메뉴 건너뛰기




Volumn 4, Issue 5, 2004, Pages 336-347

Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; H1 ANTIGEN; PD1 PROTEIN; PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

EID: 2442585121     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri1349     Document Type: Review
Times cited : (1123)

References (97)
  • 2
    • 0031888608 scopus 로고    scopus 로고
    • Immunological ignorance of silent antigens as an explanation of tumor evasion
    • Chen, L. Immunological ignorance of silent antigens as an explanation of tumor evasion. Immunol. Today 19, 27-30 (1998).
    • (1998) Immunol. Today , vol.19 , pp. 27-30
    • Chen, L.1
  • 3
    • 0141609073 scopus 로고    scopus 로고
    • Co-stimulatory members of the TNFR family: Keys to effective T-cell immunity?
    • Croft, M. Co-stimulatory members of the TNFR family: keys to effective T-cell immunity? Nature Rev. Immunol. 3, 609-620 (2003).
    • (2003) Nature Rev. Immunol. , vol.3 , pp. 609-620
    • Croft, M.1
  • 4
    • 0035059417 scopus 로고    scopus 로고
    • Complexities of CD28/B7: CTLA-4 co-stimulatory pathway in autoimmunity and transplantation
    • Salomon, B. & Bluestone, J. A. Complexities of CD28/B7: CTLA-4 co-stimulatory pathway in autoimmunity and transplantation. Annu. Rev. Immunol. 19, 225-252 (2001).
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 225-252
    • Salomon, B.1    Bluestone, J.A.2
  • 5
    • 0036593175 scopus 로고    scopus 로고
    • Activation rules: The two-signal theories of immune activation
    • Baxter, A. G. & Hodgkin, P. D. Activation rules: the two-signal theories of immune activation. Nature Rev. Immunol. 2, 439-446 (2002).
    • (2002) Nature Rev. Immunol. , vol.2 , pp. 439-446
    • Baxter, A.G.1    Hodgkin, P.D.2
  • 6
    • 0042470540 scopus 로고    scopus 로고
    • Dose the immune system see tumors as foreign or self?
    • Pardoll, D. Dose the immune system see tumors as foreign or self? Annu. Rev. Immune. 21, 807-839 (2003).
    • (2003) Annu. Rev. Immune. , vol.21 , pp. 807-839
    • Pardoll, D.1
  • 7
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical regulatory role of CTLA-4
    • Tivol, E. A. et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical regulatory role of CTLA-4. Immunity 3, 541-547 (1995).
    • (1995) Immunity , vol.3 , pp. 541-547
    • Tivol, E.A.1
  • 8
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4
    • Waterhouse, P. et al. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 270, 932-933 (1995). References 7 and 8 show that cytotoxic T lymphocyte antigen 4 (CTLA4) is crucial for the control of autoimmunity, because lack of CTLA4 by gene targeting induces lymphoproliferative diseases and organ destruction in the fetus.
    • (1995) Science , vol.270 , pp. 932-933
    • Waterhouse, P.1
  • 9
    • 0033579816 scopus 로고    scopus 로고
    • B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen (CTLA-4)
    • Mandelbrot, D. A., McAdam, A. J. & Sharpe, A. H. B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen (CTLA-4). J. Exp. Med. 189, 435-440 (1999).
    • (1999) J. Exp. Med. , vol.189 , pp. 435-440
    • Mandelbrot, D.A.1    McAdam, A.J.2    Sharpe, A.H.3
  • 10
    • 0035056017 scopus 로고    scopus 로고
    • CTLA-4-mediated inhibition in regulation of T cell responses: Mechanisms and manipulation in tumor immunotherapy
    • Chambers, C.A., Kuhns, M. S., Egen, J. G. & Allison, J. P. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu. Rev. Immunol. 19, 565-594 (2001).
    • (2001) Annu. Rev. Immunol. , vol.19 , pp. 565-594
    • Chambers, C.A.1    Kuhns, M.S.2    Egen, J.G.3    Allison, J.P.4
  • 11
    • 0037815115 scopus 로고    scopus 로고
    • Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to cytotoxic T lymphocyte-associated antigen 4
    • Sugita, S. & Streilein, J. W. Iris pigment epithelium expressing CD86 (B7-2) directly suppresses T cell activation in vitro via binding to cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 198, 161-171 (2003).
