et al. Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin. Proc Natl Acad Sci U S A 1999;96:12778-12783.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 12778-12783
    • Gerhard, M.1    Lehn, N.2    Neumayer, N.3    Boren, T.4    Rad, R.5    Schepp, W.6
  • 93
    • 0034256060 scopus 로고    scopus 로고
    • The Helicobacter pylori vacA s1, m1 genotype and cagA is associated with gastric carcinoma in Germany
    • Miehlke S, Kirsch C, Agha-Amiri K, Gunther T, Lehn N, Malfertheiner P, et al. The Helicobacter pylori vacA s1, m1 genotype and cagA is associated with gastric carcinoma in Germany. Int J Cancer 2000;87:322-327.
    • (2000) Int J Cancer , vol.87 , pp. 322-327
    • Miehlke, S.1    Kirsch, C.2    Agha-Amiri, K.3    Gunther, T.4    Lehn, N.5    Malfertheiner, P.6
  • 94
    • 0035048621 scopus 로고    scopus 로고
    • Helicobacter pylori vacA, iceA, and cagA status and pattern of gastritis in patients with malignant and benign gastroduodenal disease
    • Miehlke S, Yu J, Schuppler M, Kirsch C, Negraszus N, Morgner A, et al. Helicobacter pylori vacA, iceA, and cagA status and pattern of gastritis in patients with malignant and benign gastroduodenal disease. Am J Gastroenterol 2001;96:1008-1013.
    • (2001) Am J Gastroenterol , vol.96 , pp. 1008-1013
    • Miehlke, S.1    Yu, J.2    Schuppler, M.3    Kirsch, C.4    Negraszus, N.5    Morgner, A.6
  • 95
    • 0035664426 scopus 로고    scopus 로고
    • The relationship between Helicobacter pylori infection, the virulence genotypes of the infecting strain and gastric cancer in the African setting
    • Louw JA, Kidd MS, Kummer AF, Taylor K, Kotze U, Hanslo D. The relationship between Helicobacter pylori infection, the virulence genotypes of the infecting strain and gastric cancer in the African setting. Helicobacter 2001;6:268-273.
    • (2001) Helicobacter , vol.6 , pp. 268-273
    • Louw, J.A.1    Kidd, M.S.2    Kummer, A.F.3    Taylor, K.4    Kotze, U.5    Hanslo, D.6
  • 96
    • 0031032033 scopus 로고    scopus 로고
    • Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori
    • Atherton JC, Peek RM Jr, Tham KT, Cover TL, Blaser MJ. Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology 1997;112:92-99.
    • (1997) Gastroenterology , vol.112 , pp. 92-99
    • Atherton, J.C.1    Peek Jr., R.M.2    Tham, K.T.3    Cover, T.L.4    Blaser, M.J.5
  • 97
    • 0029080739 scopus 로고
    • Role of the Helicobacter pylori virulence factors vacuolating cytotoxin, CagA, and urease in a mouse model of disease
    • Ghiara P, Marchetti M, Blaser MJ, Tummum MK, Cover TL, Segal ED, et al. Role of the Helicobacter pylori virulence factors vacuolating cytotoxin, CagA, and urease in a mouse model of disease. Infect Immun 1995;63:4154-4160.
    • (1995) Infect Immun , vol.63 , pp. 4154-4160
    • Ghiara, P.1    Marchetti, M.2    Blaser, M.J.3    Tummum, M.K.4    Cover, T.L.5    Segal, E.D.6
  • 98
    • 0037370481 scopus 로고    scopus 로고
    • Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori
    • Fujikawa A, Shirasaka D, Yamamoto S, Ota H, Yahiro K, Fukada M, et al. Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori. Nature Genet 2003;33:375-381.
    • (2003) Nature Genet , vol.33 , pp. 375-381
    • Fujikawa, A.1    Shirasaka, D.2    Yamamoto, S.3    Ota, H.4    Yahiro, K.5    Fukada, M.6
  • 99
    • 0032532381 scopus 로고    scopus 로고
    • Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis
    • Rudi J, Kuck D, Strand S, von Herbay A, Mariani SM, Krammer PH, et al. Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis. J Clin Invest 1998;102:1506-1514.
    • (1998) J Clin Invest , vol.102 , pp. 1506-1514
    • Rudi, J.1    Kuck, D.2    Strand, S.3    von Herbay, A.4    Mariani, S.M.5    Krammer, P.H.6
  • 100
    • 0343384216 scopus 로고    scopus 로고
    • Helicobacter pylori strain-specific genotypes and modulation of the gastric epithelial cell cycle
    • Peek RM Jr, Blaser MJ, Mays DJ, Forsyth MH, Cover TL, Song SY, et al. Helicobacter pylori strain-specific genotypes and modulation of the gastric epithelial cell cycle. Cancer Res 1999;59:6124-6131.
    • (1999) Cancer Res , vol.59 , pp. 6124-6131
    • Peek Jr., R.M.1    Blaser, M.J.2    Mays, D.J.3    Forsyth, M.H.4    Cover, T.L.5    Song, S.Y.6
  • 101
    • 0034388020 scopus 로고    scopus 로고
    • The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release
    • Galmiche A, Rassow J, Doye A, Cagnol S, Chambard JC, Contamin S, et al. The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release. EMBO J 2000;19:6361-6370.
    • (2000) EMBO J , vol.19 , pp. 6361-6370
    • Galmiche, A.1    Rassow, J.2    Doye, A.3    Cagnol, S.4    Chambard, J.C.5    Contamin, S.6
  • 102
    • 0037373880 scopus 로고    scopus 로고
    • Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin
    • Cover TL, Krishna US, Israel DA, Peek RM Jr. Induction of gastric epithelial cell apoptosis by Helicobacter pylori vacuolating cytotoxin. Cancer Res 2003;63:951-957.
    • (2003) Cancer Res , vol.63 , pp. 951-957
    • Cover, T.L.1    Krishna, U.S.2    Israel, D.A.3    Peek Jr., R.M.4
  • 103
    • 0346850825 scopus 로고    scopus 로고
    • Cellular vacuolation and mitochondrial cytochrome c release are independent outcomes of Helicobacter pylori vacuolating cytotoxin activity that are each dependent on membrane channel formation
    • Willhite DC, Cover TL, Blanke SR. Cellular vacuolation and mitochondrial cytochrome c release are independent outcomes of Helicobacter pylori vacuolating cytotoxin activity that are each dependent on membrane channel formation. J Biol Chem 2003;278:48204-48209.
    • (2003) J Biol Chem , vol.278 , pp. 48204-48209
    • Willhite, D.C.1    Cover, T.L.2    Blanke, S.R.3
  • 104
    • 0032528956 scopus 로고    scopus 로고
    • Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin
    • Papini E, Satin B, Norais N, de Bernard M, Telford JL, Rappuoli R, et al. Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin. J Clin Invest 1998;102:813-820.
