Inhibitory effects of isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methylthiazol-2 -yl)carbamoyl]acetate (YH439) on benzo[a]pyrene-induced skin carcinogenesis and micronucleated reticulocyte formation in mice

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 423, Issue 1-2, 1999, Pages 149-153

  Surh, Young Joon ^a   Kim, Seong Gon ^b   Liem, Amy ^b   Lee, Jong Wook ^c   Miller, James A ^b  

^a Seoul National University   (South Korea)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c Yuhan Research Center   (South Korea)

Author keywords

Chemoprevention; Diallyl sulfide; Isopropyl 2 (1,3 dithietane 2 ylidene) 2 N (4 methyl 2 thiazol 2 yl)carbamoyl acetate (YH439); Organosulfur compound

Indexed keywords

2 (1,3 DITHIETAN 2 YLIDENE) 2 [N (4 METHYL 2 THIAZOLYL)CARBAMOYL]ACETIC ACID ISOPROPYL ESTER; ALLYL SULFIDE; ANTIMUTAGENIC AGENT; ANTINEOPLASTIC AGENT; BENZO[A]PYRENE; CARCINOGEN; CYTOCHROME P450; MUTAGENIC AGENT; OLTIPRAZ; ORGANOSULFUR DERIVATIVE; POLYCYCLIC AROMATIC COMPOUND; SULINDAC;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRASSICA; CHEMOPROPHYLAXIS; FEMALE; GARLIC; METABOLISM; MICRONUCLEUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETICULOCYTE; SKIN CARCINOGENESIS; TRANSCRIPTION INITIATION;

ANIMALS; ANTICARCINOGENIC AGENTS; ANTIMUTAGENIC AGENTS; ANTINEOPLASTIC AGENTS; BENZO(A)PYRENE; CROSSES, GENETIC; FEMALE; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MICRONUCLEUS TESTS; PAPILLOMA; RETICULOCYTES; SKIN NEOPLASMS; THIAZOLES;

ALLIUM SATIVUM; ANIMALIA; BRASSICA;

EID: 0033601850     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(98)00236-X     Document Type: Article

References (25)

