-
1
-
-
9444245809
-
Morphology and toxicity of Aβ (1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease
-
Roher AE, Chaney MO, Kuo YM, et al. Morphology and toxicity of Aβ (1-42) dimer derived from neuritic and vascular amyloid deposits of Alzheimer's disease. J Biol Chem 1996; 271: 20631-20635
-
(1996)
J Biol Chem
, vol.271
, pp. 20631-20635
-
-
Roher, A.E.1
Chaney, M.O.2
Kuo, Y.M.3
-
2
-
-
0030799122
-
Amyloid β-protein fibrillogenesis. Detection of a protofibrillar intermediate
-
Walsh DM, Lomakin A, Benedek GB, et al. Amyloid β-protein fibrillogenesis. Detection of a protofibrillar intermediate. J Biol Chem 1997; 272: 22364-22372
-
(1997)
J Biol Chem
, vol.272
, pp. 22364-22372
-
-
Walsh, D.M.1
Lomakin, A.2
Benedek, G.B.3
-
3
-
-
0030611858
-
Soluble amyloid Aβ(1-40) exists as a stable dimer at low concentrations
-
Garzon-Rodriguez W, Sepulveda-Becerra M, Milton S, et al. Soluble amyloid Aβ(1-40) exists as a stable dimer at low concentrations. J Biol Chem 1997; 272: 21037-21044
-
(1997)
J Biol Chem
, vol.272
, pp. 21037-21044
-
-
Garzon-Rodriguez, W.1
Sepulveda-Becerra, M.2
Milton, S.3
-
4
-
-
0031593854
-
Molecular modeling of the Aβ-42 peptide from Alzheimer's disease
-
Chaney MO, Webster SD, Kuo YM, et al. Molecular modeling of the Aβ-42 peptide from Alzheimer's disease. Protein Eng 1998; 11: 761-767
-
(1998)
Protein Eng
, vol.11
, pp. 761-767
-
-
Chaney, M.O.1
Webster, S.D.2
Kuo, Y.M.3
-
5
-
-
0031587429
-
Detection of apolipoprotein E/dimeric soluble amyloid β complexes in Alzheimer's disease brain supernatants
-
Permanne B, Perez C, Soto C, et al. Detection of apolipoprotein E/dimeric soluble amyloid β complexes in Alzheimer's disease brain supernatants. Biochem Biophys Res Commun 1997; 240: 715-720
-
(1997)
Biochem Biophys Res Commun
, vol.240
, pp. 715-720
-
-
Permanne, B.1
Perez, C.2
Soto, C.3
-
6
-
-
0035860781
-
Amyloid β-protein oligomerization: Prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins
-
Bitan G, Lomakin A, Teplow DB. Amyloid β-protein oligomerization: prenucleation interactions revealed by photo-induced cross-linking of unmodified proteins. J Biol Chem 2001; 276: 35176-35184
-
(2001)
J Biol Chem
, vol.276
, pp. 35176-35184
-
-
Bitan, G.1
Lomakin, A.2
Teplow, D.B.3
-
7
-
-
0029916711
-
The conformation of Alzheimer's β peptide determines the rate of amyloid formation and its resistance to proteolysis
-
Soto C, Castano EM. The conformation of Alzheimer's β peptide determines the rate of amyloid formation and its resistance to proteolysis. Biochem J 1996; 314: 701-707
-
(1996)
Biochem J
, vol.314
, pp. 701-707
-
-
Soto, C.1
Castano, E.M.2
-
8
-
-
0027491355
-
Morphological and biochemical analyses of amyloid plaque core proteins purified from Alzheimer disease brain tissue
-
Roher AE, Palmer KC, Yurewicz EC, et al. Morphological and biochemical analyses of amyloid plaque core proteins purified from Alzheimer disease brain tissue. J Neurochem 1993; 61: 1916-1926
-
(1993)
J Neurochem
, vol.61
, pp. 1916-1926
-
-
Roher, A.E.1
Palmer, K.C.2
Yurewicz, E.C.3
-
9
-
-
0024231238
-
Isolation and chemical characterization of Alzheimer's disease paired helical filament cytoskeletons: Differentiation from amyloid plaque core protein
-
Roher AE, Palmer KC, Chan V, et al. Isolation and chemical characterization of Alzheimer's disease paired helical filament cytoskeletons: Differentiation from amyloid plaque core protein. J Cell Biol 1988; 107: 2703-2716
-
(1988)
J Cell Biol
, vol.107
, pp. 2703-2716
-
-
Roher, A.E.1
Palmer, K.C.2
Chan, V.3
-
10
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics. Sci 2002; 297: 353-356
-
(2002)
Sci
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
11
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe DJ. Alzheimer's disease: Genes, proteins, and therapy. Physiol Rev 2001; 81: 741-766
-
(2001)
Physiol Rev
, vol.81
, pp. 741-766
-
-
Selkoe, D.J.1
-
12
-
-
0028267440
-
Normal and abnormal biology of the β-amyloid precursor protein
-
Selkoe DJ. Normal and abnormal biology of the β-amyloid precursor protein. Annu Rev Neurosci 1994; 17: 489-517
-
(1994)
Annu Rev Neurosci
, vol.17
, pp. 489-517
-
-
Selkoe, D.J.1
-
13
-
-
0035950225
-
Clearing the brain's amyloid cobwebs
-
Selkoe DJ. Clearing the brain's amyloid cobwebs. Neuron 2001; 32: 177-180
-
(2001)
Neuron
, vol.32
, pp. 177-180
-
-
Selkoe, D.J.1
-
14
-
-
0030611584
-
α2-Macroglobulin complexes with and mediates the endocytosis of β-amyloid peptide via cell surface low-density lipoprotein receptor-related protein
-
Narita M, Holtzman DM, Schwartz AL, et al. α2-Macroglobulin complexes with and mediates the endocytosis of β-amyloid peptide via cell surface low-density lipoprotein receptor-related protein. J Neurochem 1997; 69: 1904-1911
-
(1997)
J Neurochem
, vol.69
, pp. 1904-1911
-
-
Narita, M.1
Holtzman, D.M.2
Schwartz, A.L.3
-
15
-
-
0032589297
-
α2-Macroglobulin enhances the clearance of endogenous soluble β-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons
-
Qiu Z, Strickland DK, Hyman BT, et al. α2-Macroglobulin enhances the clearance of endogenous soluble β-amyloid peptide via low-density lipoprotein receptor-related protein in cortical neurons. J Neurochem 1999; 73: 1393-1398
-
(1999)
J Neurochem
, vol.73
, pp. 1393-1398
-
-
Qiu, Z.1
Strickland, D.K.2
Hyman, B.T.3
-
16
-
-
10744231924
-
Increased soluble amyloid-β peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein
-
Zerbinatti CV, Wozniak DF, Cirrito J, et al. Increased soluble amyloid-β peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein. Proc Nat Acad Sci USA 2004; 101: 1075-1080
-
(2004)
Proc Nat Acad Sci USA
, vol.101
, pp. 1075-1080
-
-
Zerbinatti, C.V.1
Wozniak, D.F.2
Cirrito, J.3
-
17
-
-
3042819085
-
Neprilysin regulates amyloid β peptide levels
-
Marr RA, Guan H, Rockenstein E, et al. Neprilysin regulates amyloid β peptide levels. J Mol Neurosci 2004; 22: 5-11
-
(2004)
J Mol Neurosci
, vol.22
, pp. 5-11
-
-
Marr, R.A.1
Guan, H.2
Rockenstein, E.3
-
18
-
-
0042827324
-
Human neprilysin is capable of degrading amyloid β peptide not only in the monomeric form but also the pathological oligomeric form
-
Kanemitsu H, Tomiyama T, Mori H. Human neprilysin is capable of degrading amyloid β peptide not only in the monomeric form but also the pathological oligomeric form. Neurosci Lett 2003; 350: 113-116
-
(2003)
Neurosci Lett
, vol.350
, pp. 113-116
-
-
Kanemitsu, H.1
Tomiyama, T.2
Mori, H.3
-
19
-
-
0037390039
-
Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo
-
