Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse

Development

Volumn 128, Issue 7, 2001, Pages 1019-1031

  Niederreither, K ^a   Vermot, J ^a   Messaddeq, N ^a   Schuhbaur, B ^a   Chambon, P ^a   Dolle P ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

Author keywords

Cardiomyocyte differentiate; Heart development; Left right patterning; Mouse mutant; Myocardium; Raldh2; Retinaldehyde dehydrogenase; Retinoids; Tbx5

Indexed keywords

RETINOIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENE DISRUPTION; GENE EXPRESSION; HEART ATRIUM; HEART DEVELOPMENT; HEART LEFT VENTRICLE OUTFLOW TRACT; HEART MUSCLE CELL; HEART SEPTUM DEFECT; HEART VENTRICLE WALL; HISTOPATHOLOGY; MORPHOGENESIS; MOUSE; MUTANT; NEURAL CREST CELL; NONHUMAN; PRIORITY JOURNAL; SINUS VENOSUS; SYNTHESIS; ULTRASTRUCTURE;

ALDEHYDE OXIDOREDUCTASES; ANIMALS; CELL DIFFERENTIATION; EMBRYONIC AND FETAL DEVELOPMENT; GENE EXPRESSION; HEART; MICE; MICE, KNOCKOUT; MICROFILAMENTS; MORPHOGENESIS; MYOCARDIUM; NEURAL CREST; RETINAL DEHYDROGENASE; TRETINOIN;

EID: 0035028993     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (70)