    • (1998) J Clin Invest , vol.102 , pp. 813-820
    • Papini, E.1    Satin, B.2    Norais, N.3    de Bernard, M.4    Telford, J.L.5    Rappuoli, R.6
  • 106
    • 0007496361 scopus 로고
    • Vacuolating toxin of Helicobacter pylori
    • Hunt R, Tytgat G (eds), Kluwer Academic Publishers: Lancaster
    • Figura N, Crabtree JE. Vacuolating toxin of Helicobacter pylori. In Helicobacter pylori: Basic Mechanisms to Clinical Cure, Hunt R, Tytgat G (eds), Kluwer Academic Publishers: Lancaster, 1994; 222-231.
    • (1994) Helicobacter Pylori: Basic Mechanisms to Clinical Cure , pp. 222-231
    • Figura, N.1    Crabtree, J.E.2
  • 107
    • 0042932364 scopus 로고    scopus 로고
    • Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation
    • Gebert B, Fischer W, Weiss E, Hoffmann R, Haas R. Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation. Science 2003;301:1099-1102.
    • (2003) Science , vol.301 , pp. 1099-1102
    • Gebert, B.1    Fischer, W.2    Weiss, E.3    Hoffmann, R.4    Haas, R.5
  • 108
    • 9144220868 scopus 로고    scopus 로고
    • The Helicobacter pylori vacuolating toxin inhibits T cell activation by two independent mechanisms
    • Boncristiano M, Paccani SR, Barone S, Ulivieri C, Patrussi L, Ilver D, et al. The Helicobacter pylori vacuolating toxin inhibits T cell activation by two independent mechanisms. J Exp Med 2003;198:1887-1897.
    • (2003) J Exp Med , vol.198 , pp. 1887-1897
    • Boncristiano, M.1    Paccani, S.R.2    Barone, S.3    Ulivieri, C.4    Patrussi, L.5    Ilver, D.6
  • 109
    • 2442682964 scopus 로고    scopus 로고
    • Inhibition of primary human T cell proliferation by Helicobacter pylori vacuolating toxin (VacA) is independent of VacA effects on IL-2 secretion
    • Sundrud MS, Torres VJ, Unutmaz D, Cover TL. Inhibition of primary human T cell proliferation by Helicobacter pylori vacuolating toxin (VacA) is independent of VacA effects on IL-2 secretion. Proc Natl Acad Sci U S A 2004;101:7727-7732.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 7727-7732
    • Sundrud, M.S.1    Torres, V.J.2    Unutmaz, D.3    Cover, T.L.4
  • 110
    • 20544461311 scopus 로고    scopus 로고
    • The role of genome diversity and immune evasion in persistent infection with Helicobacter pylori
    • Cooke CL, Huff JL, Solnick JV. The role of genome diversity and immune evasion in persistent infection with Helicobacter pylori. FEMS Immunol Med Microbiol 2005;45:11-23.
    • (2005) FEMS Immunol Med Microbiol , vol.45 , pp. 11-23
    • Cooke, C.L.1    Huff, J.L.2    Solnick, J.V.3
  • 112
    • 1242319255 scopus 로고    scopus 로고
    • Modification of Helicobacter pylori outer membrane protein expression during experimental infection of rhesus macaques
    • Solnick JV, Hansen LM, Salama NR, Boonjakuakul JK, Syvanen M. Modification of Helicobacter pylori outer membrane protein expression during experimental infection of rhesus macaques. Proc Natl Acad Sci U S A 2004;101:2106-2111.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 2106-2111
    • Solnick, J.V.1    Hansen, L.M.2    Salama, N.R.3    Boonjakuakul, J.K.4    Syvanen, M.5
  • 113
    • 15444357984 scopus 로고    scopus 로고
    • Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging
    • Ilver D, Arnqvist A, Ogren JT, Frick IM, Kersulyte D, Incecik ET, et al. Helicobacter pylori adhesin binding fucosylated histo-blood group antigens revealed by retagging. Science 1998;279:373-377.
    • (1998) Science , vol.279 , pp. 373-377
    • Ilver, D.1    Arnqvist, A.2    Ogren, J.T.3    Frick, I.M.4    Kersulyte, D.5    Incecik, E.T.6
  • 114
    • 0037178771 scopus 로고    scopus 로고
    • Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation
    • Mahdavi J, Sonden B, Hurtig M, Olfat FO, Forsberg L, Roche N, et al. Helicobacter pylori SabA adhesin in persistent infection and chronic inflammation. Science 2002;297:573-578.
    • (2002) Science , vol.297 , pp. 573-578
    • Mahdavi, J.1    Sonden, B.2    Hurtig, M.3    Olfat, F.O.4    Forsberg, L.5    Roche, N.6
  • 115
    • 17644415392 scopus 로고    scopus 로고
    • The sialic acid binding SabA adhesin of Helicobacter pylori is essential for nonopsonic activation of human neutrophils
    • Unemo M, Aspholm-Hurtig M, Ilver D, Bergstrom J, Boren T, Danielsson D, et al. The sialic acid binding SabA adhesin of Helicobacter pylori is essential for nonopsonic activation of human neutrophils. J Biol Chem 2005;280:15390-15397.
    • (2005) J Biol Chem , vol.280 , pp. 15390-15397
    • Unemo, M.1    Aspholm-Hurtig, M.2    Ilver, D.3    Bergstrom, J.4    Boren, T.5    Danielsson, D.6
  • 116
    • 17644394616 scopus 로고    scopus 로고
    • Smoldering and polarized inflammation in the initiation and promotion of malignant disease
    • Balkwill F, Charles KA, Mantovani A. Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell 2005;7:211-217.
    • (2005) Cancer Cell , vol.7 , pp. 211-217
    • Balkwill, F.1    Charles, K.A.2    Mantovani, A.3
  • 117
    • 0028954621 scopus 로고
    • The association between typhoid carriage, typhoid infection and subsequent cancer at a number of sites
    • Caygill CPJ, Braddick M, Hill MJ, Knowles RL, Sharp JCM. The association between typhoid carriage, typhoid infection and subsequent cancer at a number of sites. Eur J Cancer Prev 1995;4:187-193.
    • (1995) Eur J Cancer Prev , vol.4 , pp. 187-193
    • Caygill, C.P.J.1    Braddick, M.2    Hill, M.J.3    Knowles, R.L.4    Sharp, J.C.M.5
  • 118
    • 15944390635 scopus 로고    scopus 로고
    • Bacterial toxins and cancer - A case to answer?
    • Lax AJ. Bacterial toxins and cancer - a case to answer? Nature Rev Microbiol 2005;3:343-349.