Farris W, Mansourian S, Chang Y, et al. Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo. Proc Nat Acad Sci USA 2003; 100: 4162-4167
-
(2003)
Proc Nat Acad Sci USA
, vol.100
, pp. 4162-4167
-
-
Farris, W.1
Mansourian, S.2
Chang, Y.3
-
20
-
-
0141641077
-
The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-β (Aβ) degradation and inhibits Aβ-induced neurodegeneration
-
Melchor JP, Pawlak R, Strickland S. The tissue plasminogen activator-plasminogen proteolytic cascade accelerates amyloid-β (Aβ) degradation and inhibits Aβ-induced neurodegeneration. J Neurosci 2003; 23: 8867-8871
-
(2003)
J Neurosci
, vol.23
, pp. 8867-8871
-
-
Melchor, J.P.1
Pawlak, R.2
Strickland, S.3
-
21
-
-
0028670204
-
Proteolysis of Aβ peptide from Alzheimer disease brain by gelatinase A
-
Roher AE, Kasunic TC, Woods AS, et al. Proteolysis of Aβ peptide from Alzheimer disease brain by gelatinase A. Biochem Biophys Res Commun 1994; 205: 1755-1756
-
(1994)
Biochem Biophys Res Commun
, vol.205
, pp. 1755-1756
-
-
Roher, A.E.1
Kasunic, T.C.2
Woods, A.S.3
-
22
-
-
0031890884
-
Protolytic degradation of Alzheimer's disease amyloid β-peptide by a metalloproteinase from microglia cells
-
Mentlein R, Ludwig R, Martensen I. Protolytic degradation of Alzheimer's disease amyloid β-peptide by a metalloproteinase from microglia cells. J Neurochem 1998; 70: 721-726
-
(1998)
J Neurochem
, vol.70
, pp. 721-726
-
-
Mentlein, R.1
Ludwig, R.2
Martensen, I.3
-
23
-
-
0031862969
-
Irreversible dimerization/tetramerization and post-translational modifications inhibit proteolytic degradation of Aβ peptides of Alzheimer's disease
-
Kuo YM, Webster S, Emmerling MR, et al. Irreversible dimerization/ tetramerization and post-translational modifications inhibit proteolytic degradation of Aβ peptides of Alzheimer's disease. Biochim Biophys Acta 1998; 1406: 291-298
-
(1998)
Biochim Biophys Acta
, vol.1406
, pp. 291-298
-
-
Kuo, Y.M.1
Webster, S.2
Emmerling, M.R.3
-
24
-
-
0027477463
-
Structural alterations in the peptide backbone of β-amyloid core protein may account for its deposition and stability in Alzheimer's disease
-
Roher AE, Lowenson JD, Clarke S, et al. et al. Structural alterations in the peptide backbone of β-amyloid core protein may account for its deposition and stability in Alzheimer's disease. J Biol Chem 1993; 268: 3072-3083
-
(1993)
J Biol Chem
, vol.268
, pp. 3072-3083
-
-
Roher, A.E.1
Lowenson, J.D.2
Clarke, S.3
-
25
-
-
0037339703
-
β-Amyloid racemized at the Ser26 residue in the brains of patients with Alzheimer disease: Implications in the pathogenesis of Alzheimer disease
-
Kubo T, Kumagae Y, Miller CA, et al. β-Amyloid racemized at the Ser26 residue in the brains of patients with Alzheimer disease: implications in the pathogenesis of Alzheimer disease. J Exp Neuropath Exp Neurol 2003; 62: 248-259
-
(2003)
J Exp Neuropath Exp Neurol
, vol.62
, pp. 248-259
-
-
Kubo, T.1
Kumagae, Y.2
Miller, C.A.3
-
26
-
-
0031559602
-
Isolation, chemical characterization, and quantitation of Aβ 3-pyroglutamyl peptides from neuritic plaques and vascular amyloid deposits
-
Kuo YM, Emmerling MR, Woods AS, et al. Isolation, chemical characterization, and quantitation of Aβ 3-pyroglutamyl peptides from neuritic plaques and vascular amyloid deposits. Biochem Biophys Res Commun 1997; 237: 188-191
-
(1997)
Biochem Biophys Res Commun
, vol.237
, pp. 188-191
-
-
Kuo, Y.M.1
Emmerling, M.R.2
Woods, A.S.3
-
27
-
-
0033045848
-
In vitro peroxidase oxidation induces stable dinners of β-amyloid (1-42) through dityrosine bridge formation
-
Galeazzi L, Ronchi P, Franceschi C, et al. In vitro peroxidase oxidation induces stable dinners of β-amyloid (1-42) through dityrosine bridge formation. Amyloid 1999; 6: 7-13
-
(1999)
Amyloid
, vol.6
, pp. 7-13
-
-
Galeazzi, L.1
Ronchi, P.2
Franceschi, C.3
-
28
-
-
0242417426
-
Dityrosine cross-linked Aβ peptides: Fibrillar β-structure in Aβ(1-40) is conducive to formation of dityrosine cross-links but a dityrosine cross-link in Aβ (8-14) does not induce β-structure
-
Yoburn JC, Tian W, Brower JO, et al. Dityrosine cross-linked Aβ peptides: fibrillar β-structure in Aβ(1-40) is conducive to formation of dityrosine cross-links but a dityrosine cross-link in Aβ (8-14) does not induce β-structure. Chem Res Toxicol 2003; 16: 531-535
-
(2003)
Chem Res Toxicol
, vol.16
, pp. 531-535
-
-
Yoburn, J.C.1
Tian, W.2
Brower, J.O.3
-
29
-
-
0035159785
-
Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease
-
Glabe C. Intracellular mechanisms of amyloid accumulation and pathogenesis in Alzheimer's disease. J Mol Neurosci 2001; 17: 137-145
-
(2001)
J Mol Neurosci
, vol.17
, pp. 137-145
-
-
Glabe, C.1
-
30
-
-
0026778656
-
Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/β protein
-
Knauer MF, Soreghan B, Burdick D, et al. Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/β protein. Proc Nat Acad Sci USA 1992; 89: 7437-7441
-
(1992)
Proc Nat Acad Sci USA
, vol.89
, pp. 7437-7441
-
-
Knauer, M.F.1
Soreghan, B.2
Burdick, D.3
-
31
-
-
0031583916
-
Amyloid β-protein (Aβ) associated with lipid molecules: Immunoreactivity distinct from that of soluble Aβ
-
Yanagisawa K, McLaurin J, Michikawa M, et al. Amyloid β-protein (Aβ) associated with lipid molecules: immunoreactivity distinct from that of soluble Aβ. FEBS Lett 1997; 420: 43-46
-
(1997)
FEBS Lett
, vol.420
, pp. 43-46
-
-
Yanagisawa, K.1
McLaurin, J.2
Michikawa, M.3
-
32
-
-
11144356498
-
Dimeric amyloid β protein rapidly accumulates in lipid rafts followed by apolipo-protein e and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease
-
Kawarabayashi T, Shoji M, Younkin LH, et al. Dimeric amyloid β protein rapidly accumulates in lipid rafts followed by apolipo-protein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease. J Neurosci 2004; 24: 3801-3809
-
(2004)
J Neurosci
, vol.24
, pp. 3801-3809
-
-
Kawarabayashi, T.1
Shoji, M.2
Younkin, L.H.3
-
33
-
-
0031781795
-
Quantitation of amyloid β-protein (Aβ) in the cortex during aging and in Alzheimer's disease
-
Funato H, Yoshimura M, Kusui K, et al. Quantitation of amyloid β-protein (Aβ) in the cortex during aging and in Alzheimer's disease. Am J Pathol 1998; 152: 1633-1640
-
(1998)
Am J Pathol
, vol.152
, pp. 1633-1640
-
-
Funato, H.1
Yoshimura, M.2
Kusui, K.3
-
34
-
-
0030700593
-
The CERAD neuropathology protocol and consensus recommendations for the postmortem diagnosis of Alzheimer's disease: A commentary
-
Mirra SS. The CERAD neuropathology protocol and consensus recommendations for the postmortem diagnosis of Alzheimer's disease: A commentary. Neurobiol Aging 1997; 18: S91-S94