    • (2003) J. Exp. Med. , vol.198 , pp. 161-171
    • Sugita, S.1    Streilein, J.W.2
  • 12
    • 0037810672 scopus 로고    scopus 로고
    • The inhibitory function of B7 co-stimulators in T cell responses to foreign and self-antigens
    • Lohr, J., Knoechel, B., Jiang, S., Sharpe, A. H. & Abbas, A. K. The inhibitory function of B7 co-stimulators in T cell responses to foreign and self-antigens. Nature Immunol. 4, 664-669 (2003).
    • (2003) Nature Immunol. , vol.4 , pp. 664-669
    • Lohr, J.1    Knoechel, B.2    Jiang, S.3    Sharpe, A.H.4    Abbas, A.K.5
  • 13
    • 0347994958 scopus 로고    scopus 로고
    • B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via R-T interactions
    • Taylor, P. A. et al. B7 expression on T cells down-regulates immune responses through CTLA-4 ligation via R-T interactions. J. Immunol. 172, 34-39 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 34-39
    • Taylor, P.A.1
  • 15
    • 0030966217 scopus 로고    scopus 로고
    • Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
    • Perez, V. L. et al. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6, 411-417 (1997).
    • (1997) Immunity , vol.6 , pp. 411-417
    • Perez, V.L.1
  • 17
    • 0033613173 scopus 로고    scopus 로고
    • In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance
    • Sotomayor E. M., Borrello, I., Tubb, E., Allison, J. P. & Levitsky, H. I. In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance. Proc. Natl Acad. Sci. USA 98, 11476-11481 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 11476-11481
    • Sotomayor, E.M.1    Borrello, I.2    Tubb, E.3    Allison, J.P.4    Levitsky, H.I.5
  • 19
    • 0035801335 scopus 로고    scopus 로고
    • + regulatory T cells is mediated by cell surface-bound transforming growth factor β
    • + regulatory T cells is mediated by cell surface-bound transforming growth factor β. J. Exp. Med. 194, 629-644 (2001).
    • (2001) J. Exp. Med. , vol.194 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 20
    • 0036172220 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse in regulated by TCR signal strength
    • Egen J. G. & Allison, J. P. Cytotoxic T lymphocyte antigen-4 accumulation in the immunological synapse in regulated by TCR signal strength. Immunity 16, 23-35 (2002).
    • (2002) Immunity , vol.16 , pp. 23-35
    • Egen, J.G.1    Allison, J.P.2
  • 21
    • 0037141091 scopus 로고    scopus 로고
    • Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation
    • Darlington, P. J. et al. Surface cytotoxic T lymphocyte-associated antigen 4 partitions within lipid rafts and relocates to the immunological synapse under conditions of inhibition of T cell activation. J. Exp. Med. 195, 1337-1347 (2002).
    • (2002) J. Exp. Med. , vol.195 , pp. 1337-1347
    • Darlington, P.J.1
  • 23
    • 0032545452 scopus 로고    scopus 로고
    • Molecular basis of T cell inactivation by CTLA-4
    • Lee, K. M. et al. Molecular basis of T cell inactivation by CTLA-4. Science 282, 2263-2266 (1998).
    • (1998) Science , vol.282 , pp. 2263-2266
    • Lee, K.M.1
  • 24
    • 0037244012 scopus 로고    scopus 로고
    • Negative regulation of cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4
    • Chikuma, S., Imboden, J. B. & Bluestone, J. A. Negative regulation of cell receptor-lipid raft interaction by cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 197, 129-135 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 129-135
    • Chikuma, S.1    Imboden, J.B.2    Bluestone, J.A.3
  • 25
    • 0033682056 scopus 로고    scopus 로고
    • + immunoregulatory T cells that control autoimmune diabetes
    • + immunoregulatory T cells that control autoimmune diabetes. Immunity 12, 431-440 (2000).
    • (2000) Immunity , vol.12 , pp. 431-440
    • Salomon, B.1
  • 26
    • 0034679560 scopus 로고    scopus 로고
    • + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4
    • + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192, 303-310 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 303-310
    • Takahashi, T.1
  • 27
    • 0034679567 scopus 로고    scopus 로고
    • + regulatory cells that control intestinal inflammation
    • + regulatory cells that control intestinal inflammation. J. Exp. Med. 192, 295-302 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 28
    • 0033135564 scopus 로고    scopus 로고
    • CTLA4Ig-mediated blockade of T-cell co-stimulation in patients with psoriasis vulgaris
    • Abrams, J. R. et al. CTLA4Ig-mediated blockade of T-cell co-stimulation in patients with psoriasis vulgaris. J. Clin. Invest. 103, 1243-1252 (1999). The first clinical evidence that CTLA4-immunoglobulin fusion protein is effective for the treatment of patients with advanced psoriasis vulgaris.
