Involvement of the CD95 (APO-1/Fas) receptor and ligand system in Helicobacter pylori-induced gastric epithelial apoptosis

Journal of Clinical Investigation

Volumn 102, Issue 8, 1998, Pages 1506-1514

  Rudi, Jochen ^a   Kuck, Dirk ^a   Strand, Susanne ^a,c   Von Herbay, Axel ^a   Mariani, Sara M ^b   Krammer, Peter H ^b   Galle, Peter R ^a,c   Stremmel, Wolfgang ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Fluorescence activated cell scanning; Gastric epithelial cell line; Helicobacter pylori associated chronic gastritis; In situ hybridization; Lymphoma cell line

Indexed keywords

FAS ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR;

ADULT; AGED; APOPTOSIS; ARTICLE; CHRONIC GASTRITIS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTER; HELICOBACTER PYLORI; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; LAMINA PROPRIA; MALE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STOMACH EPITHELIUM;

EID: 0032532381     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI2808     Document Type: Article

References (57)

1. NIH Consensus Conference. 1994. Helicobacter pylori in peptic ulcer disease. NIH Consensus development panel. J. Am. Med. Assoc. 272:65-69.
2. Marshall, B.J., and J.R. Warren. 1994. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. i:1311-1314.
3. Dixon, M.F., R.M. Genta, J.H. Yardley, P. Correa, and the International Workshop on the Histopathology of Gastritis, Houston 1994. 1996. Classification and grading of gastritis. The updated Sydney system. Am. J. Surg. Pathol. 20:1161-1181.
4. Fan, X.G., D. Kelleher, X.J. Fan, H.X. Xia, and P.W. Keeling. 1996. Helicobacter pylori increases proliferation of gastric epithelial cells. Gut. 38:19-22.
5. Robert, M.E., and W.M. Weinstein. 1993. Helicobacter pylori-associated gastric pathology. Gastroenterol. Clin. N. Am. 22:59-72.
6. Bursch, W., F. Oberhammer, and R. Schulte-Hermann. 1992. Cell death by apoptosis and its protective role against disease. Trends Pharmacol. Sci 13: 245-251.
7. Evans, V.G. 1993. Multiple pathways to apoptosis. Cell. Biol. Int. 17:461-475.
8. Nagata, S. 1997. Apoptosis by death factor. Cell. 88:355-365.
9. Pickup, D.J., B.S. Ink, W. Hu, C.A. Ray, and W. Kinoklik. 1986. Hemorrhage in lesions caused by cowpox virus is induced by a viral protein that is related to plasma protein inhibitors of serine proteases. Proc. Natl. Acad. Sci. USA. 83:7698-7702.
10. White, E., P. Sabbatini, M. Debbas, W.S.M. Wold, D.I. Kusher, and L.R. Gooding. 1992. The 19kD adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by TNF. Mol. Cell. Biol 12:2570-2580.
11. Roberts, J.M., J.W. Searle, and W.G. Cooksley. 1993. Histological patterns of prolonged hepatitis C infection. Gastroenterology. 26:37-41.
12. Apasov, S., F. Redegeld, and M. Sitkovsky. 1993. Cell-mediated cytotoxicity: contact and secreted factors. Curr. Opin. Immunol. 5:404-410.
13. 2+-independent T cell-mediated cytotoxicity. J. Exp. Med. 177:195-200.
14. Lowin, B., M. Hahne, C. Mattmann, and J. Tschopp. 1994. Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways. Nature. 370:650-652.
15. Kägi, D., F. Vignaux, B. Ledermann, K. Bürki, V. Depraetere, S. Nagata, H. Hengartner, and P. Golstein. 1994. Fas and perforin pathways as major mechanisms of T-cell-mediated cytotoxicity. Science. 265:528-530.
16. Kägi, D., B. Lermann, K. Bürki, P. Seiler, B. Odermatt, K.J. Olsen, E.R. Podack, R.M. Zinkernagel, and H. Hengartner. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature. 369:31-37.
17. Itoh, N., S. Yonehara, A. Ishii, M. Yonehara, S.I. Mizuchima, M. Sameshima, A. Hase, Y. Seto, and S. Nagata. 1991. The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell. 66: 2333-2343.