-
(1997)
Neurobiol Aging
, vol.18
-
-
Mirra, S.S.1
-
35
-
-
0003181187
-
-
The National Institute on Aging and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease. Neurobiol Aging 1997; 18: S1-2
-
(1997)
Neurobiol Aging
, vol.18
-
-
-
36
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berlin) 1991; 82: 239-259
-
(1991)
Acta Neuropathol (Berlin)
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
37
-
-
0036669881
-
Amyloid-β oligomers: Their production, toxicity and theraputic inhibition
-
Walsh DM, Klyubin I, Fadeeva JV, et al. Amyloid-β oligomers: their production, toxicity and theraputic inhibition. Biochem Soc Trans 2002; 30: 552-557
-
(2002)
Biochem Soc Trans
, vol.30
, pp. 552-557
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
-
38
-
-
0036450037
-
Cerebrovascular disease is a major factor in the failure of elimination of Aβ from the aging human brain: Implications for therapy of Alzheimer's disease
-
Weller RO, Yow HY, Preston SD, et al. Cerebrovascular disease is a major factor in the failure of elimination of Aβ from the aging human brain: implications for therapy of Alzheimer's disease. Ann NY Acad Sci 2002; 977: 162-168
-
(2002)
Ann NY Acad Sci
, vol.977
, pp. 162-168
-
-
Weller, R.O.1
Yow, H.Y.2
Preston, S.D.3
-
39
-
-
0242628969
-
Circle of Willis atherosclerosis is a risk factor for sporadic Alzheimer's disease
-
Roher AE, Esh C, Kokjohn TA, et al. Circle of Willis atherosclerosis is a risk factor for sporadic Alzheimer's disease. Arterioscler Thromb Vasc Biol 2003; 23: 2055-2062
-
(2003)
Arterioscler Thromb Vasc Biol
, vol.23
, pp. 2055-2062
-
-
Roher, A.E.1
Esh, C.2
Kokjohn, T.A.3
-
40
-
-
10744225278
-
Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer's disease
-
Roher AE, Kuo YM, Esh C, et al. Cortical and leptomeningeal cerebrovascular amyloid and white matter pathology in Alzheimer's disease. Mol Med 2003; 9: 112-122
-
(2003)
Mol Med
, vol.9
, pp. 112-122
-
-
Roher, A.E.1
Kuo, Y.M.2
Esh, C.3
-
41
-
-
0027332081
-
β-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: Implications for the pathology of Alzheimer's disease
-
Roher AE, Lowenstein JD, Clarke S, et al. β-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: Implications for the pathology of Alzheimer's disease. Proc Nat Acad Sci USA 1993; 90: 10836-10840
-
(1993)
Proc Nat Acad Sci USA
, vol.90
, pp. 10836-10840
-
-
Roher, A.E.1
Lowenstein, J.D.2
Clarke, S.3
-
42
-
-
0028984802
-
Gerstmann-Straussler-Scheinker disease and the Indiana kindred
-
Ghetti B, Dlouhy SR, Giaccone G, et al. Gerstmann-Straussler-Scheinker disease and the Indiana kindred. Brain Pathol 1995; 5: 61-75
-
(1995)
Brain Pathol
, vol.5
, pp. 61-75
-
-
Ghetti, B.1
Dlouhy, S.R.2
Giaccone, G.3
-
43
-
-
0033228346
-
Variant Gerstmann-Straussler syndrome with the P105L prion gene mutation: An unusual case with nigral degeneration and widespread neurofibrillary tangles
-
Yamazaki M, Oyanagi K, Mori O, et al. Variant Gerstmann-Straussler syndrome with the P105L prion gene mutation: An unusual case with nigral degeneration and widespread neurofibrillary tangles. Acta Neuropathol (Berlin) 1999; 98: 506-511
-
(1999)
Acta Neuropathol (Berlin)
, vol.98
, pp. 506-511
-
-
Yamazaki, M.1
Oyanagi, K.2
Mori, O.3
-
44
-
-
0032616547
-
Gerstmann-Straussler-Scheinker disease and the French-Alsatian A117V variant
-
Mohr M, Tranchant C, Steinmetz G, et al. Gerstmann-Straussler-Scheinker disease and the French-Alsatian A117V variant. Clin Exp Pathol 1999; 47: 161 -175
-
(1999)
Clin Exp Pathol
, vol.47
, pp. 161-175
-
-
Mohr, M.1
Tranchant, C.2
Steinmetz, G.3
-
45
-
-
0041862480
-
Variable phenotype in a P102L Gerstmann-Straussler-Scheinker Italian family
-
De Michele G, Pocchiari M, Petraroli R, et al. Variable phenotype in a P102L Gerstmann-Straussler-Scheinker Italian family. Can J Neurol Sci 2003; 30: 233-236
-
(2003)
Can J Neurol Sci
, vol.30
, pp. 233-236
-
-
De Michele, G.1
Pocchiari, M.2
Petraroli, R.3
-
46
-
-
0023722317
-
Clinical significance of types of cerebellar amyloid plaques in human spongiform encephalopathies
-
Pearlman RL, Towfighi J, Pezeshkpour GH, et al. Clinical significance of types of cerebellar amyloid plaques in human spongiform encephalopathies. Neurology 1988; 38: 1249-1254
-
(1988)
Neurology
, vol.38
, pp. 1249-1254
-
-
Pearlman, R.L.1
Towfighi, J.2
Pezeshkpour, G.H.3
-
47
-
-
0031817970
-
Creutzfeldt-Jakob disease with long duration and panencephalopathic lesions: Molecular analysis of one case
-
Ghorayeb I, Series C, Parchi P, et al. Creutzfeldt-Jakob disease with long duration and panencephalopathic lesions: molecular analysis of one case. Neurology 1998; 51: 271-274
-
(1998)
Neurology
, vol.51
, pp. 271-274
-
-
Ghorayeb, I.1
Series, C.2
Parchi, P.3
-
48
-
-
0030837960
-
Cerebral metabolism in fatal familial insomnia: Relation to duration, neuropathology, and distribution of protease-resistant prion protein
-
Cortelli P, Perani D, Parchi P, et al. Cerebral metabolism in fatal familial insomnia: relation to duration, neuropathology, and distribution of protease-resistant prion protein. Neurology 1997; 49: 126-133
-
(1997)
Neurology
, vol.49
, pp. 126-133
-
-
Cortelli, P.1
Perani, D.2
Parchi, P.3
-
49
-
-
0034030312
-
A case of sporadic Creutzfeldt-Jakob disease with both plaque and synaptic-type deposition of prion protein
-
Tanaka S, Ota M, Ohama E. A case of sporadic Creutzfeldt-Jakob disease with both plaque and synaptic-type deposition of prion protein. Neuropathology 2000; 20: 49-55
-
(2000)
Neuropathology
, vol.20
, pp. 49-55
-
-
Tanaka, S.1
Ota, M.2
Ohama, E.3
-
50
-
-
0034590715
-
Ultrastructural analysis of the florid plaque in variant Creutzfeldt-Jakob disease
-
Liberski PP, Ironside J, McCardle L, et al. Ultrastructural analysis of the florid plaque in variant Creutzfeldt-Jakob disease. Folia Neuropathol 2000; 38: 167-170
-
(2000)
Folia Neuropathol
, vol.38
, pp. 167-170
-
-
Liberski, P.P.1
Ironside, J.2
McCardle, L.3
-
51
-
-
0141625979
-
Differences in the density and spatial distribution of florid and diffuse plaques in variant Creutzfeldt-Jakob disease (vCJD)
-
Armstrong RA, Lantos PL, Ironside JW, et al. Differences in the density and spatial distribution of florid and diffuse plaques in variant Creutzfeldt-Jakob disease (vCJD). Clin Neuropathol 2003; 22: 209-214
-
(2003)
Clin Neuropathol
, vol.22
, pp. 209-214
-
-
Armstrong, R.A.1
Lantos, P.L.2
Ironside, J.W.3
-
52
-
-
0036671447
-
Properties of neurotoxic peptides related to the BRI gene
-