    • (2005) Nature Rev Microbiol , vol.3 , pp. 343-349
    • Lax, A.J.1
  • 119
    • 0026787520 scopus 로고
    • Effect of Helicobacter pylori on gastric somatostatin in duodenal ulcer disease
    • Moss SF, Legon S, Bishop AE, Polak JM, Calam J. Effect of Helicobacter pylori on gastric somatostatin in duodenal ulcer disease. Lancet 1992;340:930-932.
    • (1992) Lancet , vol.340 , pp. 930-932
    • Moss, S.F.1    Legon, S.2    Bishop, A.E.3    Polak, J.M.4    Calam, J.5
  • 120
    • 0031461026 scopus 로고    scopus 로고
    • Host mechanisms: Are they the key to various clinical outcomes in Helicobacter pylori infection?
    • Calam J. Host mechanisms: are they the key to various clinical outcomes in Helicobacter pylori infection? Ital J Gastroenterol Hepatol 1997;29:375-382.
    • (1997) Ital J Gastroenterol Hepatol , vol.29 , pp. 375-382
    • Calam, J.1
  • 121
    • 0031922551 scopus 로고    scopus 로고
    • Interleukin 1 beta and tumour necrosis factor alpha inhibit acid secretion in cultured rabbit parietal cells by multiple pathways
    • Beales IL, Calam J. Interleukin 1 beta and tumour necrosis factor alpha inhibit acid secretion in cultured rabbit parietal cells by multiple pathways. Gut 1998;42:227-234.
    • (1998) Gut , vol.42 , pp. 227-234
    • Beales, I.L.1    Calam, J.2
  • 122
    • 0031058991 scopus 로고    scopus 로고
    • Functional impairment of rat enterochromaffin-like cells by interleukin 1
    • Prinz C, Neumayer N, Mahr S, Classen M, Schepp W. Functional impairment of rat enterochromaffin-like cells by interleukin 1. Gastroenterology 1997;112:364-375.
    • (1997) Gastroenterology , vol.112 , pp. 364-375
    • Prinz, C.1    Neumayer, N.2    Mahr, S.3    Classen, M.4    Schepp, W.5
  • 123
    • 0025885785 scopus 로고
    • Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori-associated gastritis
    • Crabtree JE, Shallcross TM, Heatley RV, Wyatt JI. Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori-associated gastritis. Gut 1991;32:1473-1477.
    • (1991) Gut , vol.32 , pp. 1473-1477
    • Crabtree, J.E.1    Shallcross, T.M.2    Heatley, R.V.3    Wyatt, J.I.4
  • 124
    • 0036893170 scopus 로고    scopus 로고
    • Effect of interleukin 1 polymorphisms on gastric mucosal interleukin 1 production in Helicobacter pylori infection
    • Hwang IR, Kodama T, Kikuchi S, Sakai K, Peterson LE, Graham GY, et al. Effect of interleukin 1 polymorphisms on gastric mucosal interleukin 1 production in Helicobacter pylori infection. Gastroenterology 2002;123:1793-1803.
    • (2002) Gastroenterology , vol.123 , pp. 1793-1803
    • Hwang, I.R.1    Kodama, T.2    Kikuchi, S.3    Sakai, K.4    Peterson, L.E.5    Graham, G.Y.6
  • 125
    • 0029947116 scopus 로고    scopus 로고
    • Mononuclear cells and cytokines stimulate gastrin release from canine antral G cells in primary culture
    • Lehmann FS, Golodner EH, Wang J, Chen MC, Avedian D, Calam J, et al. Mononuclear cells and cytokines stimulate gastrin release from canine antral G cells in primary culture. Am J Physiol 1996;270:G783-G788.
    • (1996) Am J Physiol , vol.270
    • Lehmann, F.S.1    Golodner, E.H.2    Wang, J.3    Chen, M.C.4    Avedian, D.5    Calam, J.6
  • 127
    • 0030054193 scopus 로고    scopus 로고
    • Gastrin secretion from primary cultures of rabbit antral G cells: Stimulation by inflammatory cytokines
    • Weigert N, Schaffer K, Schusdziarra V, Classen M, Schepp W. Gastrin secretion from primary cultures of rabbit antral G cells: stimulation by inflammatory cytokines. Gastroenterology 1996;110:147-154.
    • (1996) Gastroenterology , vol.110 , pp. 147-154
    • Weigert, N.1    Schaffer, K.2    Schusdziarra, V.3    Classen, M.4    Schepp, W.5
  • 128
    • 0030835756 scopus 로고    scopus 로고
    • Effect of Helicobacter pylori products and recombinant cytokines on gastrin release from cultured canine G cells
    • Beales ILP, Blaser MJ, Srinivasan S, Calam J, Perez-Perez GI, Yamada T, et al. Effect of Helicobacter pylori products and recombinant cytokines on gastrin release from cultured canine G cells. Gastroenterology 1997;113:465-471.
    • (1997) Gastroenterology , vol.113 , pp. 465-471
    • Beales, I.L.P.1    Blaser, M.J.2    Srinivasan, S.3    Calam, J.4    Perez-Perez, G.I.5    Yamada, T.6
  • 129
    • 0031014529 scopus 로고    scopus 로고
    • Effects of transforming growth factor-alpha and interleukin-8 on somatostatin release from canine fundic G cells
    • Beales I, Calam J, Post L, Srinivasan S, Yamada T, del Valle J. Effects of transforming growth factor-alpha and interleukin-8 on somatostatin release from canine fundic G cells. Gastroenterology 1997;112:136-143.
    • (1997) Gastroenterology , vol.112 , pp. 136-143
    • Beales, I.1    Calam, J.2    Post, L.3    Srinivasan, S.4    Yamada, T.5    del Valle, J.6
  • 131
    • 1142311551 scopus 로고    scopus 로고
    • Gastric mucosal cytokine and epithelial cell responses to Helicobacter pylori infection in Mongolian gerbils
    • Crabtree JE, Court M, Aboshkiwa MA, Jeremy AHT, Dixon MF, Robinson PA. Gastric mucosal cytokine and epithelial cell responses to Helicobacter pylori infection in Mongolian gerbils. J Pathol 2004;202:197-207.
    • (2004) J Pathol , vol.202 , pp. 197-207
    • Crabtree, J.E.1    Court, M.2    Aboshkiwa, M.A.3    Jeremy, A.H.T.4    Dixon, M.F.5    Robinson, P.A.6
  • 133
    • 0033958048 scopus 로고    scopus 로고
    • Helicobacter pylori alters gastric epithelial cell cycle events and gastrin secretion in Mongolian gerbils
    • Peek RM, Wirth HP, Moss SF, Yang M, Abdalla AM, Tham KT, et al. Helicobacter pylori alters gastric epithelial cell cycle events and gastrin secretion in Mongolian gerbils. Gastroenterology 2000;118:48-59.
