GDNF acutely modulates excitability and A-type K+ channels in midbrain dopaminergic neurons

Nature Neuroscience

Volumn 4, Issue 11, 2001, Pages 1071-1078

  Yang, Feng ^a,c   Feng, Linyin ^a,c   Zheng, Fang ^d   Yang, F ^d   Wu, Chien Ping ^a   Shen, Liya ^e  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^d NONE

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; POTASSIUM CHANNEL; TYROSINE 3 MONOOXYGENASE;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CHANNEL GATING; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; EMBRYO; MESENCEPHALON; NERVE CELL CULTURE; NERVE CELL EXCITABILITY; NERVE CELL NECROSIS; NEUROMODULATION; NEUROPROTECTION; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

4-AMINOPYRIDINE; ANESTHETICS, LOCAL; ANIMALS; CELLS, CULTURED; CULTURE MEDIA, SERUM-FREE; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT DYES; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; MALE; MEMBRANE POTENTIALS; MESENCEPHALON; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE GROWTH FACTORS; NERVE TISSUE PROTEINS; NEURONS; NEUROPROTECTIVE AGENTS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, VOLTAGE-GATED; RATS; RATS, SPRAGUE-DAWLEY; TETRAETHYLAMMONIUM; TETRODOTOXIN;

EID: 0035706917     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn734     Document Type: Article

References (50)

1. GDNF family neurotrophic factor signaling: Four masters, one servant?
2. The GDNF family ligands and receptors - Implications for neural development
3. GDNF signalling through the Ret receptor tyrosine kinase
4. GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF
5. Characterization of a multicomponent receptor for GDNF
6. Functional receptor for GDNF encoded by the c-ret proto-oncogene
7. Differential signaling of glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor in cultured ventral mesencephalic neurons
8. Receptors of the glial cell line-derived neurotrophic factor family of neurotrophic factors signal cell survival through the phosphatidylinositol 3-kinase pathway in spinal cord motoneurons
9. GDNF: A glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons
10. Protection and repair of the nigrostriatal dopaminergic system by GDNF in vivo
11. Functional recovery in parkinsonian monkeys treated with GDNF
12. Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo
13. Glial cell line-derived neurotrophic factor but not transforming growth factor beta 3 prevents delayed degeneration of nigral dopaminergic neurons following striatal 6-hydroxydopamine lesion
14. GDNF selectively protects dopamine neurons over serotonin neurons against the neurotoxic effects of methamphetamine
15. Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain
16. The therapeutic potential of neurotrophic factors in the treatment of Parkinson's disease
17. Therapeutical usage of neurotrophic factors: Patent analysis
18. Neurotrophins and hippocampal synaptic plasticity
19. Neurotrophins and synaptic plasticity
20. Glial cell line-derived neurotrophic factor promotes the survival and morphologic differentiation of Purkinje cells
21. Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian perioheral neurons
22. Glial cell line-derived neurotrophic factor and developing mammalian motoneurons: Regulation of programmed cell death among motoneuron subtypes
23. Hyperinnervation of neuromuscular junctions caused by GDNF overexpression in muscle
24. 2+ channels
25. Ionic basis for the electro-responsiveness and oscillatory properties of guinea-pig thalamic neurones in vitro
26. Differential effects of GDNF and BDNF on cultured ventral mesencephalic neurons
27. Two cell types in rat substantia nigra zona compacta distinguished by membrane properties and the actions of dopamine and opioids
28. Prediction of repetitive firing behaviour from voltage clamp data on an isolated neurone soma
29. The intrinsic electrophysiological properties of mammalian neurons: Insights into central nervous system function
30. A model of the electrophysiologlcal properties of thalamocortical relay neurons
31. Potassium conductances underlying repolarization and after-hyperpolarization in rat CA1 hippocampal interneurones
32. The A-type potassium channel kv4.2 is a substrate for the mitogen-activated protein kinase ERK
33. Two types of neurons in the rat ventral tegmental area and their synaptic inputs
34. Neurotrophin-evoked rapid excitation through TrkB receptors
35. Activation of a TRPC3-dependent cation current through the neurotrophin BDNE
36. + (A-type) currents in rat brain
37. Immunohistochemical study on the distribution of six members of the Kv1 channel subunits in the rat basal ganglia
38. Early postnatal development of substantia nigra neurons in rat midbrain slices: Hyperpolarization-activated inward current and dopamine-activated current
39. Properties of the hyperpolarization-activated cation current Ih in rat midbrain dopaminergic neurons
40. Renal and neuronal abnormalities in mice lacking GDNF
41. Renal agenesis and the absence of enteric neurons in mice lacking GDNF
42. GFRα 1 is an essential receptor component for GDNF in the developing nervous system and kidney
43. Glial cell line-derived neurotrophic factor is essential for postnatal survival of midbrain dopamine neurons
44. Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons
45. GDNF Induces a dystonia-like state in neonatal rats and stimulates dopamine and serotonin synthesis
46. Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo
47. Functional effects of GDNF in normal rat striatum: Presynaptic studies using in vivo electrochemistry and microdialysis
48. Neurotrophin 3 potentiates neuronal activity and inhibits g-aminobutyratergic synaptic transmission in cortical neurons
49. 2+ channels in motoneurons of the rat facial nucleus
50. Thresholds of action potentials evoked by synapses on the dendrites of pyramidal cells in the rat hippocampus in vitro