Austen B, el-Agnaf O, Nagala S, et al. Properties of neurotoxic peptides related to the BRI gene. Biochem Soc Trans 2002; 30: 557-559
-
(2002)
Biochem Soc Trans
, vol.30
, pp. 557-559
-
-
Austen, B.1
El-Agnaf, O.2
Nagala, S.3
-
53
-
-
0347087364
-
Oligomerization and neurotoxicity of the amyloid ADan peptide implicated in familial Danish dementia
-
Gibson G, Gunasekera N, Lee M, et al. Oligomerization and neurotoxicity of the amyloid ADan peptide implicated in familial Danish dementia. J Neurochem 2004; 88: 281-290
-
(2004)
J Neurochem
, vol.88
, pp. 281-290
-
-
Gibson, G.1
Gunasekera, N.2
Lee, M.3
-
54
-
-
0035137042
-
Regional distribution of amyloid-Bri deposition and its association with neurofibrillary degeneration in familial British dementia
-
Holton JL, Ghiso J, Lashley T, et al. Regional distribution of amyloid-Bri deposition and its association with neurofibrillary degeneration in familial British dementia. Am J Pathol 2001; 158: 515-526
-
(2001)
Am J Pathol
, vol.158
, pp. 515-526
-
-
Holton, J.L.1
Ghiso, J.2
Lashley, T.3
-
55
-
-
0036194067
-
Familial Danish dementia: A novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-β
-
Holton JL, Lashley T, Ghiso J, et al. Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-β. J Neuropathol Exp Neurol 2002; 61: 254-2670
-
(2002)
J Neuropathol Exp Neurol
, vol.61
, pp. 254-2670
-
-
Holton, J.L.1
Lashley, T.2
Ghiso, J.3
-
56
-
-
0031722421
-
Pathology of cerebrospinal fluid and interstitial fluid of the CNS: Significance for Alzheimer disease, prion disorders and multiple sclerosis
-
Weller RO. Pathology of cerebrospinal fluid and interstitial fluid of the CNS: significance for Alzheimer disease, prion disorders and multiple sclerosis. J Neuropathol Exp Neurol 1998; 57: 885-894
-
(1998)
J Neuropathol Exp Neurol
, vol.57
, pp. 885-894
-
-
Weller, R.O.1
-
57
-
-
0034095485
-
Cerebral amyloid angiopathy: Accumulation of Aβ in interstitial fluid drainage pathways in Alzheimer's disease
-
Weller RO, Massey A, Kuo YM, et al. Cerebral amyloid angiopathy: accumulation of Aβ in interstitial fluid drainage pathways in Alzheimer's disease. Ann NY Acad Sci 2000; 903: 110-117
-
(2000)
Ann NY Acad Sci
, vol.903
, pp. 110-117
-
-
Weller, R.O.1
Massey, A.2
Kuo, Y.M.3
-
58
-
-
0031679480
-
Cerebral amyloid angiopathy: Amyloid-β accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease
-
Weller RO, Massey A, Newman TA, et al. Cerebral amyloid angiopathy: Amyloid-β accumulates in putative interstitial fluid drainage pathways in Alzheimer's disease. Am J Pathol 1998; 153: 725-733
-
(1998)
Am J Pathol
, vol.153
, pp. 725-733
-
-
Weller, R.O.1
Massey, A.2
Newman, T.A.3
-
59
-
-
0026928760
-
Pathways of fluid drainage from the brain-morphological aspects and immunological significance in rat and man
-
Weller RO, Kida S, Zhang ET. Pathways of fluid drainage from the brain-morphological aspects and immunological significance in rat and man. Brain Pathol 1992; 2: 277-284
-
(1992)
Brain Pathol
, vol.2
, pp. 277-284
-
-
Weller, R.O.1
Kida, S.2
Zhang, E.T.3
-
60
-
-
0025992189
-
Albumin outflow into deep cervical lymph from different regions of rabbit brain
-
Yamada S, DePasquale M, Patlak CS, et al. Albumin outflow into deep cervical lymph from different regions of rabbit brain. Am J Physiol 1991; 261: H1197-1204
-
(1991)
Am J Physiol
, vol.261
-
-
Yamada, S.1
Depasquale, M.2
Patlak, C.S.3
-
61
-
-
0026929035
-
Drainage of brain extracellular fluid into blood and deep cervical lymph and its immunological significance
-
Cserr HF, Harling-Berg CJ, Knopf PM. Drainage of brain extracellular fluid into blood and deep cervical lymph and its immunological significance. Brain Pathol 1992; 2: 269-276
-
(1992)
Brain Pathol
, vol.2
, pp. 269-276
-
-
Cserr, H.F.1
Harling-Berg, C.J.2
Knopf, P.M.3
-
62
-
-
0033809909
-
Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons
-
Van Dorpe J, Smeijers L, Dewachter I, et al. Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons. Am J Pathol 2000; 157: 1283-1298
-
(2000)
Am J Pathol
, vol.157
, pp. 1283-1298
-
-
Van Dorpe, J.1
Smeijers, L.2
Dewachter, I.3
-
63
-
-
0028181396
-
Soluble amyloid β-protein is a marker of Alzheimer amyloid in brain but not in cerebrospinal fluid
-
Tabaton M, Nunzi MG, Xue R, et al. Soluble amyloid β-protein is a marker of Alzheimer amyloid in brain but not in cerebrospinal fluid. Biochem Biophys Res Commun 1994; 200: 1598-1603
-
(1994)
Biochem Biophys Res Commun
, vol.200
, pp. 1598-1603
-
-
Tabaton, M.1
Nunzi, M.G.2
Xue, R.3
-
64
-
-
0029078815
-
Modified amyloid β protein ending at 42 or 40 with different solubility accumulates in the brain of Alzheimer's disease
-
Harigaya Y, Shoji M, Kawarabayashi T, et al. Modified amyloid β protein ending at 42 or 40 with different solubility accumulates in the brain of Alzheimer's disease. Biochem Biophys Res Commun 1995; 211: 1015-1022
-
(1995)
Biochem Biophys Res Commun
, vol.211
, pp. 1015-1022
-
-
Harigaya, Y.1
Shoji, M.2
Kawarabayashi, T.3
-
65
-
-
0028096692
-
Biochemical evidence for the long-tail form (Aβ 1-42/43) of amyloid β protein as a seed molecule in cerebral deposits of Alzheimer's disease
-
Tamoaka A, Kondo T, Odaka A, et al. Biochemical evidence for the long-tail form (Aβ 1-42/43) of amyloid β protein as a seed molecule in cerebral deposits of Alzheimer's disease. Biochem Biophys Res Commun 1994; 205: 834-842
-
(1994)
Biochem Biophys Res Commun
, vol.205
, pp. 834-842
-
-
Tamoaka, A.1
Kondo, T.2
Odaka, A.3
-
66
-
-
0028952749
-
Aggregation of secreted amyloid β-protein into sodium dodecyl sulfate-stable oligomers in cell culture
-
Podlisny MB, Ostaszewski BL, Squazzo EL, et al. Aggregation of secreted amyloid β-protein into sodium dodecyl sulfate-stable oligomers in cell culture. J Biol Chem 1995; 270: 9564-9570
-
(1995)
J Biol Chem
, vol.270
, pp. 9564-9570
-
-
Podlisny, M.B.1
Ostaszewski, B.L.2
Squazzo, E.L.3
-
67
-
-
0032539975
-
Oligomerization of endogenous and synthetic amyloid β-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red
-
Podlisny MB, Walsh DM, Amarante P, et al. Oligomerization of endogenous and synthetic amyloid β-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red. Biochem 1998; 37: 3602-3611
-
(1998)
Biochem
, vol.37
, pp. 3602-3611
-
-
Podlisny, M.B.1
Walsh, D.M.2
Amarante, P.3
-
68
-
-
13344293701
-
Presence of soluble amyloid β-peptide precedes amyloid plaque formation in Down's syndrome
-
Teller JK, Russo C, DeBusk LM, et al. Presence of soluble amyloid β-peptide precedes amyloid plaque formation in Down's syndrome. Nat Med 1996; 2: 93-95
-
(1996)