    • (1999) J. Clin. Invest. , vol.103 , pp. 1243-1252
    • Abrams, J.R.1
  • 29
    • 0034605033 scopus 로고    scopus 로고
    • Blockade of T lymphocyte co-stimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells
    • Abrams, J. R. et al. Blockade of T lymphocyte co-stimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells. J. Exp. Med. 192, 681-694 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 681-694
    • Abrams, J.R.1
  • 30
    • 0242574700 scopus 로고    scopus 로고
    • Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA 4Ig
    • Kremer, J. M. et al. Treatment of rheumatoid arthritis by selective inhibition of T-cell activation with fusion protein CTLA4Ig. N. Engl. J. Med. 349, 1907-1915 (2003).
    • (2003) N. Engl. J. Med. , vol.349 , pp. 1907-1915
    • Kremer, J.M.1
  • 31
    • 0036852170 scopus 로고    scopus 로고
    • CTLA-4-Ig regulates trytophan catabolism in vivo
    • Grohmann, U. et al. CTLA-4-Ig regulates trytophan catabolism in vivo. Nature Immunol. 3, 1097-1101 (2002).
    • (2002) Nature Immunol. , vol.3 , pp. 1097-1101
    • Grohmann, U.1
  • 32
    • 0346119234 scopus 로고    scopus 로고
    • Modulation of tryptophan catabolism by regulatory T cells
    • Fallarino, F. et al. Modulation of tryptophan catabolism by regulatory T cells. Nature Immunol. 4, 1206-1212 (2003). References 31 and 32 describe a new reverse signalling mechanism for CTLA4 in the suppression of immune responses.
    • (2003) Nature Immunol. , vol.4 , pp. 1206-1212
    • Fallarino, F.1
  • 33
    • 0033215041 scopus 로고    scopus 로고
    • Tryptophan catabolism and T-cell tolerance: Immunosuppression by starvation?
    • Mellor, A. L. & Munn, D. H. Tryptophan catabolism and T-cell tolerance: Immunosuppression by starvation? Immunol. Today 20, 469-473 (1999).
    • (1999) Immunol. Today , vol.20 , pp. 469-473
    • Mellor, A.L.1    Munn, D.H.2
  • 34
    • 0036790338 scopus 로고    scopus 로고
    • T cell apoptosis by tryptophan catabolism
    • Fallarino, F. et al. T cell apoptosis by tryptophan catabolism. Cell Death Differ. 9, 1069-1077 (2002).
    • (2002) Cell Death Differ. , vol.9 , pp. 1069-1077
    • Fallarino, F.1
  • 35
    • 0026700235 scopus 로고
    • Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death
    • Ishida, Y., Agata, Y., Shibahara, K. & Honjo, T. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 11, 3887-3895 (1992.)
    • (1992) EMBO J. , vol.11 , pp. 3887-3895
    • Ishida, Y.1    Agata, Y.2    Shibahara, K.3    Honjo, T.4
  • 36
    • 0030005099 scopus 로고    scopus 로고
    • Expression of the PD-1 on the surface of stimulated mouse and B lymphocytes
    • Agata Y. et al. Expression of the PD-1 on the surface of stimulated mouse T and B lymphocytes. Int. Immunol. 8, 765-772 (1996).
    • (1996) Int. Immunol. , vol.8 , pp. 765-772
    • Agata, Y.1
  • 37
    • 0033180181 scopus 로고    scopus 로고
    • Development of lupos-like autoimmune disease by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    • Nishimura, H., Nose, M., Hiai, H., Minato, N. & Honjo. T. Development of lupos-like autoimmune disease by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 11, 141-151 (1999). This is the first study showing the development of systemic autoimmune diseases in programmed cell death 1 (Pd1)-knockout mice.
    • (1999) Immunity , vol.11 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3    Minato, N.4    Honjo, T.5
  • 38
    • 0035846991 scopus 로고    scopus 로고
    • Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice
    • Nishimura, H. et al. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 291, 319-322 (2001).
    • (2001) Science , vol.291 , pp. 319-322
    • Nishimura, H.1
  • 39
    • 10744220884 scopus 로고    scopus 로고
    • Autoantibodies against cardiac troponin 1 are responsible for dilated cardiomyopathy in PD-1 deficient mice
    • Okazaki, T. et al. Autoantibodies against cardiac troponin 1 are responsible for dilated cardiomyopathy in PD-1 deficient mice. Nature Med. 9, 1477-1483 (2003).
