Calsenilin Is a Substrate for Caspase-3 that Preferentially Interacts with the Familial Alzheimer's Disease-associated C-terminal Fragment of Presenilin 2

Journal of Biological Chemistry

Volumn 276, Issue 22, 2001, Pages 19197-19204

  Choi, Eun Kyoung ^a   Zaidi, Nikhat F ^a   Miller, Janice S ^a   Crowley, Annette C ^a   Merriam, David E ^a   Lilliehook, Christina ^b   Buxbaum, Joseph D ^b   Wasco, Wilma ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CELLS; MUTAGENESIS; PROTEINS;

PHOSPHORYLATION;

BIOCHEMISTRY;

C TERMINAL FRAGMENT; CALCIUM BINDING PROTEIN; CALSENILIN; CASPASE 3; PEPTIDE FRAGMENT; PRESENILIN 1; PRESENILIN 2; UNCLASSIFIED DRUG; CALCIUM; CASP3 PROTEIN, HUMAN; CASPASE; CSEN PROTEIN, HUMAN; ENZYME INHIBITOR; KV CHANNEL INTERACTING PROTEIN; MEMBRANE PROTEIN; PSEN2 PROTEIN, HUMAN; REPRESSOR PROTEIN; STAUROSPORINE;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL CULTURE; CONTROLLED STUDY; ENZYME SUBSTRATE; FAMILIAL DISEASE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; ANIMAL; APOPTOSIS; BINDING SITE; BIOLOGICAL MODEL; CELL FRACTIONATION; CELL MEMBRANE; CELL STRAIN COS1; CHEMISTRY; CONFOCAL MICROSCOPY; DOSE RESPONSE; FLUORESCENCE MICROSCOPY; GENETICS; METABOLISM; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SERODIAGNOSIS; WESTERN BLOTTING;

ANIMALIA; MAMMALIA;

ALZHEIMER DISEASE; ANIMALS; APOPTOSIS; BINDING SITES; BLOTTING, WESTERN; CALCIUM; CALCIUM-BINDING PROTEINS; CASPASE 3; CASPASES; CELL MEMBRANE; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; KV CHANNEL-INTERACTING PROTEINS; MEMBRANE PROTEINS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHOSPHORYLATION; PRECIPITIN TESTS; PRESENILIN-2; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; STAUROSPORINE; SUBCELLULAR FRACTIONS; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0035374675     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M008597200     Document Type: Article

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