Molecular Mimicry between Helicobacter pylori Antigens and H +,K+-Adenosine Triphosphatase in Human Gastric Autoimmunity

Journal of Experimental Medicine

Volumn 198, Issue 8, 2003, Pages 1147-1156

  Amedei, Amedeo ^a   Bergman, Mathijs P ^b   Appelmelk, Ben J ^b   Azzurri, Annalisa ^a   Benagiano, Marisa ^a   Tamburini, Carlo ^a   Van der Zee, Ruurd ^c   Telford, John L ^d   Vandenbroucke Grauls, Christina M J E ^b   D'Elios, Mario M ^a,e   Del Prete, Gianfranco ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

^d CHIRON VACCINES   (Italy)

^e UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Autoreactive T cells; Helicobacter pylori; Mimicry; Mucosal immunity; T cell epitopes

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); B CELL ACTIVATING FACTOR; B CELL ACTIVATING FACTOR RECEPTOR; BACTERIAL ANTIGEN; CD4 ANTIGEN; UNCLASSIFIED DRUG;

ADULT; ANTIBODY SPECIFICITY; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNE DISEASE; CASE REPORT; CELL PROLIFERATION; DISEASE COURSE; FEMALE; GASTRITIS; GENETIC SUSCEPTIBILITY; HELICOBACTER PYLORI; HELPER CELL; HUMAN; MOLECULAR CLONING; MOLECULAR MIMICRY; MUCOSAL IMMUNITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; STOMACH DISEASE; T LYMPHOCYTE ACTIVATION;

ADULT; ANTIGENS, BACTERIAL; AUTOANTIGENS; AUTOIMMUNE DISEASES; CROSS REACTIONS; EPITOPES, T-LYMPHOCYTE; FEMALE; GASTRIC MUCOSA; GASTRITIS, ATROPHIC; H(+)-K(+)-EXCHANGING ATPASE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; LYMPHOCYTE ACTIVATION; MIDDLE AGED; MOLECULAR MIMICRY; STOMACH; T-LYMPHOCYTES;

EID: 0142219254     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20030530     Document Type: Article

References (40)

