Retinoids and TRAIL: Two Cooperating Actors to Fight Against Cancer

Vitamins and Hormones

Volumn 67, Issue , 2004, Pages 319-345

  Altucci, Lucia ^a   Gronemeyer, Hinrich ^b  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

^b INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS REGULATORY PROTEIN; MEMBRANE PROTEIN; RETINOIC ACID RECEPTOR; RETINOID; RETINOID X RECEPTOR; TNFSF10 PROTEIN, HUMAN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANIMAL; APOPTOSIS; GENETICS; HUMAN; NEOPLASM; PATHOLOGY; PHYSIOLOGY; PROMYELOCYTIC LEUKEMIA; REVIEW;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; MEMBRANE GLYCOPROTEINS; NEOPLASMS; RECEPTORS, RETINOIC ACID; RECEPTORS, TUMOR NECROSIS FACTOR; RETINOID X RECEPTORS; RETINOIDS; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 3042782924     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0083-6729(04)67017-8     Document Type: Article

References (126)

1. A Almasan A Ashkenazi Apo2L⧸TRAIL: Apoptosis signaling, biology, and potential for cancer therapy Cytokine Growth Factor Rev. 14 2003 337 348
2. L Altucci H Gronemeyer The promise of retinoids to fight against cancer Nature Rev. Cancer 1 2001 181 193
3. L Altucci H Gronemeyer Decryption of the retinoid death code in leukemia J. Clin. Immunol. 22 2002 117 123
4. L Altucci A Rossin W Raffelsberger A Reitmair C Chomienne H Gronemeyer Retinoic acid-induced apoptosis in leukemia cells is mediated by paracrine action of tumor-selective death ligand TRAIL Nat. Med. 7 2001 680 686
5. M.A Anzano S.W Byers J.M Smith C.W Peer L.T Mullen C.C Brown A.B Roberts M.B Sporn Prevention of breast cancer in the rat with 9-cis-retinoic acid as a single agent and in combination with tamoxifen Cancer Res. 54 1994 4614 4617
6. A Arora Y Shukla Induction of apoptosis by diallyl sulfide in DMBA-induced mouse skin tumors Nutr. Cancer 44 2002 89 94
7. B Belandia R.L Orford H.C Hurst M.G Parker Targeting of SWI⧸SNF chromatin remodelling complexes to estrogen-responsive genes EMBO J. 21 2002 4094 4103
8. G Benoit L Altucci M Flexor S Ruchaud J Lillehaug W Raffelsberger H Gronemeyer M Lanotte RAR-independent RXR signaling induces t(15;17) leukemia cell maturation EMBO J. 18 1999 7011 7018
9. G.R Benoit M Flexor F Besancon L Altucci A Rossin J Hillion Z Balajthy L Legres E Segal-Bendirdjian H Gronemeyer Autonomous rexinoid death signaling is suppressed by converging signaling pathways in immature leukemia cells Mol. Endocrinol. 15 2001 1154 1169
10. E.D Bischoff M.M Gottardis T.E Moon R.A Heyman W.W Lamph Beyond tamoxifen: The retinoid X receptor-selective ligand LGD1069 (TARGRETIN) causes complete regression of mammary carcinoma Cancer Res. 58 1998 479 484
11. J.L Bodmer P Meier J Tschopp P Schneider Cysteine 230 is essential for the structure and activity of the cytotoxic ligand TRAIL J. Biol. Chem. 275 2000 20632 20637
12. B Bonavida C.P Ng A Jazirehi G Schiller Y Mizutani Selectivity of TRAIL-mediated apoptosis of cancer cells and synergy with drugs: The trail to non-toxic cancer therapeutics (review) Int. J. Oncol. 15 1999 793 802
13. W Bourguet P Germain H Gronemeyer Nuclear receptor ligand-binding domains: Three-dimensional structures, molecular interactions and pharmacological implications Trends Pharmacol. Sci. 21 2000 381 388
