Four kinetically distinct depolarization-activated K+ currents in adult mouse ventricular myocytes

Journal of General Physiology

Volumn 113, Issue 5, 1999, Pages 661-677

  Xu, Haodong ^a   Guo, Weinong ^a   Nerbonne, Jeanne M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Delayed rectifier; I(to,f); I(to,s); Transgenic mice; Transient outward currents

Indexed keywords

4 AMINOPYRIDINE; CALCIUM; POTASSIUM ION; TETRYLAMMONIUM; TOXIN;

ADOLESCENT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART VENTRICLE SEPTUM; MEMBRANE DEPOLARIZATION; MOUSE; NONHUMAN; POTASSIUM CURRENT; STEADY STATE;

ANIMALS; ELECTROPHYSIOLOGY; HEART VENTRICLES; KINETICS; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MYOCARDIUM; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS;

EID: 0032962380     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.113.5.661     Document Type: Article

References (42)

1. Antzelevitch, C., S. Sicouri, A. Lukas, V.V. Nesterenko, D.-W. Liu, and J.M. DiDiego. 1995. Regional differences in the electrophysiology of ventricular cells: physiological implications. In Cardiac Electrophysiology: From Cell to Bedside. D.P. Zipes and J. Jalife, editors. W. B. Saunders Co., Philadelphia. 228-245.
2. Anumonwo, J.M.B., L.C. Freeman, W.M. Kwok, and R.S. Kass. 1991. Potassium channels in the heart: electrophysiology and pharmacological regulation. Cardiovasc. Drug Rev. 9:299-316.
3. Barry, D.M., and J.M. Nerbonne. 1996. Myocardial potassium channels: electrophysiological and molecular diversity. Annu. Rev. Physiol. 58:363-394.
4. + channels. Circ. Res. 77:361-369.
5. Barry, D.M., H. Xu, R.B. Schuessler, and J.M. Nerbonne. 1998. Functional knockout of the cardiac transient outward current, long QT syndrome and cardiac remodelling in mice expressing a dominant negative Kv4 α subunit. Circ. Res. 83:560-567.
6. Benndorf, K., F. Markwardt, and B. Nilius. 1987. Two types of transient outward currents in cardiac ventricular cells of mice. Pflügers Arch. 409:641-643.
7. Benndorf, K., and B. Nilius. 1988. Properties of an early outward current in single cells of the mouse ventricle. Gen. Physiol. Biophys. 7:449-466.
8. Boyden, P.A., and C.D. Jeck. 1995. Ion channel function in disease. Circulation. 29:312-318.
9. 10) phenotypes and distribution of fast-inactivating potassium channel alpha subunits in ferret ventricular myocytes. J. Gen. Physiol. 113:581-600.
10. Campbell, D.L., R.L. Rasmusson, M.B. Comer, and H.C. Strauss. 1995. The cardiac calcium-independent transient outward potassium current: kinetics, molecular properties, and role in ventricular repolarization. In Cardiac Electrophysiology: From Cell to Bedside. 2nd ed. D.P. Zipes and J. Jalife, editors. W. B. Saunders Co., Philadelphia. 83-96.
11. to-like potassium channel from ferret ventricle. Am. J. Physiol. 267:H1388-H1395.
12. Deal, K.K., S.K. England, and M.M. Tamkun. 1996. Molecular physiology of cardiac potassium channels. Physiol. Rev. 76:49-67.
13. Dixon, J.E., and D. McKinnon. 1994. Quantitative analysis of mRNA expression in atrial and ventricular muscle of rats. Circ. Res. 75:252-260.
14. Dixon, J.E., W. Shi, H.S. Wang, C. McDonald, H. Yu, R.S. Wymore, I.S. Cohen, and D. McKinnon. 1996. The role of the Kv4.3 potassium channel in ventricular muscle. Circ. Res. 79:659-668.
15. + current in rat ventricle. J. Physiol. (Camb.). 500:51-64.
16. Fiset, C., R.B. Clark, T.S. Larsen, and W.R. Giles. 1998. A rapidly activating, sustained current modulates repolarization and excitation-contraction coupling in adult mouse ventricle. J. Physiol. (Camb.). 504:557-563.
17. Folco, E., R. Mathur, Y. Mori, P. Buckett, and G. Koren. 1997. A cellular model for Long QT Syndrome. Trapping of heteromultimeric complexes consisting of truncated Kv1.1 potassium channel polypeptides and native Kv1.4 and Kv1.5 channels in the endoplasmic reticulum. J. Biol. Chem. 272:26505-26510.