1. Rose, N.R., and C. Bona. 1993. Defining criteria for autoimmune diseases (Witebsky's postulates revisited). Immunol. Today. 14:426-430.
2. Oldstone, M.B.A. 1998. Molecular mimicry and immune-mediated diseases. FASEB J. 12:1255-1265.
3. Theofilopoulos, A.N., and D.H. Kono. 1998. Mechanisms and genetics of autoimmunity. Ann. NY Acad. Sci. 841:225-235.
4. Lori, J.A., and R.D. Inman. 1999. Molecular mimicry and autoimmunity. N. Engl. J. Med. 341:2068-2074.
5. Benoist, C., and D. Mathis. 2001. Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry? Nat. Immunol. 2:797-801.
6. Wucherpfennig, K.W. 2001. Mechanisms for the induction of autoimmunity by infectious agents. J. Clin. Invest. 108:1097-1104.
7. Schrer, M.T., L. Ignatowicz, G.M. Winslow, J.W. Kappler, and P. Marrack. 1993. Superantigens: bacterial and viral proteins that manipulate the immune system. Annu. Rev. Cell Biol. 9:101-128.
8. Lehmann, P.V., T. Forsthuber, A. Miller, and E.E. Sercarz. 1992. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature. 358:155-157.
9. Miller, S.D., C.L. Vanderlugt, W.S. Begolka, W. Pao, R.L. Yauch, K.L. Neville, Y. Katz-Levy, A. Carrizosa, and B.S. Kim. 1997. Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading. Nat. Med. 3:1133-1136.
10. Murali-Krishna, K., J.D. Altman, M. Suresh, DJ. Sourdive, A.J. Zajac, J.D. Miller, J. Slansky, and R. Ahmed. 1998. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity. 8:177-187.
11. Bachmaier, K., N. Neu, L.M. de la Maza, S. Pal, A. Hessel, and J.M. Penninger. 1999. Chlamydia infections and heart disease linked through antigenic mimicry. Science. 283:1335-1339.
12. Rose, N.R., and I.R. Mackay. 2000. Molecular mimicry: a critical look at exemplary instances in human diseases. Cell. Mol. Life Sci. 57:542-551.
13. Hemmer, B., B. Gran, Y. Zhao, A. Marques, J. Pascal, A. Tzou, T. Kondo, I. Cortese, B. Bielekova, S.E. Straus, et al. 1999. Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease. Nat. Med. 5:1375-1382.
14. Martin, R., B. Gran, Y. Zhao, S. Markovic-Plese, B. Bielekova, A. Marques, M.H. Sung, B. Hemmer, R. Simon, H.F. McFarland, and C. Pinilla. 2001. Molecular mimicry and antigen-specific T cell responses in multiple sclerosis and chronic CNS Lyme disease. J. Autoimmun. 16:187-192.
15. Toh, B.H., I.R. van Driel, and P.A. Gleeson. 1997. Pernicious anemia. N. Engl. J. Med. 337:1441-1448.
16. +-adenosine triphosphatase of the stomach. J. Clin. Invest. 81:475-479.
17. + ATPase (proton pump). Autoimmunity. 13:165-172.
18. D'Elios, M.M., M.P. Bergman, A. Azzurri, A. Amedei, M. Benagiano, J.J. De Pont, F. Cianchi, C.M. Vandenbroucke-Grauls, S. Romagnani, B.J. Appelmelk, and G. Del Prete. 2001. H(+),K(+)-ATPase (proton pump) is the target autoantigen of Th1-type cytotoxic T cells in autoimmune gastritis. Gastroenterology. 120:377-386.
19. Suerbaum, S., and P. Michetti. 2002. Helicobacter pylori infection. N. Engl. J. Med. 347:1175-1186.
20. Appelmelk, B.J., G. Faller, D. Claeys, T. Kirchner, and C.M.J.E. Vandenbroucke-Grauls. 1998. Bugs on trial: the case of Helicobacter pylori and autoimmunity. Immunol. Today. 19:296-299.
21. Faller, G., M. Winter, H. Steininger, N. Lehn, A. Meining, E. Bayerdorffer, and T. Kirchner. 1999. Decrease of antigastric autoantibodies in Helicobacter pylori gastritis after cure of infection. Pathol. Res. Pract. 195:243-246.
22. Swarts, H.G., T.J. Van Uem, S. Hoving, J.A. Fransen, and J.J. De Pont. 1991. Effect of free fatty acids and detergents on H,K-ATPase. The steady-state ATP phosphorylation level and the orientation of the enzyme in membrane preparations. Biochim. Biophys. Acta. 1070:283-292.
23. +)-ATPase. Biochem. Biophys. Res. Commun. 157:203-206.
