N-terminal palmitoylation of PSD-95 regulates association with cell membranes and interaction with K+ channel K(v)1.4

Neuron

Volumn 20, Issue 1, 1998, Pages 125-134

  Topinka, J Rick ^a   Bredt, David S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALNEXIN; LONG CHAIN FATTY ACID; PALMITIC ACID; POTASSIUM CHANNEL; THIOESTER;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BRAIN HOMOGENATE; CELL CULTURE; CHROMATOGRAPHY; DROSOPHILA MELANOGASTER; GENE EXPRESSION; GENETIC TRANSFECTION; MUTAGENESIS; NONHUMAN; PALMITOYLATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; SIGNAL TRANSDUCTION;

EID: 0031932282     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)80440-7     Document Type: Article

References (50)

1. Anderson, R.G. (1993). Caveolae: where incoming and outgoing messengers meet. Proc. Natl. Acad. Sci. USA 90, 10909-10913.
2. Bouvier, M., Loisel, T.P., and Hebert, T. (1995). Dynamic regulation of G-protein coupled receptor palmitoylation: potential role in receptor function. Biochem. Soc. Trans. 23, 577-581.
3. Brenman, J.E., and Bredt, D.S. (1997). Synaptic signaling by nitric oxide. Curr. Opin. Neurobiol. 7, 374-378.
4. Brenman, J.E., Chao, D.S., Gee, S.H., McGee, A.W., Craven, S.E., Santillano, D.R., Huang, F., Xia, H., Peters, M.F., Froehner, S.C., and Bredt, D.S. (1996a). Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and α-1 syntrophin mediated by PDZ motifs. Cell 84, 757-767.
5. Brenman, J.E., Christopherson, K.S., Craven, S.E., McGee, A.W., and Bredt, D.S. (1996b). Cloning and characterization of postsynaptic density 93 (PSD-93), a nitric oxide synthase interacting protein. J. Neurosci. 16, 7407-7415.
6. Casey, P.J. (1994). Lipid modifications of G proteins. Curr. Opin. Cell Biol. 6, 219-225.
7. Chevesich, J., Kreuz, A.J., and Montell, C. (1997). Requirement for the PDZ domain protein, INAD, for localization of the TRP store-operated channel to a signaling complex. Neuron 18, 95-105.
8. Cho, K.O., Hunt, C.A., and Kennedy, M.B. (1992). The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein. Neuron 9, 929-942.
9. + channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation. Neuron 17, 759-767.
10. Das, A.K., Dasgupta, B., Bhattacharya, R., and Basu, J. (1997). Purification and biochemical characterization of a protein-palmitoyl acyltransferase from human erythrocytes. J. Biol. Chem. 272, 11021-11025.
11. Dong, H., O'Brien, R.J., Fung, E.T., Lanahan, A.A., Worley, P.F., and Huganir, R.L. (1997). GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors. Nature 386, 279-284.
12. Feron, O., Belhassen, L., Kobzik, L., Smith, T.W., Kelly, R.A., and Michel, T. (1996). Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells. J. Biol. Chem. 271, 22810-22814.
13. Froehner, S.C. (1993). Regulation of ion channel distribution at synapses. Annu. Rev. Neurosci. 16, 347-368.
14. Garcia-Cardena, G., Oh, P., Liu, J., Schnitzer, J.E., and Sessa, W.C. (1996). Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. Proc. Natl. Acad. Sci. USA 93, 6448-6453.
15. Guan, B., Hartmann, B., Kho, Y.H., Gorczyca, M., and Budnik, V. (1996). The Drosophila tumor suppressor gene, dlg, is involved in structural plasticity at a glutamatergic synapse. Curr. Biol. 6, 695-706.
16. Hall, Z.W., and Sanes, J.R. (1993). Synaptic structure and development: the neuromuscular junction. Cell 72/Neuron 10 (Suppl.), 99-121.
17. Hardy, S., Kitamura, M., Harris-Stansil, T., Dai, Y., and Phipps, M.L. (1997). Construction of adenovirus vectors through Cre-lox recombination. J. Virol. 71, 1842-1849.
18. Hess, D.T., Patterson, S.I., Smith, D.S., and Skene, J.H. (1993). Neuronal growth cone collapse and inhibition of protein fatty acylation by nitric oxide. Nature 366, 562-565.
19. Hsueh, Y.P., Kim, E., and Sheng, M. (1997). Disulfide-linked head-to-head multimerization in the mechanism of ion channel clustering by PSD-95. Neuron 18, 803-814.
20. Irie, M., Hata, Y., Takeuchi, M., Ichtchenko, K., Toyoda, A., Hirao, K., Takai, Y., Rosahl, T.W., and Sudhof, T.C. (1997). Binding of neuroligins to PSD-95. Science 277, 1511-1515.
21. Johnson, D.R., Bhatnagar, R.S., Knoll, L.J., and Gordon, J.I. (1994). Genetic and biochemical studies of protein N-myristoylation. Annu. Rev. Biochem. 63, 869-914.
22. + channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases. Neuropharmacology 35, 993-1000.
23. + channels by direct interaction with the PSD-95/SAP90 family of membrane-associated guanylate kinases. Nature 378, 85-88.
24. Kim, E., Cho, K.-O., Rothschild, A., and Sheng, M. (1996). Heteromultimerization and NMDA receptor clustering activity of chapsyn-110, a novel member of the PSD-95 family of synaptic proteins. Neuron 17, 103-113.