Nat Med
, vol.2
, pp. 93-95
-
-
Teller, J.K.1
Russo, C.2
Debusk, L.M.3
-
69
-
-
0029671451
-
Water-soluble Aβ (N-40, N-42) oligimers in normal and Alzheimer disease brains
-
Kuo YM, Emmerling MR, Vigo-Pelfrey C, et al. Water-soluble Aβ (N-40, N-42) oligimers in normal and Alzheimer disease brains. J Biol Chem 1996; 271: 4077-4081
-
(1996)
J Biol Chem
, vol.271
, pp. 4077-4081
-
-
Kuo, Y.M.1
Emmerling, M.R.2
Vigo-Pelfrey, C.3
-
70
-
-
11544279355
-
Diffusible, nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins
-
Lambert MP, Barlow AK, Chromy BA, et al. Diffusible, nonfibrillar ligands derived from Aβ1-42 are potent central nervous system neurotoxins. Proc Nat Acad Sci USA 1998; 95: 6448-6453
-
(1998)
Proc Nat Acad Sci USA
, vol.95
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
-
71
-
-
18544386562
-
Increased Aβ peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer's disease
-
Roher AE, Weiss N, Kokjohn TA, et al. Increased Aβ peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer's disease. Biochem 2002; 41: 11080-11090
-
(2002)
Biochem
, vol.41
, pp. 11080-11090
-
-
Roher, A.E.1
Weiss, N.2
Kokjohn, T.A.3
-
72
-
-
0031871740
-
Detection of single amyloid β-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy
-
Pitschke M, Prior R, Haupt M, et al. Detection of single amyloid β-protein aggregates in the cerebrospinal fluid of Alzheimer's patients by fluorescence correlation spectroscopy. Nat Med 1998; 4: 832-834
-
(1998)
Nat Med
, vol.4
, pp. 832-834
-
-
Pitschke, M.1
Prior, R.2
Haupt, M.3
-
73
-
-
0034609516
-
The oligomerization of amyloid β-protein begins intracellularly in cells derived from human brain
-
Walsh DM, Tseng BP, Rydel RE, et al. The oligomerization of amyloid β-protein begins intracellularly in cells derived from human brain. Biochem 2000; 39: 10831-10839
-
(2000)
Biochem
, vol.39
, pp. 10831-10839
-
-
Walsh, D.M.1
Tseng, B.P.2
Rydel, R.E.3
-
74
-
-
0347122965
-
Amyloid-β peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway
-
Lee JT, Xu J, Lee JM, et al. Amyloid-β peptide induces oligodendrocyte death by activating the neutral sphingomyelinase-ceramide pathway. J Cell Biol 2004; 164: 123-131
-
(2004)
J Cell Biol
, vol.164
, pp. 123-131
-
-
Lee, J.T.1
Xu, J.2
Lee, J.M.3
-
75
-
-
0028804827
-
Structural model for the β-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptide
-
Lansbury PT Jr, Costa PR, Griffiths JM, et al. Structural model for the β-amyloid fibril based on interstrand alignment of an antiparallel-sheet comprising a C-terminal peptide. Nat Struct Biol 1995; 2: 990-998
-
(1995)
Nat Struct Biol
, vol.2
, pp. 990-998
-
-
Lansbury Jr., P.T.1
Costa, P.R.2
Griffiths, J.M.3
-
76
-
-
0034718024
-
Oligomerization and fibril assembly of the amyloid-β protein
-
Roher AE, Baudry J, Chaney MO, et al. Oligomerization and fibril assembly of the amyloid-β protein. Biochim Biophys Acta 2000; 1502: 31-43
-
(2000)
Biochim Biophys Acta
, vol.1502
, pp. 31-43
-
-
Roher, A.E.1
Baudry, J.2
Chaney, M.O.3
-
77
-
-
0346099098
-
Residues 17-20 and 30-35 of β-amyloid play critical roles in aggregation
-
Liu R, McAllister C, Lyubchenko Y, Sierks MR. Residues 17-20 and 30-35 of β-amyloid play critical roles in aggregation. J Neurosci Res 2004; 75: 162-171
-
(2004)
J Neurosci Res
, vol.75
, pp. 162-171
-
-
Liu, R.1
McAllister, C.2
Lyubchenko, Y.3
Sierks, M.R.4
-
78
-
-
0037462946
-
Alternate aggregation pathways of the Alzheimer β-amyloid peptide: Aβ association kinetics at endosomal pH
-
Gorman PM, Yip CM, Fraser PE, et al. Alternate aggregation pathways of the Alzheimer β-amyloid peptide: Aβ association kinetics at endosomal pH. J Mol Biol 2003; 325: 743-757
-
(2003)
J Mol Biol
, vol.325
, pp. 743-757
-
-
Gorman, P.M.1
Yip, C.M.2
Fraser, P.E.3
-
79
-
-
0034677660
-
Structural studies of soluble oligomers of the Alzheimer β-amyloid peptide
-
Huang THJ, Yang DS, Plaskos NP, et al. Structural studies of soluble oligomers of the Alzheimer β-amyloid peptide. J Mol Biol 2000; 297: 73-87
-
(2000)
J Mol Biol
, vol.297
, pp. 73-87
-
-
Huang, T.H.J.1
Yang, D.S.2
Plaskos, N.P.3
-
80
-
-
0037975676
-
Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase 1/glycogen synthase kinase-3β
-
Hoshi M, Sato M, Matsumoto S, et al. Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase 1/glycogen synthase kinase-3β. Proc Nat Acad Sci USA 2003; 100: 6370-6375
-
(2003)
Proc Nat Acad Sci USA
, vol.100
, pp. 6370-6375
-
-
Hoshi, M.1
Sato, M.2
Matsumoto, S.3
-
82
-
-
0029802659
-
Fusogenic properties of the C-terminal domain of the Alzheimer β-amyloid peptide
-
Pillot T, Goethals M, Vanloo B, et al. Fusogenic properties of the C-terminal domain of the Alzheimer β-amyloid peptide. J Biol Chem 1996; 271: 28757-28765
-
(1996)
J Biol Chem
, vol.271
, pp. 28757-28765
-
-
Pillot, T.1
Goethals, M.2
Vanloo, B.3
-
83
-
-
0027490362
-
Giant multilevel cation channels formed by Alzheimer disease amyloid β-protein in bilayer membranes
-
Arispe N, Pollard HB, Rojas E. Giant multilevel cation channels formed by Alzheimer disease amyloid β-protein in bilayer membranes. Proc Natl Acad Sci USA 1993; 90: 10573-10577
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 10573-10577
-
-
Arispe, N.1
Pollard, H.B.2
Rojas, E.3
-
84
-
-
0035159553
-
Amyloid β forms ion channels: Implications for Alzheimer's disease pathophysiology
-
Lin H, Bhatia R, Lal R. Amyloid β forms ion channels: Implications for Alzheimer's disease pathophysiology. FASEB J 2001; 15: 2433-2444
-
(2001)
FASEB J
, vol.15
, pp. 2433-2444
-
-
Lin, H.1
Bhatia, R.2
Lal, R.3
-
85
-
-
0027944284
-
Theoretical models of the ion channel structure of amyloid β-protein
-
Durell SR, Guy HR, Arispe N, et al. Theoretical models of the ion channel structure of amyloid β-protein. Biophys J 1994; 67: 2137-2145
-
(1994)
Biophys J
, vol.67
, pp. 2137-2145
-
-
Durell, S.R.1
Guy, H.R.2
Arispe, N.3
-
86
-
-
0035997234
-
The channel hypothesis of Alzheimer's disease: Current status
-
Kagan BL, Hirakura Y, Azimov R, et al. The channel hypothesis of Alzheimer's disease: Current status. Peptides 2002; 23: 1311-1315
-
(2002)
Peptides
, vol.23
, pp. 1311-1315
-
-
Kagan, B.L.1
Hirakura, Y.2
Azimov, R.3
-
87
-
-
0027374494
-
A new hypothesis for the mechanism of amyloid toxicity, based on the calcium channel activity of amyloid β protein (AβP) in phospholipid bilayer mechanism
-
Pollard HB, Rojas E, Arispe N. A new hypothesis for the mechanism of amyloid toxicity, based on the calcium channel activity of amyloid β protein (AβP) in phospholipid bilayer mechanism. Ann NY Acad Sci 1993; 695: 165-168
