Hippocampal Aβ42 levels correlate with spatial memory deficit in APP and PS1 double transgenic mice

Neurobiology of Disease

Volumn 9, Issue 3, 2002, Pages 339-347

  Puoliväli, Jukka ^a   Wang, Jun ^a   Heikkinen, Taneli ^a   Heikkilä, Matti ^a   Tapiola, Tero ^a   Van Groen, Thomas ^a,b   Tanila, Heikki ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; PRESENILIN 1;

AGE; AGING; AMNESIA; ARTICLE; BRAIN SIZE; CORRELATION ANALYSIS; DISCRIMINATION LEARNING; HIPPOCAMPUS; MAZE TEST; MEMORY CONSOLIDATION; MOUSE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; TRANSGENIC MOUSE;

EID: 0036235633     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.2002.0481     Document Type: Article

References (23)

1. Progressive, agerelated behavioral impairments in transgenic mice carrying both mutant amyloid precursor protein and presenilin-1 transgenes
2. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins
3. Neuropathological stageing of Alzheimer-related changes
4. Morphological criteria for the recognition of Alzheimer's disease and the distribution pattern of cortical changes related to this disorder
5. A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease
6. Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice
7. A cortical-hippocampal system for declarative memory
8. Rapid, reliable and economical silver stain for neurofibrillary tangles and senile plaques
9. Correlation between cognitive deficits and Abeta deposits in transgenic APP + PS1 mice
10. Amyloid, the presenilins and Alzheimer's disease
11. Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: Lack of association with amyloid deposits
12. Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
13. Alzheimer's disease: Cell-specific pathology isolates the hippocampal formation
14. Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease
15. The load and distribution of beta-amyloid in brain tissue of patients with Alzheimer's disease
16. Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
17. Place navigation impaired in rats with hippocampal lesions
18. Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein
19. Correlation between elevated levels of amyloid beta-peptide in the brain and cognitive decline
20. Strategies used by hippocampal- and caudate-putamenlesioned rats in a learning task
21. Quantitative morphology and regional and laminar distributions of senile plaques in Alzheimer's disease
22. Projections from the anterodorsal and anteroventral nucleus of the thalamus to the limbic cortex in the rat