Helicobacter pylori vacuolating cytotoxin inhibits T lymphocyte activation

Science

Volumn 301, Issue 5636, 2003, Pages 1099-1102

  Gebert, Bettina ^a   Fischer, Wolfgang ^a   Weiss, Evelyn ^a   Hoffmann, Reinhard ^a   Haas, Rainer ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; DRUG DOSAGE; ENZYMES; IMMUNOLOGY; TOXICITY;

NUCLEAR TRANSLOCATION;

CELLS;

BACTERIAL PROTEIN; CALCINEURIN; CALCIUM ION; CALMODULIN; CYTOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2; T LYMPHOCYTE RECEPTOR; TACROLIMUS; UNCLASSIFIED DRUG; VACUOLATING TOXIN;

MICROBIOLOGY;

ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL NUCLEUS; CELL PROLIFERATION; CELL VACUOLE; EPITHELIUM CELL; HELICOBACTER INFECTION; HELICOBACTER PYLORI; IMMUNE RESPONSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; T LYMPHOCYTE;

BACTERIA (MICROORGANISMS); HELICOBACTER; HELICOBACTER PYLORI;

EID: 0042932364     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1086871     Document Type: Article

References (26)

1. M. J. Blaser, Sci. Am. 274, 104 (1996).
2. U. Knipp, S. Birkholz, W. Kaup, K. Mahnke, W. Opferkuch, FEMS Immunobiol. Med. Microbiol. 8, 157 (1994).
3. T. H. Ermak et al., J. Exp. Med. 188, 2277 (1998).
4. B. Lucas et al., Infect. Immun. 69, 1714 (2001).
5. S. Odenbreit et al., Science 287, 1497 (2000).
6. S. Odenbreit, B. Gebert, J. Püls, W. Fischer, R. Haas, Cell. Microbiol. 3, 21 (2001).
7. H. Mimuro et al., Mol. Cell 10, 745 (2002).
8. J. C. Atherton et al., J. Biol. Chem. 270, 17771 (1995).
9. M. Molinari et al., J. Exp. Med. 187, 135 (1998).
10. A. Galmiche et al., EMBO J. 19, 6361 (2000).
11. C. A. Whitehouse et al., Infect. Immun. 66, 1934 (1998).
12. B. Ryffel, J. L. Willcocks, N. Brooks, G. Woerly, Immunopharmacology 30, 199 (1995).
13. H. Shirin et al., Cancer Res. 59, 2277 (1999).
14. J. Jain, C. Loh, A. Rao, Curr. Opin. Immunol. 7, 333 (1995).
15. H. P. Kim, W. J. Leonard, EMBO J. 21, 3051 (2002).
16. M. Lara-Tejero, J. E. Galan, Science 290, 354 (2000).
17. R. H. Kehlenbach, A. Dickmanns, L. Gerace, J. Cell Biol. 141, 863 (1998).
18. R. Glynne et al., Nature 403, 672 (2000).
19. T. Yoshida et al., J. Immunol. 163, 3295 (1999).
20. F. Macian, C. Garcia-Rodriguez, A. Rao, EMBO J. 19, 4783 (2000).
21. I. C. Boulton, S. D. Gray-Owen, Nature Immunol. 3, 229 (2002).
22. N. R. Salama, G. Otto, L. Tompkins, S. Falkow, Infect. Immun. 69, 730 (2001).
23. S. Krauss-Etschmann et al., Clin. Diagn. Lab Immunol. 10, 22 (2003).
24. M. R. Amieva et al., Science 300, 1430 (2003).
25. U. E. Mai et al., J. Exp. Med. 175, 517 (1992).
26. We would like to thank many research labs for valuable contributions of plasmids, especially those of G. R. Crabtree, M. Iwashima, A. Weiss, R. Kehlenbach, P. B. Rothman, and R. Kincaid. We also thank T. Brocker and J. Heesemann for reviewing the manuscript, J. Haas for helpful discussions, and P. Boquet for the generous gift of purified VacA from Hp 60190. Funded by a grant from the Deutsche Forschungsgemeinschaft (SFB 576, project B1) to R.H. and by the Nationales Genom Forschungsnetz (NGFN) (project IE-S15T09).