Concordant expression of KChIP2 mRNA, protein and transient outward current throughout the canine ventricle

Journal of Physiology

Volumn 548, Issue 3, 2003, Pages 815-822

  Rosati, Barbara ^a   Grau, Frederic ^a   Rodriguez, Samantha ^a   Li, Huilin ^b   Nerbonne, Jeanne M ^b   McKinnon, David ^a  

^a STONY BROOK UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; POTASSIUM CHANNEL; POTASSIUM ION; PROTEIN KCHIP2; REGULATOR PROTEIN; UNCLASSIFIED DRUG; PROTEIN ANTIBODY; SHAL POTASSIUM CHANNEL;

ANIMAL TISSUE; BETA CHAIN; CONTROLLED STUDY; CROSS REACTION; DNA MICROARRAY; DOG; GENE EXPRESSION; HEART VENTRICLE; HEART VENTRICLE SEPTUM; HUMAN; HUMAN TISSUE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REVIEW; TRANSCRIPTION REGULATION; ADULT; ANIMAL EXPERIMENT; ARTICLE; ENDOCARDIUM; EPICARDIUM; GENE; HEART LEFT VENTRICLE; HEART RIGHT VENTRICLE; HUMAN CELL; KCHIP2 GENE; MOUSE; SPONTANEOUS TRANSIENT OUTWARD CURRENT; TISSUE MICROARRAY;

ANIMALS; CALCIUM-BINDING PROTEINS; CEREBRAL VENTRICLES; DOGS; FUNCTIONAL LATERALITY; GENE EXPRESSION REGULATION; HEART; KV CHANNEL-INTERACTING PROTEINS; MEMBRANE POTENTIALS; MICE; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; PROTEIN BIOSYNTHESIS; TRANSCRIPTION, GENETIC;

EID: 0037986479     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2002.033704     Document Type: Review

References (20)

1. An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS & Rhodes KJ (2000). Modulation of A-type potassium channels by a family of calcium sensors. Nature 403, 553-556.
2. Bolstad BM, Irizarry RA, Astrand M & Speed TP (2003). A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19, 185-193.
3. Deschenes I, DiSilvestre D, Juang GJ, Wu RC, An WF & Tomaselli GF (2002). Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)? Circulation 106, 423-429.
4. Di Diego JM, Sun ZQ & Antzelevitch C (1996). I(to) and action potential notch are smaller in left vs. right canine ventricular epicardium. Am J Physiol 271, H548-561.
5. Dixon JE & McKinnon D (1994). Quantitative analysis of potassium channel mRNA expression in atrial and ventricular muscle of rats. Circ Res 75, 252-260.
6. Dixon JE, Shi W, Wang H-S, MacDonald C, Yu H, Wymore R, Cohen IS & McKinnon D (1996). Role of the Kv4.3 potassium channel in ventricular muscle: a molecular correlate for the transient outward current. Circ Res 79, 659-668.
7. Dudoit S, Yang YH, Callow MJ & Speed TP (2002). Statistical methods for identifying differentially expressed genes in replicated cDNA microarray experiments. Statistica Sinica 12, 111-139.
8. + currents. Circ Res 90, 586-593.
9. Ihaka R & Gentleman R (1996). R: A language for data analysis and graphics. J Comp Graph Stat 5, 299-314.
10. Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U & Speed TP (2003). Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics (in the Press).
11. Kuo HC, Cheng CF, Clark RB, Lin JJ, Lin JL, Hoshijima M, Nguyen-Tran VT, Gu Y, Ikeda Y, Chu PH, Ross J, Giles WR & Chien KR (2001). A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia. Cell 107, 801-813.
12. Liu DW, Gintant GA & Antzelevitch C (1993). Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle. Circ Res 72, 671-687.
13. Nabauer M, Beuckelmann DJ, Uberfuhr P & Steinbeck G (1996). Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation 93, 168-177.
14. + channels. Neuron 37, 449-461.
15. + channel diversity in the mammalian myocardium. J Physiol 525, 285-298.
16. Patel SP, Campbell DL, Morales MJ & Strauss HC (2002). Heterogeneous expression of KChIP2 isoforms in the ferret heart. J Physiol 539, 649-656.
17. Rosati B, Pan Z, Lypen S, Wang HS, Cohen I, Dixon JE & McKinnon D (2001). Regulation of KChIP2 potassium channel β subunit gene expression underlies the gradient of transient outward current in canine and human ventricle. J Physiol 533, 119-125.
18. + currents ITO1 and IKs are larger in right than left canine ventricular midmyocardium. Circulation 99, 206-210.
19. Wettwer E, Amos GJ, Posival H & Ravens U (1994). Transient outward current in human ventricular myocytes of subepicardial and subendocardial origin. Circ Res 75, 473-482.
20. f in adult canine cardiac ventricular myocytes. J Physiol 485, 469-483.