24. Van der Zee, R., S.M. Anderton, C.A.F. Buskens, E. Alonso de Velasco, and W. Van Eden. 1995. Heat shock protein T cell epitopes as immunogenic carriers in subunit vaccines. In Peptides 1994, Proceedings of the Twenty-Third Peptide Symposium. H.L.S. Maya, editor. ESCOM, Leiden, Netherlands. 842.
25. Sing, H., and G.P.S. Raghava. 2001. ProPred: prediction of HLA-DR binding sites. Bioinformatics. 17:1236-1237.
26. D'Elios, M.M., M. Manghetti, M. De Carli, F. Costa, C.T. Baldari, D. Burroni, J.L. Telford, S. Romagnani, and G. Del Prete. 1997. Th1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease. J. Immunol. 158:962-967.
27. Vergelli, M., B. Hemmer, P.A. Muraro, L. Tranquill, W.E. Biddison, A. Sarin, H.F. McFarland, and R. Martin. 1997. Human autoreactive CD4 T cell clones use perforin or Fas/Fas ligand-mediated pathways for target cell lysis. J. Immunol. 158:2756-2761.
28. D'Elios, M.M., M. Manghetti, F. Almerigogna, A. Amedei, F. Costa, D. Burroni, C.T. Baldari, S. Romagnani, J.L. Telford, and G. Del Prete. 1997. Different cytokine profile and antigen-specificity repertoire in Helicobacter pylori-specific T cell clones from the antrum of chronic gastritis patients with or without peptic ulcer. Eur. J. Immunol. 27:1751-1755.
29. Kersh, G.J., and P.M. Allen. 1996. Structural basis for T cell recognition of altered peptide ligands: a single T cell receptor can productively recognize a large continuum of related ligands. J. Exp. Med. 184:1259-1268.
30. Hemmer, B., M. Vergelli, C. Pinilla, R. Houghten, and R. Martin. 1998. Probing degeneracy in T-cell recognition using combinatorial peptide libraries. Immunol. Today. 19:163-168.
31. Benagiano, M., A. Azzurri, A. Ciervo, A. Amedei, C. Tamburini, M. Ferrari, J.L. Telford, C.T. Baldari, S. Romagnani, A. Cassone, et al. 2003. T helper type 1 lymphocytes drive inflammation in human atherosclerotic lesions. Proc. Natl. Acad. Sci. USA. 100:6658-6663.
32. Wucherpfennig, K.W., D.A. Hafler, and J.L. Strominger. 1995. Structure of human T-cell receptors specific for an immunodominant myelin basic protein peptide: positioning of T-cell receptors on HLA-DR2/peptide complexes. Proc. Natl. Acad. Sci. USA. 92:8896-8900.
33. Wucherpfennig, K.W., A. Sette, S. Southwood, C. Oseroff, M. Matsui, J.L. Strominger, and D.A. Hafler. 1994. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J. Exp. Med. 179:279-290.
34. Bachmaier, K., N. Neu, L.M. de la Maza, S. Pal, A. Hessel, and J.M. Penninger. 1999. Chlamydia infections and heart disease linked through antigenic mimicry. Science. 283:1335-1339.
35. Lang, H.L., H. Jacobsen, S. Ikemizu, C. Andersson, K. Harlos, L. Madsen, P. Hjorth, L. Sondergaard, A. Svejgaard, K. Wucherpfennig, et al. 2002. A functional and structural basis for TCR cross-reactivity in multiple sclerosis. Nat. Immunol. 3:940-943.
36. Lengl-Janssen, B., A.F. Strauss, A.C. Steere, and T. Kamradt. 1994. The T helper cell response in Lyme arthritis: differential recognition of Borrelia burgdorferi outer surface protein A in patients with treatment-resistant or treatment-responsive Lyme arthritis. J. Exp. Med. 180:2069-2078.
37. Gross, D.M., T. Forsthuber, M. Tary-Lehmann, C. Etling, K. Ito, Z.A. Nagy, J.A. Field, A.C. Steere, and B.T. Huber. 1998. Identification of LFA-1 as a candidate autoantigen in treatment-resistant Lyme arthritis. Science. 281:703-706.
38. Akin, E., J. Aversa, and A.C. Steere. 2001. Expression of adhesion molecules in synovia of patients with treatment-resistant Lyme arthritis. Infect. Immun. 69:1774-1780.
39. McDevitt, H.O. 2000. Discovering the role of the major histocompatibility complex in the immune response. Annu. Rev. Immunol. 18:1-17.
40. Ma, J.-Y., K. Borch, S.E. Sjöstrand, L. Janzon, and S. Mårdh. 1994. Positive correlation between H,K-adenosine triphosphatase autoantibodies and Helicobacter pylori antibodies in patients with pernicious anemia. Scand. J. Gastroenterol. 29:961-965.