25. Kistner, U., Wenzel, B.M., Veh, R.W., Cases-Langhoff, C., Garner, A.M., Appeltauer, U., Voss, B., Gundelfinger, E.D., and Garner, C.C. (1993). SAP90, a rat presynaptic protein related to the product of the Drosophila tumor suppressor gene dlg-A. J. Biol. Chem. 268, 4580-4583.
26. Kordeli, E., Davis, J., Trapp, B., and Bennett, V. (1990). An isoform of ankyrin is localized at nodes of Ranvier in myelinated axons of central and peripheral nerves. J. Cell Biol. 110, 1341-1352.
27. Kornau, H.-C., Schenker, L.T., Kennedy, M.B., and Seeburg, P.H. (1995). Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95. Science 269, 1737-1740.
28. Kornau, H.-C., Seeburg, P.M., and Kennedy, M.B. (1997). Interaction of ion channels and receptors with PDZ domains. Curr. Opin. Neurobiol. 7, 368-373.
29. Kuhse, J., Betz, H., and Kirsch, J. (1995). The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex. Curr. Opin. Neurobiol. 5, 318-323.
30. Lisanti, M.P., Tang, Z., Scherer, P.E., Kubler, E., Koleske, A.J., and Sargiacomo, M. (1995). Caveolae, transmembrane signaling and cellular transformation. Mol. Membr. Biol. 12, 121-124.
31. Littman, D.R., Thomas, Y., Maddon, P.J., Chess, L., and Axel, R. (1985). The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes. Cell 40, 237-246.
32. Liu, J., Garcia-Cardena, G., and Sessa, W.C. (1995). Biosynthesis and palmitoylation of endothelial nitric oxide synthase: mutagenesis of palmitoylation sites, cysteines-15 and/or -26, argues against depalmitoylation-induced translocation of the enzyme. Biochemistry 34, 12333-12340.
33. Milligan, G., Grassie, M.A., Wise, A., MacEwan, D.J., Magee, A.I., and Parenti, M. (1995a). G-protein palmitoylation: regulation and functional significance. Biochem. Soc. Trans. 23, 583-587.
34. Milligan, G., Parenti, M., and Magee, A.I. (1995b). The dynamic role of palmitoylation in signal transduction. Trends Biochem. Sci. 20, 181-187.
35. Muller, B.M., Kistner, U., Veh, R.W., Cases-Langhoff, C., Becker, B., Gundelfinger, E.D., and Garner, C.C. (1995). Molecular characterization and spatial distribution of SAP97, a novel presynaptic protein homologous to SAP90 and the Drosophila discs-large tumor suppressor protein. J. Neurosci. 15, 2354-2366.
36. Muller, B.M., Kistner, U., Kindler, S., Chung, W.K., Kuhlendahl, S., Fenster, S.D., Lau, L-F., Veh, R.W., Huganir, R.L., Gundelfinger, E.D., and Garner, C.C. (1996). SAP102, a novel postsynaptic protein that interacts with NMDA receptor complexes in vivo. Neuron 17, 255-265.
37. Mumby, S.M. (1997). Reversible palmitoylation of signaling proteins. Curr. Opin. Cell Biol. 9, 148-154.
38. Robinson, L.J., Busconi, L., and Michel, T. (1995). Agonist-modulated palmitoylation of endothelial nitric oxide synthase. J. Biol. Chem. 270, 995-998.
39. Ruff, P., Speicher, D.W., and Husain-Chishti, A. (1991). Molecular identification of a major palmitoylated erythrocyte membrane protein containing the src homology 3 motif. Proc. Natl. Acad. Sci. USA 88, 6595-6599.
40. Sheng, M. (1996). PDZs and receptor/channel clustering: rounding up the latest suspects. Neuron 17, 575-578.
41. 2+ channel by INAD in Drosophila photoreceptors. Neuron 16, 991-998.
42. Srinivasan, Y., Elmer, L., Davis, J., Bennett, V., and Angelides, K. (1988). Ankyrin and spectrin associate with voltage-dependent sodium channels in brain. Nature 333, 177-80.
43. + channels in vivo. J. Neurosci. 17, 152-159.
44. Tsunoda, S., Sierralta, J., Sun, Y., Bodner, R., Suzuki, E., Becker, A., Socolich, M., and Zuker, C.S. (1997). A multivalent PDZ-domain protein assembles signaling complexes in a G-protein-coupled cascade. Nature 388, 243-249.
45. Tu, Y.P., Wang, J., and Ross, E.M. (1997). Inhibition of brain G(z) GAP and other RGS proteins by palmitoylation of G protein alpha subunits. Science 278, 1132-1135.
46. van't Hof, W., and Resh, M.D. (1997). Rapid plasma membrane anchoring of newly synthesized p59fyn: selective requirementfor NH2-terminal myristoylation and palmitoylation at cysteine-3. J. Cell Biol. 136, 1023-1035.
47. Wedegaertner, P.B., and Bourne, H.R. (1994). Activation and depalmitoylation of Gs alpha. Cell 77, 1063-1070.
48. Woods, D.F., and Bryant, P.J. (1991). The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Cell 66, 451-464.
49. Yurchak, L.K., and Sefton, B.M. (1995). Palmitoylation of either Cys-3 or Cys-5 is required for the biological activity of the Lck tyrosine protein kinase. Mol. Cell. Biol. 15, 6914-6922.
50. Zhang, F.L., and Casey, P.J. (1996). Protein prenylation: molecular mechanisms and functional consequences. Annu. Rev. Biochem 65, 241-269.