1. Wattenberg L.W. An overview of chemoprevention: current status and future perspectives. Proc. Soc. Exp. Biol. Med. 216:1997;133-141.
2. Stoner G.D., Morse M.A., Kelloff G.J. Perspectives in cancer chemoprevention. Environ. Health Perspect. 105:1997;945-954. Suppl. 4.
3. 1 in the rat. Toxicol. Appl. Pharmacol. 93:1988;442-451.
4. Davies M.H., Schamber G.J., Schnell R.C. Oltipraz-induced amelioration of acetaminophen hepatotoxicity in hamsters. Toxicol. Appl. Pharmacol. 109:1991;17-28.
5. Helzlsouer K.J., Kensler T.W. Cancer chemoprotection by oltipraz: experimental and clinical considerations. Prev. Med. 22:1993;783-795.
6. Kensler T.W., Helzlsouer K.J. Oltipraz: clinical opportunities for cancer chemoprevention. J. Cell. Biochem. 22:1995;101-107. Suppl.
7. Langouët S., Mahéo K., Berthou F., Morel B., Lagadic-Grossman L.D., Glaise D., Coles B., Ketterer B., Guillouzo A. Effects of administration of the chemopreventive agent oltipraz on CYP1A and CYP2B in rat liver and rat hepatocytes in culture. Carcinogenesis. 18:1997;1343-1349.
8. Buetler T.M., Gallagher E.P., Wang C., Stahl D.L., Hayes J.D., Eaton D.L. Induction of phase I and phase II drug-metabolizing enzyme mRNA, protein, and activity by BHA, ethoxyquin, and oltipraz. Toxicol. Appl. Pharmacol. 135:1995;45-57.
9. Kensler T.W. Chemoprevention by inducers of carcinogen detoxication enzymes. Environ. Health Perspect. 105:1997;965-970. Suppl. 4.
10. Reddy B.S. Chemoprevention of colon cancer by minor dietary constituents and their synthetic analogues. Prev. Med. 25:1996;48-50.
11. Morgan G. Aspirin chemoprevention of colorectal and oesophageal cancers. An overview of the literature and homeopathic explanation. Eur. J. Cancer Prev. 5:1996;439-443.
12. Waddell W.R. The effect of sulindac on colon polyps: circumvention of a transformed phenotype - a hypothesis. J. Surg. Oncol. 55:1994;52-55.
13. Jung H.H., Jeong H.G., Jeong T.C., Chun Y.-J., Lee M., Yang K.-H. Effect of dithiol malonate derivatives (DMDs) on carbon tetrachloride-induced hepatotoxicity in primary cultures of adult rat hepatocytes. Korean J. Toxicol. 9:1993;167-175.
14. Surh Y.-J., Shlyankevixh M., Lee J.W., Yoo J.-K. Inhibition of covalent DNA binding and mutagenicity of benzo[a]pyrene by isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methylthiazol-2-yl)carbamoyl]acetate (YH439), a novel hepatoprotective agent. Mutat. Res. 367:1996;219-224.
15. Hayashi M., Morita T., Kodama Y., Sofuni T., Ishidate M. Jr. The micronucleus assay with mouse peripheral blood reticulocytes using acridine orange-coated slides. Mutat. Res. 141:1984;165-169.
16. Choi E.Y., Kim S.G., Lee J.W., Yoo J.K., Shin J.K., Kim N.D. Suppression of rat hepatic cytochrome P-450 2E1 expression by isopropyl-2-(1,3-dithioetane-2-ylidene)-2-[N-(4-methylthiazol-2-yl)carbamoyl]acetate (YH439), an experimental hepatoprotectant: protective role against hepatic injury. Biochem. Pharmacol. 52:1996;1219-1225.
17. Jeong K.S., Lee I.J., Roberts B.J., Soh Y., Yoo J.K., Lee J.W., Song B.J. Transcriptional inhibition of cytochrome P-450 2E1 (CYP2E1) by a synthetic compound, YH439. Arch. Biochem. Biophys. 326:1996;137-144.
18. Kim S.G., Surh Y.-J., Sohn Y., Yoo J.-K., Lee J.W., Liem A., Miller J.A. Inhibition of vinyl carbamate-induced hepatotoxicity, mutagenicity, and tumorigenicity by isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methylthiazol-2-yl)carbamoyl]acetate (YH439). Carcinogenesis. 19:1998;687-690.
19. Lee I.J., Jeong K.S., Roberts B.J., Kallarakal A.T., Fernandez-Salguero P., Gonzalez F.J., Song B.J. Transcriptional induction of the cytochrome P-450 1A1 gene by a thiazolium compound YH439. Mol. Pharmacol. 49:1996;980-988.
20. 1 hepatocarcinogenesis in rainbow trout. Fundam. Chem. Toxicol. 33:1995;841-850.
21. M. Xu, A.C. Bailey, J.F. Hernaez, C.R. Taoka, H.A. Schut, R.H. Dashwood, Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat, Carcinogenesis (1996) 1419-1434.
22. Begleiter A., Leith M.K., Curphey T.J., Doherty G.P. Induction of DT-diaphorase in cancer chemoprevention and chemotherapy. Oncol. Res. 9:1997;371-382.
23. Sparnins V.L., Barany G., Wattenberg L. Effects of organosulfur compounds from garlic and onions on benzo[a]pyrene-induced neoplasia and glutathione S-transferase activity in the mouse. Carcinogenesis. 9:1988;131-134.
24. Harber D., Siess M.-H., Canivenc-Lavier M.-C., Le Bon A.-M., Suschetet M. Differential effects of dietary diallyl sulfide and diallyl disulfide on rat intestinal and hepatic drug-metabolizing enzymes. J. Toxicol. Environ. Health. 44:1995;423-434.
25. Mahéo K., Morel F., Langouet S., Kramer H., Le Ferrec E., Ketterer B., Guillouzo A. Inhibition of cytochrome P-450 and induction of glutathione S-transferases by sulforaphane in primary human and rat hepatocytes. Cancer Res. 57:1997;3649-3652.