    • (2003) Nature Med. , vol.9 , pp. 1477-1483
    • Okazaki, T.1
  • 40
    • 0037477605 scopus 로고    scopus 로고
    • The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice
    • Ansari, M. J. et al. The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice. J. Exp. Med. 196, 63-69
    • J. Exp. Med. , vol.196 , pp. 63-69
    • Ansari, M.J.1
  • 41
    • 0037477604 scopus 로고    scopus 로고
    • Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis
    • Salama, A. D. et al. Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis. J. Exp. Med. 196, 71-78 (2003).
    • (2003) J. Exp. Med. , vol.196 , pp. 71-78
    • Salama, A.D.1
  • 42
    • 0242366612 scopus 로고    scopus 로고
    • Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses
    • Tsushima, F. et al. Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses. Eur. J. Immunol 33, 2773-2782 (2003).
    • (2003) Eur. J. Immunol. , vol.33 , pp. 2773-2782
    • Tsushima, F.1
  • 43
    • 0041845131 scopus 로고    scopus 로고
    • Blockade of programmed death-1 engagement accelerate graft-verus-host disease lathality by an IFN-γ-dependent mechanism
    • Blazar, B. R. et al. Blockade of programmed death-1 engagement accelerate graft-verus-host disease lathality by an IFN-γ-dependent mechanism. J. Immunol. 71, 1272-1277 (2003).
    • (2003) J. Immunol. , vol.71 , pp. 1272-1277
    • Blazar, B.R.1
  • 44
    • 0037815272 scopus 로고    scopus 로고
    • PD-1 inhibits antiviral immunity at the effector phase in the liver
    • Iwai, Y., Terawaki, S., Ikegawa, M., Okazaki, T. & Honjo, T. PD-1 inhibits antiviral immunity at the effector phase in the liver. J. Exp. Med. 196, 39-50 (2003).
    • (2003) J. Exp. Med. , vol.196 , pp. 39-50
    • Iwai, Y.1    Terawaki, S.2    Ikegawa, M.3    Okazaki, T.4    Honjo, T.5
  • 45
    • 0028081358 scopus 로고
    • Structure and chromosomal localization of the human PD-1 gene (PDCD1)
    • Shinohara, T., Taniwaki, M., Ishida, Y., Kawaichi, M. & Honjo, T. Structure and chromosomal localization of the human PD-1 gene (PDCD1). Genomics 23, 704-706 (1994).
    • (1994) Genomics , vol.23 , pp. 704-706
    • Shinohara, T.1    Taniwaki, M.2    Ishida, Y.3    Kawaichi, M.4    Honjo, T.5
  • 46
    • 0030845707 scopus 로고    scopus 로고
    • The human PD-1 gene: Complete cDNA, genomic organization, and developmentally regulated expression in T cell progenitors
    • Finger, L. R. et al. The human PD-1 gene: complete cDNA, genomic organization, and developmentally regulated expression in T cell progenitors. Gene 197, 177-187 (1997).
    • (1997) Gene , vol.197 , pp. 177-187
    • Finger, L.R.1
  • 47
    • 0035923535 scopus 로고    scopus 로고
    • PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
    • Okazaki, T., Maeda, A., Nishimura, H., Kurosaki, T. & Honjo, T. PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine. Proc. Natl Acad. Sci. USA 96, 13866-13871 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 13866-13871
    • Okazaki, T.1    Maeda, A.2    Nishimura, H.3    Kurosaki, T.4    Honjo, T.5
  • 48
    • 5844264920 scopus 로고    scopus 로고
    • PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    • Latchman, Y. et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nature Immunol. 2, 261-268 (2001).
    • (2001) Nature Immunol. , vol.2 , pp. 261-268
    • Latchman, Y.1
  • 49
    • 0142149029 scopus 로고    scopus 로고
    • Absence of programmed death receptor 1 alters thymic development and enhances generation of CD4/CD8 double negative TCR-transgenic T cells
    • Blank, C. et al. Absence of programmed death receptor 1 alters thymic development and enhances generation of CD4/CD8 double negative TCR-transgenic T cells. J. Immunol. 171, 4574-4581 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 4574-4581
    • Blank, C.1
  • 50
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by novel B7 family member leads to negative regulation lymphocyte activation
    • Freeman, G. J. et al. Engagement of the PD-1 immunoinhibitory receptor by novel B7 family member leads to negative regulation lymphocyte activation. J. Exp. Med. 192, 1027-1034 (2000).