14. V Bovenzi R.L Momparler Antineoplastic action of 5-aza-2′-deoxycytidine and histone deacetylase inhibitor and their effect on the expression of retinoic acid receptor beta and estrogen receptor alpha genes in breast carcinoma cells Cancer Chemother. Pharmacol. 48 2001 71 76
15. D Burakov L.A Crofts C.P Chang L.P Freedman Reciprocal recruitment of DRIP⧸mediator and p160 coactivator complexes in vivo by estrogen receptor J. Biol. Chem. 277 2002 14359 14362
16. W.C Chang J.H Jeng C.C Shieh Y.C Tsai Y.S Ho H.R Guo H.I Liu C.C Lee S.Y Ho Y.J Wang Skin tumor-promoting potential and systemic effects of pentachlorophenol and its major metabolite tetrachlorohydroquinone in CD-1 mice Mol. Carcinogen. 36 2003 161 170
17. J.Y Chen J Clifford C Zusi J Starrett D Tortolani J Ostrowski P.R Reczek P Chambon H Gronemeyer Two distinct actions of retinoid-receptor ligands Nature 382 1996 819 822
18. J.Y Chen S Penco J Ostrowski P Balaguer M Pons J.E Starrett P Reczek P Chambon H Gronemeyer RAR-specific agonist⧸antagonists which dissociate transactivation and AP1 transrepression inhibit anchorage-independent cell proliferation EMBO J. 14 1995 1187 1197
19. Y Chen J Buck F Derguini Anhydroretinol induces oxidative stress and cell death Cancer Res. 59 1999 3985 3990
20. M.Y Chiang D Misner G Kempermann T Schikorski V Giguere H.M Sucov F.H Gage C.F Stevens R.M Evans An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression Neuron 21 1998 1353 1361
21. F Chytil Retinoids in lung development Faseb J. 10 1996 986 992
22. M Clagett-Dame H.F DeLuca The role of vitamin A in mammalian reproduction and embryonic development Annu. Rev. Nutr. 22 2002 347 381
23. E Cretney K Takeda H Yagita M Glaccum J.J Peschon M.J Smyth Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice J. Immunol. 168 2002 1356 1361
24. M.I Dawson P.D Hobbs V.J Peterson M Leid C.W Lange K.C Feng G Chen J Gu H Li S.K Kolluri Apoptosis induction in cancer cells by a novel analogue of 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalenecarboxylic acid lacking retinoid receptor transcriptional activation activity Cancer Res. 61 2001 4723 4730
25. A.M de Urquiza S Liu M Sjoberg R.H Zetterstrom W Griffiths J Sjovall T Perlmann Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain Science 290 2000 2140 2144
26. M.A Degli-Esposti W.C Dougall P.J Smolak J.Y Waugh C.A Smith R.G Goodwin The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain Immunity 7 1997 813 820
27. M.A Degli-Esposti P.J Smolak H Walczak J Waugh C.P Huang R.F DuBose R.G Goodwin C.A Smith Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family J. Exp. Med. 186 1997 1165 1170
28. A Dey S Minucci K Ozato Ligand-dependent occupancy of the retinoic acid receptor beta 2 promoter in vivo Mol. Cell. Biol. 14 1994 8191 8201
29. L Di Croce V.A Raker M Corsaro F Fazi M Fanelli M Faretta F Fuks F Lo Coco T Kouzarides C Nervi Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor Science 295 2002 1079 1082
30. F.J Dilworth C Fromental-Ramain K Yamamoto P Chambon ATP-Driven chromatin remodeling activity and histone acetyltransferases act sequentially during transactivation by RAR⧸RXR in vitro Mol. Cell 6 2000 1049 1058
31. Z Dong M.J Birrer R.G Watts L.M Matrisian N.H Colburn Blocking of tumor promoter-induced AP-1 activity inhibits induced transformation in JB6 mouse epidermal cells Proc. Natl. Acad. Sci. USA 91 1994 609 613
