Expression of voltage-gated K+ channels in human atrium

Basic Research in Cardiology

Volumn 97, Issue 6, 2002, Pages 424-433

  Bertaso, Federica ^b   Sharpe, Claire C ^b   Hendry, Bruce M ^b   James, Andrew F ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Kv1.4; KvLQT1; mRNA expression; Semi quantitative RT PCR; Sustained outward K+ current

Indexed keywords

4 AMINOPYRIDINE; MESSENGER RNA; POTASSIUM CHANNEL BLOCKING AGENT; VOLTAGE GATED CHANNEL FORMING PROTEIN; VOLTAGE GATED POTASSIUM CHANNEL; ISOPROTEIN; KCND2 PROTEIN, HUMAN; SHAL POTASSIUM CHANNEL;

ADULT; AGED; ARTICLE; CELL ISOLATION; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); DRUG EFFECT; DRUG INHIBITION; DRUG TARGETING; FEMALE; GENE EXPRESSION; HEART ARRHYTHMIA; HEART ATRIUM; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART REPOLARIZATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; NUCLEOTIDE SEQUENCE; PATCH CLAMP; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; DRUG ANTAGONISM; ELECTRIC CONDUCTIVITY; GENETICS; HEART MUSCLE; METABOLISM; MIDDLE AGED; PHYSIOLOGY;

4-AMINOPYRIDINE; ELECTRIC CONDUCTIVITY; FEMALE; HEART ATRIA; HUMANS; MALE; MIDDLE AGED; MYOCARDIUM; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, VOLTAGE-GATED; PROTEIN ISOFORMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SHAL POTASSIUM CHANNELS;

EID: 1842847282     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00395-002-0377-4     Document Type: Article

References (58)

