The Helicobacter pylori vacA sl, ml genotype and cagA is associated with gastric carcinoma in Germany

International Journal of Cancer

Volumn 87, Issue 3, 2000, Pages 322-327

  Miehlke, Stephan ^a   Kirsch, Christian ^a   Agha Amiri, Karin ^b   Günther, Thomas ^b   Lehn, Norbert ^c   Malfertheiner, Peter ^b   Stolte, Manfred ^d   Ehninger, Gerhard ^a   Bayerdörffer, Ekkehard ^a  

^a UNIVERSITY HOSPITAL CARL GUSTAV CARUS   (Germany)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

^c UNIVERSITY OF REGENSBURG   (Germany)

^d INSTITUTE OF PATHOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; CYTOTOXIN; VIRULENCE FACTOR;

ADULT; AGED; ARTICLE; CANCER RISK; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; GASTRITIS; GASTROINTESTINAL INFECTION; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; GERMANY; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NONHUMAN; PRIORITY JOURNAL; STOMACH CANCER;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; FEMALE; GASTRIC MUCOSA; GASTRITIS; GENES, BACTERIAL; GENOTYPE; GERMANY; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MALE; MIDDLE AGED; STOMACH NEOPLASMS; VIRULENCE;

EID: 0034256060     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0215(20000801)87:3<322::AID-IJC3>3.0.CO;2-M     Document Type: Article

References (35)