    • (2000) Gastroenterology , vol.118 , pp. 48-59
    • Peek, R.M.1    Wirth, H.P.2    Moss, S.F.3    Yang, M.4    Abdalla, A.M.5    Tham, K.T.6
  • 134
    • 0035089842 scopus 로고    scopus 로고
    • Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses
    • Israel DA, Salama N, Arnold CN, Moss SF, Ando T, Wirth HP, et al. Helicobacter pylori strain-specific differences in genetic content, identified by microarray, influence host inflammatory responses. J Clin Invest 2001;107:611-620.
    • (2001) J Clin Invest , vol.107 , pp. 611-620
    • Israel, D.A.1    Salama, N.2    Arnold, C.N.3    Moss, S.F.4    Ando, T.5    Wirth, H.P.6
  • 135
    • 0035043972 scopus 로고    scopus 로고
    • The gastrins: Their production and biological activities
    • Dockray GJ, Varro A, Dimaline R, Wang T. The gastrins: their production and biological activities. Annu Rev Physiol 2001;63:119-139.
    • (2001) Annu Rev Physiol , vol.63 , pp. 119-139
    • Dockray, G.J.1    Varro, A.2    Dimaline, R.3    Wang, T.4
  • 136
    • 19044366273 scopus 로고    scopus 로고
    • Helicobacter pylori cag-type IV secretion system facilitates corpus colonization to induce precancerous conditions in Mongolian gerbils
    • Rieder G, Merchant J, Haas R. Helicobacter pylori cag-type IV secretion system facilitates corpus colonization to induce precancerous conditions in Mongolian gerbils. Gastroenterology 2005;128:1229-1242.
    • (2005) Gastroenterology , vol.128 , pp. 1229-1242
    • Rieder, G.1    Merchant, J.2    Haas, R.3
  • 137
    • 85047691456 scopus 로고    scopus 로고
    • Helicobacter pylori persistence: Biology and disease
    • Blaser MJ, Atherton JC. Helicobacter pylori persistence: biology and disease. J Clin Invest 2004;113:321-333.
    • (2004) J Clin Invest , vol.113 , pp. 321-333
    • Blaser, M.J.1    Atherton, J.C.2
  • 138
    • 19044400283 scopus 로고    scopus 로고
    • The biology of cag in the Helicobacter pylori-human interaction
    • Blaser MJ. The biology of cag in the Helicobacter pylori-human interaction. Gastroenterology 2005;128:1512-1515.
    • (2005) Gastroenterology , vol.128 , pp. 1512-1515
    • Blaser, M.J.1
  • 139
    • 0031844839 scopus 로고    scopus 로고
    • Acid tolerance response in Helicobacter pylori and differences between cagA+ and cagA-strains
    • Karita M, Blaser MJ. Acid tolerance response in Helicobacter pylori and differences between cagA+ and cagA-strains. J Infect Dis 1998;178:213-219.
    • (1998) J Infect Dis , vol.178 , pp. 213-219
    • Karita, M.1    Blaser, M.J.2
  • 140
    • 0031714446 scopus 로고    scopus 로고
    • Helicobacter pylori infection induces gastric cancer in Mongolian gerbils
    • Watanabe T, Tada M, Nagai H, Sasaki S, Nakao M. Helicobacter pylori infection induces gastric cancer in Mongolian gerbils. Gastroenterology 1998;115:642-648.
    • (1998) Gastroenterology , vol.115 , pp. 642-648
    • Watanabe, T.1    Tada, M.2    Nagai, H.3    Sasaki, S.4    Nakao, M.5
  • 141
    • 0032189467 scopus 로고    scopus 로고
    • Development of Helicobacter pylori-induced gastric carcinoma in Mongolian gerbils
    • Honda S, Fujioka T, Tokieda M, Satoh R, Nishizono A, Nasu M. Development of Helicobacter pylori-induced gastric carcinoma in Mongolian gerbils. Cancer Res 1998;58:4255-4259.
    • (1998) Cancer Res , vol.58 , pp. 4255-4259
    • Honda, S.1    Fujioka, T.2    Tokieda, M.3    Satoh, R.4    Nishizono, A.5    Nasu, M.6
  • 142
    • 0034606275 scopus 로고    scopus 로고
    • Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil
    • Ogura K, Maeda S, Nakao M, Watanabe T, Tada M, Kyutoku T, et al. Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil. J Exp Med 2000;192:1601-1610.
    • (2000) J Exp Med , vol.192 , pp. 1601-1610
    • Ogura, K.1    Maeda, S.2    Nakao, M.3    Watanabe, T.4    Tada, M.5    Kyutoku, T.6
  • 143
    • 5644292170 scopus 로고    scopus 로고
    • Development of gastric adenocarcinoma in Mongolian gerbils after long-term infection with Helicobacter pylori
    • Zheng Q, Chen XY, Shi Y, Xiao SD. Development of gastric adenocarcinoma in Mongolian gerbils after long-term infection with Helicobacter pylori. J Gastroenterol Hepatol 2004;19:1192-1198.
    • (2004) J Gastroenterol Hepatol , vol.19 , pp. 1192-1198
    • Zheng, Q.1    Chen, X.Y.2    Shi, Y.3    Xiao, S.D.4
  • 145
    • 0033960131 scopus 로고    scopus 로고
    • Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer
    • Wang TC, Dangler CA, Chen D, Goldenring JR, Koh T, Raychowdhury R, et al. Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer. Gastroenterology 2000;118:36-47.
    • (2000) Gastroenterology , vol.118 , pp. 36-47
    • Wang, T.C.1    Dangler, C.A.2    Chen, D.3    Goldenring, J.R.4    Koh, T.5    Raychowdhury, R.6
  • 146
    • 0037374131 scopus 로고    scopus 로고
    • Helicobacter pylori-associated gastric cancer in INS-GAS mice is gender specific
    • Fox JG, Rogers AB, Ihrig M, Taylor NS, Whary MT, Dockray G, et al. Helicobacter pylori-associated gastric cancer in INS-GAS mice is gender specific. Cancer Res 2003;63:942-950.
    • (2003) Cancer Res , vol.63 , pp. 942-950
    • Fox, J.G.1    Rogers, A.B.2    Ihrig, M.3    Taylor, N.S.4    Whary, M.T.5    Dockray, G.6
  • 147
    • 0037606151 scopus 로고    scopus 로고
    • Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia
    • Fox JG, Wang TC, Rogers AB, Poutahidis T, Ge Z, Taylor N, et al. Host and microbial constituents influence Helicobacter pylori-induced cancer in a murine model of hypergastrinemia. Gastroenterology 2003;124:1879-1890.
