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Volumn 17, Issue 20, 1997, Pages 7655-7661

Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein

Author keywords

Alzheimer's disease; Cerebral blood flow; Cerebral ischemia; Middle cerebral artery; Stroke; Transgenic mice

Indexed keywords

AMYLOID PROTEIN;

EID: 0030848729     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.17-20-07655.1997     Document Type: Article
Times cited : (178)

References (48)
  • 1
    • 0025762448 scopus 로고
    • Induction of HSP70 mRNA after transient ischemia in gerbil brain
    • Abe K, Tanazi RE, Kogure K (1991a) Induction of HSP70 mRNA after transient ischemia in gerbil brain. Neurosci Lett 125:166-168.
    • (1991) Neurosci Lett , vol.125 , pp. 166-168
    • Abe, K.1    Tanazi, R.E.2    Kogure, K.3
  • 2
    • 0025775107 scopus 로고
    • Selective induction of Kunitz-type protcase inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex
    • Abe K, Tanzi RE, Kogure K (1991b) Selective induction of Kunitz-type protcase inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex. Neurosci Lett 125:172-174.
    • (1991) Neurosci Lett , vol.125 , pp. 172-174
    • Abe, K.1    Tanzi, R.E.2    Kogure, K.3
  • 3
    • 0019822988 scopus 로고
    • Thresholds in cerebral ischemia -the ischemic penumbra
    • Astrup J, Siesjö BK, Symon L (1981) Thresholds in cerebral ischemia -the ischemic penumbra. Stroke 6:723-725.
    • (1981) Stroke , vol.6 , pp. 723-725
    • Astrup, J.1    Siesjö, B.K.2    Symon, L.3
  • 6
    • 0027765510 scopus 로고
    • Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemia
    • Chan PH, Kamii H, Yang G, Gafni J, Epstein CJ, Carlson E. Reola L (1993) Brain infarction is not reduced in SOD-1 transgenic mice after a permanent focal cerebral ischemia. NeuroReport 5:293-296.
    • (1993) NeuroReport , vol.5 , pp. 293-296
    • Chan, P.H.1    Kamii, H.2    Yang, G.3    Gafni, J.4    Epstein, C.J.5    Carlson, E.6    Reola, L.7
  • 7
    • 0029018863 scopus 로고
    • Cerebrovaseular responses under controlled and monitored physiological conditions in the anesthetized mice
    • Dalkara T, Irikura K, Huang Z, Panahian N, Moskowitz (1995) Cerebrovaseular responses under controlled and monitored physiological conditions in the anesthetized mice. J Cereb Blood Flow Metab 15:631-638.
    • (1995) J Cereb Blood Flow Metab , vol.15 , pp. 631-638
    • Dalkara, T.1    Irikura, K.2    Huang, Z.3    Panahian, N.4    Moskowitz5
  • 9
    • 0027057558 scopus 로고
    • Regulation of the cerebral circulation by endothulium
    • Faraci F (1992) Regulation of the cerebral circulation by endothulium. Pharmacol Ther 56:1-22.
    • (1992) Pharmacol Ther , vol.56 , pp. 1-22
    • Faraci, F.1
  • 10
    • 0031014448 scopus 로고    scopus 로고
    • Ionic effects if the Alzheimer's disease β-amyloid precursor protein and its metabolic fragments
    • Fraser SP, Suh Y-H, Djamgoz MBA (1997) Ionic effects if the Alzheimer's disease β-amyloid precursor protein and its metabolic fragments. Trends Neurosci 20:67-72.
    • (1997) Trends Neurosci , vol.20 , pp. 67-72
    • Fraser, S.P.1    Suh, Y.-H.2    Djamgoz, M.B.A.3
  • 12
    • 0027397693 scopus 로고
    • Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat
    • Garcia JH, Yoshida Y, Chen H, Li Y, Zhang ZG, Lian J, Chen S, Chopp M (1993) Progression from ischemic injury to infarct following middle cerebral artery occlusion in the rat. Am J Pathol 142:623-635.
    • (1993) Am J Pathol , vol.142 , pp. 623-635
    • Garcia, J.H.1    Yoshida, Y.2    Chen, H.3    Li, Y.4    Zhang, Z.G.5    Lian, J.6    Chen, S.7    Chopp, M.8
  • 13
    • 0028915895 scopus 로고
    • Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43)
