-
1
-
-
0027333557
-
Cellular procesisng of β-amyloid precursor protein and the genesis of amyloid β-peptide
-
Haass, C. & Selkoe, D. Cellular procesisng of β-amyloid precursor protein and the genesis of amyloid β-peptide. Cell 75, 1039-1042 (1993).
-
(1993)
Cell
, vol.75
, pp. 1039-1042
-
-
Haass, C.1
Selkoe, D.2
-
2
-
-
0024472693
-
Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease
-
Yankner, B. et al. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease. Science 245, 417-420 (1989).
-
(1989)
Science
, vol.245
, pp. 417-420
-
-
Yankner, B.1
-
3
-
-
16044373524
-
Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner, D. et al. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med. 2, 864-869 (1996).
-
(1996)
Nature Med
, vol.2
, pp. 864-869
-
-
Scheuner, D.1
-
4
-
-
0030002005
-
From genes to mechanisms to therapies: Lessons to be learned for neurological disorders
-
Roses, A. From genes to mechanisms to therapies: lessons to be learned for neurological disorders. Nature Med. 2, 267-269 (1996).
-
(1996)
Nature Med
, vol.2
, pp. 267-269
-
-
Roses, A.1
-
5
-
-
0027526419
-
Release of excess amyloid β rotein from a mutant amyloid β protein precursor
-
Cai, X., Golde, T. & Younkin, S. Release of excess amyloid β rotein from a mutant amyloid β protein precursor. Science 259, 514-516 (1993).
-
(1993)
Science
, vol.259
, pp. 514-516
-
-
Cai, X.1
Golde, T.2
Younkin, S.3
-
6
-
-
0028180518
-
A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: Relevance to Alzheimer disease
-
Hensley, K. et al. A model for β-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease. Proc. Natl Acad. Sci. USA 91, 3270-3274 (1994).
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 3270-3274
-
-
Hensley, K.1
-
7
-
-
0024990330
-
Neurotrophic and neurotoxic effects of amyloid β protein: Reversal by tachykinin neuropeptides
-
Yankner, B., Duffy, L. & Kirschner, D. Neurotrophic and neurotoxic effects of amyloid β protein: reversal by tachykinin neuropeptides. Science 250, 279-282 (1990).
-
(1990)
Science
, vol.250
, pp. 279-282
-
-
Yankner, B.1
Duffy, L.2
Kirschner, D.3
-
8
-
-
0029145084
-
Are reactive oxygen species involved in Alzheimer's disease?
-
Benzi, G. & Moretti, A. Are reactive oxygen species involved in Alzheimer's disease? Neurobiol. Aging 16, 661-674 (1995).
-
(1995)
Neurobiol. Aging
, vol.16
, pp. 661-674
-
-
Benzi, G.1
Moretti, A.2
-
9
-
-
0029245289
-
A potential role for apoptosis in neurodegeneration and Alzheimer's disease
-
Cotman, C. & Anderson, A. A potential role for apoptosis in neurodegeneration and Alzheimer's disease. Mol. Neurobiol. 10, 19-45 (1995).
-
(1995)
Mol. Neurobiol.
, vol.10
, pp. 19-45
-
-
Cotman, C.1
Anderson, A.2
-
10
-
-
0013615899
-
RAGE in Alzheimer's disease: A receptor mediating amyloid-β peptide-induced oxidant stress and neurotoxicity, and microglial activation
-
Yan, S.-D. et al. RAGE in Alzheimer's disease: a receptor mediating amyloid-β peptide-induced oxidant stress and neurotoxicity, and microglial activation. Nature 382, 685-691 (1996).
-
(1996)
Nature
, vol.382
, pp. 685-691
-
-
Yan, S.-D.1
-
11
-
-
0030248270
-
Microglial cells internalize aggregates of the Alzheimer's disease amyloid β-protein via a scavenger receptor
-
Paresce, D., Ghosh, R. & Maxfirled, F. Microglial cells internalize aggregates of the Alzheimer's disease amyloid β-protein via a scavenger receptor Neuron 17, 553-565 (1996).
-
(1996)
Neuron
, vol.17
, pp. 553-565
-
-
Paresce, D.1
Ghosh, R.2
Maxfirled, F.3
-
12
-
-
0029787599
-
Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils
-
El-Khoury, J. et al. Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils. Nature 382, 685-691 (1996).
