Isolation and characterization of the human gene encoding I(to): Further diversity by alternative mRNA splicing

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 275, Issue 6 44-6, 1998, Pages

  Kong, Wei ^a   Po, Sunny ^a   Yamagishi, Toshio ^a   Ashen, M Dominique ^a   Stetten, Gail ^a   Tomaselli, Gordon F ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chromosome 1; Fluorescence in situ hybridization; Heterologous expression; Kv4.2; Kv4.3; Potassium channel; Xenopus oocytes

Indexed keywords

POTASSIUM CHANNEL;

ARTICLE; CHROMOSOME 1; FLUORESCENCE IN SITU HYBRIDIZATION; GENE ISOLATION; GENETIC VARIABILITY; HEART ELECTROPHYSIOLOGY; HEART REPOLARIZATION; HUMAN; HUMAN CELL; HUMAN TISSUE; POTASSIUM CURRENT; PRIORITY JOURNAL; RNA SPLICING; XENOPUS;

EID: 0032447140     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.1998.275.6.h1963     Document Type: Article

References (44)

1. Amos, G. J., E. Wettwer, F. Metzger, Q. Li, H. M. Himmel, and U. Ravens. Differences between outward currents of human atrial and subepicardial ventricular myocytes. J. Physiol. (Lond.) 491: 31-50, 1996.
2. + current in rat ventricular myocytes. Proc. Natl. Acad. Sci. USA 85: 8756-8760, 1988.
3. Barry, D. M., and J. M. Nerbonne. Myocardial potassium channels: electrophysiological and molecular diversity. Annu. Rev. Physiol. 58: 363-394, 1996.
4. Barry, P. H. JPCalc, a software package for calculating liquid junction potential corrections in patch-clamp, intracellular, epithelial, and bilayer measurements and for correcting junction potential measurements. J. Neurosci. Methods 5: 107-116, 1994.
5. Berger, F., U. Borchard, and D. Hafner. Effects of (+)- and (+/-)-sotalol on repolarizing outward currents and pacemaker current in sheep cardiac Purkinje fibres. Naunyn Schmiedebergs Arch. Pharmacol. 340: 696-704, 1989.
6. + currents in isolated human ventricular myocytes from patients with terminal heart failure. Circ. Res. 73: 379-385, 1993.
7. + channel subunits in ferret epicardial and endocardial left ventricular myocytes (Abstract). Circulation 96: 1-498, 1997.
8. Braun, A. P., D. Fedida, R. B. Clark, and W. R. Giles. Intracellular mechanisms for alpha 1-adrenergic regulation of the transient outward current in rabbit atrial myocytes. J. Physiol. (Lond.) 431: 689-712, 1990.
9. Coraboeuf, E., and E. Carmeliet. Existence of two transient outward currents in sheep cardiac Purkinje fibers. Pflügers Arch. 392: 352-359, 1982.
10. to in young and adult human atrial myocytes: evidence for developmental changes. Am. J. Physiol. 268 (Heart Circ. Physiol. 37): H1335-H1342, 1995.
11. Dixon, J. E., and D. McKinnon. Quantitative analysis of potassium channel mRNA expression in atrial and ventricular muscle of rats. Circ. Res. 75: 252-260, 1994.
12. + channel in ventricular muscle. A molecular correlate for the transient outward current. Circ. Res. 79: 659-668, 1996.
13. Fedida, D., and R. A. Bouchard. Mechanisms for the positive inotropic effect of alpha 1-adrenoceptor stimulation in rat cardiac myocytes. Circ. Res. 71: 673-688, 1992.
14. Firek, L., and W. R. Giles. Outward currents underlying repolarization in human atrial myocytes. Cardiovasc. Res. 30: 31-38, 1995.
15. Folander, K., J. Douglass, and R. Swanson. Confirmation of the assignment of the gene encoding Kv1.3, a voltage-gated potassium channel (KCNA3) to the proximal short arm of chromosome 1. Genomics 23: 295-296, 1994.
16. + channel genes in left ventricular remodeled myocardium after experimental myocardial infarction. Circ. Res. 79: 669-675, 1996.
17. Gross, G. J., R. P. Burke, and N. A. Castle. Characterisation of transient outward current in young human atrial myocytes. Cardiovasc. Res. 29: 112-117, 1995.
18. Hatem, S. N., A. Benardeau, C. Rucker-Martin, J. L. Samuel, E. Coraboeuf, and J. J. Mercadier. Differential regulation of voltage-activated potassium currents in cultured human atrial myocytes. Am. J. Physiol. 271 (Heart Circ. Physiol. 40): H1609-H1619, 1996.
19. Hille, B. Ionic Channels of Excitable Membranes. Sunderland, MA: Sinauer, 1992.
20. Kääb, S., J. Dixon, J. Due, M. D. Ashen, M. Näbauer, D. J. Beuckelmann, G. Steinbeck, D. McKinnon, and G. F. Tomaselli. Molecular basis of transient outward current down-regulation in human heart failure. Circulation. In press.