    • Gravina SA, Ho L, Eckman CB, Long KE, Otvos LJ, Younkin LH, Suzuki N, Younkin SG (1995) Amyloid beta protein (A beta) in Alzheimer's disease brain. Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43). J Biol Chem 270:700-7016.
    • (1995) J Biol Chem , vol.270 , pp. 700-7016
    • Gravina, S.A.1    Ho, L.2    Eckman, C.B.3    Long, K.E.4    Otvos, L.J.5    Younkin, L.H.6    Suzuki, N.7    Younkin, S.G.8
  • 14
    • 0023492685 scopus 로고
    • The cerebral ischemic penumbra
    • Hakim AM (1987) The cerebral ischemic penumbra. Can J Neurol Sci 14:557-559.
    • (1987) Can J Neurol Sci , vol.14 , pp. 557-559
    • Hakim, A.M.1
  • 15
    • 0001698201 scopus 로고
    • Cerebral circulation
    • Abboud F, Shephard J, eds, Bethesda, MD: American Physiological Society
    • Heistad D, Kontos H (1983) Cerebral circulation. In: Handbook of physiology: the cardiovascular system III (Abboud F, Shephard J, eds), pp 137-182. Bethesda, MD: American Physiological Society.
    • (1983) Handbook of Physiology: the Cardiovascular System III , pp. 137-182
    • Heistad, D.1    Kontos, H.2
  • 16
    • 0029064572 scopus 로고
    • Early Alzheimer disease-like histopathology increases in frequency with age in mice transgenic for beta-APP751
    • Higgins LS, Rodems JM, Catalano R, Ouon D, Cordell B (1995) Early Alzheimer disease-like histopathology increases in frequency with age in mice transgenic for beta-APP751. Proc Natl Acad Sci USA 92:4402-4406.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4402-4406
    • Higgins, L.S.1    Rodems, J.M.2    Catalano, R.3    Ouon, D.4    Cordell, B.5
  • 17
    • 0027982679 scopus 로고
    • Viability thresholds and the penumbra of focal ischemia
    • Hossmann K-A (1994) Viability thresholds and the penumbra of focal ischemia. Ann Neurol 36:557-565.
    • (1994) Ann Neurol , vol.36 , pp. 557-565
    • Hossmann, K.-A.1
  • 21
    • 0026560429 scopus 로고
    • Does nitric oxide mediate the increases in cerebral blood flow elicited by hypercapnia?
    • Iadecola C (1992) Does nitric oxide mediate the increases in cerebral blood flow elicited by hypercapnia? Proc Natl Acad Sci USA 89:3913-3916.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 3913-3916
    • Iadecola, C.1
  • 22
    • 1842367912 scopus 로고    scopus 로고
    • Cerebral circulatory dysregulation in ischemia
    • (Ginsberg MD, Bogousslavsky J, eds). Cambridge, MA: Blackwell Science, in press
    • Iadecola C, (1997) Cerebral circulatory dysregulation in ischemia. In: Cerebrovascular diseases (Ginsberg MD, Bogousslavsky J, eds). Cambridge, MA: Blackwell Science, in press.
    • (1997) Cerebrovascular Diseases
    • Iadecola, C.1
  • 23
    • 0029859511 scopus 로고    scopus 로고
    • Permissive and obligatory roles of NO in cerebrovascular responses to hypercapnia and acetylcholine
    • Iadecola C, Zhang F (1996) Permissive and obligatory roles of NO in cerebrovascular responses to hypercapnia and acetylcholine. Am J Physiol 271:990-1001.
    • (1996) Am J Physiol , vol.271 , pp. 990-1001
    • Iadecola, C.1    Zhang, F.2
  • 24
    • 0028891572 scopus 로고
    • Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage
    • Iadecola C, Zhang F, Xu X (1995) Inhibition of inducible nitric oxide synthase ameliorates cerebral ischemic damage. Am J Physiol 268:286-292.
    • (1995) Am J Physiol , vol.268 , pp. 286-292
    • Iadecola, C.1    Zhang, F.2    Xu, X.3
  • 26
    • 0030479691 scopus 로고    scopus 로고
    • Delayed postischemic hyperthermia in awake ruts worsens the histopathological outcome of transient focal cerebral ischemia
    • Kim Y, Busto R, Dietrich WD, Kraydieh S, Ginsberg MD (1996) Delayed postischemic hyperthermia in awake ruts worsens the histopathological outcome of transient focal cerebral ischemia. Stroke 27:2274-2280.
    • (1996) Stroke , vol.27 , pp. 2274-2280
