The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens

Nature Immunology

Volumn 4, Issue 7, 2003, Pages 664-669

  Lohr, Jens ^a   Knoechel, Birgit ^a   Jiang, Shuwei ^a   Sharpe, Arlene H ^b   Abbas, Abul K ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B7 ANTIGEN; CD4 ANTIGEN; CD5 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 2 RECEPTOR;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN FUNCTION; ANTIGEN PRESENTING CELL; ARTICLE; AUTOIMMUNITY; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; IMMUNOHISTOCHEMISTRY; IMMUNOREGULATION; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD80; ANTIGENS, DIFFERENTIATION; AUTOANTIGENS; AUTOIMMUNITY; FEMALE; IMMUNOCONJUGATES; MALE; MICE; MICE, INBRED BALB C; OVALBUMIN; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTES; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 0037810672     PISSN: 15292908     EISSN: None     Source Type: Journal    
DOI: 10.1038/ni939     Document Type: Article

References (40)

1. Banchereau, J. & Steinman, R.M. Dendritic cells and the control of immunity. Nature 392, 245-252 (1998).
2. Lanzavecchia, A. & Sallusto, F. The instructive role of dendritic cells on T cell responses: lineages, plasticity and kinetics. Curr. Opin. Immunol. 13, 291-298 (2001).
3. Coyle, A.J. & Gutierrez-Ramos, J.C. The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function. Nat. Immunol. 2, 203-209 (2001).
4. + T cells. Immunol. Rev. 165, 231-247 (1998).
5. Lenschow, D.J., Walumas, T.L. & Bluestone, J.A. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14, 233-258 (1996).
6. Shahinian, A. et al. Differential T cell costimulatory requirements in CD28-deficient mice. Science 261, 609-612 (1993).
7. Borriello, F. et al. B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation. Immunity 6, 303-313 (1997).
8. Sharpe, A.H. & Freeman, G.J. The B7-CD28 superfamily. Nat. Rev. Immunol. 2, 116-126 (2002).
9. Ranheim, E.A. & Kipps, T.J. Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal. J. Exp. Men. 177, 925-935 (1993).
10. Larsen, C.P. et al. Regulation of immunostimulatory function and costimulatory molecule (B7-1 and B7-2) expression on murine dendritic cells. J. Immunol. 152, 5208-5219 (1994).
11. de Boer, M. et al. Ligation of B7 with CD28/CTLA-4 on T cells results in CD40 ligand expression, interleukin-4 secretion and efficient help for antibody production by B cells. Eur. J. Immunol. 23, 3120-3125 (1993).
12. Lenschow, D.J. et al. Long-term survival of xenogeneic pancreatic islet grafts induced by CTLA4Ig. Science 257, 789-792 (1992).
13. Linsley, P.S. et al. Immunosuppression in vivo by a soluble form of the CTLA-4 T cell activation molecule. Science 257, 792-795 (1992).
14. Inaba, K. et al. The tissue distribution of the B7-2 costimulator in mice: abundant expression on dendritic cells in situ and during maturation in vitro. J. Exp. Med. 180, 1849-1860 (1994).
15. Azuma, M. et al. B70 antigen is a second ligand for CTLA-4 and CD28. Nature 366, 76-79 (1993).
16. Kearney, E.R., Pape, K.A., Loh, D.Y. & Jenkins, M.K. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity 1, 327-339 (1994).
17. Kurts, C. et al. Constitutive class I-restricted exogenous presentation of self antigens in vivo. J. Exp. Med. 184, 923-930 (1996).
18. Camacho, S.A. et al. A key role for ICAM-1 in generating effector cells mediating inflammatory responses. Nat. Immunol. 2, 523-529 (2001).
19. + immunoregulatory T cells that control autoimmune diabetes. Immunity 12, 431-440 (2000).
20. Tivol, E.A. et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multi-organ tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3, 541-547 (1995).
21. Waterhouse, P. et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science 270, 985-988 (1995).
22. Krummel, M.F. & Allison, J.P. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J. Exp. Med. 183, 2533-2540 (1996).
23. Walunas, T.L., Bakker, C.Y. & Bluestone, J.A. CTLA-4 ligation blocks CD28-dependent T cell activation. J. Exp. Med. 183, 2541-2550 (1996).
24. Perez, V.L. et al. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6, 411-417 (1997).
25. Greenwald, R.J., Boussiotis, V.A., Lorsbach, R.B., Abbas, A.K. & Sharpe, A.H. CTLA-4 regulates induction of anergy in vivo. Immunity 14, 145-155 (2001).
26. + regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192, 303-310 (2000).
27. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. & Toda, M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155, 1151-1164 (1995).
28. + naturally anergic and suppressive T cells: induction of autoimmune disease by breaking their anergic/suppressive state. Int. Immunol. 10, 1969-1980 (1998).
29. + regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease. J. Immunol. 168, 5979-5983 (2002).
30. Onizuka, S. et al. Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor α) monoclonal antibody. Cancer Res. 59, 3128-3133 (1999).
31. + immunoregulatory T cells in the induction of autoimmune gastritis. Immunol. Cell. Biol. 80, 567-573 (2002).
32. Racke, M.K. et al. Distinct roles for B7-1 (CD-80) and B7-2 (CD-86) in the initiation of experimental allergic encephalomyelitis. J. Clin. Invest. 96, 2195-2203 (1995).
33. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188, 287-296 (1998).
34. Maloy, K.J. & Powrie, F. Regulatory T cells in the control of immune pathology. Nat. Immunol. 2, 816-822 (2001).
35. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2, 389-400 (2002).
36. Apostolou I, Sarukhan, A., Klein, L. & von Boehmer, H. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3, 756-763 (2002).
37. Lutz, M.B. et al. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 223, 77-92 (1999).
38. Howland, K.C., Ausubel, L.J., London, C.A. & Abbas, A.K. The roles of CD28 and CD40 ligand in T cell activation and tolerance. J. Immunol. 164, 4465-4470 (2000).
39. Overbergh, L., Valckx, D., Waer, M. & Mathieu, C. Quantification of murine cytokine mRNAs using real time quantitative reverse transcriptase PCR. Cytokine 11, 305-312 (1999).
40. Grogan, J.L. et al. Early transcription and silencing of cytolkine genes underlie polarization of T helper cell subsets. Immunity 14, 205-215 (2001).