Acquisition of oncogenic potential by RAR chimeras in acute promyelocytic leukemia through formation of homodimers

Molecular Cell

Volumn 5, Issue 5, 2000, Pages 821-830

  Lin, Richard J ^a,c   Evans, Ronald M ^b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL NUCLEUS RECEPTOR; HYBRID PROTEIN; LUCIFERASE; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; TRANSCRIPTION FACTOR;

ACUTE MYELOBLASTIC LEUKEMIA; ARTICLE; BINDING AFFINITY; CELL DIFFERENTIATION; CELL STRAIN U937; CELL TRANSFORMATION; CHIMERA; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DELETION MUTANT; DIMERIZATION; GENE OVEREXPRESSION; GENE REPRESSION; GENETIC REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LEUKEMOGENESIS; NONHUMAN; ONCOGENE; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

EID: 0033634946     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80322-6     Document Type: Article

References (52)

1. Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
2. The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor alpha in acute promyelocytic-like leukemia
3. Characterization of the retinoid binding properties of the major fusion products present in acute promyelocytic leukemia cells
4. A transcriptional co-repressor that interacts with nuclear hormone receptors
5. Distinct leukemia phenotypes in transgenic mice and different corepressor interactions generated by promyelocytic leukemia variant fusion genes PLZF-RARα and NPM-RARα
6. The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR
7. Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein
8. Suprabasal expression of a dominant-negative RXR alpha mutant in transgenic mouse epidermis impairs regulation of gene transcription and basal keratinocyte proliferation by RAR-selective retinoids
9. Increasing the complexity of coactivation in nuclear receptor signaling
10. The acute promyelocytic leukemia-specific PML-RARα fusion protein inhibits differentiation and promotes survival of myeloid precursor cells
11. Effects on differentiation by the promyelocytic leukemia PML/RARα protein depend on the fusion of PML protein dimerization and RARα DNA binding domains
12. Fusion proteins of the retinoic acid receptor-α recruit histone deacetylase in promyelocytic leukemia
13. Formation of PML/RAR alpha high molecular weight nuclear complexes through the PML coiled-coiled region is essential for the PML/RAR alpha-mediated retinoic acid response
14. Reduced retinoic acid-sensitivities of nuclear receptor co-repressor binding to PML- and PLZF-RARα underlie molecular pathogenesis and treatment of acute promyelocytic leukemia
15. Versatile retroviral vectors for potential use in gene therapy
16. Distinct interactions of PML-RARα and PLZF-RARα with co-repressors determine differential responses to RA in APL
17. In vivo analysis of the molecular pathogenesis of acute promyelocytic leukemia in the mouse and its therapeutic implications
18. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression
19. SMRT corepressor interacts with PLZF and with the PML-retinoic acid receptor alpha (RARα) and PLZF-RARα oncoproteins associated with acute promyelocytic leukemia
20. Ligand-independent repression by the thyroid hormone receptor is mediated by a nuclear receptor co-repressor, N-CoR
21. The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors
22. Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia
23. Multimeric complexes of the PML-retinoic acid receptor α fusion protein in acute promyelocytic leukemia cells and interference with retinoid and peroxisome-proliferator signaling pathways
24. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR with a novel putative transcription factor, PML
25. Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signaling
26. Identification of critical residues for heterodimerization within the ligand-binding domain of retinoid X receptor
27. Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17)
28. Role of the histone deacetylase complex in acute promyelocytic leukemia
29. Molecular genetics of acute promyelocytic leukemia
30. The RXR heterodimers and orphan receptors
31. Reconstructing a disease: RARα, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia
32. Oligomerization of RAR and AML1 transcription factors as a novel mechanism of oncogenic activation
33. Control of macrophage cell differentiation in human promyelocytic HL-60 leukemia cells by 1,25-dihydroxyvitamin D3 and phorbol-12-myristate-13-acetate
34. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase
35. Mechanism of corepressor binding and release from nuclear hormone receptors
36. The pCL vector system: Rapid production of helper-free, high titer, recombinant retroviruses
37. Characterization of the PML-RARα chimeric product of the acute promyelocytic leukemia-specific t(15;17) translocation
38. Unique forms of human and mouse nuclear receptor corepressor SMRT
39. PMLRAR homodimers: Distinct DNA binding properties and heterodimeric interactions with RXR
40. Two distinct dimerization interfaces differentially modulate target gene specificity of nuclear hormone receptors
41. Molecular determinants of nuclear reporter-corepressor interaction
42. The PML-RARα gene product of the t(15;17) translocation inhibits retinoic acid-induced granulocytic differentiation and mediated transactivation in human myeloid cells
43. Opposite effects of the acute promyelocytic leukemia PML-retinoic acid receptor α (RARα) and PLZF-RARα fusion proteins on retinoic acid signaling
44. Activation and repression by nuclear hormone receptors: Hormone modulates and equilibrium between active and repressive states
45. The PML nuclear bodies: Actors or extras?
46. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
47. Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid)
48. Acute promyelocytic leukemia
49. Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators
50. Stoichiometric and steric principles governing repression by nuclear hormone receptors
51. Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors
52. A novel role for helix 12 of retinoid X receptor in regulating repression