Metabolic basis of decreased transient outward K+ current in ventricular myocytes from diabetic rats

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 271, Issue 5 40-5, 1996, Pages

  Xu, Zhi ^a   Patel, Kaushik P ^a   Rozanski, George J ^a,b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

dichloroacetate; heart; insulin; L carnitine

Indexed keywords

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; HEART MUSCLE CELL; HEART MUSCLE METABOLISM; HEART VENTRICLE WALL; MALE; NONHUMAN; PATHOPHYSIOLOGY; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; STREPTOZOCIN DIABETES;

EID: 33745343652     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1996.271.5.h2190     Document Type: Article

References (30)

1. Abdel-aleem, A., S. Sharwi, M. Badr, M. Sayed-Ahmed, M. P. Anstadt, and J. E. Lowe. Reduced induction of carbohydrate utilization by inhibition of fatty acid oxidation in myocytes from diabetic animals. Horm. Metab. Res. 27: 104-106, 1995.
2. Bremer, J. Carnitine metabolism and functions. Physiol. Rev. 36: 413-459, 1984.
3. Broderick, T. L., G. Haloftis, and D. J. Paulson. L-Propionylcarnitine enhancement of substrate oxidation and mitochondrial respiration in the diabetic rat heart. J. Mol. Cell. Cardiol. 28: 331-340, 1996.
4. Broderick, T. L., H. A. Quinney, and G. D. Lopaschuk. L-Carnitine increases glucose metabolism and mechanical function following ischaemia in diabetic rat heart. Cardiovasc. Res. 29: 373-378, 1995.
5. Chen, V., D. Ianuzzo, B. C. Fong, and J. J. Spritzer. The effects of acute and chronic diabetes on myocardial metabolism in rats. Diabetes 33: 1078-1084, 1984.
6. Eckel, J., B. Asskamp, and H. Reinauer. Induction of insulin resistance in primary cultured cardiac myocytes. Endocrinology 129: 345-352, 1991.
7. Eckel, J., and H. Reinauer. Insulin action on glucose transport in isolated cardiac myocytes: signalling pathways and diabetes-induced alterations. Biochem. Soc. Trans. 18: 1125-1127, 1990.
8. Fein, F. S., R. S. Aronson, C. Nordin, B. Miller-Green, and E. H. Sonnenblick, Altered myocardial response to ouabain in diabetic rats: mechanics and electrophysiology. J. Mol. Cell. Cardiol. 15: 769-784, 1983.
9. Fein, F. S., J. E. Strobeck, A. Malhotra, J. Scheuer, and E. H. Sonnenblick. Reversibility of diabetic cardiomyopathy with insulin in rats. Circ. Res. 49: 1251-1261, 1981.
10. 2- transport. In: The Diabetic Heart, edited by M. Nagano and N. S. Dhalla. New York: Raven, 1991, p. 35-70.
11. Jourdon, P., and D. Feuvray. Calcium and potassium currents in ventricular myocytes isolated from diabetic rats. J. Physiol. Lond. 470: 411-429, 1993.
12. + pump concentration in skeletal muscles, heart ventricular muscle, and peripheral nerves of rat. Diabetes 36: 842-848, 1987.
13. Magyar, J., Z. Cseresnyes, Z. Rusznak, I. Sipos, G. Szucs, and L. Kovacs. Effects of insulin on potassium currents of rat ventricular myocytes in streptozotocin diabetes. Gen. Physiol. Biophys. 14: 191-201, 1995.
14. Magyar, J., Z. Rusznak, G. Szentesi, G. Szucs, and L. Kovacs. Action potentials and potassium currents in rat ventricular muscle during experimental diabetes. J. Mol. Cell. Cardiol. 24: 841-853, 1992.
15. Mene, P., G. Pugliese, F. Pricci, U. DiMario, G. A. Cinotti, and F. Pugliese. High glucose inhibits calcium signaling in cultured rat mesangial cells. Kidney Int. 43: 585-591, 1993.
16. Nabauer, M., D. J. Beuckelmann, and E. Erdmann. Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure. Circ. Res. 73: 386-394, 1993.
17. 2- channel. Cardiovasc. Res. 24: 381-389, 1990.
18. Ogbaghebriel, A., and A. Shrier. Inhibition of metabolism abolishes transient outward current in rabbit atrial myocytes. Am. J. Physiol. 266 (Heart. Circ. Physiol. 35): H182-H190, 1994.
19. Paulson, D. J., A. L. Shug, and J. Zhao. Protection of the ischemic diabetic heart by L-propionylcarnitine therapy. Mol. Cell. Biochem. 116: 131-137, 1992.
20. Pieper, G. M., W. J. Murray, J. M. Salhany, S. Wu, and R. S. Elliot. Salient effects of L-carnitine on adenine-nucleotide loss and coenzyme A acylation in the diabetic heart perfused with excess palmitic acid. A phosphorus-31 NMR and chemical extraction study. Biochan. Biophys. Acta 803: 241-249, 1984.
21. --ATPase activity in diabetic rat heart. Am. J. Physiol. 245 (Cell Physiol. 14): C241-C247, 1983.
22. - exchange in cardiac sarcolemmal vesicles isolated from diabetic rats. Am. J. Physiol. 258 (Heart Circ. Physiol. 27): H255-H261, 1990.
23. Rodrigues, B., M. C. Cam, and J. H. McNeill. Myocardial substrate metabolism: implications for diabetic cardiomyopathy. J. Mol. Cell. Cardiol 27: 169-179, 1995.
24. Shehadeh, A., and T. J. Began. Cardiac consequences of diabetes mellitus. Clin. Cardiol. 18: 301-305, 1995.
25. + currents in rat ventricular myocytes. Circ. Res. 74: 620-628, 1994.
26. Stacpoole, P. W. The pharmacology of dichloroacetate. Metabolism 38: 1124-1144, 1989.
27. Tsuchida, K., H. Watajima, and S. Otomo. Calcium current in rat diabetic ventricular myocytes. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H2280-H2289, 1994.
28. Wallenstein, S., C. L. Zucker, and J. L. Fleiss. Some statistical methods in circulation research. Circ. Res. 47: 1-9, 1980.
29. 2- currents in ventricular myocytes from rats with chronic diabetes. Am. J. Physiol. 268 (Heart Circ. Physiol. 37): H1288-H1296, 1995.
30. Xu, Z., K. P. Patel, and G. J. Rozanski. Inhibition of transient outward potassium current by intracellular protons in ventricular myocytes from diabetic rats. Am. J. Physiol. 271 (Heart Circ. Physiol. 40): H2154-H2161, 1996.