The role of PML in tumor suppression

Cell

Volumn 108, Issue 2, 2002, Pages 165-170

  Salomoni, Paolo ^a   Pandolfi, Pier Paolo ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

APOPTOSIS; BIOGENESIS; CANCER INHIBITION; CARCINOGENESIS; CELL NUCLEUS INCLUSION BODY; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHROMOSOME TRANSLOCATION; GENETIC STABILITY; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN LOCALIZATION; REVIEW; SENESCENCE;

EID: 0037169341     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(02)00626-8     Document Type: Review

References (29)

1. The promyelocytic leukemia gene product (PML) forms stable complexes with the retinoblastoma protein
2. PML is induced by oncogenic ras and promotes premature senescence
3. Regulation of p53 activity in nuclear bodies by a specific PML isoform
4. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
5. The function of PML in p53-dependent apoptosis
6. Regulation of p53 activity by its interaction with homeodomain-interacting protein
7. PML protein isoforms and the RBCC/TRIM motif
8. Role of PML and PML-RARα in Mad-mediated transcriptional repression
9. PML-RARα alleviates the transcriptional repression mediated by tumor suppressor Rb
10. Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor α degradation
11. Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis
12. Sequestration and inhibition of Daxx-mediated transcriptional repression by PML
13. Deconstructing a disease: RARα, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia
14. Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis
15. The theory of APL
16. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
17. TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation
18. PML induces a novel caspase-independent death process
19. A bcr-3 isoform of RARα-PML potentiates the development of PML-RARα-driven acute promyelocytic leukemia
20. The central effectors of cell death in the immune system
21. Role of promyelocytic leukemia (PML) protein in tumor suppression
22. PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies
23. Cytoplasmic recruitment of INI1 and PML on incoming HIV preintegration complexes: Interference with early steps of viral replication
24. Role of PML in cell growth and the retinoic acid pathway
25. PML is essential for multiple apoptotic pathways
26. A role for PML and the nuclear body in genomic stability
27. Role of SUMO-1-modified PML in nuclear body formation
28. The transcriptional role of PML and the nuclear body
29. Promyelocytic leukemia protein (PML) and Daxx participate in a novel nuclear pathway for apoptosis