Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells

Journal of Experimental Medicine

Volumn 191, Issue 4, 2000, Pages 593-602

  Asahi, Momoyo ^a   Azuma, Takeshi ^b   Ito, Shigeji ^b   Ito, Yoshiyuki ^b   Suto, Hiroyuki ^b   Nagai, Yukifumi ^b   Tsubokawa, Misao ^c   Tohyama, Yumi ^d   Maeda, Shin ^e   Omata, Masao ^e   Suzuki, Toshihiko ^f   Sasakawa, Chihiro ^f  

^a FUKUI PREFECTURAL UNIVERSITY   (Japan)

^b UNIVERSITY OF FUKUI   (Japan)

^c Tsubokawa Clinic   (Japan)

^d KYOTO UNIVERSITY   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

^f UNIVERSITY OF TOKYO   (Japan)

Author keywords

Bacterial adhesion; Bacterial infection; Bacterial protein; Protein tyrosine kinase; Signal transduction

Indexed keywords

BACTERIAL PROTEIN; BACTERIUM LYSATE; CYTOTOXIN ASSOCIATED GENE A ANTIGEN; INTERLEUKIN 8; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; BACTERIUM ADHERENCE; CELL LYSATE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GRAM NEGATIVE INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STOMACH EPITHELIUM;

AMINO ACID SEQUENCE; ANTIGENS, BACTERIAL; BACTERIAL PROTEINS; CELL LINE; GASTRIC MUCOSA; HELICOBACTER PYLORI; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PEPTIDE MAPPING; PHOSPHORYLATION; PHOSPHOTYROSINE; POLYMERASE CHAIN REACTION; RECEPTOR, EPIDERMAL GROWTH FACTOR; SRC-FAMILY KINASES; STOMACH ULCER;

EID: 0034695875     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.191.4.593     Document Type: Article

References (38)

1. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration
2. Campylobacter pyloridis, gastritis, and peptic ulceration
3. Helicobacter pylori and the pathogenesis of gastroduodenal inflammation
4. Helicobacter pylori infection and the risk of gastric carcinoma
5. Helicobacter pylori infection and gastric lymphoma
6. Divergence of genetic sequences for the vacuolating cytotoxin among Helicobaaer pylori strains
7. Cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors
8. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration
9. Development of a mouse model of Helicobacter pylori infection that mimics human disease
10. The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity
11. Molecular characterization of the 128-kDa immunodominant antigen of Helicobacter pylori associated with cytotoxicity and duodenal ulcer
12. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adeno-carcinoma of the stomach
13. Helicobacter pylori attachment to gastric cells induces cytoskeletal rearrangements and tyrosine phosphorylation of host cell proteins
14. Consequences of attachment of Helicobacter pylori to gastric cells
15. Induction of host signal transduction pathways by Helicobacter pylori
16. Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype
17. Activation of IL-8 gene expression by Helicobacter pylori is regulated by transcription factor nuclear factor-kappa B in gastric epithelial cells
18. Mechanisms involved in Helicobacter pylori-induced interleukin-8 production by a gastric cancer cell line, MKN45
19. Helicobacter pylori virulence and genetic geography
20. Helicobacter pylori: Molecular evolution of a bacterial quasi-species
21. Helicobacter pylori cagA gene and expression of cytokine messenger RNA in gastric mucosa
22. High seropositivity of anti-CagA antibody I Helicobacter pylori infected patients irrelevant to peptic ulcers and normal mucosa in Japan
23. In-gel digestion of proteins for internal sequence analysis after one- or two-dimensional gel electrophoresis
24. Toxigenicity of Helicobacter pylori isolates possessing cagA gene and vacuolating cytotoxin
25. Antibody response of patients against a 120 kDa surface protein of Campylobacter pylori
26. Expression of 120 kilo-dalton protein and cytotoxicity in Helicobacter pylori
27. Characterization of and human serologic response to proteins in Helicobacter pylori broth culture supernatants with vacuolizing cytotoxin activity
28. Pathogenic mechanisms of Helicobacter pylori: Production of cytotoxin
29. Adherence of Helicobacter pylori to cultured human gastric epithelial cells
30. Proteins encoded by the cag pathogenicity island of Helicobacter pylori are required for NF-κB activation
31. Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells
32. Phosphorylation of tyrosine 474 of the enteropathogenic Escherichia coli (EPEC) tir receptor molecule is essential for actin nucleating activity and is preceded by additional host modifications
33. How is the intracellular fate of the Legionella pneumophila phagosome determined?
34. The genome sequence of Rickettsia prowazekki and the origin of nitochondria
35. Adaptation of a conjugal transfer system for the export of pathogenic macromolecules
36. Signal transduction between enteropathogenic Escherichia coli and epithelial cells: EPEC induces tyrosine phosphorylation of host cell proteins to initiate cytoskeletal rearrangement and bacterial uptake
37. A pathogenic bacterium triggers epithelial signals to form a functional bacterial receptor that mediates actin pseudopod formation
38. Comparison of Helicobacter pylori and attaching-effacing Escherichia coli adhesion to eukaryotic cells