    • (2000) J. Exp. Med. , vol.192 , pp. 1027-1034
    • Freeman, G.J.1
  • 51
    • 0032736029 scopus 로고    scopus 로고
    • B7-H1, a third member of the B7 family, co-stimulate T-cell proliferation and interleukin-10 secretion
    • Dong, H., Zhu, G., Tamada, K. & Chen, L. B7-H1, a third member of the B7 family, co-stimulate T-cell proliferation and interleukin-10 secretion. Nature Med. 5, 1365-1369 (1999).
    • (1999) Nature Med. , vol.5 , pp. 1365-1369
    • Dong, H.1    Zhu, G.2    Tamada, K.3    Chen, L.4
  • 52
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
    • Dong, H. et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nature Med. 8, 793-800 (2002). The study demonstrated broad expression of B7-H1 by human cancers and shows that tumour-associated B7-H1 could prevent tumour immunity by inducing apoptosis of effector. T cells in vitro and in vivo. This paper also indicates that B7-H1 has an additional receptor other than PD1.
    • (2002) Nature Med. , vol.8 , pp. 793-800
    • Dong, H.1
  • 53
    • 0035869569 scopus 로고    scopus 로고
    • B7-H1 co-stimulation preferentially enhances CD28-independent T-helper cell function
    • Tamura, H. et al. B7-H1 co-stimulation preferentially enhances CD28-independent T-helper cell function. Blood 97, 1809-1818 (2001).
    • (2001) Blood , vol.97 , pp. 1809-1818
    • Tamura, H.1
  • 54
    • 0037111483 scopus 로고    scopus 로고
    • Expression of programmed death 1 ligands by murine T cells and APC
    • Yamazaki, T. et al. Expression of programmed death 1 ligands by murine T cells and APC. J. Immunol. 169, 5538-5545 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 5538-5545
    • Yamazaki, T.1
  • 55
    • 0036785604 scopus 로고    scopus 로고
    • B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis
    • Mazanet M. M. & Hughes, C. C. B7-H1 is expressed by human endothelial cells and suppresses T cell cytokine synthesis. J. Immunol. 169, 3581-3588 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 3581-3588
    • Mazanet, M.M.1    Hughes, C.C.2
  • 56
    • 3142728923 scopus 로고    scopus 로고
    • B7 family molecules: Novel immunomodulators at the maternal-fetal interface
    • Petroff, M. G., Chen, L., Phillips, T. A. & Hunt, J. S. B7 family molecules: novel immunomodulators at the maternal-fetal interface. Placenta 23 (Suppl A), S95-S101 (2002).
    • (2002) Placenta , vol.23 , Issue.SUPPL. A
    • Petroff, M.G.1    Chen, L.2    Phillips, T.A.3    Hunt, J.S.4
  • 57
    • 0038784354 scopus 로고    scopus 로고
    • B7-H1 is upregulated in HIV infection and is a novel surrogate marker of disease progression
    • Trabattoni, D. et al. B7-H1 is upregulated in HIV infection and is a novel surrogate marker of disease progression. Blood 101, 2514-2520 (2003).
    • (2003) Blood , vol.101 , pp. 2514-2520
    • Trabattoni, D.1
  • 58
    • 0242584894 scopus 로고    scopus 로고
    • B7 family molecules are favorably positioned at the human maternal-fetal interface
    • Petroff, M. G. et al. B7 family molecules are favorably positioned at the human maternal-fetal interface. Biol. Reprod. 68, 1496-1504 (2003).
    • (2003) Biol. Reprod. , vol.68 , pp. 1496-1504
    • Petroff, M.G.1
  • 59
    • 0037377967 scopus 로고    scopus 로고
    • B7-H1 (programmed death-1 ligand) on dendritic cells is involved in the induction and maintenance of T cell anergy
    • Selenko-Gebauer, N. et al. B7-H1 (programmed death-1 ligand) on dendritic cells is involved in the induction and maintenance of T cell anergy. J. Immunol. 170, 3637-3644 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 3637-3644
    • Selenko-Gebauer, N.1
  • 60
    • 0037469056 scopus 로고    scopus 로고
    • Karatinocytes induce local tolerance to skin graft by active interleukin-10-secreting T cells in the context of co-stimulation molecule B7-H1
    • Cao, Y. et al. Karatinocytes induce local tolerance to skin graft by active interleukin-10-secreting T cells in the context of co-stimulation molecule B7-H1. Transplantation 75, 1390-1396 (2003).