-
(1996)
Nature
, vol.382
, pp. 685-691
-
-
El-Khoury, J.1
-
13
-
-
0030952217
-
Intracellular generation and accumulation of Aβ terminating at amino acid 42
-
Wild-Bode, C. et al. Intracellular generation and accumulation of Aβ terminating at amino acid 42. J. Biol. Chem. 272, 16085-16088 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 16085-16088
-
-
Wild-Bode, C.1
-
14
-
-
16944365745
-
Enhanced production and oligomerization of the 42-residue amyloid β-protein by chinese hamster ovary cells stably expressing mutant presenilins
-
Xia, W. et al. Enhanced production and oligomerization of the 42-residue amyloid β-protein by chinese hamster ovary cells stably expressing mutant presenilins. J. Biol. Chem. 272, 7977-7982 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 7977-7982
-
-
Xia, W.1
-
15
-
-
0030963605
-
Generation of Alzheimer β-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation
-
Xu, H. et al. Generation of Alzheimer β-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation. Proc. Natl Acad. Sci. USA 94, 3748-3752 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 3748-3752
-
-
Xu, H.1
-
16
-
-
0030966774
-
Intracellular and secreted Alzheimer β-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons
-
Tiernari, P. et al. Intracellular and secreted Alzheimer β-amyloid species are generated by distinct mechanisms in cultured hippocampal neurons. Proc. Natl Acad. Sci. USA 94, 4125-4130 (1997).
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 4125-4130
-
-
Tiernari, P.1
-
17
-
-
0026779680
-
Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor
-
Yoshikawa, K., Aizawa, T. & Hayashi, Y. Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor. Nature 359, 64-67 (1992).
-
(1992)
Nature
, vol.359
, pp. 64-67
-
-
Yoshikawa, K.1
Aizawa, T.2
Hayashi, Y.3
-
18
-
-
0028980783
-
Intracellular produciton of βA4 amyloid of Alzheimer's disease: Modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein
-
Fuller, S. et al. Intracellular produciton of βA4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein. Biochemistry 34, 8091-8098 (1995).
-
(1995)
Biochemistry
, vol.34
, pp. 8091-8098
-
-
Fuller, S.1
-
19
-
-
0028953780
-
Secretion and accumulation of Alzheimer's β-protein by cultured vascular smooth muscle cells from old and young dogs
-
Frackowiak, J. et al. Secretion and accumulation of Alzheimer's β-protein by cultured vascular smooth muscle cells from old and young dogs. Brain Res. 676, 225-230 (1995).
-
(1995)
Brain Res
, vol.676
, pp. 225-230
-
-
Frackowiak, J.1
-
20
-
-
0024406857
-
A novel genetic system ot detect protein-protein interactions
-
Fields, S. & Song, O.-K. A novel genetic system ot detect protein-protein interactions. Nature 340, 245-246 (1991).
-
(1991)
Nature
, vol.340
, pp. 245-246
-
-
Fields, S.1
Song, O.-K.2
-
21
-
-
0023665902
-
An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs
-
Kozak, M. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acids Res. 15, 8125-8131 (1987).
-
(1987)
Nucleic Acids Res
, vol.15
, pp. 8125-8131
-
-
Kozak, M.1
-
22
-
-
0017411710
-
The Protein Data Bank: A computer-based archival file for macromolecular structures
-
Bernstein, F. et al. The Protein Data Bank: a computer-based archival file for macromolecular structures. J. Mol. Biol. 112, 535-542 (1977).
-
(1977)
J. Mol. Biol.
, vol.112
, pp. 535-542
-
-
Bernstein, F.1
-
23
-
-
0021760092
-
A comprehensive set of sequence analysis programs for the VAX
-
Devereux, J., Haeberli, P. & Smithies, O. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 12, 387-395 (1984).
-
(1984)
Nucleic Acids Res
, vol.12
, pp. 387-395
-
-
Devereux, J.1
Haeberli, P.2
Smithies, O.3
-
24
-
-
0025838697
-
Three-dimensional structure of holo 3α,20β-hydroxysteroid dehydrogenase: A member of a short-chain dehydrogenase family. Proc
-
Ghosh, D. et al. Three-dimensional structure of holo 3α,20β-hydroxysteroid dehydrogenase: a member of a short-chain dehydrogenase family. Proc. Natl Acad. Sci. USA 88, 10064-10068 (1991).
