Role of phase 2 enzyme induction in chemoprotection by dithiolethiones

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 480-481, Issue , 2001, Pages 305-315

  Kwak, Mi Kyoung ^a   Egner, Patricia A ^a   Dolan, Patrick M ^a   Ramos Gomez, Minerva ^a   Groopman, John D ^a   Itoh, Ken ^b   Yamamoto, Masayuki ^b   Kensler, Thomas W ^a  

^a Johns Hopkins University   (United States)

^b UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

1,2 Dithiole 3 thiones; Aflatoxin; Chemoprotection; Glutathione S transferases; Nrf2; Oltipraz

Indexed keywords

1,2 DITHIOLE 3 THIONE DERIVATIVE; ACETYLCYSTEINE; AFLATOXIN B1; ANTINEOPLASTIC AGENT; ANTISCHISTOSOMAL AGENT; CARCINOGEN; DITHIOLETHIONE DERIVATIVE; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; ISOTHIOCYANATE SULFORAPHANE; OLTIPRAZ; PLACEBO; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SULFUR DERIVATIVE; TERPENOID; THIOKETONE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENESIS; CHEMOPROPHYLAXIS; CHINA; CLINICAL TRIAL; DETOXIFICATION; DOSE RESPONSE; DOSE TIME EFFECT RELATION; ENZYME INDUCTION; GENE ACTIVATION; GENE EXPRESSION; GENE REPRESSION; HIGH RISK POPULATION; HUMAN; LIVER CANCER; LIVER CARCINOGENESIS; METABOLISM; MONITORING; MUTAGENESIS; OXIDATIVE STRESS; PRIORITY JOURNAL; REGULATORY MECHANISM; RODENT; TOXICITY;

ANIMALIA; RODENTIA;

EID: 0035451390     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(01)00190-7     Document Type: Article

References (62)

1. Chemoprevention of cancer
2. Mechanisms of inhibitors of mutagenesis and carcinogenesis. Classification and overview
3. Recent advances in chemoprevention of cancer
4. Progress in clinical chemoprevention
5. Some historical perspectives on the metabolism of xenobiotic chemicals to reactive intermediates
6. Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons. G.H.A. Clowes Memorial Lecture
7. Detoxication enzymes and chemoprevention
8. Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis
9. Protection against 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyrimidine (N-OH-PhIP) cytotoxicity and DNA adduct formation in human prostate by glutathione S-transferase P1
10. Chemoprotective functions of glutathione S-transferases in cell lines induced to express specific isozymes by stable transfection
11. Transfection of glutathione S-transferase (GST)-pi antisense complementary DNA increases the sensitivity of a colon cancer cell line to adriamycin, cisplatin, melphalan, and etoposide
12. Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases
13. 1 in the rat and mouse
14. Mammalian class theta GST and differential susceptibility to carcinogens
15. Isolation and identification of kahweol palmitate and cafestrol palmitate as active constituents of green coffee beans that enhance glutathione S-transferase activity in the mouse
16. A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation of structure
17. Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates
18. Broccoli sprouts: An exceptionally rich source of inducers of enzymes that protect against chemical carcinogens
19. The antischistosomal activity of oltipraz
20. Isolation of cDNAs representing dithiolethione-responsive genes
21. 4 12-dehydrogenase: Implications for chemoprevention
22. Chemoprotective 3H-1,2-dithiole-3-thione induces antioxidant genes in vivo
23. Chemoprotective effects of two dithiolthiones and of butylhydroxyanisole against carbon tetrachloride and acetaminophen toxicity
24. Oltipraz-induced amelioration of acetaminophen hepatotoxicity in hamsters. I. Lack of dependence on glutathione
25. 1 in the rat
26. Inhibitory effects of 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) on carcinogenesis induced by benzo[a]pyrene, diethylnitrosamine and uracil mustard
27. Strategy and planning for chemopreventive drug development: Clinical development plans
28. Oltipraz: Clinical opportunities for chemoprevention
29. Chemopreventive effect of oltipraz during different stages of experimental colon carcinogenesis induced by azoymethane in male F344 rats
30. 1-induced hepatocarcinogenesis in F344 rats by 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz): Predictive role for short-term molecular dosimetry
31. Mechanism of protection against aflatoxin tumorigenicity in rats fed 5-(2-pyrazinyl)-4-methyl-1,2-dithiol-3-thione (oltipraz) and related 1,2-dithiol-3-thiones and 1,2-dithiol-3-ones
32. Regulation of glutathione S-transferase Ya subunit gene expression: Identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds
33. Increased synthesis of glutathione S-transferase in response to anticarcinogenic antioxidants. Cloning and measurement of messenger RNA
34. Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver
35. Organization and function of a dioxin-responsive enhancer
36. 1 metabolism in human hepatocytes in primary culture
37. Inhibition of human cytochrome P450 enzymes by 1,2-dithiole-3-thione, oltipraz and its derivatives, and sulforaphane
38. Intermittent dosing with oltipraz: Relationship between chemoprevention of aflatoxin-induced tumorigenesis and induction of glutathione S-transferases
39. Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis
40. Chemical and molecular regulation of enzymes that detoxify carcinogens
41. Xenobiotic-inducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element
42. Antioxidant response element
43. Functional antioxidant responsive elements
44. Regulation of phase 2 enzyme induction by oltipraz and other dithiolethiones
45. Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast
46. Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the β-globin locus control region
47. 1 gene
48. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
49. Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the chemopreventive agent, 3H-1,2-dithiole-3-thione
50. Sensitivity to carcinogenesis in increased and chemoprotective efficacy of enzymes inducers is lost in nrf2 transcription factor-deficient mice
51. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
52. Role of a mitogen-activated protein kinase pathway in the induction of phase II detoxifying enzymes by chemicals
53. p38 mitogen-activated protein kinase negatively regulates the induction of phase II drug-metabolizing enzymes that detoxify carcinogens
54. Regulation of the antioxidant response element by protein kinase C-mediated phosphorylation of NF-E2-related factor 2
55. Approaches to the development and marketing approval of drugs that prevent cancer
56. Pharmacokinetics and pharmacodynamics of oltipraz as a chemopreventive agent
57. Oltipraz: A laboratory and clinical review
58. Modulation of gene expression in subjects at risk for colorectal cancer by the chemopreventive dithiolethione oltipraz
59. Temporal patterns of aflatoxin-albumin adducts in hepatitis B surface antigen-positive and antigen-negative residents of Daxin, Qidong County, People's Republic of China
60. Oltipraz chemoprevention trial in Qidong, People's Republic of China: Study design and clinical outcomes
61. Oltipraz chemoprevention trial in Qidong, People's Republic of China: Modulation of serum aflatoxin albumin adduct biomarkers
62. 1 by oltipraz in residents of Qidong, People's Republic of China