1. ATHERTON, J.C., CAO, P., PEEK, R.M., TUMMURU, M.K.R., BLASER, M.J. and COVER, T.L., Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. J. biol. Chem., 270, 17771-17777 (1995).
2. ATHERTON, J.C., PEEK, R.M., THAM, K.T., COVER, T.L. and BLASER, M.J., Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori. Gastroenterology 112, 92-99 (1997).
3. BASSO, D., NAVAGLIA, F., BRIGATO, L., PIVA, M.G., TOMA, A., GRECO, E., DI MARIO, F., GALEOTTI, F., ROVERNI, G., CORSINI, A. and PLEBANI, M., Analysis of Helicobacter pylori vacA and cagA genotypes and serum antibody profile in benign and malignant diseases. Gut, 43, 182-186 (1998).
4. BLASER, M.J., PEREZ-PEREZ, G.I., KLEANTHOUS, H., COVER, T., PEEK, R., CHYOU, P.H., STEMMERMANN, G.N. and NOMURA, A., Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res., 55, 2111-2115 (1995).
5. CENSINI, S., LANGE, C., XIANG, Z., CRABTREE, J.E., GHIARA, P., BORODOVSKY, M., RAPPUOLI, R. and COVACCI, A., cag, a pathogenicity island of Helicobacter pylori encodes type I-specific and disease-associated virulence factors. Proc. nat. Acad. Sci. (Wash.), 93, 14648-14653 (1996).
6. COVACCI, A. and RAPPUOLI, R., PCR amplification of gene sequences from Helicobacter pylori strains. In: Helicobacter pylori: techniques for clinical diagnosis & basic research, pp. 94-109, W.B. Saunders (1996).
7. DIXON, M.F., GENTA, R.M., YARDLEY, J.H., CORREA, P. and THE PARTICIPANTS IN THE INTERNATIONAL WORKSHOP ON THE HISTOPATHOLOGY OF GASTRITIS, HOUSTON 1994., Classification and grading of gastritis: the updated Sydney System. Amer. J. Surg. Pathol. 20, 1161-1181 (1996).
8. FORMAN, D., NEWELL, D.G., FULLERTON, F., YARNELL, Y.W.G., STACEY, A.R., WALD, N. and SITAS, F., Association between infection with Helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation. Brit. Med. J., 302, 1302-1305 (1991).
9. GO, M.F., CISELL, L. and GRAHAM, D.Y., Failure to confirm association of the vacA gene mosaicism with duodenal ulcer disease. Scand. J. Gastroenterol., 33, 132-136 (1998).
10. INTERNATIONAL AGENCY FOR RESEARCH ON CANCER, Schistosomes, liver flukes and Helicobacter pylori. Working Group on the Evaluation of Carcinogenic Risks to Humans. IARC Monogr. Eval. Carcinog. Risks Hum., 61, 177-241 (1994).
11. ITO, Y., AZUMA, T., ITO, S., MIYAJI, H., HIRAI, M., YAMAZAKI, Y., SATO, F., KATO, T., KOHLI, Y. and KURIYAMA, M., Analysis and typing of the vacA gene from cagA-positive strains of Helicobacter pylori isolated in Japan. J. Clin. Microbiol., 35, 1710-1714 (1997).
12. KIDD, M., LASTOVICA, A.J., ATHERTON, J.C. and LOUW, J.A., Heterogeneity in the Helicobacter pylori vacA and cagA genes: association with gastroduodenal disease in South Africa? Gut, 45, 499-502 (1999).
13. LAUREN, P., The two main histological types of gastric carcinoma: diffuse and so-called intestinal type carcinoma. An attempt at a histo-clinical classification. Acta Pathol. Microbiol. Scand., 64, 31-39 (1965).
14. MAEDA, S., OGURA, K., YOSHIDA, H., KANAI, F., IKENOUE, T., KATO, N., SHIRATORI, Y. and OMATA, M., Major virulence factors, VacA and CagA, are commonly positive in Helicobacter pylori isolates in Japan. Gut, 42, 338-343 (1998).
15. MATSUKURA, N., ONDA, M., KATO, S., HASEGAWA, H., OKAWA, K., SHIRAKAWA, T., TOKUNAGA, A., YAMASHITA, K. and HAYASHI, A., Cytotoxin genes of Helicobacter pylori in chronic gastritis, gastroduodenal ulcer and gastric cancer: an age and gender matched case-control study. Jpn. J. Cancer Res., 88, 532-536 (1997).
16. MEINING, A., STOLTE, M., HATZ, R., LEHN, N., MIEHLKE, S., MORGNER, A. and BAYERDÖRFFER, E., Differing degree and distribution of gastritis in Helicobacter pylori associated diseases. Virchows Arch., 431, 11-15 (1997).
17. MEINING, A., BAYERDÖRFFER, E. and STOLTE, M., Helicobacter pylori gastritis of the gastric cancer phenotype in relatives of gastric carcinoma patients. Europ. J. Gastroenterol. Hepatol., 11, 717-720 (1999).