    • (2003) Transplantation , vol.75 , pp. 1390-1396
    • Cao, Y.1
  • 61
    • 0037152153 scopus 로고    scopus 로고
    • Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues
    • Ishida, M. et al. Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues. Immunol. Lett. 84, 57-62 (2002).
    • (2002) Immunol. Lett. , vol.84 , pp. 57-62
    • Ishida, M.1
  • 62
    • 0037307930 scopus 로고    scopus 로고
    • Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production
    • Brown, J. A. et al. Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J. Immunol. 170, 1257-1266 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 1257-1266
    • Brown, J.A.1
  • 63
    • 0035794314 scopus 로고    scopus 로고
    • B7-DC, a new dendritic cell molecule with potent co-stimulatory properties for T cells
    • Tseng, S. Y. et al. B7-DC, a new dendritic cell molecule with potent co-stimulatory properties for T cells. J. Exp. Med. 193, 839-848 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 839-848
    • Tseng, S.Y.1
  • 64
    • 0038491416 scopus 로고    scopus 로고
    • + T cells independent of the PD-1 receptor
    • + T cells independent of the PD-1 receptor. J. Exp. Med. 196, 31-38 (2003).
    • (2003) J. Exp. Med. , vol.196 , pp. 31-38
    • Shin, T.1
  • 66
    • 0141889125 scopus 로고    scopus 로고
    • Blockade of B7-H1 suppresses the development of chronic intestinal inflammation
    • Kanal, T. et al. Blockade of B7-H1 suppresses the development of chronic intestinal inflammation. J. Immunol. 171, 4156-4163 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 4156-4163
    • Kanal, T.1
  • 67
    • 85047690551 scopus 로고    scopus 로고
    • Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection
    • Subudhi, S. K. et al. Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection. J. Clin. Invest. 113, 694-700 (2004).
    • (2004) J. Clin. Invest. , vol.113 , pp. 694-700
    • Subudhi, S.K.1
  • 68
    • 0037867039 scopus 로고    scopus 로고
    • B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism
    • Liu, X. et al. B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism. J. Exp. Med. 197, 1721-1730 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 1721-1730
    • Liu, X.1
  • 69
    • 0038185203 scopus 로고    scopus 로고
    • Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple most co-stimulatory function from PD-1 interaction
    • Wang, S. et al. Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple most co-stimulatory function from PD-1 interaction. J. Exp. Med. 197, 1083-1091 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 1083-1091
    • Wang, S.1
  • 70
    • 0037312070 scopus 로고    scopus 로고
    • Co-stimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis
    • Dong, H. et al. Co-stimulating aberrant T cell responses by B7-H1 autoantibodies in rheumatoid arthritis. J. Clin. Invest. 111, 363-370 (2003).
    • (2003) J. Clin. Invest. , vol.111 , pp. 363-370
    • Dong, H.1
  • 71
    • 0037131988 scopus 로고    scopus 로고
    • Crosslinking the B7 family molecule B7-DC directly activates immune functions of dendritic cells
    • Nguyen, L. T. et al. Crosslinking the B7 family molecule B7-DC directly activates immune functions of dendritic cells. J. Exp. Med. 196, 1393-1398 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 1393-1398
    • Nguyen, L.T.1
  • 72
    • 0037442244 scopus 로고    scopus 로고
    • Naturally occurring human IgM antibody that binds B7 DC and potentiates T cell stimulation by dendritic cells
    • Radhakrishnan, S. et al. Naturally occurring human IgM antibody that binds B7 DC and potentiates T cell stimulation by dendritic cells. J. Immunol. 170, 1830-1838 (2003).
    • (2003) J. Immunol. , vol.170 , pp. 1830-1838
    • Radhakrishnan, S.1
  • 74
    • 0037270978 scopus 로고    scopus 로고
    • Hepatic T cells and liver tolerance
    • Crispe, I. N. Hepatic T cells and liver tolerance. Nature Rev. Immunol. 3, 51-62 (2003).
    • (2003) Nature Rev. Immunol. , vol.3 , pp. 51-62
    • Crispe, I.N.1
  • 75
    • 1642306942 scopus 로고    scopus 로고
    • + T lymphocytes
    • + T lymphocytes. Immunity 20, 327-336 (2004).
