Molecular basis for hepatic detoxifying enzyme induction by 2- (allylthio)pyrazlne in rats in comparison with oltipraz: Effects on prooxidant production and DNA degradation

Drug Metabolism and Disposition

Volumn 27, Issue 6, 1999, Pages 667-673

  Kim, Sang Geon ^a   Cho, Min Kyung ^b   Choi, Sung Hee ^b   Kim, Hye Jung ^b   Kwak, Mi Kyong ^a   Kim, Nak Doo ^a  

^a Seoul National University   (South Korea)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

2 (ALLYLTHIO)PYRAZINE; OLTIPRAZ; PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CHEMOPROPHYLAXIS; DNA DAMAGE; DNA DEGRADATION; DRUG EFFECT; ENZYME ACTIVATION; ENZYME INDUCTION; GENE EXPRESSION; MALE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTIOXIDANTS; BLOTTING, NORTHERN; BUTHIONINE SULFOXIMINE; CYSTEINE; CYTOCHROME P-450 CYP2E1; DNA DAMAGE; ENZYME INDUCTION; ENZYME INHIBITORS; EPOXIDE HYDROLASES; GLUTATHIONE; GLUTATHIONE TRANSFERASE; IMMUNOBLOTTING; LIVER; MALE; METABOLIC DETOXICATION, DRUG; MICROSOMES, LIVER; NF-KAPPA B; OXIDANTS; PYRAZINES; RATS; RATS, SPRAGUE-DAWLEY; SUBCELLULAR FRACTIONS;

ANIMALIA;

EID: 0345104370     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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