18. MIEHLKE, S., KIBLER, K., KIM, J.G., FIGURA, N., SMALL, S.M., GRAHAM, D.Y. and GO, M.F., Allelic variation in Helicobacter pylori cagA gene from Korea compared to the United States. Amer. J. Gastroenterol., 91, 1322-1325 (1996).
19. MIEHLKE, S., GO, M.F., KIM, J.G., GRAHAM, D.Y. and FIGURA, N., Serologic detection of Helicobacter pylori infection with cagA+ strains in duodenal ulcer, gastric cancer, and asymptomatic gastritis. J. Gastroenterol., 33 (Suppl. 10), 18-21 (1998a).
20. MIEHLKE, S., HACKELSBERGER, A., MEINING, A., HATZ, R., LEHN, N., STOLTE, M. and BAYERDÖRFFER, E., Severe expression of corpus gastritis is characteristic in gastric cancer patients infected with Helicobacter pylori. Brit. J. Cancer, 78, 263-266 (1998b).
21. MIEHLKE, S., MEINING, A., MORGNER, A., BAYERDÖRFFER, E., LEHN, N., STOLTE, M., GRAHAM, D.Y. and GO, M.F., Frequency of vacA genotypes and cytotoxin activity in Helicobacter pylori associated with gastric MALT-lymphoma. J. clin. Microbiol., 36, 2369-2370 (1998c).
22. MITCHELL, H.M., HAZELL, S.L., LI, Y.Y. and HU, P.J., Serological response to specific Helicobacter pylori antigens: antibody against CagA is not predictive of gastric cancer in a developing country. Amer. J. Gastroenterol. 91, 1785-1788 (1996).
23. MOBLEY, H.L.T., Helicobacter pylori factors associated with disease development. Gastroenterology, 113, S21-S28 (1997).
24. NOMURA, A., STEMMERMANN, G.N., CHYOU, P.H., KATO, I., PEREZ-PEREZ, G.I. and BLASER, M.J., Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii. N. Engl. J. Med., 325, 1132-1136 (1991).
25. PARSONNET, J., FRIEDMAN, G.D., VANDERSTEEN, D.P., CHANG, Y., VOGELMAN, J.H., ORENTREICH, N. and SIBLEY, R.K., Helicobacter pylori infection and the risk of gastric carcinoma. N. Engl. J. Med., 325, 1127-1131 (1991).
26. RUDI, J., KOLB, C., MAIWALD, M., KUCK, D., SIEG, A., GALLE, P.R. and STREMMEL, W., Diversity of Helicobacter pylori vacA and cagA genes and relationship to VacA and CagA protein expression, cytotoxin production, and associated diseases. J. clin. Microbiol., 36, 944-948 (1998).
27. RUDI, J., KOLB, C., MAIWALD, M., ZUNA, I., GALLE, P.R. and STREMMEL, W., Serum antibodies against Helicobacter pylori proteins CagA and VacA are associated with an increased risk for gastric adenocarcinoma. Dig. Dis. Sci., 42, 1652-1659 (1997).
28. SHIMOYAMA, T., YOSHIMURA, T., MIKAMI, T., FUKUDA, S., CRABTREE, J.E. and MUNAKATA, A., Evaluation of Helicobacter pylori vacA genotypes in Japanese patients with gastric cancer. J. clin. Pathol., 51, 299-301 (1998).
29. STEPHENS, J.C., STEWART, J.A.D., FOLWELL, A.M. and RATHBONE, B.J., Helicobacter pylori cagA status,. vacA genotypes and ulcer disease. Europ. J. Gastroenterol. Hepatol., 10, 381-384 (1998).
30. VAN DOORN, L.J. and 16 OTHERS, Geographic distribution of vacA allelic types of Helicobacter pylori. Gastroenterology, 116, 823-830 (1999).
31. VAN DOORN, L.J., FIGUEIREDO, C., ROSSAU, R., JANNES, G., VAN ASBROEK, M., SOUSA, J.C., CARNEIRO, F. and QUINT, W.G., Typing of Helicobacter pylori vacA gene and detection of cagA gene by PCR and reverse hybridization. J. clin. Microbiol., 36, 1271-1276 (1998a).
32. VAN DOORN, L.J., FIGUEIREDO, C., SANNA, R., PLAISIER, A., SCHNEEBERGER, P., DE BOER, W. and QUINT, W., Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori. Gastroenterology, 115, 58-66 (1998b).
33. WANG, H.J., KUO, C.H., YEH, A.A., CHANG, P.C. and WANG, W.C., Vacuolating toxin production in clinical isolates of Helicobacter pylori with different vacA genotypes. J Infect. Dis., 178, 207-212 (1998).
34. XIANG, Z., CENSINI, S., BAYELI, P.F., TELFORD, J.L., FIGURA, N., RAPPUOLI, R. and COVACCI, A., Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating toxin. Infect. Immun., 63, 94-98 (1995).
35. YAMAOKA, Y., KODAMA, T., KITA, M., IMANISHI, J., KASHIMA, K. and GRAHAM, D.Y., Relationship of vacA genotypes of Helicobacter pylori to cagA status, cylotoxin production, and clinical outcome. Helicobacter, 3, 241-253 (1998).