32. C Du M Fang Y Li L Li X Wang Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition Cell 102 2000 33 42
33. M Duvic K Hymes P Heald D Breneman A.G Martin P Myskowski C Crowley R.C Yocum Bexarotene is effective and safe for treatment of refractory advanced-stage cutaneous T-cell lymphoma: Multinational phase II-III trial results J. Clin. Oncol. 19 2001 2456 2471
34. J.A Dyck G.G Maul W.H Miller Jr. J.D Chen A Kakizuka R.M Evans A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein Cell 76 1994 333 343
35. P.G Ekert J Silke C.J Hawkins A.M Verhagen D.L Vaux DIABLO promotes apoptosis by removing MIHA⧸XIAP from processed caspase 9 J. Cell Biol. 152 2001 483 490
36. J.G Emery P McDonnell M.B Burke K.C Deen S Lyn C Silverman E Dul E.R Appelbaum C Eichman R DiPrinzio Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL J. Biol. Chem. 273 1998 14363 14367
37. F.J Esteva J Glaspy S Baidas L Laufman L Hutchins M Dickler D Tripathy R Cohen A DeMichele R.C Yocum Multicenter phase II study of oral bexarotene for patients with metastatic breast cancer J. Clin. Oncol. 21 2003 999 1006
38. P Fenaux C Chomienne L Degos All-trans retinoic acid and chemotherapy in the treatment of acute promyelocytic leukemia Semin. Hematol. 38 2001 13 25
39. L.E French J Tschopp The TRAIL to selective tumor death [news; comment] Nat. Med. 5 1999 146 147
40. S.D Gamage E.D Bischoff K.D Burroughs W.W Lamph M.M Gottardis C.L Walker R Fuchs-Young Efficacy of LGD1069 (Targretin), a retinoid X receptor-selective ligand, for treatment of uterine leiomyoma J. Pharmacol. Exp. Ther. 295 2000 677 681
41. A Gavalas ArRAnging the hindbrain Trends Neurosci. 25 2002 61 64
42. P Germain J Iyer C Zechel H Gronemeyer Coregulator recruitment and the mechanism of retinoic acid receptor synergy Nature 415 2002 187 192
43. C.K Glass M.G Rosenfeld The coregulator exchange in transcriptional functions of nuclear receptors Genes Dev. 14 2000 121 141
44. M.M Gottardis E.D Bischoff M.A Shirley M.A Wagoner W.W Lamph R.A Heyman Chemoprevention of mammary carcinoma by LGD1069 (Targretin): An RXR-selective ligand Cancer Res. 56 1996 5566 5570
45. M Gottlicher S Heck P Herrlich Transcriptional cross-talk, the second mode of steroid hormone receptor action J. Mol. Med. 76 1998 480 489
46. D.A Greenhalgh D.J Welty A Player S.H Yuspa Two oncogenes, v-fos and v-ras, cooperate to convert normal keratinocytes to squamous cell carcinoma Proc. Natl. Acad. Sci. USA 87 1990 643 647
47. F Grignani S De Matteis C Nervi L Tomassoni V Gelmetti M Cioce M Fanelli M Ruthardt F.F Ferrara I Zamir Fusion proteins of the retinoic acid receptor-alpha recruit histone deacetylase in promyelocytic leukaemia Nature 391 1998 815 818
48. F Grignani V Gelmetti M Fanelli D Rogaia S De Matteis F.F Ferrara D Bonci C Nervi P.G Pelicci Formation of PML⧸RAR alpha high molecular weight nuclear complexes through the PML coiled-coil region is essential for the PML⧸RAR alpha-mediated retinoic acid response Oncogene 18 1999 6313 6321
49. A Guo P Salomoni J Luo A Shih S Zhong W Gu P Paolo Pandolfi The function of PML in p53-dependent apoptosis Nat. Cell Biol. 2 2000 730 736
50. L.Z He F Guidez C Tribioli D Peruzzi M Ruthardt A Zelent P.P Pandolfi Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL Nat. Genet. 18 1998 126 135
