Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells

Journal of Experimental Medicine

Volumn 192, Issue 5, 2000, Pages 681-693

  Abrams, Judith R ^a,h   Kelley, Susan L ^a   Hayes, Elizabeth ^b   Kikuchi, Toyoko ^b   Brown, Michael J ^a   Kang, Sewon ^c   Lebwohl, Mark G ^d   Guzzo, Cynthia A ^e   Jegasothy, Brian V ^f   Linsley, Peter S ^g   Krueger, James G ^b  

^a BRISTOL MYERS SQUIBB PHARMACEUTICAL RESEARCH INSTITUTE   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

^c UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^d MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

^f UNIVERSITY OF PITTSBURGH   (United States)

^g ROSETTA INPHARMATICS   (United States)

^h NOVARTIS PHARMA AG   (Switzerland)

Author keywords

B7; CTLA4Ig; Dendritic cells; Psoriasis vulgaris; T cell costimulation

Indexed keywords

B7 ANTIGEN; CD40 ANTIGEN; CD83 ANTIGEN; CD86 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; HLA DR ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MEMBRANE PROTEIN;

ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DENDRITIC CELL; DRUG EFFECT; DRUG SCREENING; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPHARMACOLOGY; KERATINOCYTE; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; PSORIASIS VULGARIS; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD; ANTIGENS, CD28; ANTIGENS, DIFFERENTIATION; DENDRITIC CELLS; ENDOTHELIUM, VASCULAR; FLOW CYTOMETRY; HUMANS; IMMUNOCONJUGATES; IMMUNOSUPPRESSIVE AGENTS; INTEGRIN ALPHAXBETA2; INTEGRINS; KERATINOCYTES; LYMPHOCYTE ACTIVATION; NEUTROPHILS; PSORIASIS; SELECTINS; T-LYMPHOCYTES;

EID: 0034605033     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.5.681     Document Type: Article

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