Translocation of the Helicobacter pylori CagA protein in gastric epithelial cells by a type IV secretion apparatus

Cellular Microbiology

Volumn 2, Issue 2, 2000, Pages 155-164

  Backert, Steffen ^a   Ziska, Elke ^a   Brinkmann, Volker ^a   Zimny Arndt, Ursula ^a   Fauconnier, Alan ^b   Jungblut, Peter R ^a   Naumann, Michael ^a   Meyer, Thomas F ^a  

^a MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^b FREE UNIVERSITY OF BRUSSELS   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACTERIAL TRANSLOCATION; BACTERIAL VIRULENCE; HELICOBACTER PYLORI; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STOMACH EPITHELIUM; STOMACH SECRETION;

ADENOCARCINOMA; AMINO ACID SEQUENCE; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CELL MEMBRANE; CYTOPLASM; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; EPITHELIAL CELLS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED;

BACTERIA (MICROORGANISMS); HELICOBACTER PYLORI; VIR;

EID: 0034042694     PISSN: 14625814     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1462-5822.2000.00043.x     Document Type: Article

References (37)

1. Aihara, M., Tsuchimoto, D., Takizawa, H., Azuma, A., Wakebe, H., Ohmoto, Y., et al. (1997) Mechanisms involved in Helicobacter pylori-induced interleukin-8 production by a gastric cancer cell line, MKN45. Infect Immun 65: 3218-3224.
2. Akopyants, N.S., Clifton, S.W., Kersulyte, D., Crabtree, J.E., Youree, B.E., Reece, C.A., et al. (1998) Analyses of the cag pathogenicity island of Helicobacter pylori. Mol Microbiol 28: 37-53.
3. Alm, R.A., Ling, L.S., Moir, D.T., King, B.L., Brown, E.D., Doig, P.C., et al. (1999) Genomic sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori. Nature 397: 176-180 [published erratum in Nature 397: 719].
4. Andersson, S.G., Zomorodipour, A., Andersson, J.O., Sicheritz-Ponten, T., Alsmark, U.C., Podowski, R.M., et al. (1998) The genome sequence of Rickettsia prowazekii and the origin of mitochondria. Nature 396: 133-140.
5. Backert, S., Von Nickisch-Rosenegk, E., and Meyer, T.F. (1998) Potential role of two Helicobacter pylori relaxases in DNA transfer? Mol Microbiol 30: 673-674.
6. Censini, S., Lange, C., Xiang, Z., Crabtree, J.E., Ghiara, P., Borodovsky, M., et al. (1996) cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc Natl Acad Sci USA 93: 14648-14653.
7. Christie, P.J. (1997) Agrobacterium tumefaciens T-complex transport apparatus: a paradigm for a new family of multi-functional transporters in eubacteria. J Bacteriol 179: 3085-3094.
8. Corthesy-Theulaz, I., Porta, N., Pringault, E., Racine, L., Bogdanova, A., Kraehenbuhl, J.P., et al. (1996) Adhesion of Helicobacter pylori to polarized T84 human intestinal cell monolayers is pH dependent. Infect Immun 64: 3827-3832.
9. Covacci, A., Telford, J.L., del Giudice, G., Parsonnet, J., and Rappuoli, R. (1999) Helicobacter pylori virulence and genetic geography. Science 21: 1328-1333.
10. Cover, T.L., and Blaser, M.J. (1999) Helicobacter pylori factors associated with disease. Gastroenterology 117: 257-261.
11. Gomez-Duarte, O.G., Lucas, B., Yan, Z.X., Panthel, K., Haas, R., and Meyer, T.F. (1998) Protection of mice against gastric colonization by Helicobacter pylori by single oral dose immunization with attenuated Salmonella typhimurium producing urease subunits A and B. Vaccine 16: 460-471.
12. Guruge, J.L., Falk, P.G., Lorenz, R.G., Dans, M., Wirth, H.P., Blaser, M.J., et al. (1998) Epithelial attachment alters the outcome of Helicobacter pylori infection. Proc Natl Acad Sci USA 95: 3925-3930.
13. Haas, R., Meyer, T.F., and van Putten, J.P. (1993) Aflagellated mutants of Helicobacter pylori generated by genetic transformation of naturally competent strains using transposon shuttle mutagenesis. Mol Microbiol 8: 753-760.
14. Jungblut, P.R., and Seifert, R. (1990) Analysis by high-resolution two-dimensional electrophoresis of differentiation-dependent alterations in cytosolic protein pattern of HL-60 leukemic cells. J Biochem Biophys Methods 21: 47-58.
15. Jungblut, P.R., Schaible, U.E., Mollenkopf, H.J., Zimny-Arndt, U., Raupach, B., Mattow, J., et al. (1999) Comparative proteome analysis of Mycobacterium tuberculosis and Mycobacterium bovis BCG strains: towards functional genomics of microbial pathogens. Mol Microbiol 33: 1103-1117.
16. Keates, S., Hitti, Y.S., Upton, M., and Kelly, C.P. (1997) Helicobacter pylori infection activates NF-kappa B in gastric epithelial cells. Gastroenterology 113: 1099-1109.
