In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-β metabolism and half-life

Journal of Neuroscience

Volumn 23, Issue 26, 2003, Pages 8844-8853

  Cirrito, John R ^a   May, Patrick C ^b   O'Dell, Mark A ^a   Taylor, Jennie W ^a   Parsadanian, Maia ^a   Cramer, Jeffrey W ^b   Audia, James E ^b   Nissen, Jeffrey S ^b   Bales, Kelly R ^b   Paul, Steven M ^b,c   DeMattos, Ronald B ^b   Holtzman, David M ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer; Amyloid; Gamma secretase; Half life; Interstitial fluid; Microdialysis

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; HALF LIFE TIME; HIPPOCAMPUS; INTERSTITIAL FLUID; MEASUREMENT; MICRODIALYSIS; MOUSE; NERVE CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN METABOLISM; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; SENILE PLAQUE; STEADY STATE;

EID: 0141529993     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-26-08844.2003     Document Type: Article

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