-
(1993)
Ann NY Acad Sci
, vol.695
, pp. 165-168
-
-
Pollard, H.B.1
Rojas, E.2
Arispe, N.3
-
88
-
-
0034087948
-
Fresh and globular amyloid β protein (1-42) induces rapid cellular degeneration: Evidence for AβP channel-mediated cellular toxicity
-
Bhatia R, Lin H, Lal R. Fresh and globular amyloid β protein (1-42) induces rapid cellular degeneration: evidence for AβP channel-mediated cellular toxicity. FASEB J 2000; 14: 1233-1243
-
(2000)
FASEB J
, vol.14
, pp. 1233-1243
-
-
Bhatia, R.1
Lin, H.2
Lal, R.3
-
89
-
-
0034089960
-
Fresh and nonfibrillar amyloid β protein(1-40) induces rapid cellular degeneration in aged human fibroblasts: Evidence for AβP-channel-mediated cellular toxicity
-
Zhu YJ, Lin H, Lal R. Fresh and nonfibrillar amyloid β protein(1-40) induces rapid cellular degeneration in aged human fibroblasts: Evidence for AβP-channel-mediated cellular toxicity. FASEB J 2000; 14: 1244-1254
-
(2000)
FASEB J
, vol.14
, pp. 1244-1254
-
-
Zhu, Y.J.1
Lin, H.2
Lal, R.3
-
90
-
-
0034319190
-
Molecular mechanism of neurodegeneration induced by Alzheimer's β-amyloid protein: Channel formation and disruption of calcium homeostasis
-
Kawahara M, Kuroda Y. Molecular mechanism of neurodegeneration induced by Alzheimer's β-amyloid protein: Channel formation and disruption of calcium homeostasis. Brain Res Bull 2000; 53: 389-397
-
(2000)
Brain Res Bull
, vol.53
, pp. 389-397
-
-
Kawahara, M.1
Kuroda, Y.2
-
91
-
-
0034856924
-
Diversity of amyloid β protein fragment [1-40]-formed channels
-
Kourie JI, Henry CL, Farrely P. Diversity of amyloid β protein fragment [1-40]-formed channels. Cell Mol Neurobiol 2001; 21: 255-284
-
(2001)
Cell Mol Neurobiol
, vol.21
, pp. 255-284
-
-
Kourie, J.I.1
Henry, C.L.2
Farrely, P.3
-
92
-
-
0036369164
-
Heterogeneous amyloid-formed ion channels as a common cytotoxic mechanism: Implications for therapeutic strategies against amyloidosis
-
Kourie JI, Culverson AL, Farrelly PV, et al. Heterogeneous amyloid-formed ion channels as a common cytotoxic mechanism: Implications for therapeutic strategies against amyloidosis. Cell Biochem Biophys 2002; 36: 191-207
-
(2002)
Cell Biochem Biophys
, vol.36
, pp. 191-207
-
-
Kourie, J.I.1
Culverson, A.L.2
Farrelly, P.V.3
-
93
-
-
0037130174
-
Neurodegenerative disease: Amyloid pores from pathogenic mutations
-
Lashuel HA, Hartley D, Petre BM, et al. Neurodegenerative disease: Amyloid pores from pathogenic mutations. Nature 2002; 418: 291-291
-
(2002)
Nature
, vol.418
, pp. 291-291
-
-
Lashuel, H.A.1
Hartley, D.2
Petre, B.M.3
-
94
-
-
0032590054
-
Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
-
McLean CA, Cherny RA, Fraser FW, et al. Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol 1999; 46: 860-866
-
(1999)
Ann Neurol
, vol.46
, pp. 860-866
-
-
McLean, C.A.1
Cherny, R.A.2
Fraser, F.W.3
-
95
-
-
0032888131
-
Soluble amyloid-β peptide concentration as a predictor of synaptic change in Alzheimer's disease
-
Lue LF, Kuo YM, Roher AE, et al. Soluble amyloid-β peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am J Pathol 1999; 155: 853-862
-
(1999)
Am J Pathol
, vol.155
, pp. 853-862
-
-
Lue, L.F.1
Kuo, Y.M.2
Roher, A.E.3
-
96
-
-
0029811105
-
Specific domains of β-amyloid from Alzheimer's plaque elicit neuron killing in human microglia
-
Giulian D, Haverkamp L, Yu J, et al. Specific domains of β-amyloid from Alzheimer's plaque elicit neuron killing in human microglia. J Neurosci 1996; 16: 6021-6037
-
(1996)
J Neurosci
, vol.16
, pp. 6021-6037
-
-
Giulian, D.1
Haverkamp, L.2
Yu, J.3
-
97
-
-
0032491435
-
The HHQK domain of β-amyloid provides a structural basis for the immunopathology of Alzheimer's disease
-
Giulian D, Haverkamp LJ, Yu J, et al. The HHQK domain of β-amyloid provides a structural basis for the immunopathology of Alzheimer's disease. J Biol Chem 1998; 273: 29719-29726
-
(1998)
J Biol Chem
, vol.273
, pp. 29719-29726
-
-
Giulian, D.1
Haverkamp, L.J.2
Yu, J.3
-
98
-
-
0032473596
-
Amyloid-β peptide activates cultured astrocytes: Morphological alterations, cytokine induction and nitric oxide release
-
Hu J, Akama KT, Krafft CA, et al. Amyloid-β peptide activates cultured astrocytes: Morphological alterations, cytokine induction and nitric oxide release. Brain Res 1998; 785: 195-206
-
(1998)
Brain Res
, vol.785
, pp. 195-206
-
-
Hu, J.1
Akama, K.T.2
Krafft, C.A.3
-
99
-
-
0037023277
-
Inducible nitric oxide synthase and argininosuccinate synthetase: Coinduction in brain tissue of patients with Alzheimer's dementia and following stimulation with β-amyloid 1-42 in vitro
-
Haas J, Storch-Hagenlocher B, Biessmann A, et al. Inducible nitric oxide synthase and argininosuccinate synthetase: Coinduction in brain tissue of patients with Alzheimer's dementia and following stimulation with β-amyloid 1-42 in vitro. Neurosci Lett 2002; 322: 121-125
-
(2002)
Neurosci Lett
, vol.322
, pp. 121-125
-
-
Haas, J.1
Storch-Hagenlocher, B.2
Biessmann, A.3
-
100
-
-
13044287361
-
Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models
-
Hsia AY, Masliah E, McConlogue L, et al. Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc Natl Acad Sci USA 1999; 96: 3228-3233
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 3228-3233
-
-
Hsia, A.Y.1
Masliah, E.2
McConlogue, L.3
-
101
-
-
0034213718
-
High-level neuronal expression of Aβ 1-42 in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation
-
Mucke L, Masliah E, Yu GQ, et al. High-level neuronal expression of Aβ 1-42 in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation. J Neurosci 2000; 20: 4050-4058
-
(2000)
J Neurosci
, vol.20
, pp. 4050-4058
-
-
Mucke, L.1
Masliah, E.2
Yu, G.Q.3
-
102
-
-
0037041426
-
Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
-
Walsh DM, Klyubin I, Fadeeva JV, et al. Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo. Nature 2002; 416: 535-539
-
(2002)
Nature
, vol.416
, pp. 535-539
-
-
Walsh, D.M.1
Klyubin, I.2
Fadeeva, J.V.3
-
103
-
-
0036235633
-
Hippocampal Aβ 42 levels correlate with spatial memory deficit in APP and PS1 double transgenic mice
-
Puolivali J, Wang J, Heikkinen T, et al. Hippocampal Aβ 42 levels correlate with spatial memory deficit in APP and PS1 double transgenic mice. Neurobiol Dis 2002; 9; 339-347
-
(2002)
Neurobiol Dis
, vol.9
, pp. 339-347
-
-
Puolivali, J.1
Wang, J.2
Heikkinen, T.3
-
104
-
-
0035807829
-
Specific spatial learning deficits become severe with age in β-amyloid precursor protein transgenic mice that harbor diffuse β-amyloid deposits but do not form plaques
-