    • (2003) Gastroenterology , vol.124 , pp. 1879-1890
    • Fox, J.G.1    Wang, T.C.2    Rogers, A.B.3    Poutahidis, T.4    Ge, Z.5    Taylor, N.6
  • 148
    • 20444440611 scopus 로고    scopus 로고
    • Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer
    • Takaishi S, Cui G, Frederick DM, Carlson JE, Houghton J, Varro A, et al. Synergistic inhibitory effects of gastrin and histamine receptor antagonists on Helicobacter-induced gastric cancer. Gastroenterology 2005;128:1965-1983.
    • (2005) Gastroenterology , vol.128 , pp. 1965-1983
    • Takaishi, S.1    Cui, G.2    Frederick, D.M.3    Carlson, J.E.4    Houghton, J.5    Varro, A.6
  • 149
    • 0036107819 scopus 로고    scopus 로고
    • B receptor expression in AGS cells is associated with direct inhibition and indirect stimulation of cell proliferation via paracrine activation of the epidermal growth factor receptor
    • B receptor expression in AGS cells is associated with direct inhibition and indirect stimulation of cell proliferation via paracrine activation of the epidermal growth factor receptor. Gut 2002;50:827-833.
    • (2002) Gut , vol.50 , pp. 827-833
    • Varro, A.1    Noble, P.J.2    Wroblewski, L.E.3    Bishop, L.4    Dockray, G.J.5
  • 150
    • 16444361865 scopus 로고    scopus 로고
    • Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma
    • Zavros Y, Eaton KA, Kang W, Rathinavelu S, Katukuri V, Kao JY, et al. Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma. Oncogene 2005;24:2354-2366.
    • (2005) Oncogene , vol.24 , pp. 2354-2366
    • Zavros, Y.1    Eaton, K.A.2    Kang, W.3    Rathinavelu, S.4    Katukuri, V.5    Kao, J.Y.6
  • 151
    • 9144249648 scopus 로고    scopus 로고
    • Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp 130
    • Judd LM, Alderman BM, Howlett M, Shulkes A, Dow C, Moverley J, et al. Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp 130. Gastroenterology 2004;126:196-207.
    • (2004) Gastroenterology , vol.126 , pp. 196-207
    • Judd, L.M.1    Alderman, B.M.2    Howlett, M.3    Shulkes, A.4    Dow, C.5    Moverley, J.6
  • 153
    • 0041633845 scopus 로고    scopus 로고
    • Helicobacter pylori infection interferes with epithelial Stat6-mediated interleukin-4 signal transduction independent of cagA, cagE, or VacA
    • Ceponis PJM, McKay DM, Menaker RJ, Galindo-Mata E, Jones NL. Helicobacter pylori infection interferes with epithelial Stat6-mediated interleukin-4 signal transduction independent of cagA, cagE, or VacA. J Immunol 2003;171:2035-2041.
    • (2003) J Immunol , vol.171 , pp. 2035-2041
    • Ceponis, P.J.M.1    McKay, D.M.2    Menaker, R.J.3    Galindo-Mata, E.4    Jones, N.L.5
  • 154
    • 0034027476 scopus 로고    scopus 로고
    • Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces Helicobacter-induced gastric atrophy
    • Fox JG, Beck P, Dangler CA, Whary M, Wang TC, Shi HN, et al. Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces Helicobacter-induced gastric atrophy. Nature Med 2000;6:536-542.
    • (2000) Nature Med , vol.6 , pp. 536-542
    • Fox, J.G.1    Beck, P.2    Dangler, C.A.3    Whary, M.4    Wang, T.C.5    Shi, H.N.6
  • 157
    • 31144465901 scopus 로고    scopus 로고
    • Helicobacter pylori and Schistosoma japonicum co-infection in a Chinese population: Helminth infection alters humoral responses to H. pylori and serum pepsinogen I/II ratio
    • (in press)
    • Du Y, Agnew A, Ye X, Robinson PA, Forman D, Crabtree JE. Helicobacter pylori and Schistosoma japonicum co-infection in a Chinese population: helminth infection alters humoral responses to H. pylori and serum pepsinogen I/II ratio. Microbes Infect 2005;7:(in press).
    • (2005) Microbes Infect , vol.7
    • Du, Y.1    Agnew, A.2    Ye, X.3    Robinson, P.A.4    Forman, D.5    Crabtree, J.E.6
  • 158
    • 3142751982 scopus 로고    scopus 로고
    • CD25 + CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development
    • McKee AS, Pearce EJ. CD25 + CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J Immunol 2004;173:1224-1231.
    • (2004) J Immunol , vol.173 , pp. 1224-1231
    • McKee, A.S.1    Pearce, E.J.2
  • 159
    • 8544242704 scopus 로고    scopus 로고
    • Regulatory T cells: Friend or foe in immunity to infection?
    • Mills KHG. Regulatory T cells: friend or foe in immunity to infection? Nature Rev Immunol 2004;4:841-855.
    • (2004) Nature Rev Immunol , vol.4 , pp. 841-855
    • Mills, K.H.G.1
  • 161
    • 0037795727 scopus 로고    scopus 로고
    • Absence of CD4 + CD25+ regulatory T cells is associated with a loss of regulation leading to increased pathology in Helicobacter-infected mice
    • Raghavan S, Fredriksson M, Svennerholm AM, Holmgren J, Suri-Payer E. Absence of CD4 + CD25+ regulatory T cells is associated with a loss of regulation leading to increased pathology in Helicobacter-infected mice. Clin Exp Immunol 2003;132:393-400.
    • (2003) Clin Exp Immunol , vol.132 , pp. 393-400
    • Raghavan, S.1    Fredriksson, M.2    Svennerholm, A.M.3    Holmgren, J.4    Suri-Payer, E.5
  • 164
    • 0025941501 scopus 로고
    • Secretagogue-specific effects of interleukin-1 on gastric acid secretion
    • Wallace JL, Cucula M, Mugridge K, Parenete L. Secretagogue-specific effects of interleukin-1 on gastric acid secretion. Am J Physiol 1991;261:G559-G564.
    • (1991) Am J Physiol , vol.261
    • Wallace, J.L.1    Cucula, M.2    Mugridge, K.3    Parenete, L.4
  • 166
    • 0034793044 scopus 로고    scopus 로고
    • Interleukin-1 and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma
    • Machado JC, Pharoah P, Sousa S, Carvalho R, Oliveira C, Figueiredo C, et al. Interleukin-1 and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma. Gastroenterology 2001;121:823-829.