1. Kr potassium channels with HERG and is associated with cardiac arrhythmia. Cell 97: 175-187
2. Amos GJ, Wettwer E, Metzger F, Li Q, Himmel HW, Ravens U (1996) Differences between outward currents of human atrial and subepicardial ventricular myocytes. Journal of Physiology (London) 491: 31-50
3. Ks cardiac potassium current. Nature 384: 78-80
4. Barry DM, Nerbonne JM (1996) Myocardial potassium channels: electrophysiological and molecular diversity. Annual Review of Physiology 58: 363-394
5. 2+ in human atrial myocytes. Biochemical and Biophysical Research Communications 273: 10-16
6. Bertaso F, Hendry BM, Newman S, Argano V, Desai JB, Forsyth AT, Marrinan M, Meharwal ZS, Sutherland F, Zaman H, De Belder A, James AF (1997) Outward currents in isolated human cardiac atrial myocytes. Journal of Physiology (London) 504: 77P
7. Bertaso F, Sharpe CC, Hendry BM, James AF (1999) Expression of potassium channel subunits in human atrium. The Physiologist 42: 229
8. to) phenotypes and distribution of fast-inactivating potassium channel alpha subunits in ferret left ventricular myocytes. Journal of General Physiology 113: 581-600
9. + channels. Journal of the American College of Cardiology 37: 926-932
10. + current in cardiac myocytes by dofetilide. Journal of Pharmacology and Experimental Therapeutics 262: 809-817
11. Curran ME, Splawski I, Timothy KW, Vincent GM, Green ED, Keating MT (1995) A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 80: 795-803
12. Deal KK, England SK, Tamkun MM (1996) Molecular physiology of cardiac potassium channels. Physiological Reviews 76: 49-67
13. Dixon JE, McKinnon D (1994) Quantitative analysis of potassium channel mRNA expression in atrial and ventricular muscle of rats. Circulation Research 75: 252-260
14. + channel in ventricular muscle: a molecular correlate for the transient outward current. Circulation Research 79: 659-668
15. Escande D, Coulombe A, Faivre J-F, Deroubaix E, Corabeuf E (1985) Two types of transient outward currents in adult human atrial cells. American Journal of Physiology 252: H142-H148
16. + current in cultured adult human atrial myocytes. Circulation Research 80: 572-579
17. Feng J, Xu D, Wang Z, Nattel S (1998) Ultrarapid delayed rectifier current inactivation in human atrial myocytes: properties and consequences. American Journal of Physiology 275: H1717-H1725
18. Fermini B, Wang Z, Duan D, Nattel S (1992) Differences in rate dependence of transient outward current in rabbit and human atrium. American Journal of Physiology 263: H1747-H1754
19. Firek L, Giles W (1995) Outward currents underlying repolarization in human atrial myocytes. Cardiovascular Research 30: 31-38
20. Grammer JB, Bosch RF, Kuhlkamp V, Seipel L (2000) Molecular remodeling of Kv4.3 potassium channels in human atrial fibrillation. Journal of Cardiovascular Electrophysiology 11: 626-633
21. Guo W, Xu H, London B, Nerbonne JM (1999) Molecular basis of transient outward current diversity in mouse ventricular myocytes. Journal of Physiology (London) 521: 587-599
22. Iost N, Virag L, Opincariu M, Szecsi J, Varro A, Papp JG (1998) Delayed rectifier potassium current in undiseased human ventricular myocytes. Cardiovascular Research 40: 508-515
23. James AF, Tominaga T, Okada Y, Tominaga M (1996) Distribution of cAMP-activated chloride current and CFTR mRNA in the guinea pig heart. Circulation Research 79: 201-207
24. + current by dofetilide. Circulation Research 72: 75-83
25. Kääb S, Dixon J, Duc J, Ashen D, Näbauer M, Beuckelmann DJ, Steinbeck G, McKinnon D, Tomaselli GF (1998) Molecular basis of transient outward potassium current down regulation in human heart failure. Circulation 98: 1383-1393
26. Lai LP, Su MJ, Lin JL, Lin FY, Tsai CH, Chen YS, Tseng YZ, Lien WP, Huang SK (1999) Changes in the mRNA levels of delayed rectifier potassium channels in human atrial fibrillation. Cardiology 92: 248-255
27. + current in human ventricular myocytes. Circulation Research 78: 689-696
28. Kr. Nature 388: 289-292
29. to: Kv1.4 redux. Circulation Research 84: 620-622
30. Nattel S (2002) New ideas about atrial fibrillation 50 years on. Nature 415: 219-226
31. Nattel S, Yue L, Wang Z (1999) Cardiac ultrarapid delayed rectifiers: A novel potassium current family of functional similarity and molecular diversity. Cellular Physiology and Biochemistry 9: 217-226
32. Rasmussen HS, Allen MJ, Blackburn KJ, Butrous KJ, Dalrymple HW (1992) Dofetilide, a novel class III antiarrhythmic agent. Journal of Cardiovascular Pharmacology 20: S96-S105
33. Ravens U, Wettwer E (1998) Electrophysiological aspects of changes in heart rate. Basic Research in Cardiology 93: 60-65
34. Ks potassium channel. Nature 384: 80-83
35. Kr potassium channel. Cell 81: 299-307.
36. + current: Differential sensitivity to block by Class III antiarrhythmic agents. Journal of General Physiology 96: 194-214
37. Schaffer P, Pelzmann B, Bernhart E, Lang P, Løkebø JE, Mächler H, Rigler B, Koidl B (1998) Estimation of outward currents in isolated human atrial myocytes using inactivation time course analysis. Pflügers Archive: European Journal of Physiology 436: 457-468
38. Sedgwick ML, Dalrymple I, Rae AP, Cobbe SM (1995) Effects of the new class III antiarrhythmic drug dofetilide on the atrial and ventricular intracardiac monophasic action potential in patients with angina pectoris. European Heart Journal 16: 1641-1646
39. Sharpe CC, Dockrell MEC, Noor MI, Monia BP, Hendry BM (2000) Role of Ras isoforms in the stimulated proliferation of human renal fibroblasts in primary culture. Journal of the American Society of Nephrology 11: 1600-1606
40. Shibata EF, Drury T, Refsum H, Aldrete V, Giles W (1989) Contributions of a transient outward current to repolarization in human atrium. American Journal of Physiology 257: H1773-H1781
41. Skasa M, Jungling E, Picht E, Schondube F, Luckhoff A (2001) L-type calcium currents in atrial myocytes from patients with persistent and non-persistent atrial fibrillation. Basic Research in Cardiology 96: 151-159
42. to channels: Kv4.2, Kv4.3, and other possibilities? Cardiovascular Research 41: 16-18
43. + current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation. Circulation Research 80: 772-781
44. Wang Q, Curran ME, Splawski I, Burn TC, Millholland JM, WanRaay TJ, Shen J, Timothy KW, Vincent GM, De Jager T, Schwartz PJ, Toubin JA, Moss AJ, Atkinson DL, Landes GM, Connors TD, Keating MT (1996) Positional cloning of a novel potassium channel gene: KvLQT1 mutations cause cardiac arrhythmias. Nature Genetics 12: 17-23
45. + current in rabbit and human atrial myocytes. Circulation Research 84: 551-561
46. Wang Z, Fermini B, Nattel S (1993) Delayed rectifier outward current and repolarization in human atrial myocytes. Circulation Research 73: 276-285
47. + current similar to Kv1.5 cloned channel currents. Circulation Research 73: 1061-1076
48. Wang Z, Fermini B, Nattel S (1994) Rapid and slow components of delayed rectifier current in human atrial myocytes. Cardiovascular Research 28: 1540-1546
49. Wang Z, Fermini B, Nattel S (1995) Effects of flecainide, quinidine, and 4-aminopyridine on transient outward and ultrarapid delayed rectifier currents in human atrial myocytes. Journal of Pharmacology and Experimental Therapeutics 272: 184-196
50. Wang Z, Yue L, White M, Pelletier G, Nattel S (1998) Differential distribution of inward rectifier potassium channel transcripts in human atrium versus ventricle. Circulation 98: 2422-2428
51. + current in rat ventricle. American Journal of Physiology 276: H1599-H1607
52. + channel subunit in the mouse heart. Circulation Research 85: 1067-1076
53. Wong KR, Trezise AE, Vandenberg JI (2000) Developmental regulation of the gradient of cftr expression in the rabbit heart. Mech Dev 94: 195-197
54. Workman AJ, Kane KA, Rankin AC (2001) The contribution of ionic currents to changes in refractoriness of human atrial myocytes associated with chronic atrial fibrillation. Cardiovascular Research 52: 226-235
55. Xu H, Li H, Nerbonne JM (1999) Elimination of the transient outward current and action potential prolongation in mouse atrial myocytes expressing a dominant negative Kv4 α subunit. Journal of Physiology (London) 519: 11-21
56. + channel currents in rat ventricular myocytes. Journal of General Physiology 108: 405-419
57. Yang W-P, Levesque PC, Little WA, Conder ML, Shalaby FY, Blanar MA (1997) KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias. Proceedings of the National Academy of Sciences of the USA 94: 4017-4021
58. Yue L, Feng J, Li G-R, Nattel S (1996) Transient outward and delayed rectifier currents in canine atrium: Properties and role of isolation methods. American Journal of Physiology 270: H2157-H2168