Induction of xenobiotic enzymes by the map kinase pathway and the antioxidant or electrophile response element (ARE/EpRE)

Drug Metabolism Reviews

Volumn 33, Issue 3-4, 2001, Pages 255-271

  Kong, A N Tony ^a,b   Owuor, Edward ^a   Yu, Rong ^a   Hebbar, Vidya ^a   Chen, Chi ^a   Hu, Rong ^a   Mandlekar, Sandhya ^a,c  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c DUPONT COMPANY   (United States)

Author keywords

Chemopreventive agents; MAPK; Nrf2; Phase II drug metabolizing enzymes; Signal transduction

Indexed keywords

ACETYLCYSTEINE; ACTIVATING TRANSCRIPTION FACTOR 2; ANTIOXIDANT; BUTYLATED HYDROXYANISOLE; COMPLEMENTARY DNA; DRUG METABOLIZING ENZYME; EPIGALLOCATECHIN GALLATE; GLUTATHIONE; ISOTHIOCYANIC ACID DERIVATIVE; LEUCINE ZIPPER PROTEIN; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PHENETHYL ISOTHIOCYANATE; PHENOL DERIVATIVE; POLYPHENOL DERIVATIVE; PROLINE; PROTEIN C JUN; PROTEIN SERINE THREONINE KINASE; STRESS ACTIVATED PROTEIN KINASE; SULFORAPHANE; SYNAPTOPHYSIN; TERT BUTYLHYDROQUINONE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANTIOXIDANT ACTIVITY; APOPTOSIS; CANCER PREVENTION; CELL DIFFERENTIATION; CELL FATE; CELL PROLIFERATION; CELL PROTECTION; CELL SURVIVAL; DOSE TIME EFFECT RELATION; ELECTROPHILE RESPONSE ELEMENT; ENZYME ACTIVATION; ENZYME MECHANISM; FOOD PRESERVATION; NECROSIS; PROTEIN PHOSPHORYLATION; REPORTER GENE; REVIEW; SIGNAL TRANSDUCTION; STRESS; TRANSCRIPTION REGULATION; XENOBIOTIC METABOLISM;

ANIMALS; ANTIOXIDANTS; ENZYME INDUCTION; HUMANS; MAP KINASE SIGNALING SYSTEM; RESPONSE ELEMENTS; XENOBIOTICS;

EID: 0035212419     PISSN: 03602532     EISSN: None     Source Type: Journal    
DOI: 10.1081/DMR-120000652     Document Type: Review

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