51. W.F Holmes M.I Dawson R.D Soprano K.J Soprano Induction of apoptosis in ovarian carcinoma cells by AHPN⧸CD437 is mediated by retinoic acid receptors J. Cell. Physiol. 185 2000 61 67
52. B Hoyos A Imam R Chua C Swenson G.X Tong E Levi N Noy U Hammerling The cysteine-rich regions of the regulatory domains of Raf and protein kinase C as retinoid receptors J. Exp. Med. 192 2000 835 845
53. S.G Hymowitz H.W Christinger G Fuh M Ultsch M O'Connell R.F Kelley A Ashkenazi A.M de Vos Triggering cell death: The crystal structure of Apo2L⧸TRAIL in a complex with death receptor 5 Mol. Cell 4 1999 563 571
54. S.G Hymowitz M.P O'Connell M.H Ultsch A Hurst K Totpal A Ashkenazi A.M de Vos R.F Kelley A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L⧸TRAIL Biochemistry 39 2000 633 640
55. T Imai M Jiang P Chambon D Metzger Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes Proc. Natl. Acad. Sci. USA 98 2001 224 228
56. T Imai M Jiang P Kastner P Chambon D Metzger Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity Proc. Natl. Acad. Sci. USA 98 2001 4581 4586
57. A Imam B Hoyos C Swenson E Levi R Chua E Viriya U Hammerling Retinoids as ligands and coactivators of protein kinase C alpha Faseb J. 15 2001 28 30
58. M Irmler M Thome M Hahne P Schneider K Hofmann V Steiner J.L Bodmer M Schroter K Burns C Mattmann Inhibition of death receptor signals by cellular FLIP Nature 388 1997 190 195
59. M Ito R.G Roeder The TRAP⧸SMCC⧸Mediator complex and thyroid hormone receptor function Trends Endocrinol. Metab. 12 2001 127 134
60. S.Y James F Lin S.K Kolluri M.I Dawson X.K Zhang Regulation of retinoic acid receptor beta expression by peroxisome proliferator-activated receptor gamma ligands in cancer cells Cancer Res. 63 2003 3531 3538
61. K Jepsen O Hermanson T.M Onami A.S Gleiberman V Lunyak R.J McEvilly R Kurokawa V Kumar F Liu E Seto Combinatorial roles of the nuclear receptor corepressor in transcription and development Cell 102 2000 753 763
62. P Kastner M Mark P Chambon Nonsteroid nuclear receptors: What are genetic studies telling us about their role in real life? Cell 83 1995 859 869
63. P Kastner M Mark M Leid A Gansmuller W Chin J.M Grondona D Decimo W Krezel A Dierich P Chambon Abnormal spermatogenesis in RXR beta mutant mice Genes Dev. 10 1996 80 92
64. M.H Koken F Puvion-Dutilleul M.C Guillemin A Viron G Linares-Cruz N Stuurman L de Jong C Szostecki F Calvo C Chomienne The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion EMBO J. 13 1994 1073 1083
65. R.A Krathen S Ward M Duvic Bexarotene is a new treatment option for lymphomatoid papulosis Dermatology 206 2003 142 147
66. W Krezel N Ghyselinck T.A Samad V Dupe P Kastner E Borrelli P Chambon Impaired locomotion and dopamine signaling in retinoid receptor mutant mice Science 279 1998 863 867
67. V Lallemand-Breitenbach J Zhu F Puvion M Koken N Honore A Doubeikovsky E Duprez P.P Pandolfi E Puvion P Freemont Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML⧸retinoic acid receptor alpha degradation J. Exp. Med. 193 2001 1361 1371
68. Laudet, V. and Gronemeyer, H. (2002). The Nuclear Receptor Facts Book. Academic Press, San Diego
69. H.N LeBlanc A Ashkenazi Apo2L⧸TRAIL and its death and decoy receptors Cell Death Differ. 10 2003 66 75