Koistinaho M, Ort M, Cimadevilla JM, et al. Specific spatial learning deficits become severe with age in β-amyloid precursor protein transgenic mice that harbor diffuse β-amyloid deposits but do not form plaques. Proc Natl Acad Sci USA 2001; 98: 14675-14680
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 14675-14680
-
-
Koistinaho, M.1
Ort, M.2
Cimadevilla, J.M.3
-
105
-
-
0036703483
-
Reversible memory loss in a mouse transgenic model of Alzheimer's disease
-
Kotilinek LA, Bacskai B, Westerman M, et al. Reversible memory loss in a mouse transgenic model of Alzheimer's disease. J Neurosci 2002; 22: 6331-6335
-
(2002)
J Neurosci
, vol.22
, pp. 6331-6335
-
-
Kotilinek, L.A.1
Bacskai, B.2
Westerman, M.3
-
106
-
-
0036489445
-
The relationship between Aβ and memory in the Tg2576 mouse model of Alzheimer's disease
-
Westerman MA, Cooper-Blacketer D, Mariash A, et al. The relationship between Aβ and memory in the Tg2576 mouse model of Alzheimer's disease. J Neurosci 2002; 22: 1858-1867
-
(2002)
J Neurosci
, vol.22
, pp. 1858-1867
-
-
Westerman, M.A.1
Cooper-Blacketer, D.2
Mariash, A.3
-
107
-
-
0036240395
-
Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model
-
Dodart JC, Bales KR, Gannon KS, et al. Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model. Nat Neurosci 2002; 5: 452-457
-
(2002)
Nat Neurosci
, vol.5
, pp. 452-457
-
-
Dodart, J.C.1
Bales, K.R.2
Gannon, K.S.3
-
108
-
-
0029670094
-
β-Amyloid-mediated vasoactivity and vascular endothelial damage
-
Thomas T, Thomas G, McLendon C, et al. β-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature 1996; 380: 168-171
-
(1996)
Nature
, vol.380
, pp. 168-171
-
-
Thomas, T.1
Thomas, G.2
McLendon, C.3
-
110
-
-
0032032969
-
Characteristics of the in vitro vasoactivity of β-amyloid peptides
-
Crawford F, Suo Z, Fang C, et al. Characteristics of the in vitro vasoactivity of β-amyloid peptides. Exp Neurol 1998; 150: 159-168
-
(1998)
Exp Neurol
, vol.150
, pp. 159-168
-
-
Crawford, F.1
Suo, Z.2
Fang, C.3
-
111
-
-
0034940552
-
Physiological levels of β-amyloid induce cerebral vessel dysfunction and reduce endothelial nitric oxide production
-
Price JM, Chi X, Hellermann G, et al. Physiological levels of β-amyloid induce cerebral vessel dysfunction and reduce endothelial nitric oxide production. Neurological Res 2001; 23: 506-512
-
(2001)
Neurological Res
, vol.23
, pp. 506-512
-
-
Price, J.M.1
Chi, X.2
Hellermann, G.3
-
112
-
-
0034603601
-
Soluble β-amyloid peptides mediate vasoactivity via activation of a pro-inflammatory pathway
-
Paris D, Town T, Mori T, et al. Soluble β-amyloid peptides mediate vasoactivity via activation of a pro-inflammatory pathway. Neurobiol Aging 2000; 21: 183-197
-
(2000)
Neurobiol Aging
, vol.21
, pp. 183-197
-
-
Paris, D.1
Town, T.2
Mori, T.3
-
113
-
-
0034017305
-
Aβ vasoactivity: An inflammatory reaction
-
Paris D, Town T, Parker T, et al. Aβ vasoactivity: An inflammatory reaction. Ann NY Acad Sci 2000; 903: 97-109
-
(2000)
Ann NY Acad Sci
, vol.903
, pp. 97-109
-
-
Paris, D.1
Town, T.2
Parker, T.3
-
114
-
-
0032934183
-
Inhibition of Alzheimer's β-amyloid induced vasoactivity and proinflammatory response in microglia by a cGMP dependent mechanism
-
Paris D, Town T, Parker TA, et al. Inhibition of Alzheimer's β-amyloid induced vasoactivity and proinflammatory response in microglia by a cGMP dependent mechanism. Exp Neurol 1999; 157: 211-221
-
(1999)
Exp Neurol
, vol.157
, pp. 211-221
-
-
Paris, D.1
Town, T.2
Parker, T.A.3
-
115
-
-
0036121232
-
Statins inhibit Aβ-neurotoxicity in vitro and Aβ-induced vasoconstriction and imflammation in rat aortae
-
Paris D, Townsend KP, Humphrey J, et al. Statins inhibit Aβ-neurotoxicity in vitro and Aβ-induced vasoconstriction and imflammation in rat aortae. Atherosclerosis 2002; 161: 293-299
-
(2002)
Atherosclerosis
, vol.161
, pp. 293-299
-
-
Paris, D.1
Kp, T.2
Humphrey, J.3
-
117
-
-
0036176504
-
Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein
-
Niwa K, Kazama K, Younkin SG, et al. Alterations in cerebral blood flow and glucose utilization in mice overexpressing the amyloid precursor protein. Neurobiol Dis 2002; 9: 61-68
-
(2002)
Neurobiol Dis
, vol.9
, pp. 61-68
-
-
Niwa, K.1
Kazama, K.2
Younkin, S.G.3
-
118
-
-
0034662501
-
Aβ 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation
-
Niwa K, Younkin L, Ebeling C, et al. Aβ 1-40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation. Proc Natl Acad Sci USA 2000; 97: 9735-9740
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 9735-9740
-
-
Niwa, K.1
Younkin, L.2
Ebeling, C.3
-
119
-
-
0030848729
-
Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein
-
Zhang F, Eckman C, Younkin S, et al. Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein. J Neurosci 1997; 17: 7655-7661
-
(1997)
J Neurosci
, vol.17
, pp. 7655-7661
-
-
Zhang, F.1
Eckman, C.2
Younkin, S.3
-
120
-
-
0036302636
-
Cerebrovascular auto-regulation is profoundly impaired in mice overexpressing amyloid precursor protein
-
Niwa K, Kazama K, Younkin L, et al. Cerebrovascular auto-regulation is profoundly impaired in mice overexpressing amyloid precursor protein. Am J Physiol Heart Circ Physiol 2002; 283: H315-323
-
(2002)
Am J Physiol Heart Circ Physiol
, vol.283
-
-
Niwa, K.1
Kazama, K.2
Younkin, L.3
-
121
-
-
0041816291
-
Cerebrovascular effects of amyloid-β peptides: Mechanisms and implications for Alzheimer's dementia
-
Iadecola C. Cerebrovascular effects of amyloid-β peptides: mechanisms and implications for Alzheimer's dementia. Cell Mol Neurobiol 2003; 23: 681-689
-
(2003)
Cell Mol Neurobiol
, vol.23
, pp. 681-689
-
-
Iadecola, C.1
-
122
-
-
3042704848
-
Inhibition of angiogenesis by Aβ peptides
-
Paris D, Townsend K, Quadros A, et al. Inhibition of angiogenesis by Aβ peptides. Angiogenesis 2004; 7: 75-85
-
(2004)
Angiogenesis
, vol.7
, pp. 75-85
-
-
Paris, D.1
Townsend, K.2
Quadros, A.3
-
123
-
-
11144353586
-
ABAD directly links Aβ to mitochondrial toxicity in Alzheimer's disease
-
Lustbader JW, Cirilli M, Lin C, et al. ABAD directly links Aβ to mitochondrial toxicity in Alzheimer's disease. Science 2004; 304: 448-452
-
(2004)
Science
, vol.304
, pp. 448-452
-
-
Lustbader, J.W.1
Cirilli, M.2
Lin, C.3
-
124
-
-
0007895654
-
Role of ERAB/L-3-hydroxyacylcoenzyme a dehydrogenase type II activity in Aβ-induced cytotoxicity
-
Yan SD, Shi Y, Zhu A, et al. Role of ERAB/L-3-hydroxyacylcoenzyme A dehydrogenase type II activity in Aβ-induced cytotoxicity. J Biol Chem 1999; 274: 2145-2156
-
(1999)
J Biol Chem
, vol.274
, pp. 2145-2156
-
-
Yan, S.D.1
Shi, Y.2
