Triggering cell death: The crystal structure of Apo2L/TRAIL in a complex with death receptor 5

Molecular Cell

Volumn 4, Issue 4, 1999, Pages 563-571

  Hymowitz, Sarah G ^a   Christinger, Hans W ^a   Fuh, Germaine ^a   Ultsch, Mark ^a   O'Connell, Mark ^a   Kelley, Robert F ^a   Ashkenazi, Avi ^b   De Vos, Abraham M ^a  

^a Department of Protein Engineering ^*  (United States)

^b GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; CRYSTAL STRUCTURE; ESCHERICHIA COLI; NONHUMAN; OLIGOMERIZATION; PROTEIN DOMAIN; RECEPTOR AFFINITY; STRUCTURE ANALYSIS;

ANIMALIA; ESCHERICHIA COLI;

EID: 0033212968     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80207-5     Document Type: Article

References (42)

1. Ashkenazi, A., and Dixit, V.M. (1998). Death receptors: Signaling and modulation. Science 281, 1305-1308.
2. Ashkenazi, A., Pai, R.C., Fong, S., Leung, S., Lawrence, D.A., Marsters, S.A., Blackie, C., Chang, L., McMurtrey, A.E., Hebert, A., et al. (1999). Safety and anti-tumor activity of recombinant soluble Apo2 ligand. J. Clin. Invest. 104, 155-162.
3. Banner, D.W., D'Arcy, A., Janes, W., Gentz, R., Schoenfeld, HJ., Broger, C., Loetscher, H., and Lesslauer, W. (1993). Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: Implications for TNF receptor activation. Cell 73, 431-445.
4. Bazan, J.F. (1993). Emerging families of cytokines and receptors. Curr. Biol. 3, 603-606.
5. Brünger, A.T. (1992a). Free R value: A novel statistical quantity for assessing the accuracy of crystal structures. Nature 355, 472-475.
6. Brünger, A.T. (1992b). X-PLOR Manual, Version 3.1 (New Haven, Connecticut: Yale University).
7. Cha, S.-S., Kim, M.-S., Choi, Y.H., Sung, B.-J., Shin, N.K., Shin, H.-C., Sung, Y.C., and Oh, B.-H. (1999). 2.8 Å resolution crystal structure of human TRAIL, a cytokine with selective antitumor activity. Immunity 11, 253-261.
8. CCP4 (1994). The CCP4 suite: Programs for protein crystallography. Acta Crystallogr. D 50, 760-763.
9. Delgi-Esposti, M.A., Smolak, P.J., Walczak, H., Waugh, J., Huang, C.P., Dubose, R.F., Goodwin, R.G., and Smith, C.A. (1997a). Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family. J. Exp. Med. 186, 1165-1170.
10. Delgi-Esposti, M.A., Dougall, W.C., Smolak, P.J., Waugh, J.Y., Smith, C.A., and Goodwin, R.G. (1997b). The novel receptor TRAIL-R4 induces NF-κB and protects against trail-mediated apoptosis, yet retains an incomplete death domain. Immunity 7, 813-820.
11. Eck, M.J., and Sprang, S.R. (1989). The structure of tumor necrosis factor-α at 2.6 Å resolution: Implications for receptor binding. J. Biol. Chem. 264, 17595-17605.
12. Eck, M.J., Ultsch, M., Rinderknecht, E., de Vos, A.M., and Sprang, S.R. (1992). The structure of human lymphotoxin (tumor necrosis factor-β) at 1.9-Å resolution. J. Biol. Chem. 267, 2119-2122.
13. Emery, J.G., McDonnell, P., Burke, M.B., Deen, K.C., Lyn, S., Silverman, C., Dul, E., Appelbaum, E.R., Eichman, C., DiPrinzio, R., et al. (1998). Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J. Biol. Chem. 273, 14363-14367.
14. Goh, C.R., Loh, C.S., and Porter, A.G. (1991). Aspartic acid 50 and tyrosine 108 are essential for receptor binding and cytotoxic activity of tumour necrosis factor-β (lymphotoxin). Protein Eng. 4, 785-791.
15. Jacobson, M.D., Weil, M., and Raff, M.C. (1997). Programmed cell death in animal development. Cell 88, 347-354.
16. Jones, E.Y., Stuart, D.I., and Walker, N.P.C. (1989). Structure of tumour necrosis factor. Nature 338, 225-228.
17. Karpusas, M., Hsu, Y.-M., Wang, J.-H., Thompson, J., Lederman, S., Chess, L., and Thomas, D. (1995). 2 Å crystal structure of an extracellular fragment of human CD40 ligand. Structure 3, 1031-1039.
18. Kraulis, P.J. (1991). MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures. J. Appl. Cryst. 24, 946-950.
19. Laskowski, R.A., MacArthur, M.W., Moss, D.S., and Thornton, J.M. (1993). Procheck: A program to check the stereochemical quality of protein structures. J. Appl. Cryst. 26, 283-291.