70. A Leder A Kuo R.D Cardiff E Sinn P Leder v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: Effects of phorbol esters and retinoic acid Proc. Natl. Acad. Sci. USA 87 1990 9178 9182
71. H Li S.K Kolluri J Gu M.I Dawson X Cao P.D Hobbs B Lin G Chen J Lu F Lin Cytochrome c release and apoptosis induced by mitochondrial targeting of nuclear orphan receptor TR3 Science 289 2000 1159 1164
72. M Li A.K Indra X Warot J Brocard N Messaddeq S Kato D Metzger P Chambon Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis Nature 407 2000 633 636
73. B Lin G.Q Chen D Xiao S.K Kolluri X Cao H Su X.K Zhang Orphan receptor COUP-TF is required for induction of retinoic acid receptor beta, growth inhibition, and apoptosis by retinoic acid in cancer cells Mol. Cell. Biol. 20 2000 957 970
74. F Lin D Xiao S.K Kolluri X Zhang Unique anti-activator protein-1 activity of retinoic acid receptor beta Cancer Res. 60 2000 3271 3280
75. R.J Lin R.M Evans Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers Mol. Cell 5 2000 821 830
76. R.J Lin L Nagy S Inoue W Shao W.H Miller Jr. R.M Evans Role of the histone deacetylase complex in acute promyelocytic leukaemia Nature 391 1998 811 814
77. H.J List K.J Lauritsen R Reiter C Powers A Wellstein A.T Riegel Ribozyme targeting demonstrates that the nuclear receptor coactivator AIB1 is a rate-limiting factor for estrogen-dependent growth of human MCF-7 breast cancer cells J. Biol. Chem. 276 2001 23763 23768
78. G Lopez-Carballo L Moreno S Masia P Perez D Barettino Activation of the phosphatidylinositol 3-kinase⧸Akt signaling pathway by retinoic acid is required for neural differentiation of SH-SY5Y human neuroblastoma cells J. Biol. Chem. 277 2002 25297 25304
79. X Ma S Karra W Guo D.J Lindner J Hu J.E Angell E.R Hofmann S.P Reddy D.V Kalvakolanu Regulation of interferon and retinoic acid-induced cell death activation through thioredoxin reductase J. Biol. Chem. 276 2001 24843 24854
80. M MacFarlane M Ahmad S.M Srinivasula T Fernandes-Alnemri G.M Cohen E.S Alnemri Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL J. Biol. Chem. 272 1997 25417 25420
81. M Maden Retinoid signalling in the development of the central nervous system Nat. Rev. Neurosci. 3 2002 843 853
82. S.A Marsters J.P Sheridan R.M Pitti A Huang M Skubatch D Baldwin J Yuan A Gurney A.D Goddard P Godowski A novel receptor for Apo2L⧸TRAIL contains a truncated death domain Curr. Biol. 7 1997 1003 1006
83. D Massaro G.D Massaro Retinoids, alveolus formation, and alveolar deficiency: Clinical implications Am. J. Respir. Cell Mol. Biol. 28 2003 271 274
84. N.J McKenna B.W O'Malley Combinatorial control of gene expression by nuclear receptors and coregulators Cell 108 2002 465 474
85. N.J McKenna B.W O'Malley Minireview: Nuclear receptor coactivators–an update Endocrinology 143 2002 2461 2465
86. D Metzger P Chambon Site- and time-specific gene targeting in the mouse Methods 24 2001 71 80
87. S Minucci M Maccarana M Cioce P De Luca V Gelmetti S Segalla L Di Croce S Giavara C Matteucci A Gobbi Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation Mol. Cell 5 2000 811 820
88. D.L Misner S Jacobs Y Shimizu A.M de Urquiza L Solomin T Perlmann L.M De Luca C.F Stevens R.M Evans Vitamin A deprivation results in reversible loss of hippocampal long-term synaptic plasticity Proc. Natl. Acad. Sci. USA 98 2001 11714 11719