    • (2001) Gastroenterology , vol.121 , pp. 823-829
    • Machado, J.C.1    Pharoah, P.2    Sousa, S.3    Carvalho, R.4    Oliveira, C.5    Figueiredo, C.6
  • 167
    • 0345528036 scopus 로고    scopus 로고
    • Association of interleukin 1β gene polymorphisms and gastric cancer in high and low prevalence regions of China
    • Zeng ZR, Hu PJ, Hu S, Pang RP, Chen MH, Ng M, et al. Association of interleukin 1β gene polymorphisms and gastric cancer in high and low prevalence regions of China. Gut 2003;52:1684-1689.
    • (2003) Gut , vol.52 , pp. 1684-1689
    • Zeng, Z.R.1    Hu, P.J.2    Hu, S.3    Pang, R.P.4    Chen, M.H.5    Ng, M.6
  • 168
    • 3242878898 scopus 로고    scopus 로고
    • Risks of interleukin-1 genetic polymorphisms and Helicobacter pylori in the development of cancer
    • Chen A, Li CN, Hsu PI, Lia KH, Tseng HH, Hsu PN, et al. Risks of interleukin-1 genetic polymorphisms and Helicobacter pylori in the development of cancer. Aliment Pharmacol Ther 2004;20:203-211.
    • (2004) Aliment Pharmacol Ther , vol.20 , pp. 203-211
    • Chen, A.1    Li, C.N.2    Hsu, P.I.3    Lia, K.H.4    Tseng, H.H.5    Hsu, P.N.6
  • 170
    • 0042315396 scopus 로고    scopus 로고
    • Synergistic effect of Helicobacter pylori virulence factors and interleukin-1 polymorphisms for the development of severe histological changes in the gastric mucosa
    • Rad R, Prinz C, Neu B, Neuhofer M, Zeitner M, Voland P, et al. Synergistic effect of Helicobacter pylori virulence factors and interleukin-1 polymorphisms for the development of severe histological changes in the gastric mucosa. J Infect Dis 2003;188:272-281.
    • (2003) J Infect Dis , vol.188 , pp. 272-281
    • Rad, R.1    Prinz, C.2    Neu, B.3    Neuhofer, M.4    Zeitner, M.5    Voland, P.6
  • 171
    • 0035984024 scopus 로고    scopus 로고
    • Interleukin 1 polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan
    • Furuta T, El-Omar EM, Xiaoa F, Shirai N, Takashima M, Sugimurra H. Interleukin 1 polymorphisms increase risk of hypochlorhydria and atrophic gastritis and reduce risk of duodenal ulcer recurrence in Japan. Gastroenterology 2002;123:92-105.
    • (2002) Gastroenterology , vol.123 , pp. 92-105
    • Furuta, T.1    El-Omar, E.M.2    Xiaoa, F.3    Shirai, N.4    Takashima, M.5    Sugimurra, H.6
  • 172
    • 0042667008 scopus 로고    scopus 로고
    • A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma
    • Machado JC, Figueiredo C, Canedo P, Pharoah P, Carvalho R, Nabais S, et al. A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma. Gastroenterology 2003;125:364-371.
    • (2003) Gastroenterology , vol.125 , pp. 364-371
    • Machado, J.C.1    Figueiredo, C.2    Canedo, P.3    Pharoah, P.4    Carvalho, R.5    Nabais, S.6
  • 173
    • 0037622073 scopus 로고    scopus 로고
    • Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms
    • El-Omar EM, Rabkin CS, Gammon MD, Vaughn TL, Risch HA, Schoenberg JB, et al. Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms. Gastroenterology 2003;124:1193-1201.
    • (2003) Gastroenterology , vol.124 , pp. 1193-1201
    • El-Omar, E.M.1    Rabkin, C.S.2    Gammon, M.D.3    Vaughn, T.L.4    Risch, H.A.5    Schoenberg, J.B.6
  • 174
    • 20044386655 scopus 로고    scopus 로고
    • The polymorphism interleukin 8-251 A/T influences the susceptibility of Helicobacter pylori related diseases in the Japanese population
    • Ohyauchi M, Imatani A, Yonechi M, Asano N, Miura A, Iijima K, et al. The polymorphism interleukin 8-251 A/T influences the susceptibility of Helicobacter pylori related diseases in the Japanese population. Gut 2005;54:330-335.
    • (2005) Gut , vol.54 , pp. 330-335
    • Ohyauchi, M.1    Imatani, A.2    Yonechi, M.3    Asano, N.4    Miura, A.5    Iijima, K.6
  • 175
    • 0037146297 scopus 로고    scopus 로고
    • Helicobacter pylori and interleukin1 genotyping: An opportunity to identify high-risk individuals for gastric carcinoma
    • Figueiredo C, Machado JC, Pharoah P, Seruca R, Sousa S, Carvalho R, et al. Helicobacter pylori and interleukin1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma. J Natl Cancer Inst 2002;94:1680-1687.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1680-1687
    • Figueiredo, C.1    Machado, J.C.2    Pharoah, P.3    Seruca, R.4    Sousa, S.5    Carvalho, R.6
  • 178
    • 14844355257 scopus 로고    scopus 로고
    • Helicobacter pylori disrupts NADPH oxidase targeting in human neutrophils to induce extracellular superoxide release
    • Allen LAH, Beecher BR, Lynch JT, Rohner OV, Wittine LM. Helicobacter pylori disrupts NADPH oxidase targeting in human neutrophils to induce extracellular superoxide release. J Immunol 2005;174:3658-3667.
    • (2005) J Immunol , vol.174 , pp. 3658-3667
    • Allen, L.A.H.1    Beecher, B.R.2    Lynch, J.T.3    Rohner, O.V.4    Wittine, L.M.5
  • 179
    • 0031787341 scopus 로고    scopus 로고
    • Guinea pig gastric mucosal cells produce abundant superoxide anion through an NADPH oxidase-like system
    • Teshima S, Rokutan K, Nikawa T, Kishi K. Guinea pig gastric mucosal cells produce abundant superoxide anion through an NADPH oxidase-like system. Gastroenterology 1998;115:1186-1196.
    • (1998) Gastroenterology , vol.115 , pp. 1186-1196
    • Teshima, S.1    Rokutan, K.2    Nikawa, T.3    Kishi, K.4
  • 180
    • 9244225192 scopus 로고    scopus 로고
    • Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: Implications for gastric carcinogenesis
    • Xu H, Chaturvedi R, Cheng Y, Bussiere FI, Asim M, Yao MD, et al. Spermine oxidation induced by Helicobacter pylori results in apoptosis and DNA damage: implications for gastric carcinogenesis. Cancer Res 2004;64:8521-8525.