17. Kenny, B., DeVinney, R., Stein, M., Reinscheid, D.J., Frey, E.A., and Finlay, B.B. (1997) Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells. Cell 91: 511-520.
18. Krause, S., Bárcena, M., Pansegrau, W., Lurz, R., Carazo, J.M., and Lanka, E. (2000) Sequence related protein export NTPases encoded by the conjugative transfer region of RP4 and by the cag pathogenicity island of Helicobacter pylori share similar hexameric ring structures. Proc Natl Acad Sci USA 97: 3067-3072.
19. Lee, A., O'Rourke, J., De Ungria, M.C., Robertson, B., Daskalopoulos, G., and Dixon, M.F. (1997) A standardized mouse model of Helicobacter pylori infection: introducing the Sydney strain. Gastroenterology 112: 1386-1397.
20. Li, S.D., Kersulyte, D., Lindley, I.J., Neelam, B., Berg, D.E., and Crabtree, J.E. (1999) Multiple genes in the left half of the cag pathogenicity island of Helicobacter pylori are required for tyrosine kinase-dependent transcription of interleukin-8 in gastric epithelial cells. Infect Immun 67: 3893-3899.
21. Münzenmaier, A., Lange, C., Glocker, E., Covacci, A., Moran, A., Bereswill, S., et al. (1997) A secreted/shed product of Helicobacter pylori activates transcription factor nuclear factor-kappa B. J Immunol 159: 6140-6147.
22. Naumann, M., Wessler, S., Bartsch, C., Wieland, B., Covacci, A., Haas, R., et al. (1999) Activation of activator protein 1 and stress response kinases in epithelial cells colonized by Helicobacter pylori encoding the cag pathogenicity island. J Biol Chem 274: 31655-31662.
23. O'Callaghan, D., Cazevieille, C., Allardet-Servent, A., Boschiroli, M.L., Bourg, G., Foulongne, V., et al. (1999) A homologue of the Agrobacterium tumefaciens VirB and Bordetella pertussis Ptl type IV secretion systems is essential for intracellular survival of Brucella suis. Mol Microbiol 33: 1210-1220.
24. Otto, A., Thiede, B., Müller, E.-C., Scheler, C., Wittmann-Liebold, B., and Jungblut, P. (1996) Identification of human myocardial proteins separated by two-dimensional electrophoresis using an effective sample preparation for mass spectrometry. Electrophoresis 17: 1643-1650.
25. Pansegrau, W., and Lanka, E. (1996) Enzymology of DNA transfer by conjugative mechanisms. Prog Nucleic Acid Res Mol Biol 54: 197-251.
26. Schmitt, W., and Haas, R. (1994) Genetic analysis of the Helicobacter pylori vacuolating cytotoxin: structural similarities with the IgA protease type of exported protein. Mol Microbiol 12: 307-319.
27. Segal, E.D., Falkow, S., and Tompkins, L.S. (1996) Helicobacter pylori attachment to gastric cells induces cytoskeletal rearrangements and tyrosine phosphorylation of host cell proteins. Proc Natl Acad Sci USA 93: 1259-1264.
28. Segal, E.D., Lange, C., Covacci, A., Tompkins, L.S., and Falkow, S. (1997) Induction of host signal transduction pathways by Helicobacter pylori. Proc Natl Acad Sci USA 94: 7595-7599.
29. Segal, E.D., Cha, J., Lo, J., Falkow, S., and Tompkins, L.S. (1999) Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori. Proc Natl Acad Sci USA 96: 14559-14564.
30. Sharma, S.A., Tummuru, M.K., Blaser, M.J., and Kerr, L.D. (1998) Activation of IL-8 gene expression by Helicobacter pylori is regulated by transcription factor nuclear factor-kappa B in gastric epithelial cells. J Immunol 160: 2401-2407.
31. Su, B., Johansson, S., Fallman, M., Patarroyo, M., Granstrom, M., and Normark, S. (1999) Signal transduction-mediated adherence and entry of Helicobacter pylori into cultured cells. Gastroenterology 117: 595-604.
32. Taylor, D.E. (1999) Helicobacter pylori and its genome: lessons from the treasure map. Can J Gastroenterol 13: 218-223.
33. Tomb, J.F., White, O., Kerlavage, A.R., Clayton, R.A., Sutton, G.G., Fleischmann, R.D., et al. (1997) The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature 388: 539-547 [published erratum in Nature 389: 412].
34. Tummuru, M.K., Cover, T.L., and Blaser, M.J. (1993) Cloning and expression of a high-molecular-mass major antigen of Helicobacter pylori: evidence of linkage to cytotoxin production. Infect Immun 61: 1799-1809.
35. Tummuru, M.K., Sharma, S.A., and Blaser, M.J. (1995) Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells. Mol Microbiol 18: 867-876.
36. Vogel, J.P., and Isberg, R.R. (1999) Cell biology of Legionella pneumophila. Curr Opin Microbiol 2: 30-34.
37. Winans, S.C., Burns, D.L., and Christie, P.J. (1996) Adaptation of a conjugal transfer system for the export of pathogenic macromolecules. Trends Microbiol 4: 64-68.