Protein unfolding by mitochondria: The Hsp70 import motor

EMBO Reports

Volumn 1, Issue 5, 2000, Pages 404-410

  Matouschek, Andreas ^a   Pfanner, Nikolaus ^b   Voos, Wolfgang ^b  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BACILLUS AMYLOLIQUEFACIENS RIBONUCLEASE; HEAT SHOCK PROTEIN 70; RIBONUCLEASE;

ANIMAL; BIOLOGICAL MODEL; CHEMISTRY; CYTOSOL; METABOLISM; MITOCHONDRION; PHYSIOLOGY; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN TERTIARY STRUCTURE; REVIEW;

ADENOSINE TRIPHOSPHATE; ANIMALS; CYTOSOL; HSP70 HEAT-SHOCK PROTEINS; MITOCHONDRIA; MODELS, BIOLOGICAL; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, TERTIARY; RIBONUCLEASES;

EID: 0034328890     PISSN: 1469221X     EISSN: None     Source Type: Journal    
DOI: 10.1093/embo-reports/kvd093     Document Type: Article

References (21)

1. Astumian, R.D. (1997) Thermodynamics and kinetics of a Brownian motor. Science, 276, 917-922.
2. Bauer, M.F., Hofmann, S., Neupert, W. and Brunner, M. (2000) Protein translocation into mitochondria: the role of TIM complexes. Trends Cell Biol., 10, 25-31.
3. 2 branches from the general mitochondrial import pathway at the preprotein translocase of the inner membrane. J Biol. Chem., 272, 30439-30446.
4. Börner, U., Maarse, A.C., Martin, F., Geissler, A., Merlin, A., Schönfisch, B., Meijer, M., Pfanner, N. and Rassow, J. (1998) Separation of structural and dynamic functions of the mitochondrial translocase: Tim44 is crucial for the inner membrane import sites in translocation of tightly folded domains, but not of loosely folded preproteins. EMBO J., 17, 4226-4237.
5. Branden, C. and Tooze, J. (1998) Introduction to Protein Structure. Garland, New York.
6. Bukau, B. and Horwich, A.L. (1998) The Hsp70 and Hsp60 chaperone machines. Cell, 92, 351-366.
7. Chauwin, J.F., Oster, G. and Click, B.S. (1998) Strong precursor-pore interactions constrain models for mitochondrial protein import. Biophys. J., 74, 1732-1743.
8. Eilers, M. and Schatz, G. (1986) Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria. Nature, 322, 228-232.
9. Feynman, R.P., Leighton, R.B. and Sands, M. (1963) The Feynman Lectures on Physics. Addison Wesley, Reading, ch. 46.
10. Fünfschilling, U. and Rospert, S. (1999) Nascent polypeptide-associated complex stimulates protein import into yeast mitochondria. Mol. Biol. Cell., 10, 3289-3299.
11. Gambill, B.D., Voos, W., Kang, P.J., Miao, B., Langer, T., Craig, E.A. and Pfanner, N. (1993) A dual role for mitochondrial heat shock protein 70 in membrane translocation of preproteins. J. Cell Biol., 123, 109-117.
12. 2 promotes early divergence from the general mitochondrial import pathway and restricts the unfoldase activity of matrix Hsp70. EMBO J., 14, 6043-6057.
13. Gaume, B., Klaus, C., Ungermann, C., Guiard, B., Neupert, W. and Brunner, M. (1998) Unfolding of preproteins upon import into mitochondria. EMBO J., 17, 6497-6507.
14. Click, B.S. (1995) Can hsp70 proteins act as force generating motors? Cell, 80, 11-14.
15. 2 to the mitochondrial intermembrane space: the tightly folded heme-binding domain makes import dependent upon matrix ATP. Protein Sci., 2, 1901-1917.
16. Rassow, J., Hartl, F.-U., Guiard, B., Pfanner, N. and Neupert, N. (1990) Polypeptides traverse the mitochondrial envelope in an extended state. FEBS Lett., 275, 190-194.
17. Schatz, G. and Dobberstein, B. (1996) Common principles of protein translocation across membranes. Science, 271, 1519-1526.
18. Schwartz, M.P. and Matouschek, A. (1999) The dimensions of the protein import channels in the outer and inner mitochondrial membranes. Proc. Natl Acad. Sci. USA, 96, 13086-13090.
19. Schwartz, M.P., Huang, S. and Matouschek, A. (1999) The structure of precursor proteins during import into mitochondria. J. Biol. Chem., 274, 12759-12764.
20. 2 into the mitochondrial intermembrane space: specific recognition of the sorting signal. EMBO J., 12, 2295-2302.
21. Wienhues, U., Becker, K., Schleyer, M., Guiard, B., Tropschug, M., Horwich, A.L., Pfanner, N. and Neupert, W. (1991) Protein folding causes an arrest of preprotein translocation into mitochondria m vivo. J. Cell Biol., 115, 1601-1609.