Gastrin-cholecystokininB receptor expression in AGS cells is associated with direct inhibition and indirect stimulation of cell proliferation via paracrine activation of the epidermal growth factor receptor

Gut

Volumn 50, Issue 6, 2002, Pages 827-833

  Varro, A ^a   Noble, P J ^a   Wroblewski, L E ^a   Bishop, L ^b   Dockray, G J ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b ROYAL LANCASTER INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLECYSTOKININ B RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GASTRIN; GREEN FLUORESCENT PROTEIN; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; LIGAND; METALLOPROTEINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHOTRANSFERASE INHIBITOR; THYMIDINE DERIVATIVE;

ARTICLE; CELL ACTIVATION; CELL COUNT; CELL CYCLE S PHASE; CELL PROLIFERATION; COCULTURE; CONTROLLED STUDY; ENZYME ACTIVATION; FLOW CYTOMETRY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIGAND BINDING; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION;

CELL DIVISION; ENTEROCHROMAFFIN CELLS; FLOW CYTOMETRY; GREEN FLUORESCENT PROTEINS; HUMANS; LUMINESCENT PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTOR, CHOLECYSTOKININ B; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTORS, CHOLECYSTOKININ; THYMIDINE;

EID: 0036107819     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.50.6.827     Document Type: Article

References (41)

1. Gastrin
2. Effects of curative gastrinoma resectian on gastric secretory function and antisecretory drug requirement in the Zollinger-Ellison syndrome
3. Long term omeprazole therapy in peptic ulcer disease: Gastrin, endocrine cell growth and gastritis
4. Gastrin, CCK, signaling, and cancer
5. Gastrin mediates the gastric mucosal proliferative response to feeding
6. Plasma gastrin and gastric enterochromaffinlike cell activation and proliferation: Studies with omeprazole and randitidine in intact and antrectomized rats
7. Hypergastrinemia and gastric enterochromaffin-like cells
8. Processing and proliferative effects of human progastrin in transgenic mice
9. Gastrin gene expression is required for the proliferation and tumorigenicity of human colon cancer cells
10. Overexpression of glycine-extended gastrin in transgenic mice results in increased colonic proliferation
11. Glycine-extended gastrin acts as an autocrine growth factor in a nontransformed colon cell line
12. Gastrimmune raises antibodies that neutralize amidated and glycine-exended gastrin-17 and inhibit the growth of colon cancer
13. Regulation of gastrointestinal mucosal growth
14. CCK-B receptors produce similar signals but have opposite growth effects in CHO and Swiss 3T3 cells
15. Transfected cholecystokinin receptors mediate growth inhibitory effects on human pancreatic cancer cell lines
16. Immunohistochemical localization of gastrin/CCK-B receptors in the dog and guinea-pig stomach
17. Induction of heparin binding epidermal growth factor-like growth factor and amphiregulin mRNAs by gastrin in the rat stomach
18. Gastrin induces heparin-binding epidermal growth factor-like growth factor in rat gastric epithelial cells transfected with gastrin receptor
19. Synergistic interaction between hypergastrinemia and Helicobacter infection in a mouse model of gastric cancer
20. Transcriptional activation of the rat vesicular monoamine transporter 2 promoter in gastric epithelial cells: Regulation by gastrin
21. Measurement of MAP kinase activation by flow cytometry using phospho- specific antibodies to MEK and ERK: Potential for pharmacodynamic monitoring of signal transduction inhibitors
22. The gastrins: Their production and biological activities
23. Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: Conversion from juxtacrine to paracrine growth factor activity
24. Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity
25. Growth factor effects on apoptosis of rat gastric enterochromaffin-like cells
26. Molecular mechanisms for the growth factor action of gastrin
27. 2+ mobilization and clonal growth
28. The human CCKB/gastrin receptor transfected into rat1 fibroblasts mediates activation of MAP kinase, p74raf-1 kinase, and mitogenesis
29. Muscarinic cholinergic receptors activate both inhibitory and stimulatory growth mechanisms in NIH3T3 cells
30. Regulation of growth of human gastric cancer by gastrin and glycine-extended progastrin
31. EGF receptor activation stimulates endogenous gastrin gene expression in canine G cells and human gastric cell cultures
32. Signal characteristics of G protein-transactivated EGF receptor
33. The beta(2)-adrenergic receptor mediates extracellular signal-regulated kinase activation via assembly of a multi-receptor complex with the epidermal growth factor receptor
34. Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors
35. Regulation of tyrosine kinase cascades by G-protein-coupled receptors
36. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
37. Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin-binding EGF-like growth factor independently of protein kinase C
38. Pathways of processing of the gastrin precursor in rat antral mucosa
39. Gastrin biosynthesis in the antrum of patients with pernicious anemia
40. Hypergastrinaemia is a strong predictor of distal gastric adencarcinoma among Helicobacter pylori infected persons
41. Cholecystokinin-B/gastrin receptors enhance wound healing in the rat gastric mucosa