Zhu, A.3
-
125
-
-
1042278180
-
Distinct steps in dislocation of luminal endoplasmic reticulum-associated degredation substrates: Roles of endoplasmic reticulum-bound p97/Cdc48p and proteasome
-
Elkabetz Y, Shapira I, Rabinovich E, et al. Distinct steps in dislocation of luminal endoplasmic reticulum-associated degredation substrates: Roles of endoplasmic reticulum-bound p97/Cdc48p and proteasome. J Biol Chem 2004; 279: 3980-3989
-
(2004)
J Biol Chem
, vol.279
, pp. 3980-3989
-
-
Elkabetz, Y.1
Shapira, I.2
Rabinovich, E.3
-
126
-
-
1042292018
-
Endoplasmic reticulum-localized amyloid β-peptide is degraded in the cytosol by two distinct degradation pathways
-
Schmitz A, Schneider A., Kummer MP, et al. Endoplasmic reticulum-localized amyloid β-peptide is degraded in the cytosol by two distinct degradation pathways. Traffic 2004; 5: 89-101
-
(2004)
Traffic
, vol.5
, pp. 89-101
-
-
Schmitz, A.1
Schneider, A.2
Kummer, M.P.3
-
127
-
-
0013079948
-
An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease
-
Yan SD, Fu J, Soto C, et al. An intracellular protein that binds amyloid-β peptide and mediates neurotoxicity in Alzheimer's disease. Nature 1997; 389: 689-695
-
(1997)
Nature
, vol.389
, pp. 689-695
-
-
Yan, S.D.1
Fu, J.2
Soto, C.3
-
128
-
-
0034328890
-
Protein unfolding by mitochondria. The Hsp70 import motor
-
Matouschek A, Pfanner N, Voss W. Protein unfolding by mitochondria. The Hsp70 import motor. EMBO Rep 2000; 1: 404-410
-
(2000)
EMBO Rep
, vol.1
, pp. 404-410
-
-
Matouschek, A.1
Pfanner, N.2
Voss, W.3
-
129
-
-
2342495787
-
Amyloid β-peptide interactions with neuronal and glial cell plasma membrane: Binding sites and implications for Alzheimer's disease
-
Verdier Y, Zarandi M, Penke B. Amyloid β-peptide interactions with neuronal and glial cell plasma membrane: Binding sites and implications for Alzheimer's disease. J Peptide Sci 2004; 10: 229-248
-
(2004)
J Peptide Sci
, vol.10
, pp. 229-248
-
-
Verdier, Y.1
Zarandi, M.2
Penke, B.3
-
130
-
-
0037730098
-
2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency is caused by mutations in the HADH2 gene
-
Ofman R, Ruiter JP, Feenstra M, et al. 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency is caused by mutations in the HADH2 gene. Am J Hum Genet 2003; 72: 1300-1307
-
(2003)
Am J Hum Genet
, vol.72
, pp. 1300-1307
-
-
Ofman, R.1
Ruiter, J.P.2
Feenstra, M.3
-
131
-
-
0038045587
-
The production of amyloid β peptide is a critical requirement for the viability of central neurons
-
Plant LD, Boyle JP, Smith IF, et al. The production of amyloid β peptide is a critical requirement for the viability of central neurons. J Neurosci 2003; 23: 5531-5535
-
(2003)
J Neurosci
, vol.23
, pp. 5531-5535
-
-
Plant, L.D.1
Boyle, J.P.2
Smith, I.F.3
-
132
-
-
2942530513
-
Neurogenic effect of β-amyloid peptide in the development of neural stem cells
-
Lopez-Toledano M, Shelanski ML. Neurogenic effect of β-amyloid peptide in the development of neural stem cells. J Neurosci 2004; 24: 5439-5444
-
(2004)
J Neurosci
, vol.24
, pp. 5439-5444
-
-
Lopez-Toledano, M.1
Shelanski, M.L.2
-
133
-
-
0141529993
-
In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-β metabolism and half-life
-
Cirrito JR, May PC, O'Dell MA, et al. In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-β metabolism and half-life. J Neurosci 2003; 23: 8844-8853
-
(2003)
J Neurosci
, vol.23
, pp. 8844-8853
-
-
Cirrito, J.R.1
May, P.C.2
O'Dell, M.A.3
-
134
-
-
0033570337
-
Protofibrillar intermediates of amyloid β-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons
-
Hartley DM, Walsh DM, Ye CP, et al. Protofibrillar intermediates of amyloid β-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons. J Neurosci 1999; 19: 8876-8884
-
(1999)
J Neurosci
, vol.19
, pp. 8876-8884
-
-
Hartley, D.M.1
Walsh, D.M.2
Ye, C.P.3
-
135
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
Kayed R, Head E, Thompson JL, et al. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 2003; 300: 486-489
-
(2003)
Science
, vol.300
, pp. 486-489
-
-
Kayed, R.1
Head, E.2
Thompson, J.L.3
-
136
-
-
84984755327
-
Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease
-
Morgan D, Diamond DM, Gottschall PE, et al. Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature 2000; 408: 982-985
-
(2000)
Nature
, vol.408
, pp. 982-985
-
-
Morgan, D.1
Diamond, D.M.2
Gottschall, P.E.3
-
137
-
-
0029742199
-
Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
-
Hsiao K, Chapman P, Nilsen S, et al. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science 1996; 274: 99-102
-
(1996)
Science
, vol.274
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
-
138
-
-
0034837627
-
Transgenic mouse models of Alzheimer's disease
-
Janus C, Westaway D. Transgenic mouse models of Alzheimer's disease. Physiol Behav 2001; 73: 873-886
-
(2001)
Physiol Behav
, vol.73
, pp. 873-886
-
-
Janus, C.1
Westaway, D.2
-
139
-
-
0035132326
-
Amyloid β vaccination: Reduced plaques and improved cognition
-
Younkin SG. Amyloid β vaccination: reduced plaques and improved cognition. Nat Med 2001; 7: 18-19
-
(2001)
Nat Med
, vol.7
, pp. 18-19
-
-
Younkin, S.G.1
-
140
-
-
0033536163
-
Immmunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
Schenk D, Barbour R, Dunn W, et al. Immmunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999; 400: 173-177
-
(1999)
Nature
, vol.400
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
-
141
-
-
0037393454
-
Neuropathology of human Alzheimer's disease following immunization with amyloid-β-peptide: A case report
-
Nicoll JA, Wilkinson D, Holmes C, et al. Neuropathology of human Alzheimer's disease following immunization with amyloid-β-peptide: A case report. Nat Med 2003; 9: 448-452
-
(2003)
Nat Med
, vol.9
, pp. 448-452
-
-
Nicoll, J.A.1
Wilkinson, D.2
Holmes, C.3
-
142
-
-
1042265187
-
Neuropathology and pathogenesis of encephalitis following amyloid-β immunizaton in Alzheimer's disease
-
Ferrer I, Boada Rovira M, Sanchez Guerra ML, et al. Neuropathology and pathogenesis of encephalitis following amyloid-β immunizaton in Alzheimer's disease. Brain Pathol 2004; 14: 11-20
-
(2004)
Brain Pathol
, vol.14
, pp. 11-20
-
-
Ferrer, I.1
Boada Rovira, M.2
Sanchez Guerra, M.L.3
-
143
-
-
0038100154
-
Antibodies against β-amyloid slow cognitive decline in Alzheimer's disease
-
Hock C, Konietzko U, Streffer JR, et al. Antibodies against β-amyloid slow cognitive decline in Alzheimer's disease. Neuron 2003; 38: 547-554
-
(2003)
Neuron
, vol.38
, pp. 547-554
-
-
Hock, C.1
Konietzko, U.2
Streffer, J.R.3
|