-
(1991)
Natl Acad. Sci. USA
, vol.88
, pp. 10064-10068
-
-
Ghosh, D.1
-
25
-
-
0029116610
-
Phosphate concentration regulates transcription of acinetobacter polyhydroxyalkanoic acid biosynthetic genes
-
Schembri, M., Bayly, R. & Davies, J. Phosphate concentration regulates transcription of acinetobacter polyhydroxyalkanoic acid biosynthetic genes. J. Bacteriol. 177, 4501-4507 (1995).
-
(1995)
J. Bacteriol.
, vol.177
, pp. 4501-4507
-
-
Schembri, M.1
Bayly, R.2
Davies, J.3
-
26
-
-
0028233494
-
Hydrogen peroxide mediates amyloid β protein toxidty
-
Behl, C., Davis, J., Lesley, R. & Schubert, D. Hydrogen peroxide mediates amyloid β protein toxidty. Cell 77, 817-827 (1994).
-
(1994)
Cell
, vol.77
, pp. 817-827
-
-
Behl, C.1
Davis, J.2
Lesley, R.3
Schubert, D.4
-
27
-
-
0029417023
-
Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro
-
Busciglio, J. & Yankner, B. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 378, 776-779 (1995).
-
(1995)
Nature
, vol.378
, pp. 776-779
-
-
Busciglio, J.1
Yankner, B.2
-
28
-
-
0028363366
-
Advanced glycation endproducts contribute to amyloidosis in Alzheimer disease
-
Vitek, M. et al. Advanced glycation endproducts contribute to amyloidosis in Alzheimer disease. Proc. Natl. Acad. Sci. USA 91, 4766-4770 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 4766-4770
-
-
Vitek, M.1
-
29
-
-
0028023944
-
Glycated tau protein in Alzheimer disease: A mechanism for induction of oxidant stress
-
Van, S.-D. et al. Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress. Proc. Natl Acad. Sci. USA 91, 7787-7791 (1994).
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 7787-7791
-
-
Van, S.-D.1
-
30
-
-
0028065142
-
Analysis of microtubule-associated protein tau glycation in paired helical filaments
-
Ledcsma, M., Bonay, P., Colaco, C. & Avila, J. Analysis of microtubule-associated protein tau glycation in paired helical filaments. J. Biol. Chem. 269, 21614-2169 (1994).
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 21614-22169
-
-
Ledcsma, M.1
Bonay, P.2
Colaco, C.3
Avila, J.4
-
31
-
-
0029004341
-
Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
-
Sherrington, R. et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760 (1993).
-
(1993)
Nature
, vol.375
, pp. 754-760
-
-
Sherrington, R.1
-
32
-
-
16944362157
-
Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production
-
Citron, M. et al. Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production. Nature Med. 3, 67-72 (1997).
-
(1997)
Nature Med
, vol.3
, pp. 67-72
-
-
Citron, M.1
-
33
-
-
0029150716
-
A familial Alzheimer's disease locus on chromosome 1
-
Levy-Lahad, E. et al. A familial Alzheimer's disease locus on chromosome 1. Science 269, 970-972 (1995).
-
(1995)
Science
, vol.269
, pp. 970-972
-
-
Levy-Lahad, E.1
-
34
-
-
13344282063
-
Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization ot intracellular membranes in mammalian cells
-
Kovacs, D. et al. Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization ot intracellular membranes in mammalian cells. Nature Med. 2, 224-229 (1996).
-
(1996)
Nature Med
, vol.2
, pp. 224-229
-
-
Kovacs, D.1
-
35
-
-
16044366039
-
Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
-
Duff, K. et al. Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1. Nature 383, 710-713 (1996).
-
(1996)
Nature
, vol.383
, pp. 710-713
-
-
Duff, K.1
-
36
-
-
0030293676
-
Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo
-
Borchelt, D. et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron 17, 1005-1013 (1996).
-
(1996)
Neuron
, vol.17
, pp. 1005-1013
-
-
Borchelt, D.1
-
37
-
-
16044373524
-
Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner, D. et al. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med. 2, 864-869 (1996).
-
(1996)
Nature Med
, vol.2
, pp. 864-869
-
-
Scheuner, D.1
-
38
-
-
10544224542
-
Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutaiton
-
Wolozin, B. et al. Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutaiton. Science 274, 1710-1713 (1996).
-
(1996)
Science
, vol.274
, pp. 1710-1713
-
-
Wolozin, B.1
-
39
-
-
17744401440
-
Presenilin 1 required for Notch 1 and DII1 expression in the paraxial mesoderm
-
Wong, P. et al. Presenilin 1 required for Notch 1 and DII1 expression in the paraxial mesoderm. Nature 387, 288-292 (1997).
