Proteins encoded by the cag pathogenicity island of Helicobacter pylori are required for NF-κB activation

Infection and Immunity

Volumn 66, Issue 5, 1998, Pages 2346-2348

  Glocker, Erik ^a,b   Lange, Christina ^c   Covacci, Antonello ^c   Bereswill, Stefan ^b   Kist, Manfred ^b   Pahl, Heike L ^a  

^a TUMOR BIOLOGY CENTER   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c CHIRON VACCINES   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CAG PROTEIN; GENE PRODUCT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MEMBRANE PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL VIRULENCE; CHRONIC GASTRITIS; CONTROLLED STUDY; DUODENUM ULCER; GENE CLUSTER; GRAM NEGATIVE INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; INFLAMMATION; PATHOGENICITY; PRIORITY JOURNAL; STOMACH ADENOCARCINOMA; STOMACH EPITHELIUM; STRAIN DIFFERENCE;

HELICOBACTER PYLORI;

EID: 0031899363     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.66.5.2346-2348.1998     Document Type: Article

References (26)

1. Baeuerle, P.A., and D. Baltimore. 1988. I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science 242:540-546.
2. Baeuerle, P. A., and T. Henkel. 1994. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:141-179.
3. Beg, A. A., T. S. Finco, P. V. Nantermet, and A. S. Baldwin, Jr. 1993. Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of IκB-α: a mechanism for NF-κB activation. Mol. Cell. Biol. 13:3301-3310.
4. Blaser, M. J. 1990. Helicobacter pylori and the pathenogenesis of gastroduodenal inflammation. J. Infect. Dis. 161:626-633.
5. Brown, K., S. Gerstberger, L. Carlson, G. Franzoso, and U. Siebenlist. 1995. Control of IκB-α proteolysis by site-specific, signal induced phosphorylation. Science 267:1485-1488.
6. Censini, S., C. Lange, Z. Xiang, J. E. Crabtree, P. Ghiara, M. Borodovsky, R. Rappuoli, and A. Covacci. 1996. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc. Natl. Acad. Sci. USA 93:14648-14653.
7. Covacci, A., S. Censini, M. Bugnoli, R. Petracca, D. Burroni, G. Macchia, A. Massone, E. Papini, Z. Xiang, N. Figura, and R. Rappuoli. 1993. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer. Proc. Natl. Acad. Sci. USA 90:5791-5795.
8. Crabtree, J. E., S. M. Farmery, I. J. D. Lindley, N. Figura, P. Peichl, and D. S. Tompkins. 1994. CagA cytotoxic strains of Helicobacter pylori and interleukin-8 in gastric epithelial cell lines. J. Clin. Pathol. 47:945-950.
9. Crabtree, J. E., T. M. Shallcross, R. V. Heatley, and J. I. Wyatt. 1991. Mucosal tumor necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis. Gut 32:1473-1477.
10. Crabtree, J. E., J. I. Wyatt, L. K. Trejdosiewicz, P. Peichl, P. H. Nichols, N. Ramsay, J. N. Primrose, and I. J. D. Lindley. 1994. Interleukin-8 expression in Helicobacter pylori infected, normal, and neoplastic gastroduodenal mucosa. J. Clin. Pathol. 47:61-66.
11. Crabtree, J. E., Z. Xiang, I. J. D. Lindley, D. S. Tompkins, R. Rappuoli, and A. Covacci. 1995. Induction of interleukin-8 secretion from gastric epithelial cells by cagA negative isogenic mutant of Helicobacter pylori. J. Clin. Pathol. 48:967-969.
12. Gionchetti, P., D. Vaira, M. Campieri, J. Holton, M. Menegatti, A. Belluzzi, E. Bertinelli, M. Ferretti, C. Brignola, M. Migliolo, and L. Barbara. 1994. Enhanced mucosal interleukin-6 and -8 in Helicobacter pylori-positive dyspeptic patients. Am. J. Gastroenterol. 89:883-887.
13. Henkel, T., T. Machleidt, I. Alkalay, K. M. Y. Ben-Neriah, and P. A. Baeuerle. 1993. Rapid proteolysis of IκB-α is necessary for activation of transcription factor NF-κB. Nature 365:182-184.
14. Huang, J., P. W. O'Toole, P. Doig, and T. J. Trust. 1995. Stimulation of interleukin-8 in epithelial cell lines by Helicobacter pylori. Infect. Immun. 63: 1732-1738.
15. Münzenmaier, A., C. Lange, E. Glocker, A. Moran, A. Covacci, P. A. Baeuerle, M. Kist, and H. L. Pahl. A shed/secreted product of Helicobacter pylori is required for activation of the transcription factor NF-κB. J. Immunol. 159:6140-6147.
16. Noach, L. A., N. B. Bosma, J. Jansen, F. J. Hoek, S. J. H. van Deventer, and G. N. J. Tytgat. 1994. Mucosal tumor necrosis factor-α, interleukin-1β, and interleukin-8 production in patients with Helicobacter pylori infection. Scand. J. Gastroenterol. 29:425-429.
17. Nomura, A., G. N. Stemmermann, P. Chyou, I. Kato, G. I. Perez-Perez, and M. J. Blaser. 1991. Helicobacter pylori infection and gastric carcinoma in a population of Japanese-Americans in Hawaii. N. Engl. J. Med. 325:1132-1136.
18. Nomura, A., G. N. Stemmermann, P. Chyou, G. I. Perez-Perez, and M. J. Blaser. 1994. Helicobacter pylori infection and the risk for duodenal and gastric ulceration. Ann. Intern. Med. 120:977-981.
19. Pahl, H. L., and P. A. Baeuerle. 1995. A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-κB. EMBO J. 14:2580-2588.
20. Pahl, H. L., M. Sester, H.-G. Burgert, and P. A. Baeuerle. 1996. Activation of transcription factor NF-κB by adenovirus E3/19K requires its ER-retention. J. Cell Biol. 132:511-522.
21. Peek, R. M., G. G. Miller, K. T. Tham, G. I. Perez-Perez, X. Zhao, J. C. Atherton, and M. J. Blaser. 1995. Heightened inflammatory response and cytokine expression in vivo to cagA+ Helicobacter pylori strains. Lab. Invest. 71:760-770.
22. Segal, E. D., C. Lange, A. Covacci, L. S. Tompkins, and S. Falkow. 1997. Induction of host signal transduction pathways by Helicobacter pylori. Proc. Natl. Acad. Sci. USA 94:7595-7599.
23. Sharma, S. A., M. R. Tumuru, G. G. Miller, and M. J. Blaser. 1995. Interleukin-8 response of gastric epithelial cell lines to Helicobacter pylori stimulation in vitro. Infect. Immun. 63:1681-1687.
24. Sun, S.-C., P. A. Ganchi, C. Béraud, D. W. Ballard, and W. C. Greene. 1994. Autoregulation of the NF-kappa B transactivator RelA (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs. Proc. Natl. Acad. Sci. USA 87:1346-1350.
25. Traenckner, E. B.-M., H. L. Pahl, T. Henkel, K. N. Schmidt, S. Wilk, and P. A. Baeuerle. 1995. Phosphorylation of human IκB-α on serine 32 and 36 controls IκB-α proteolysis and NF-κB activation in response to diverse stimuli. EMBO J. 14:2876-2883.
26. Traenckner, E. B.-M., S. Wilk, and P. A. Baeuerle. 1994. A proteasome inhibitor prevents activation of NF-κB and stabilizes a newly phosphorylated form of IκB-α that is still bound to NF-κB. EMBO J. 13:5433-5441.