20. Mariani, S.M., Matiba, B., Armandola, E.A., and Krammer, P.H. (1997). Interleukin 1 beta-converting enzyme related proteases/caspases are involved in TRAIL-induced apoptosis of myeloma and leukemia cells. J. Cell Biol. 137, 221-229.
21. Marsters, S.A., Sheridan, J.P., Pitti, R.M., Huang, A., Skubatch, M., Baldwin, D., Yuan, J., Gurney, A., Goddard, A.D., Godowski, P., and Ashkenazi, A. (1997). A novel receptor for Apo2L/trail contains a truncated death domain. Curr. Biol. 7, 1003-1006.
22. McWhirter, S.M., Pullen, S.S., Holten, J.M., Crute, J.J., Kehry, M.R., and Alber, T. (1999). Crystallographic analysis of CD40 recognition and signaling by human TRAF2. Proc. Natl. Acad. Sci. USA 96, 8408-8413.
23. Merrit, E.A., and Murphy, M.E.P. (1994). Raster3D version 2.0, a program for photorealistic molecular graphics. Acta Crystallogr. D 50, 869-873.
24. Nagata, S. (1997). Apoptosis by death factor. Cell 88, 355-356.
25. Naismith, J.H., Devine, T.Q., Brandhuber, B.J., and Sprang, S.R. (1995). Crystallographic evidence for dimerization of unliganded tumor necrosis factor receptor. J. Biol. Chem. 270, 13303-13307.
26. Naismith, J.H., And Sprang, S.R. (1998). Modularity in the TNF-receptor family. Trends Biochem. Sci. 23, 74-79.
27. Naismith, J.H., Devine, T.Q., Kohono, T., and Sprang, S.R. (1996). Structures of the extracellular domain of the type I tumor necrosis factor receptor. Structure 4, 1251-1262.
28. Otwinowski, Z., and Minor, W. (1997). Processing of X-ray diffraction data collected in oscillation mode. Methods Enzymol. 176, 307-326.
29. Pan, G., Ni, J., Wei, Y.F., Yu, G., Gentz, R., and Dixit, V.M. (1997a). An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277, 815-818.
30. Pan, G., O'Rourke, K., Chinnaiyan, A.M., Gentz, R., Ebner, R., Ni, J., and Dixit, V.M. (1997b). The receptor for the cytotoxic ligand TRAIL. Science 276, 111-113.
31. Park, Y.C., Burkitt, V., Villa, A.R., Tong, L., And Wu, H. (1999). Structural basis for self-association and receptor recognition of human TRAF-2. Nature 398, 533-538.
32. Pitti, R.M., Marsters, S.A., Ruppert, S., Donahue, C.J., Moore, A., and Ashkenazi, A. (1996). Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 271, 12687-12690.
33. Schneider, P., Bodmer, J.-L, Holler, N., Mattmann, C., Scuderi, P., Terskikh, A., Peitsch, M.C., and Tschopp, J. (1997). Characterization of Fas (Apo-1, CD95)-Fas ligand interaction. J. Biol. Chem. 272, 18827-18833.
34. Sheridan, J.P., Marsters, S.A., Pitti, R.M., Gurney, A., Skubatch, M., Baldwin, D., Ramakrishnan, L., Gray, C.L., Baker, K., Wood, W.I., et al. (1997). Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 277, 818-821.
35. Simonet, W.S., Lacey, D.L., Dunstan, C.R., Kelley, M., Chang, M.-S., Lüthy, R., Nguyen, H.Q., Wooden, S., Bennett, L., Boone, T., et al. (1997). Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cell 89, 309-319.
36. Tartaglia, L.A., Ayes, T.M., Wong, G.H., and Goeddel, D.V. (1993). A novel domain within the 55 kd TNF receptor signals cell death. Cell 74, 845-853.
37. Thornberry, N.A., and Lazebnik, Y. (1998). Caspases: Enemies within. Science 281, 1312-1316.
38. Van Ostade, X., Tavernier, J., and Fiers, W. (1994). Structure-activity studies of human tumour necrosis factors. Protein Eng. 7, 5-22.
39. Walczak, H., Delgi-Esposti, M.A., Johnson, R.S., Smolak, P.J., Waugh, J.Y., Boiani, N., Timour, M.S., Gerhart, M.J., Schooley, K.A., Smith, C.A., et al. (1997). TRAIL-R2: A novel apoptosis-mediating receptor for TRAIL. EMBO J. 16, 5386-5397.
40. Walczak, H., Miller, R.E., Ariall, K., Gliniak, B., Griffith, T.S., Kubin, M., Chin, W., Jones, J., Woodward, A., Le, T., et al. (1999). Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat. Med. 5, 157-163.
41. Wiley, S.R., Schooley, K., Smolak, P.J., Din, W.S., Huang, C.-P., Nicholl, J.K., Sutherland, G.R., Smith, T.D., Rauch, C., Smith, C.A., and Goodwin, R.G. (1995). Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3, 673-682.
42. Yamagishi, J., Kawashima, H., Matsuo, N., Ohue, M., Yamayoshi, M., Fukui, T., Kotani, H., Furuta, R., Nakano, K., and Yamada, M. (1990). Mutational analysis of structure-activity relationships in human tumor necrosis factor-α. Protein Eng. 3, 713-719.