    • Kim, Y.1    Busto, R.2    Dietrich, W.D.3    Kraydieh, S.4    Ginsberg, M.D.5
  • 28
    • 0031057837 scopus 로고    scopus 로고
    • Exploring the etiology of Alzheimer disease using molecular genetics
    • Lendon CL, Ashall F, Goate AM (1997) Exploring the etiology of Alzheimer disease using molecular genetics. JAMA 277:825-831.
    • (1997) JAMA , vol.277 , pp. 825-831
    • Lendon, C.L.1    Ashall, F.2    Goate, A.M.3
  • 29
    • 0027519254 scopus 로고
    • Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats
    • Lin TN, Me YY, Wu G, Khan M, Hsu CY (1993) Effect of brain edema on infarct volume in a focal cerebral ischemia model in rats. Stroke 24:117-121.
    • (1993) Stroke , vol.24 , pp. 117-121
    • Lin, T.N.1    Me, Y.Y.2    Wu, G.3    Khan, M.4    Hsu, C.Y.5
  • 30
    • 0027367765 scopus 로고
    • Beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease
    • Mattson MP, Barger SW, Cheng B, Lieberburg I, Smith SV, Rydel RE (1993a) beta-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease. Trends Neurosci 16:409-414.
    • (1993) Trends Neurosci , vol.16 , pp. 409-414
    • Mattson, M.P.1    Barger, S.W.2    Cheng, B.3    Lieberburg, I.4    Smith, S.V.5    Rydel, R.E.6
  • 31
    • 0027478347 scopus 로고
    • Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein
    • Malison MP, Cheng B, Culwell AR, Esch FS, Lieberburg I, Rydel RE (1993b) Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein. Neuron 10:243-254.
    • (1993) Neuron , vol.10 , pp. 243-254
    • Malison, M.P.1    Cheng, B.2    Culwell, A.R.3    Esch, F.S.4    Lieberburg, I.5    Rydel, R.E.6
  • 32
    • 0031054724 scopus 로고    scopus 로고
    • Cellular signaling roles of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease
    • Malison MP, Barger SW, Furukawa K, Bruce AJ, Wyss CT, Mark RJ, Mucke L (1997) Cellular signaling roles of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease. Brain Res Rev 23:47-61.
    • (1997) Brain Res Rev , vol.23 , pp. 47-61
    • Malison, M.P.1    Barger, S.W.2    Furukawa, K.3    Bruce, A.J.4    Wyss, C.T.5    Mark, R.J.6    Mucke, L.7
  • 33
  • 34
    • 0028243033 scopus 로고
    • Cellular and molecular biology of Alzheimer's disease and animal models
    • Price DL, Sisodia SS (1994) Cellular and molecular biology of Alzheimer's disease and animal models. Annu Rev Med 45:435-446.
    • (1994) Annu Rev Med , vol.45 , pp. 435-446
    • Price, D.L.1    Sisodia, S.S.2
  • 35
    • 0028278366 scopus 로고
    • Spatial resolution of the primary beta-amyloidogenic process induced in postischemic hippocampus
    • Saido TC, Yokota M, Maruyama K, Yamao HW, Tani E, Ihara Y, Kawashima S (1994) Spatial resolution of the primary beta-amyloidogenic process induced in postischemic hippocampus. J Biol Chem 269:15253-15257.
    • (1994) J Biol Chem , vol.269 , pp. 15253-15257
    • Saido, T.C.1    Yokota, M.2    Maruyama, K.3    Yamao, H.W.4    Tani, E.5    Ihara, Y.6    Kawashima, S.7
  • 38
    • 0030971174 scopus 로고    scopus 로고
    • Effects of a novel inhibitor of guanylyl cyclase on dilator responses of mouse cerebral arterioles
    • Sobey CG, Faraci FM (1997) Effects of a novel inhibitor of guanylyl cyclase on dilator responses of mouse cerebral arterioles. Stroke 28:837-843.
    • (1997) Stroke , vol.28 , pp. 837-843
    • Sobey, C.G.1    Faraci, F.M.2
  • 39
    • 0026646280 scopus 로고
    • Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat
    • Stephenson DT, Rash K, Clemens JA (1992) Amyloid precursor protein accumulates in regions of neurodegeneration following focal cerebral ischemia in the rat. Brain Res 593:128-135.
    • (1992) Brain Res , vol.593 , pp. 128-135
    • Stephenson, D.T.1    Rash, K.2    Clemens, J.A.3
  • 40
    • 0028322017 scopus 로고