21. Kääb, S., H. B. Nuss, N. Chiamvimonvat, B. O'Rourke, P. H. Pak, D. A. Kass, E. Marban, and G. F. Tomaselli. Ionic mechanism of action potential prolongation in ventricular myocytes from dogs with pacing-induced heart failure. Circ. Res. 78: 262-273, 1996.
22. Kilborn, M. J., and D. Fedida. A study of the developmental changes in outward currents of rat ventricular myocytes. J. Physiol. (Lond.) 430: 37-60, 1990.
23. Le Grand, B. L., S. Hatem, E. Deroubaix, J. P. Couetil, and E. Coraboeuf. Depressed transient outward and calcium currents in dilated human atria. Cardiovasc. Res. 28: 548-556, 1994.
24. Mansourati, J., and B. Le Grand. Transient outward current in young and adult diseased human atria. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H1466-H1470, 1993.
25. Näbauer, M., D. J. Beuckelmann, and E. Erdmann. Characteristics of transient outward current in human ventricular myocytes from patients with terminal heart failure. Circ. Res. 73: 386-394, 1993.
26. Näbauer, M., D. J. Beuckelmann, P. Überfuhr, and G. Steinbeck. Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation 93: 168-177, 1996.
27. Ohya, S., M. Tanaka, T. Oku, Y. Asai, M. Watanabe, W. Giles, and Y. Imaizumi. Molecular cloning and tissue distribution of an alternatively spliced variant of an A-type K channel alpha-subunit, Kv4.3 in the rat. FEBS Lett. 420: 47-53, 1997.
28. Pearson, R. B., and B. E. Kemp. Protein kinase phosphorylation site sequences and consensus specificity motifs: tabulations. In: Methods in Enzymology. Protein Phosphorylation. Part A, edited by T. Hunter and B. M. Sefton. San Diego, CA: Academic, 1991, vol. 200, p. 62-81.
29. Pinkel, D., T. Straume, and J. W. Gray. Cytogenetic analysis using quantitative, high sensitivity, fluorescence hybridization. Proc. Natl. Acad. Sci. USA 83: 2934-2938, 1986.
30. Po, S., S. Roberds, D. J. Snyders, M. M. Tamkun, and P. B. Bennett. Heteromultimeric assembly of human potassium channels. Molecular basis of a transient outward current? Circ. Res. 72: 1326-1336, 1993.
31. Qi, A., J. A. Yeung-Lai-Wah, J. Xiao, and C. R. Kerr. Regional differences in rabbit atrial repolarization: importance of transient outward current. Am. J. Physiol. 266 (Heart Circ. Physiol. 35): H643-H649, 1994.
32. Qin, D., Z. H. Zhang, E. B. Caref, M. Boutjdir, P. Jain, and N. el-Sherif. Cellular and ionic basis of arrhythmias in postinfarction remodeled ventricular myocardium. Circ. Res. 79: 461-473, 1996.
33. + channel which maps to chromosome 1 band p21. J. Neurosci. Res. 29: 401-412, 1991.
34. Sambrook, J., E. F. Fritsch, and T. Manniatis. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 1989.
35. + channel isoforms in rat ventricle. J. Physiol. (Lond.) 500: 65-73, 1997.
36. + channel subunit mRNAs in ventricles of renovascular hypertensive rats. Circ. Res. 81: 533-539, 1997.
37. Thuringer, D., A. Coulombe, E. Deroubaix, E. Coraboeuf, and J. J. Mercadier. Depressed transient outward current density in ventricular myocytes from cardiomyopathic Syrian hamsters of different ages. J. Mol. Cell. Cardiol. 28: 387-401, 1996.
38. + current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation. Circ. Res. 80: 772-781, 1997.
39. Wahler, G. M., S. J. Dollinger, J. M. Smith, and K. L. Flemal. Time course of postnatal changes in rat heart action potential and in transient outward current is different. Am. J. Physiol. 267 (Heart Circ. Physiol. 36): H1157-H1166, 1994.
40. Wettwer, E., G. Amos, J. Gath, H. R. Zerkowski, J. C. Reidemeister, and U. Ravens. Transient outward current in human and rat ventricular myocytes. Cardiovasc. Res. 27: 1662-1669, 1993.
41. Wettwer, E., G. J. Amos, H. Posival, and U. Ravens. Transient outward current in human ventricular myocytes of subepicardial and subendocardial origin. Circ. Res. 75: 473-482, 1994.
42. + channel gene expression in rat ventricle. J. Physiol. (Lond.) 504: 271-286, 1997.
43. + channel currents in rat ventricular myocytes. J. Gen. Physiol. 108: 405-419, 1996.
44. Yamagishi, T., M. Janecki, E. Marban, and G. F. Tomaselli. Topology of the P segments in the sodium channel pore revealed by cysteine mutagenesis. Biophys. J. 73: 195-204, 1997.