18. Oehm, A., I. Behrmann, W. Falk, M. Pawlita, G. Maier, C. Klas, M. Li-Weber, S. Richards, J. Dhein, B.C. Trauth, et al. 1992. Purification and molecular cloning of the APO-1 surface antigen, a member of the TNF/NGF receptor superfamily. J. Biol. Chem. 267:10709-10715.
19. Leithäuser, F., J. Dhein, G. Mechtersheimer, K. Koretz, S. Brüderlein, C. Henne, A. Schmidt, K.M. Debatin, P.H. Krammer, and P. Möller. 1993. Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells. Lab. Invest. 69:415-429.
20. Trauth, B.C., C. Klas, A.M.J. Peters, S. Matzku, P. Möller, W. Falk, K.M. Debatin, and P.H. Krammer. 1989. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science. 245:301-305.
21. Yonehara, S., A. Ishii, and M. Yonehara. 1989. A cell-killing monoclonal antibody (anti-Fas) to cell surface antigen co-downregulated with the receptor of tumor necrosis factor. J. Exp. Med. 169:1747-1756.
22. Suda, T., T. Takahashi, P. Golstein, and S. Nagata. 1993. Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell. 75:1169-1178.
23. Suda, T., and S. Nagata. 1994. Purification and characterization of the Fas-ligand that induces apoptosis. J. Exp. Med. 179:873-879.
24. Galle, P.R., W.J. Hofmann, H. Walczak, H. Schaller, G. Otto, W. Stremmel, P.H. Krammer, and L. Runkel. 1995. Involvement of the CD95 (APO-1/ Fas) receptor and ligand in liver damage. J. Exp. Med. 182:1223-1230.
25. Riley, L.K., C.L. Franklin, R.R. Hook, Jr., and C. Besch-Williford. 1996. Identification of murine Helicobacters by PCR and restriction enzyme analyses. J. Clin. Microbiol. 34:942-946.
26. Rudi, J., C. Kolb, M. Maiwald, D. Kuck, A. Sieg, and W. Stremmel. 1998. Diversity of Helicobacter pylori vacA and cagA genes and relationship to VacA and CagA expression, cytotoxin production, and associated diseases. J. Clin. Microbiol. 36:944-948.
27. Dhein, J., P.T. Daniel, B.C. Trauth, A. Oehm, P. Möller, and P.H. Krammer. 1992. Induction of apoptosis by monoclonal antibody anti-APO-1 class switch variants is dependent on cross-linking of APO-1 cell surface antigens. J. Immunol. 149:3166-3173.
28. Angerer, L.M., and R.C. Angerer. 1992. In situ hybridization to cellular RNA with radiolabeled RNA probes. In In Situ Hybridization. A Practical Approach. D.G. Wilkinson, editor. Oxford University Press, New York. 15-32.
29. Atherton, J.C., P. Cao, R.M. Peek, M.K.R. Tummuru, M.J. Blaser, and T.L. Cover. 1995. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. J. Biol. Chem. 270:17771-17777.
30. Peter, M.E., J. Dhein, A. Ehret, S. Hellbardt, H. Walczak, G. Moldenhauer, and P.H. Krammer. 1995. APO-1 (CD95)-dependent and -independent antigen receptor-induced apoptosis in human T and B cell lines. Int. Immunol. 7:1873-1877.
31. Wong, G.H.W., and D. Goeddel. 1994. Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways. J. Immunol. 152:1751-1755.
32. Nicoletti, I., G. Migliorati, M.C. Paggliacci, F. Grignani, and C. Riccardi. 1991. A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry. J. Immunol. Methods. 39:271-279.
33. Dhein, J., H. Walczak, C. Bäumler, K.M. Debatin, and P.H. Krammer. 1995. Autocrine T-cell suicide mediated by APO-1 (Fas/CD95). Nature. 373: 438-441.
34. Moss, S.F., J. Calam, B. Agarwal, S. Wang, and P.R. Holt. 1996. Induction of gastric epithelial apoptosis by Helicobacter pylori. Gut. 38:498-501.
35. Mannick, E.E., L.E. Bravo, G. Zarama, J.L. Realpe, X.-J. Zhang, B. Ruiz, E.T.H. Fontham, R. Mera, M.J.S. Miller, and P. Correa. 1996. Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants. Cancer Res. 56:3238-3243.
36. Peek, R.M., S.F. Moss, and K.T. Tham. 1997. Helicobacter pylori cagA+ strains and dissociation of gastric epithelial cell proliferation from apoptosis. J. Natl. Cancer Inst. 89:863-868.
37. Vignaux, F., and P. Golstein. 1994. Fas-based lymphocyte-mediated cytotoxicity against syngeneic activated lymphocytes: a regulatory pathway? Eur. J. Immunol. 24:923-927.