    • (2004) Immunity , vol.20 , pp. 327-336
    • Dong, H.1
  • 76
    • 2442424308 scopus 로고    scopus 로고
    • B7-H4, a molecule of the B7 family, negative regulates T cell immunity
    • Sica, G. L. et al. B7-H4, a molecule of the B7 family, negative regulates T cell immunity. Immunity 16, 849-861 (2000.)
    • (2000) Immunity , vol.16 , pp. 849-861
    • Sica, G.L.1
  • 77
    • 0038433329 scopus 로고    scopus 로고
    • B7S1, a novel B7 family member that negatively regulates T cell activation
    • Prasad, D. V., Richards, S., Mai, X. M. & Dong, C. B7S1, a novel B7 family member that negatively regulates T cell activation. Immunity 18, 863-873 (2003).
    • (2003) Immunity , vol.18 , pp. 863-873
    • Prasad, D.V.1    Richards, S.2    Mai, X.M.3    Dong, C.4
  • 78
    • 0042337394 scopus 로고    scopus 로고
    • B7x: A widely expressed B7 family member that inhibits T cell activation
    • Zang, X., Loke, P., Kim, J., Murphy, K., Waitz, R. & Allison, J. P. B7x: a widely expressed B7 family member that inhibits T cell activation. Proc. Natl Acad. Sci. USA 100, 10388-10392 (2003). References 76-78 Identity 76-78 Identity a new B7 homologue with suppressive function in vivo (references 76 and 77) and in vitro.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 10388-10392
    • Zang, X.1    Loke, P.2    Kim, J.3    Murphy, K.4    Waitz, R.5    Allison, J.P.6
  • 79
    • 10744220428 scopus 로고    scopus 로고
    • Genomic organization and expression analysis of B7-H4: An immune inhibitory molecule of the B7 family
    • Choi, I. H. et al. Genomic organization and expression analysis of B7-H4: an immune inhibitory molecule of the B7 family. J. Immunol. 171, 4650-4654 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 4650-4654
    • Choi, I.H.1
  • 80
    • 0037810670 scopus 로고    scopus 로고
    • BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
    • Watanabe, N. et al. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nature Immunol. 4, 670-679 (2003). This study reports the cloning of B and T lymphocyte attenuator (BTLA) and shows that Btla-knockout mica have enhanced T-cell responses. It also claims that BTLA is a receptor for B7-H4.
    • (2003) Nature Immunol. , vol.4 , pp. 670-679
    • Watanabe, N.1
  • 81
    • 5844252552 scopus 로고    scopus 로고
    • B7-H3: A co-stimulatory molecule for T cell activation and IFN-γ production
    • Chapoval, A. I. et al. B7-H3: a co-stimulatory molecule for T cell activation and IFN-γ production. Nature Immunol. 2, 269-274 (2001).
    • (2001) Nature Immunol. , vol.2 , pp. 269-274
    • Chapoval, A.I.1
  • 82
    • 85037019505 scopus 로고    scopus 로고
    • Characterization of mouse and human B7-H3 gene
    • Sun, M. et al. Characterization of mouse and human B7-H3 gene. J. Immunol. 168, 8294-6297 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 8294-6297
    • Sun, M.1
  • 83
    • 2442428549 scopus 로고    scopus 로고
    • (ed. L. Chen) (Kluwer Academic, Plenum Publishers, New York)
    • Chapoval, A. I. & Chen, L. in The B7-CD28 Family Molecules (ed. L. Chen) 91-99 (Kluwer Academic, Plenum Publishers, New York, 2003).
    • (2003) The B7-CD28 Family Molecules , pp. 91-99
    • Chapoval, A.I.1    Chen, L.2
  • 84
    • 0041381300 scopus 로고    scopus 로고
    • The B7 family B7-H3 preferentially downregulates T helper type 1-mediated immune responses
    • Suh, W. K. et al. The B7 family B7-H3 preferentially downregulates T helper type 1-mediated immune responses. Nature Immunol. 4, 899-906 (2003).
    • (2003) Nature Immunol. , vol.4 , pp. 899-906
    • Suh, W.K.1
  • 85
    • 0043123303 scopus 로고    scopus 로고
    • Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: Divergent history of functional redundancy and exon loss
    • Ling, V. et al. Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss. Genomics 82, 365-377 (2003).