    • (2004) Cancer Res , vol.64 , pp. 8521-8525
    • Xu, H.1    Chaturvedi, R.2    Cheng, Y.3    Bussiere, F.I.4    Asim, M.5    Yao, M.D.6
  • 181
    • 1342333153 scopus 로고    scopus 로고
    • Long term infection with Helicobacter felis and inactivation of p53 tumour suppressor gene cumulatively enhance the gastric mutation frequency in Big Blue transgenic mice
    • Jenks PJ, Jeremy AHT, Robinson PA, Walker MM, Crabtree JE. Long term infection with Helicobacter felis and inactivation of p53 tumour suppressor gene cumulatively enhance the gastric mutation frequency in Big Blue transgenic mice. J Pathol 2003;201:596-602.
    • (2003) J Pathol , vol.201 , pp. 596-602
    • Jenks, P.J.1    Jeremy, A.H.T.2    Robinson, P.A.3    Walker, M.M.4    Crabtree, J.E.5
  • 185
    • 0031879649 scopus 로고    scopus 로고
    • The gastric H+K+-ATPase is a major autoantigen in chronic Helicobacter pylori gastritis with body corpus atrophy
    • Claeys D, Faller G, Appelmelk BI, Negrini R, Kirchner T. The gastric H+K+-ATPase is a major autoantigen in chronic Helicobacter pylori gastritis with body corpus atrophy. Gastroenterology 1998;115:340-347.
    • (1998) Gastroenterology , vol.115 , pp. 340-347
    • Claeys, D.1    Faller, G.2    Appelmelk, B.I.3    Negrini, R.4    Kirchner, T.5
  • 186
    • 0030666984 scopus 로고    scopus 로고
    • Antigastric autoantibodies in Helicobacter pylori infection: Implications of clinical and histological parameters of gastritis
    • Faller G, Steininger H, Kranzlein J, Maul H, Kerkau T, Hensen J, et al. Antigastric autoantibodies in Helicobacter pylori infection: implications of clinical and histological parameters of gastritis. Gut 1997;41:619-623.
    • (1997) Gut , vol.41 , pp. 619-623
    • Faller, G.1    Steininger, H.2    Kranzlein, J.3    Maul, H.4    Kerkau, T.5    Hensen, J.6
  • 187
    • 0031982195 scopus 로고    scopus 로고
    • Antigastric autoantibodies and gastric secretory function in Helicobacter pylori-infected patients with duodenal ulcer and non-ulcer dyspepsia
    • Faller G, Winter M, Steininger P, Konturek P, Konturek SJ, Kirchner T. Antigastric autoantibodies and gastric secretory function in Helicobacter pylori-infected patients with duodenal ulcer and non-ulcer dyspepsia. Scand J Gastroenterol 1998;33:276-282.
    • (1998) Scand J Gastroenterol , vol.33 , pp. 276-282
    • Faller, G.1    Winter, M.2    Steininger, P.3    Konturek, P.4    Konturek, S.J.5    Kirchner, T.6
  • 188
    • 9344248024 scopus 로고    scopus 로고
    • Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity
    • Appelmelk BJ, Faller G, Claeys D, Moran AP, Aspinall GO, Forte JG, et al. Potential role of molecular mimicry between Helicobacter pylori lipopolysaccharide and host Lewis blood group antigens in autoimmunity. Infect Immun 1996;64:2031-2040.
    • (1996) Infect Immun , vol.64 , pp. 2031-2040
    • Appelmelk, B.J.1    Faller, G.2    Claeys, D.3    Moran, A.P.4    Aspinall, G.O.5    Forte, J.G.6
  • 190
    • 0035121541 scopus 로고    scopus 로고
    • H + K+-ATP-ase (proton pump) is the target autoantigen of Th1-type cytotoxic T cells in autoimmune gastritis
    • D'Elios MM, Bergman MP, Azzurri A, Amedei A, Benagiano M, De Pont JJ, et al. H + K+-ATP-ase (proton pump) is the target autoantigen of Th1-type cytotoxic T cells in autoimmune gastritis. Gastroenterology 2001;120:377-386.
    • (2001) Gastroenterology , vol.120 , pp. 377-386
    • D'Elios, M.M.1    Bergman, M.P.2    Azzurri, A.3    Amedei, A.4    Benagiano, M.5    De Pont, J.J.6
  • 191
    • 0142219254 scopus 로고    scopus 로고
    • Molecular mimicry between Helicobacter pylori antigens and H+, K+-adenosine triphosphate in human gastric autoimmunity
    • Amedei A, Bergman MP, Appelmelk BJ, Azzurri A, Benagiano M, Tamburini C, et al. Molecular mimicry between Helicobacter pylori antigens and H+, K+-adenosine triphosphate in human gastric autoimmunity. J Exp Med 2003;198:1147-1156.
    • (2003) J Exp Med , vol.198 , pp. 1147-1156
    • Amedei, A.1    Bergman, M.P.2    Appelmelk, B.J.3    Azzurri, A.4    Benagiano, M.5    Tamburini, C.6
  • 192
    • 0036838775 scopus 로고    scopus 로고
    • Gastric Helicobacter species infection in murine and gerbil models: Comparative analysis of effects of H. pylori and H. felis on gastric epithelial cell proliferation
    • Court M, Robinson PA, Dixon MF, Crabtree JE. Gastric Helicobacter species infection in murine and gerbil models: comparative analysis of effects of H. pylori and H. felis on gastric epithelial cell proliferation. J Infect Dis 2002;186:1348-1352.
    • (2002) J Infect Dis , vol.186 , pp. 1348-1352
    • Court, M.1    Robinson, P.A.2    Dixon, M.F.3    Crabtree, J.E.4
  • 193
    • 0036262344 scopus 로고    scopus 로고
    • Reduced activation of inflammatory responses in host cells by mouse-adapted Helicobacter pylori isolates
    • Philpott DJ, Belaid D, Troubadour P, Thiberge JM, Tankovic J, Labigne A, et al. Reduced activation of inflammatory responses in host cells by mouse-adapted Helicobacter pylori isolates. Cell Microbiol 2002;4:285-296.
    • (2002) Cell Microbiol , vol.4 , pp. 285-296
    • Philpott, D.J.1    Belaid, D.2    Troubadour, P.3    Thiberge, J.M.4    Tankovic, J.5    Labigne, A.6
  • 194
    • 0030451867 scopus 로고    scopus 로고
    • Atrophic gastric changes in both Helicobacter felis and Helicobacter pylori infected mice are host dependent and separate from antral gastritis
    • Sakagami T, Dixon M, O'Rourke J, Howlett R, Alderuccio F, Vella J, et al. Atrophic gastric changes in both Helicobacter felis and Helicobacter pylori infected mice are host dependent and separate from antral gastritis. Gut 1996;39:639-648.