-
(1997)
Nature
, vol.387
, pp. 288-292
-
-
Wong, P.1
-
40
-
-
0030779784
-
Skeletal and CNS defects in presenilin-1-deficient mice
-
Shen, J. et al. Skeletal and CNS defects in presenilin-1-deficient mice. Cell 89, 629-639 (1997).
-
(1997)
Cell
, vol.89
, pp. 629-639
-
-
Shen, J.1
-
41
-
-
0026778656
-
Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/β protein
-
Knauer, M. et al. Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/β protein. Proc. Natl Acad. Sci. USA 89, 7437-7441 (1992).
-
(1992)
Proc. Natl Acad. Sci. USA
, vol.89
, pp. 7437-7441
-
-
Knauer, M.1
-
42
-
-
0029664624
-
42 are generated intracellularly in cultured human neurons and their secretion increases with maturation
-
42 are generated intracellularly in cultured human neurons and their secretion increases with maturation. J. Biol. Chem. 271, 8966-8970 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 8966-8970
-
-
Turner, R.S.1
-
43
-
-
0028980783
-
Intracellular production of βA4 amyloid of Alzheimer's disease: Modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein
-
Fuller, S. et al. Intracellular production of βA4 amyloid of Alzheimer's disease: modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein. Biochem. 34, 8091-8098 (1995).
-
(1995)
Biochem
, vol.34
, pp. 8091-8098
-
-
Fuller, S.1
-
44
-
-
0029057814
-
Intracellular Aβ1-42 aggregates stimulate the accumulation of stable, insoluble amyloidogenic fragments of the amyloid precursor protein in transfected cells
-
Yang, A., Knauer, M., Burdick, D. & Glabe, C. Intracellular Aβ1-42 aggregates stimulate the accumulation of stable, insoluble amyloidogenic fragments of the amyloid precursor protein in transfected cells. J. Biol. Chem. 270, 14786-14792 (1995).
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 14786-14792
-
-
Yang, A.1
Knauer, M.2
Burdick, D.3
Glabe, C.4
-
45
-
-
0030793522
-
Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Aβ stabilization
-
La Feria, F. et al. Neuronal cell death in Alzheimer's disease correlates with apoE uptake and intracellular Aβ stabilization. J. Clin. Invest. 100, 310-320 (1997).
-
(1997)
J. Clin. Invest.
, vol.100
, pp. 310-320
-
-
La Feria, F.1
-
46
-
-
0030833577
-
Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a protein pathway: Implications for cerebral amyloid angiopathy
-
Urmoneit, B. et al. Cerebrovascular smooth muscle cells internalize Alzheimer amyloid beta protein via a protein pathway: implications for cerebral amyloid angiopathy. Lab. Invest. 77 157-166 (1997).
-
(1997)
Lab. Invest.
, vol.77
, pp. 157-166
-
-
Urmoneit, B.1
-
47
-
-
0030014990
-
ApoJ and Alzheimer's amyloid-β solubility
-
Matsubara, E., Soto, C., Governale, S., Frangione, B. & Ghiso, J. ApoJ and Alzheimer's amyloid-β solubility. Biochem. J. 316, 671-679 (1996).
-
(1996)
Biochem. J.
, vol.316
, pp. 671-679
-
-
Matsubara, E.1
Soto, C.2
Governale, S.3
Frangione, B.4
Ghiso, J.5
-
48
-
-
0029915707
-
Purification and characterization of a novel stress protein, ORP150, from cultured rat astrocytes and its expression in ischemic mouse brain
-
Kuwabara, K. et al. Purification and characterization of a novel stress protein, ORP150, from cultured rat astrocytes and its expression in ischemic mouse brain. J. Biol. Chem. 271, 5025-5032 (1996).
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 5025-5032
-
-
Kuwabara, K.1
-
49
-
-
0030582387
-
Amino- And carboxyl-terminal heterogeneity of β-amyloid peptides deposited in human brain
-
Saido, T. et al. Amino- and carboxyl-terminal heterogeneity of β-amyloid peptides deposited in human brain. Neurosci. Lett. 215, 173-176 (1996).
-
(1996)
Neurosci. Lett.
, vol.215
, pp. 173-176
-
-
Saido, T.1
-
50
-
-
0029076397
-
Nonenzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid-β peptide
-
Yan, S.-D, et al. Nonenzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid-β peptide. Nature Med. 1, 693-699 (1995).
-
(1995)
Nature Med
, vol.1
, pp. 693-699
-
-
Yan, S.-D.1
|