89. J Mongkolsapaya A.E Cowper X.N Xu G Morris A.J McMichael J.I Bell G.R Screaton Lymphocyte inhibitor of TRAIL (TNF-related apoptosis-inducing ligand): A new receptor protecting lymphocytes from the death ligand TRAIL J. Immunol. 160 1998 3 6
90. J Mongkolsapaya J.M Grimes N Chen X.N Xu D.I Stuart E.Y Jones G.R Screaton Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation Nat. Struct. Biol. 6 1999 1048 1053
91. L Nagy V.A Thomazy G.L Shipley L Fesus W Lamph R.A Heyman R.A Chandraratna P.J Davies Activation of retinoid X receptors induces apoptosis in HL-60 cell lines Mol. Cell. Biol. 15 1995 3540 3551
92. K Niederreither J Vermot N Messaddeq B Schuhbaur P Chambon P Dolle Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse Development 128 2001 1019 1031
93. G Pan J Ni Y.F Wei G Yu R Gentz V.M Dixit An antagonist decoy receptor and a death domain-containing receptor for TRAIL Science 277 1997 815 818
94. G Pan K O'Rourke A.M Chinnaiyan R Gentz R Ebner J Ni V.M Dixit The receptor for the cytotoxic ligand TRAIL Science 276 1997 111 113
95. P.P Pandolfi Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia Hum. Mol. Genet. 10 2001 769 775
96. M Pearson R Carbone C Sebastiani M Cioce M Fagioli S Saito Y Higashimoto E Appella S Minucci P.P Pandolfi PML regulates p53 acetylation and premature senescence induced by oncogenic Ras Nature 406 2000 207 210
97. F Piazza C Gurrieri P.P Pandolfi The theory of APL Oncogene 20 2001 7216 7222
98. R.M Pitti S.A Marsters S Ruppert C.J Donahue A Moore A Ashkenazi Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family J. Biol. Chem. 271 1996 12687 12690
99. C Rachez L.P Freedman Mediator complexes and transcription Curr. Opin. Cell Biol. 13 2001 274 280
100. G Reid M.R Hubner R Metivier H Brand S Denger D Manu J Beaudouin J Ellenberg F Gannon Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling Mol. Cell 11 2003 695 707
101. M Resche-Rigon H Gronemeyer Therapeutic potential of selective modulators of nuclear receptor action Curr. Opin. Chem. Biol. 2 1998 501 507
102. C Rochette-Egly Nuclear receptors: Integration of multiple signalling pathways through phosphorylation Cell Signal 15 2003 355 366
103. I Rogatsky H.F Luecke D.C Leitman K.R Yamamoto Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts Proc. Natl. Acad. Sci. USA 99 2002 16701 16706
104. M Sakaue H Adachi M Dawson A.M Jetten Induction of Egr-1 expression by the retinoid AHPN in human lung carcinoma cells is dependent on activated ERK1⧸2 Cell Death Differ. 8 2001 411 424
105. P Salomoni P.P Pandolfi The role of PML in tumor suppression Cell 108 2002 165 170
106. G.R Screaton J Mongkolsapaya X.N Xu A.E Cowper A.J McMichael J.I Bell TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL Curr. Biol. 7 1997 693 696
107. Y Shang X Hu J DiRenzo M.A Lazar M Brown Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription Cell 103 2000 843 852
108. Y Shang M Myers M Brown Formation of the androgen receptor transcription complex Mol. Cell 9 2002 601 610
109. J.P Sheridan S.A Marsters R.M Pitti A Gurney M Skubatch D Baldwin L Ramakrishnan C.L Gray K Baker W.I Wood Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors Science 277 1997 818 821
110. W.S Simonet D.L Lacey C.R Dunstan M Kelley M.S Chang R Luthy H.Q Nguyen S Wooden L Bennett T Boone Osteoprotegerin: A novel secreted protein involved in the regulation of bone density Cell 89 1997 309 319