    • (1996) Gut , vol.39 , pp. 639-648
    • Sakagami, T.1    Dixon, M.2    O'Rourke, J.3    Howlett, R.4    Alderuccio, F.5    Vella, J.6
  • 195
    • 0036468866 scopus 로고    scopus 로고
    • Germ-line p53-targeted disruption inhibits Helicobacter-induced premalignant lesions and invasive gastric carcinoma through down-regulation of Th1 proinflammatory responses
    • Fox JG, Sheppard BJ, Dangler CA, Whary MT, Ihrig M, Wang TC. Germ-line p53-targeted disruption inhibits Helicobacter-induced premalignant lesions and invasive gastric carcinoma through down-regulation of Th1 proinflammatory responses. Cancer Res 2002;62:696-702.
    • (2002) Cancer Res , vol.62 , pp. 696-702
    • Fox, J.G.1    Sheppard, B.J.2    Dangler, C.A.3    Whary, M.T.4    Ihrig, M.5    Wang, T.C.6
  • 196
    • 10244252625 scopus 로고    scopus 로고
    • Gastric mucosa abnormalities and tumorigenesis in mice lacking the Ps2 trefoil protein
    • Lefebvre O, Chenard MP, Masson R, Linares J, Dierich A, LeMeur M, et al. Gastric mucosa abnormalities and tumorigenesis in mice lacking the Ps2 trefoil protein. Science 1996;274:259-262.
    • (1996) Science , vol.274 , pp. 259-262
    • Lefebvre, O.1    Chenard, M.P.2    Masson, R.3    Linares, J.4    Dierich, A.5    LeMeur, M.6
  • 197
    • 0034611611 scopus 로고    scopus 로고
    • Haploid loss of the tumour suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice
    • Xu X, Brodie SG, Yang X, Im YH, Parks WT, Chen L, et al. Haploid loss of the tumour suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice. Oncogene 2000;19:1868-1874.
    • (2000) Oncogene , vol.19 , pp. 1868-1874
    • Xu, X.1    Brodie, S.G.2    Yang, X.3    Im, Y.H.4    Parks, W.T.5    Chen, L.6
  • 198
    • 18344389720 scopus 로고    scopus 로고
    • Causal relationship between the loss of RUNX3 expression and gastric cancer
    • Li QL, Ito K, Sakaakura C, Fukamachi H, Inoue K, Chi XZ, et al. Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell 2002;109:113-124.
    • (2002) Cell , vol.109 , pp. 113-124
    • Li, Q.L.1    Ito, K.2    Sakaakura, C.3    Fukamachi, H.4    Inoue, K.5    Chi, X.Z.6
  • 199
    • 7444238266 scopus 로고    scopus 로고
    • Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice
    • Mutoh H, Sakurai S, Satoh K, Tamada K, Kita H, Osama H, et al. Development of gastric carcinoma from intestinal metaplasia in Cdx2-transgenic mice. Cancer Res 2004;64:7740-7747.
    • (2004) Cancer Res , vol.64 , pp. 7740-7747
    • Mutoh, H.1    Sakurai, S.2    Satoh, K.3    Tamada, K.4    Kita, H.5    Osama, H.6
  • 200
    • 0036796060 scopus 로고    scopus 로고
    • Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice
    • Tebbutt NC, Giraud AS, Inglese M, Jenkins B, Waring P, Clay FJ, et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nature Med 2002;8:1089-1097.
    • (2002) Nature Med , vol.8 , pp. 1089-1097
    • Tebbutt, N.C.1    Giraud, A.S.2    Inglese, M.3    Jenkins, B.4    Waring, P.5    Clay, F.J.6
  • 201
    • 13244273712 scopus 로고    scopus 로고
    • Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon
    • Perreault N, Sackett SD, Katz JP, Furth EE, Kaestner KH. Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon. Genes Dev 2005;19:311-315.
    • (2005) Genes Dev , vol.19 , pp. 311-315
    • Perreault, N.1    Sackett, S.D.2    Katz, J.P.3    Furth, E.E.4    Kaestner, K.H.5
  • 202
    • 2342587509 scopus 로고    scopus 로고
    • Hyperplastic gastric tumors induced by activated macrophages in Cox-2/mPGES-1 transgenic mice
    • Oshimo H, Oshima M, Inaba K, Taketo M. Hyperplastic gastric tumors induced by activated macrophages in Cox-2/mPGES-1 transgenic mice. EMBO J 2004;23:1669-1678.
    • (2004) EMBO J , vol.23 , pp. 1669-1678
    • Oshimo, H.1    Oshima, M.2    Inaba, K.3    Taketo, M.4
  • 203
    • 0032995903 scopus 로고    scopus 로고
    • Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase-2 in Helicobacter pylori gastritis
    • Fu S, Ramanujam KS, Wong A, Fantry GT, Drachenberg CB, James SP, et al. Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase-2 in Helicobacter pylori gastritis. Gastroenterology 1999;116:1319-1329.
    • (1999) Gastroenterology , vol.116 , pp. 1319-1329
    • Fu, S.1    Ramanujam, K.S.2    Wong, A.3    Fantry, G.T.4    Drachenberg, C.B.5    James, S.P.6
  • 204
    • 10744226726 scopus 로고    scopus 로고
    • Helicobacter pylori stimulates host cyclooxygenase-2 gene: Critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors
    • Jüttner S, Cramer T, Wessler S, Walduck A, Schmitz F, Wunder C, et al. Helicobacter pylori stimulates host cyclooxygenase-2 gene: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors. Cell Microbiol 2003;5:821-834.
    • (2003) Cell Microbiol , vol.5 , pp. 821-834
    • Jüttner, S.1    Cramer, T.2    Wessler, S.3    Walduck, A.4    Schmitz, F.5    Wunder, C.6
  • 205
    • 9144220789 scopus 로고    scopus 로고
    • Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: A randomized controlled trial
    • Wong BC, Lam SK, Wong WM, Chen JS, Zheng TT, Feng RE, et al. Helicobacter pylori eradication to prevent gastric cancer in a high-risk region of China: a randomized controlled trial. J Am Med Assoc 2004;291:187-194.
    • (2004) J Am Med Assoc , vol.291 , pp. 187-194
    • Wong, B.C.1    Lam, S.K.2    Wong, W.M.3    Chen, J.S.4    Zheng, T.T.5    Feng, R.E.6
  • 206
    • 18844380630 scopus 로고    scopus 로고
    • Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice
    • Cai X, Carlson J, Stoicov C, Li H, Wang TC, Houghton J. Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice. Gastroenterology 2005;128:1937-1952.
    • (2005) Gastroenterology , vol.128 , pp. 1937-1952
    • Cai, X.1    Carlson, J.2    Stoicov, C.3    Li, H.4    Wang, T.C.5    Houghton, J.6


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