Helicobacter pylori strain-specific differences in genetic content, identified by microarray influence host inflammatory responses

Journal of Clinical Investigation

Volumn 107, Issue 5, 2001, Pages 611-620

  Israel, Dawn A ^a   Salama, Nina ^b   Arnold, Carrie N ^b   Moss, Steven F ^c   Ando, Takafumi ^a   Wirth, Hans Peter ^a   Tham, Kyi T ^d,e   Camorlinga, Margorita ^a   Blaser, Martin J ^a,e   Falkow, Stanley ^b   Peek Jr , Richard M ^a,e  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BROWN UNIVERSITY   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BACTERIAL COLONIZATION; CELL PROLIFERATION; CHROMOSOME MAP; CHRONIC GASTRITIS; COLONY FORMING UNIT; CONTROLLED STUDY; DNA HYBRIDIZATION; DNA MICROARRAY; GASTRITIS; GENETIC ANALYSIS; GENOME; GERBIL; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATION; NONHUMAN; PATHOGENESIS; PATHOGENICITY; PEPTIC ULCER; PRIORITY JOURNAL; STOMACH CANCER; STOMACH MUCOSA; STRAIN DIFFERENCE;

HELICOBACTER PYLORI;

EID: 0035089842     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI11450     Document Type: Article

References (55)

1. Helicobacter pylori and peptic ulcer disease
2. Helicobacter pylori infection and gastric carcinoma among Japanese Americans in Hawaii
3. Helicobacter pylori infection and the risk of gastric carcinoma
4. Gastric precancerous process in a high risk population: Cohort follow-up
5. The risk of stomach cancer in patients with gastric or duodenal ulcer disease
6. Induction of gastric epithelial apoptosis by Helicobacter pylori
7. Helicobacter pylori cagA+ strains and dissociation of gastric epithelial cell proliferation from apoptosis
8. Experimental infection of Mongolian gerbils with wild-type and mutant Helicobacter pylori strains
9. Helicobacter pylori alters gastric epithelial cell cycle events and gastrin secretion in Mongolian gerbils
10. Helicobacter pylori infection induces gastric cancer in Mongolian gerbils
11. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors
12. Helicobacter pylori picB, a homologue of the Bordetella potussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells
13. Mucosal IgA recognition of Helicobacter pylori 120 kDa protein, peptic ulcerarion, and gastric pathology
14. Helicobacter pylori and atrophic gastritis: Importance of the cagA status
15. Systemic and mucosal humoral responses to Helicobacter pylori in gastric cancer
16. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach
17. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori: Association of specific vacA types with cytotoxin production and peptic ulceration
18. Adherence to gastric epithelial cells reduces expression of a Helicobacter pylori gene, iceA, that is associated with clinical outcome
19. Clinical relevance of the cagA, vacA, and iceA status of Helicobacter pylori
20. Sequence analysis and clinical significance of the iceA gene from Helicobacter pylori strains in Japan
21. High seropositivity of anti-CagA antibody in Helicobacter pylori-infected patients irrelevant to peptic ulcers and normal mucosa in Japan
22. The complete genome sequence of the gastric pathogen Helicobacter pylori
23. Genomic-sequence comparison of two unrelated isolates of the human gastric pathogen Helicobacter pylori
24. A whole genome microarray reveals genetic diversity among Helicobacter pylori strains
25. Helicobacter pylori strain-specific genotypes and modulation of the gastric epithelial cell cycle
26. Analyses of the cag pathogenicity island of Helicobacter pylori
27. DNA arrays for analysis of gene expression
28. Cluster analysis and display of genome-wide expression patterns
29. Epithelial attachment alters the outcome of Helicobacter pylori infection
30. Heightened inflammatory response and cytokine expression in vitro to cagA+ Helicobacter pylori strains
31. Gastric interleukin-8 and IgA IL-8 autoantibodies in Helicobacter pylori infection
32. PCR-based subtractive hybridization and differences in gene content among strains of Helicobacter pylori
33. Identification of type II restriction and modification systems in Helicobacter pylori reveals their substantial diversity among strains
34. Restriction-modification system differences in Helicobacter pylori are a barrier to intetstrain plasmid transfer
35. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion
36. Tyrosine phosphorylation of the Helicobacter pylori CagA antigen afret cag-driven host cell translocation
37. Helicobacter pylori CagA protein can be tyrosine phosphorylated in gastric epithelial cells
38. Altered srates: Involvement pf phosphorylated CagA in rhe induction of host cellular growth changes by Helicobacter pylori
39. Helicobacter pylori infection activates NF-kappa B in gastric epithelial cells
40. Helicobacter pylori urease binds to class II MHC on gastric epithelial cells and induces their apoptosis
41. Helicobacter-specific cell-mediated immune responses display a predominant Th 1 phenotype and promote a delayed-type hypersensitive response in the stomachs of mice
42. Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype
43. Regulation of gastric epithelial cell growth by Helicobacter pylori: Evidence for a major role of apoptosis
44. Helicobacter pylori modulates lymphoepithelial cell interactions leading to epithelial cell damage through Fas/Fas ligand interactions
45. Role of gamma interferon in Helicobacter pylori-induced gastric inflammatory responses in a mouse model
46. Helicobacter pylori-induced mucosal inflammation is Th 1 mediated and exacerbated in IL-4, but not IFN-γ, gene deficient mice
47. Murine CD4 T-cell responses to Helicobacter infection: TH1 cells enhance gastritis and TH2 cells reduce bacterial load
48. Concurrent enteric helminrh infection modulates inflammation and gastric immune responses and reduces Helicobacter-induced gastric atrophy
49. In vivo disruption of the Fas pathway abrogates gastric growth alterations secondary to Helicobacter infection
50. Mice lacking secretory phospholipase A2 show altered apoptosis and differentiation with Helicobacter felis infection
51. Interleukin-1 polymorphisins associated with increased risk of gastric cancer
52. Healing of Helicobacter pylori-induced gastric ulcers in Mongolian gerbils: Combined treatment with omeptazole and clarithromycin
53. The effects of Helicobacter pylori on gastric acid secretion and setum gastrin levels in Mongolian gerbils with reference to interleukin-1β