    • An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants
    • Suzuki N, Cheung TT, Cai XD, Odaka A, Otvos U, Eckman C, Golde TE, Younkin SG (1994) An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. Science 264:1336-1340.
    • (1994) Science , vol.264 , pp. 1336-1340
    • Suzuki, N.1    Cheung, T.T.2    Cai, X.D.3    Odaka, A.4    Otvos, U.5    Eckman, C.6    Golde, T.E.7    Younkin, S.G.8
  • 41
    • 0029670094 scopus 로고    scopus 로고
    • β-Amyloid-mediated vasoactivity and vascular endothelial damage
    • Thomas T, Thomas G, McLendon C, Sutton T, Mullan M (1996) β-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature 380:168-171.
    • (1996) Nature , vol.380 , pp. 168-171
    • Thomas, T.1    Thomas, G.2    McLendon, C.3    Sutton, T.4    Mullan, M.5
  • 42
    • 0026493941 scopus 로고
    • Regional accumulation of amyloid beta/A4 protein precursor in the gerbil brain following transient cerebral ischemia
    • Wakita H, Tomimoto H, Akiguchi I, Ohnishi K, Nakamura S, Kimura J (1992) Regional accumulation of amyloid beta/A4 protein precursor in the gerbil brain following transient cerebral ischemia. Neurosci Lett 146:135-138.
    • (1992) Neurosci Lett , vol.146 , pp. 135-138
    • Wakita, H.1    Tomimoto, H.2    Akiguchi, I.3    Ohnishi, K.4    Nakamura, S.5    Kimura, J.6
  • 43
    • 0026437699 scopus 로고
    • Effects in cats of inhibition of nitric oxide synthesis on cerebral vasodilation and endothelium-derived relaxing factor from acetylcholine
    • Wei EP, Kukreja R, Kontos HA (1992) Effects in cats of inhibition of nitric oxide synthesis on cerebral vasodilation and endothelium-derived relaxing factor from acetylcholine. Stroke 23:1623-1628.
    • (1992) Stroke , vol.23 , pp. 1623-1628
    • Wei, E.P.1    Kukreja, R.2    Kontos, H.A.3
  • 44
    • 0029907514 scopus 로고    scopus 로고
    • Cytotoxic fragment of amyloid precursor protein accumulates in hippocampus after global forebrain ischemia
    • Yokota M, Saido TC, Tani E, Yamaura I, Minami N (1996) Cytotoxic fragment of amyloid precursor protein accumulates in hippocampus after global forebrain ischemia. J Cereb Blood Flow Metab 16:1219-1223.
    • (1996) J Cereb Blood Flow Metab , vol.16 , pp. 1219-1223
    • Yokota, M.1    Saido, T.C.2    Tani, E.3    Yamaura, I.4    Minami, N.5
  • 45
    • 0026661694 scopus 로고
    • Stimulation of the fastigial nucleus enhances EEC recovery and reduces tissue damage after focal cerebral ischemia
    • Zhang F, Iadecola C (1992) Stimulation of the fastigial nucleus enhances EEC recovery and reduces tissue damage after focal cerebral ischemia. J Cereb Blood Flow Metab 12:962-970.
    • (1992) J Cereb Blood Flow Metab , vol.12 , pp. 962-970
    • Zhang, F.1    Iadecola, C.2
  • 46
    • 0027452476 scopus 로고
    • Fastigial stimulation increases ischemic blood flow and reduces brain damage after focal ischemia
    • Zhang F, Iadecola C (1993) Fastigial stimulation increases ischemic blood flow and reduces brain damage after focal ischemia. J Cereb Blood Flow Metab 13:1013-1019.
    • (1993) J Cereb Blood Flow Metab , vol.13 , pp. 1013-1019
    • Zhang, F.1    Iadecola, C.2
  • 48
    • 0028140030 scopus 로고
    • Nitric oxide donors increase blood flow and reduce brain damage in focal ischemia: Evidence that nitric oxide is beneficial in the early stages of cerebral ischemia
    • Zhang F, White JG, Iadecola C (1994) Nitric oxide donors increase blood flow and reduce brain damage in focal ischemia: evidence that nitric oxide is beneficial in the early stages of cerebral ischemia. J Cereb Blood Flow Metab 14:217-226.
    • (1994) J Cereb Blood Flow Metab , vol.14 , pp. 217-226
    • Zhang, F.1    White, J.G.2    Iadecola, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.