111. S.M Sirchia M Ren R Pili E Sironi G Somenzi R Ghidoni S Toma G Nicolo N Sacchi Endogenous reactivation of the RARbeta2 tumor suppressor gene epigenetically silenced in breast cancer Cancer Res. 62 2002 2455 2461
112. S.Y Sun P Yue R.A Chandraratna Y Tesfaigzi W.K Hong R Lotan Dual mechanisms of action of the retinoid CD437: Nuclear retinoic acid receptor-mediated suppression of squamous differentiation and receptor-independent induction of apoptosis in UMSCC22B human head and neck squamous cell carcinoma cells Mol. Pharmacol. 58 2000 508 514
113. S.Y Sun P Yue W.K Hong R Lotan Augmentation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by the synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) through up-regulation of TRAIL receptors in human lung cancer cells Cancer Res. 60 2000 7149 7155
114. S.Y Sun P Yue W.K Hong R Lotan Induction of fas expression and augmentation of Fas⧸Fas ligand-mediated apoptosis by the synthetic retinoid CD437 in human lung cancer cells Cancer Res. 60 2000 6537 6543
115. K Takeda M.J Smyth E Cretney Y Hayakawa N Kayagaki H Yagita K Okumura Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development J. Exp. Med. 195 2002 161 169
116. D.G Tenen Disruption of differentiation in human cancer: AML shows the way Nat. Rev. Cancer 3 2003 89 101
117. A Truneh S Sharma C Silverman S Khandekar M.P Reddy K.C Deen M.M McLaughlin S.M Srinivasula G.P Livi L.A Marshall Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor J. Biol. Chem. 275 2000 23319 23325
118. S.S Tulachan R Doi Y Kawaguchi S Tsuji S Nakajima T Masui M Koizumi E Toyoda T Mori D Ito All-trans retinoic acid induces differentiation of ducts and endocrine cells by mesenchymal⧸epithelial interactions in embryonic pancreas Diabetes 52 2003 76 84
119. H Walczak M.A Degli-Esposti R.S Johnson P.J Smolak J.Y Waugh N Boiani M.S Timour M.J Gerhart K.A Schooley C.A Smith TRAIL-R2: A novel apoptosis-mediating receptor for TRAIL EMBO J. 16 1997 5386 5397
120. J Wang A.A Lobito F Shen F Hornung A Winoto M.J Lenardo Inhibition of Fas-mediated apoptosis by the B cell antigen receptor through c-FLIP Eur. J. Immunol. 30 2000 155 163
121. K Weis S Rambaud C Lavau J Jansen T Carvalho M Carmo-Fonseca A Lamond A Dejean Retinoic acid regulates aberrant nuclear localization of PML-RAR alpha in acute promyelocytic leukemia cells Cell 76 1994 345 356
122. S Westin M.G Rosenfeld C.K Glass Nuclear receptor coactivators Adv. Pharmacol. 47 2000 89 112
123. M Widschwendter J Berger M Hermann H.M Muller A Amberger M Zeschnigk A Widschwendter B Abendstein A.G Zeimet G Daxenbichler Methylation and silencing of the retinoic acid receptor-beta2 gene in breast cancer J. Natl. Cancer Inst. 92 2000 826 832
124. S.R Wiley K Schooley P.J Smolak W.S Din C.P Huang J.K Nicholl G.R Sutherland T.D Smith C Rauch C.A Smith Identification and characterization of a new member of the TNF family that induces apoptosis Immunity 3 1995 673 682
125. C.W Wong M.L Privalsky Transcriptional silencing is defined by isoform- and heterodimer-specific interactions between nuclear hormone receptors and corepressors Mol. Cell. Biol. 18 1998 5724 5733
126. S Zhong P Salomoni P.P Pandolfi The transcriptional role of PML and the nuclear body Nat. Cell Biol. 2 2000 E85 E90