18. Gadsby, D. 1995. Effects of β-adrenergic catecholamines on membrane currents in cardiac cells. In Cardiac Physiology: A Textbook. M.R. Rosen, M.J. Janse, and A.L. Wit, editors. Futura Publishing Co., Mt. Kisco, NY. 857-876.
19. 2+-independent transient outward current in mammalian heart. In Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters. M. Morad, Y. Kurachi, A. Noma, and M. Hosada, editors. Kluwer Press, Ltd., Amsterdam, Netherlands. 141-168.
20. Hamill, O.P., A. Marty, E. Neher, B. Sakmann, and F.J. Sigworth. 1981. Improved patch-clamp techniques for high resolution current recordings from cells and membrane patches. Pflügers Arch. 391:85-100.
21. + channel gene: reduced body weight, impaired motor skill, and muscle contraction, but no seizures. Proc. Natl. Acad. Sci. USA. 94:1533-1538.
22. Johns, D.C., H.B. Nuss, and E. Marban. 1997. Suppression of neuronal and cardiac transient outward currents by viral gene transfer of dominant negative Kv4.2 constructs. J. Biol. Chem. 272: 24109-24112.
23. Kass, R.S. 1995. Delayed potassium channels in the heart: cellular, molecular, and regulatory properties. In Cardiac Electrophysiology: From Cell to Bedside. 2nd ed. D.P. Zipes and J. Jalife, editors. W. B. Saunders Co., Philadelphia. 74-82.
24. + channel. Proc. Natl. Acad. Sci. USA. 95:2926-2931.
25. London, B., D.W. Wang, J.A. Hill, and P.B. Bennett. 1998b. The transient outward current in targeted mice lacking the potassium channel gene Kv1.4. J. Physiol. (Lond.). 509:171-182.
26. Lyons, G.E., S. Schiaffino, D. Sasson, P. Barton, and M. Buckingham. 1990. Developmental regulation of myosin gene expression in mouse cardiac muscle. J. Cell Biol. 111:2427-2436.
27. Näbauer, M., and S. Kääb. 1998. Potassium channel down regulation in heart failure. Cardiovasc. Res. 37:324-334.
28. Näbauer, M., D.J. Beuckelmann, and E. Erdmann. 1993. Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure. Circ. Res. 73:386-394.
29. + channel expression in the developing mammalian myocardium. J. Neurobiol. 37: 37-59.
30. Ng, W.A., I.L. Grupp, A. Subramaniam, and J. Robbins. 1991. Cardiac myosin heavy chain mRNA expression and myocardial function in the mouse heart. Circ. Res. 68:1742-1750.
31. Palermo, J., J. Gulick, M. Colbert, J. Fewell, and J. Robbins. 1996. Transgenic remodelling of the contractile apparatus in the mammalian heart. Circ. Res. 78:504-509.
32. + channels. Neuron. 11:353-358.
33. + currents in mammalian cell lines and cardiac myocytes. Pflügers Arch. 437:381-392.
34. Ribera, A.B. 1996. Homogeneous development of electrical excitability via heterogeneous ion channel expression. J. Neurosci. 16: 1123-1130.
35. Smart, S.L., V. Lopantsev, C.L. Zhang, C.A. Robbins, H. Wang, S.Y. Chin, P.A. Schwartzkroin, A. Messing, and B.L. Tempel. 1998. Deletion of the Kv1.1 potassium channel causes epilepsy in mice. Neuron. 20:809-819.
36. Ten Eick, R.E., J.R. Houser, and A.L. Bassett. 1989. Cardiac hypertrophy and altered cellular activity of the myocardium. In Physiology and Pathophysiology of the Heart. 2nd ed. N. Sperelakis, editor. Martinus Nijhoff, Boston, MA. 573-594.
37. Tseng-Crank, J.C.L., G.-N. Tseng, A. Schwartz, and M.A. Tanouye. 1990. Molecular cloning and functional expression of a potassium channel cDNA isolated from a rat cardiac library. FEBS Lett. 268:63-68.
38. + current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation. Circ. Res. 80:772-781.
39. Wang, L., and H.J. Duff. 1997. Developmental changes in transient outward current in mouse ventricle. Circ. Res. 81:120-127.
40. Wilde, A.A.M., and M.W. Veldkamp. 1997. Ion channels, the QT interval and arrhythmias. Pace (Pacing Clin. Electrophysiol.). 20:2048-2051.
41. + channel currents in rat ventricular myocytes. J. Gen. Physiol. 108:405-419.
42. Zhou, J., A. Jeron, B. London, X. Han, and G. Koren. 1998. Characterization of a slowly inactivating outward current in adult mouse ventricular myocytes. Circ. Res. 83:806-814.