1. PPARγ is required for placental, cardiac, and adipose tissue development
2. Differential distribution of retinoic acid synthesis in the chicken embryo as determined by immunolocalization of the retinoic acid synthetic enzyme, RALDH-2
3. Homeodomain factor NKx2-5 controls left/right asymmetric expression of the bHLH gene eHand during murine heart development
4. Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrom
5. The homebox gene Pitx2: Mediator of asymmetric left-right signaling in vertebrate heart and gut looping
6. Mechanisms of left-right determination in vertebrates
7. Retinoic acid is required in the mouse embryo for left-right asymmetry determination and heart morphogenesis
8. Ventricular muscle-restricted targeting of the RXRalha gene reveals a non-cell-autonomous requireent in cardiac chamber morphogenesis
9. Chamber formation and morphogenesis in the developing mammalian heart
10. Patterning the embryonic heart: Identification of five mouse Iroquois homeobox genes in the developing heart
11. Relationship between asymmetric nodal expression and the direction of embryonic turning
12. In situ hybridization to cellular RNA
13. Induction of normal cardiovascular development in the vitamin A-deprived quail embryo by natural retinoids
14. Selective regulation of cardiomyocyte gene expression and cardiac morphogenesis by retinoic acid
15. Retinoic acid can block differentiation of the myocardium after heart specification
16. Families of retinoid dehydrogenases regulating vitamin A function: Production of visual pigment and retinoic acid
17. Cis-acting regulatory sequences governing Wnt-1 expression in the developing mouse CNS
18. Migration of cardiac neural crest cells in Splotch embryo
19. Contribution of retinoic acid receptor β isoforms to the formation of the conotruncal septum of the embryonic heart
20. RXRα deficiency confers genetic susceptibility for aortic sac, atrioventricular cushion and ventricular defects in mice
21. Seeking a regulatory roadmap for heart morphogenesis
22. Effects of retinoid deficiency on the development of the heart and vascular system of the quail embryo
23. Fate of the mammalian cardiac neural crest
24. Genetic analysis of RXRα developmental function: Convergence of RXR and RAR signalling pathways in heart and eye morphogenesis
25. Vitamin A deficiency and mutations of RXRα, RXRβ and RARα lead to early differentiation of embryonic ventricular cardiomyocytes
26. Contribution of neural crest to heart and vessel morphology
27. Recruitment of nuclear receptor corepressor and coactivator to the retinoic acid receptor by retinoid ligands
28. Retinoid signaling required for normal heart development regulates GATA-4 in a pathway distinct from cardiomyocyte differentiation
29. GATA4 transcription factor is required for ventral morphogenesis and heart tube formation
30. A retinoic acid synthesizing enzyme in vental retina and telencephalon of the embryonic mouse
31. Ventricular expression of tbx5 inhibits normal heart chamber development
32. Control of mouse cardiac morphogenesis and myogenesis by transcription factor MEF2C
33. Pitx2 regulates lung asymmetry, cardiac positioning and pituitary and tooth morphogenesis
34. A role for fibronectin in the migration of avian precardiac cells. I. Dose-dependent effects of fibronectin antibody
35. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5
36. Regulation of Hoxa2 in cranial neural crest cells involves members of the AP-2 family
37. Two rhombomeres are altered in Hoxa-1 mutant mice
38. The RXRα oigand-dependent activation function (AF-2) is important for mouse development
39. Regulation of retinoic acid signaling in the embryonic nervous system: A master differentiation factor
40. The roles of retinoids in vertebrate development
41. Function of the retinoic acid receptors (RARs) during development. II. Multiple abnormalities at various stages of organogenesis in RAR double mutants
42. Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: Their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos
43. Mechanisms of segmentation, septation, and remodeling of the tubular heart: Endocardial cushion fate and cardiac looping
44. Requirement of the transcription factor GATA4 for heat tube formation and ventral morphogenesis
45. Dynamic patterns of retinoic acid synthesis and response in the developing mammalian heart
46. The MLC-2 paradigm for ventricular heart chamber specification, maturation, and morphogenesis
47. Restricted expression and retinoic acid-induced downregulation of the retinaldehyde dehydrogenase type 2 (RALDH-2) gene during mouse development
48. 35S-labelled probes for retinoid receptors
49. Embryonic retinoic acid synthesis is essential for early mouse post-implantation development
50. Retinoic acid synthesis and hindbrain patterning in the mouse embryo
51. Molecular pathways controlling heart development
52. The effects of retinoic acid on heart formation in the early chick embryo
53. Stra3/lefty, a retinoic acid-inducible novel member of the transforming growth factor-beta superfamily
54. Expression of a retinoic acid response element-hsplacZ transgene defines specific domains of transcriptional activity during mouse embryogenesis
55. Defects of the chorioallantoic placenta in mouse RXRα null fetuses
56. Differential expression of transcripts encoding retinoid binding proteins and retinoic acid receptors during placentation of the mouse
57. RXRα mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis
58. Plasticity in mouse neural crest cells reveals a new patterning role for cranial mesoderm
59. -/- mutant mice unveil a convergence of the shh and retinoic acid pathways in the control of Lefty-1
60. Identification of endogenous retinoids, enzymes, binding proteins, and receptors during early postimplantation development in mouse: Important role of retinal dehydrogenase type 2 in synthesis of all-transretinoic acid
61. Expression of enzymes synthetizing (Aldh1 and Raldh2) and metabolizing (CYP26) retinoic acid in the mouse female reproductive system
62. Retinoic acid affects left-right pattern
63. Retinoid X receptors are essential for early mouse development and placentogenesis
64. Aortic arch and cardiac anomalies in the offspring of vitamin A deficient rats
65. A retinoic acid-inducible transgenic marker of sino-atrial development in the mouse heart
66. Expression of the atrial-specific myosin heavy chain AMHC1 and the establishment of anteroposterior polarity in the developing chicken heart
67. Molecular identification of a major retinoic acid-synthesizing enzyme, a retinaldehyde dehydrogenase
68. Retinoic acid synthesis and expression of cellular retinol-binding protein and cellular retinoic acid-binding protein type II are concurrent with decidualization of rat uterine stromal cells
69. Retinoid signaling is required to complete the vertebrate cardiac left/right aymmetry pathway