    • (2003) Genomics , vol.82 , pp. 365-377
    • Ling, V.1
  • 86
    • 10744232878 scopus 로고    scopus 로고
    • Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains
    • Steinberger, P. et al. Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains. J. Immunol. 172, 2352-2359 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 2352-2359
    • Steinberger, P.1
  • 87
    • 0344341626 scopus 로고    scopus 로고
    • Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
    • Hodl, F. S. et al. Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc. Natl Acad. Sci. USA 100, 4712-4717 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 4712-4717
    • Hodl, F.S.1
  • 88
    • 0038153907 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
    • Phan, G. Q. et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc. Natl Acad. Sci. USA 100, 8372-8377 (2003). References 87 and 88 show that infusion of humanized CTLA4-specific antagonist monoclonal antibody induces clinical responses in advanced stages of melanoma accompanied by marked self-reactivity.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 8372-8377
    • Phan, G.Q.1
  • 89
    • 0242442492 scopus 로고    scopus 로고
    • Expression of the B7-related molecule B7-H1 by glioma cells: A potential mechanism of immune paralysis
    • Wintterie, S. et al. Expression of the B7-related molecule B7-H1 by glioma cells: a potential mechanism of immune paralysis. Cancer Res. 63, 7462-7467 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 7462-7467
    • Wintterie, S.1
  • 90
    • 0141953992 scopus 로고    scopus 로고
    • B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma
    • Strome, S. E. et al. B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma. Cancer Res. 63, 6501-6505 (2003).
    • (2003) Cancer Res. , vol.63 , pp. 6501-6505
    • Strome, S.E.1
  • 91
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • Iwai, Y. et al. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc. Natl Acad. Sci. USA 99, 12293-12297 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 12293-12297
    • Iwai, Y.1
  • 92
    • 0038796692 scopus 로고    scopus 로고
    • B7-H1 pathway and its role in the evasion of tumor immunity
    • Dong, H. & Chen, L. B7-H1 pathway and its role in the evasion of tumor immunity. J. Mol. Med. 81, 281-287 (2003).
    • (2003) J. Mol. Med. , vol.81 , pp. 281-287
    • Dong, H.1    Chen, L.2
  • 93
    • 0038273853 scopus 로고    scopus 로고
    • Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
    • Curiel, T. J. et al. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nature Med. 9, 562-567 (2003). This paper reports that dendritic cells (DCs) isolated from human ovarian cancers have upregulated expression of B7-H1, which suppression T-cell responses. Blockade of DC-associated B7-H1 by specific monoclonal antibody enhances tumour immunity.
    • (2003) Nature Med. , vol.9 , pp. 562-567
    • Curiel, T.J.1
  • 94
    • 0036884356 scopus 로고    scopus 로고
    • Programmed death-1 targeting can promote allograft survival
    • Ozkaynak, E. et al. Programmed death-1 targeting can promote allograft survival. J. Immunol. 169, 6546-6553 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 6546-6553
    • Ozkaynak, E.1
  • 95
    • 0141433189 scopus 로고    scopus 로고
    • Stimulating PD-1-negative signals concurrent with blocking CD154 co-stimulation induces long-term isle allograft survival
    • Gao, W., Demirci, G., Strom, T. B. & Li, X. C. Stimulating PD-1-negative signals concurrent with blocking CD154 co-stimulation induces long-term isle allograft survival. Transplantation 76, 994-999 (2003).
    • (2003) Transplantation , vol.76 , pp. 994-999
    • Gao, W.1    Demirci, G.2    Strom, T.B.3    Li, X.C.4
  • 96
    • 0242422840 scopus 로고    scopus 로고
    • Human muscle cells express a B7-related molecule, B7-H1, with strong negative immune regulatory potential; a novel mechanism of counterbalancing the immune attack in idiopathic inflammatory myopathies
    • Wiendl, H. et al. Human muscle cells express a B7-related molecule, B7-H1, with strong negative immune regulatory potential; a novel mechanism of counterbalancing the immune attack in idiopathic inflammatory myopathies. FASEB J. 17, 1892-1894 (2003).
    • (2003) FASEB J. , vol.17 , pp. 1892-1894
    • Wiendl, H.1
  • 97
    • 0142259712 scopus 로고    scopus 로고
    • Unifying concepts in CD28, ICOS and CTLA-4 co-receptor signaling
    • Rudd, C. E. & Schneider, H. Unifying concepts in CD28, ICOS and CTLA-4 co-receptor signaling. Nature Rev. Immunol. 3, 544-656 (2003).
    • (2003) Nature Rev. Immunol. , vol.3 , pp. 544-656
    • Rudd, C.E.1    Schneider, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.