38. Mita, E., N. Hayashi, S. Iio, T. Takehara, T. Hijioka, A. Kasahra, H. Fusamoto, and T. Kamada. 1994. Role of Fas ligand in apoptosis induced by hepatitis C virus infection. Biochem. Biophys. Res. Commun. 204:468-474.
39. Giordano, C., G. Stassi, R. De Maria, M. Todaro, P. Richiusa, G. Papoff, G. Ruberti, M. Bagnasco, R. Testi, and A. Galluzo. 1997. Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis. Science. 275:960-963.
40. Strand, S., W.J. Hofmann, H. Hug, M. Müller, G. Otto, D. Strand, S.M. Mariani, W. Stremmel, P.H. Krammer, and P.R. Galle. 1996. Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells: a mechanism of immune evasion? Nat. Med. 2:1361-1366.
41. Tanaka, M., T. Itai, M. Adachi, and S. Nagata. 1998. Downregulation of Fas ligand by shedding. Nat. Med. 4:31-36.
42. Crabtree, J.E., T.M. Shallcross, R.V. Heatley, and J.I. Wyatt. 1991. Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis. Gut. 32:1473-1477.
43. Moss, S.F., S. Legon, J. Davies, and J. Calam. 1994. Cytokine gene expression in Helicobacter pylori associated antral gastritis. Gut. 35:1567-1570.
44. Genta, R.M. 1997. The immunobiology of Helicobacter pylori gastritis. Semin. Gastrointest. Dis. 8:2-11.
45. Wagner, S., W. Beil, J. Westermann, R.P.H. Logan, C.T. Bock, C. Trautwein, J.S. Bleck, and M.P. Manns. 1997. Regulation of gastric epithelial cell growth by Helicobacter pylori: evidence for a major role of apoptosis. Gastroenterology. 113:1836-1847.
46. Cover, T.L., C.P. Dooley, and M.J. Blaser. 1990. Characterization of and human serologic response to proteins in Helicobacter pylori broth culture supernatants with vacuolizing cytotoxin activity. Infect. Immun. 58:603-610.
47. Smoot, D.T., J.H. Resau, M.H. Earlington, M. Simpson, and T.L. Cover. 1996. Effects of Helicobacter pylori vacuolating cytotoxin on primary cultures of human gastric epithelial cells. Gut. 39:795-799.
48. Harris, R.P., T.L. Cover, D.R. Crowe, J.M. Orenstein, M.F. Graham, M.J. Blaser, and P.D. Smith. 1996. Helicobacter pylori cytotoxin induces vacuolation of primary human mucosal epithelial cells. Infect. Immun. 64:4867-4871.
49. Cover, T.L., P. Cao, C.D. Lind, K.T. Tham, and M.J. Blaser. 1993. Correlation between vacuolating cytotoxin production by Helicobacter pylori isolates in vitro and in vivo. Infect. Immun. 61:5008-5012.
50. Censini, S., C. Lange, Z. Xiang, J.E. Crabtree, P. Ghiara, M. Borodovsky, R. Rappuoli, and A. Covacci. 1996. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc. Natl. Acad. Sci. USA. 93:14648-14653.
51. Tummuru, M.K., S.A. Sharma, and M.J. Blaser. 1995. Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells. Mol. Microbiol. 18:867-876.
52. Peek, R.M., G.G. Miller, K.T. Tham, G.I. Perez-Perez, X. Zhao, J.C. Atherton, and M.J. Blaser. 1995. Heightened inflammatory response and cytokine expression in vivo to cagA+ Helicobacter pylori strains. Lab. Invest. 71: 760-770.
53. Yamaoka, Y., M. Kita, T. Kodama, N. Sawai, and J. Imanishi. 1996. Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa. Gastroenterology. 110:1744-1752.
54. Sharma, S.A., M.K. Tummuru, G.G. Miller, and M.J. Blaser. 1995. Interleukin-8 response of gastric epithelial cell lines to Helicobacter pylori stimulation in vitro. Infect. Immun. 63:1681-1687.
55. Piotrowski, J., D. Skrodzka, A. Slomiany, and B.L. Slomiany. 1996. Helicobacter pylori lipopolysaccharide induces gastric epithelial cell apoptosis. Biochem. Mol Biol. Int. 40:597-602.
56. Papini, E., E. Gottardi, B. Satin, M. De Bernhard, P. Massari, J. Telford, R. Rappuoli, S.B. Sato, and C. Montecucco. 1996. The vacuolar ATPase proton pump is present on intracellular vacuoles induced by Helicobacter pylori. J. Med. Microbiol. 45:84-89.
57. Kerr, J.F., A.M. Wyllie, and A.R. Curries. 1972. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer. 26:239-257.