Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction

Journal of Experimental Medicine

Volumn 197, Issue 9, 2003, Pages 1083-1091

  Wang, Shengdian ^a   Bajorath, Jürgen ^b,c   Flies, Dallas B ^a   Dong, Haidong ^a   Honjo, Tasuku ^d   Chen, Lieping ^a  

^a MAYO CLINIC   (United States)

^b ALBANY MOLECULAR RESEARCH INC   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

Costimulation; Mutagenesis; PD 1 ligands; T cell activation

Indexed keywords

HLA B7 ANTIGEN; HLA B7 DC ANTIGEN; HLA B7 H1 ANTIGEN; LIGAND; PD 1; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; EPITOPE MAPPING; FEMALE; IMMUNOSTIMULATION; LYMPHOCYTE PROLIFERATION; MOLECULAR MODEL; MOUSE; MUTANT; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; RECEPTOR BINDING; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; T LYMPHOCYTE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD80; ANTIGENS, SURFACE; APOPTOSIS REGULATORY PROTEINS; BLOOD PROTEINS; CHO CELLS; CRICETINAE; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDES; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0038185203     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20021752     Document Type: Article

References (36)

1. Lenschow, D.J., T.L. Walunas, and J.A. Bluestone. 1996. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14:233-258.
2. Chambers, C.A., and J.P. Allison. 1997. Co-stimulation in T cell responses. Curr. Opin. Immunol. 9:396-404.
3. Rathmell, J.C., and C.B. Thompson. 1999. The central effectors of cell death in the immune system. Annu. Rev. Immunol. 17:781-828.
4. Krummel, M.F., and J.P. Allison. 1996. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J. Exp. Med. 183:2533-2540.
5. Walunas, T.L., C.Y. Bakker, and J.A. Bluestone. 1996. CTLA-4 ligation blocks CD28-dependent T cell activation. J. Exp. Med. 183:2541-2550.
6. Dong, H., G. Zhu, K. Tamada, and L. Chen. 1999. B7-H1, a third member of the B7 family, co-stimulates T cell proliferation and interleukin-10 secretion. Nat. Med. 5:1365-1369.
7. Freeman, G.J., A.J. Long, Y. Iwai, K. Bourque, T. Chernova, H. Nishimura, L.J. Fitz, N. Malenkovich, T. Okazaki, M.C. Byrne, et al. 2000. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192:1027-1034.
8. Tseng, S.Y., M. Otsuji, K. Huang, J.E. Slansky, S.I. Pai, A. Shalabi, T. Shin, D.M. Pardoll, and H. Tsuchiya. 2001. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J. Exp. Med. 193:839-846.
9. Latchman, Y., C.R. Wood, T. Chernova, D. Chaudhary, M. Borde, I. Chernova, Y. Iwai, A.J. Long, J.A. Brown, R. Nunes, et al. 2001. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol. 2:261-269.
10. Wang, S., G. Zhu, A.I. Chapoval, H. Dong, K. Tamada, J. Ni, and L. Chen. 2000. Costimulation of T cells by B7-H2, a B7-like molecule that binds ICOS. Blood. 96:2808-2813.
11. Swallow, M.M., J.J. Wallin, and W.C. Sha. 1999. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha. Immunity. 11:423-432.
12. Yoshinaga, S.K., J.S. Whoriskey, S.D. Khare, U. Sarmiento, J. Guo, T. Horan, G. Shih, M. Zhang, M.A. Coccia, T. Kohno, et al. 1999. T-cell co-stimulation through B7RP-1 and ICOS. Nature. 402:827-832.
13. Chapoval, A., J. Ni, J.S. Lau, R.A. Wilcox, D.B. Flies, D. Liu, H. Dong, G.L. Sica, G. Zhu, K. Tamada, and L. Chen. 2001. B7-H3: a costimulatory molecule for T cell activation and IFN-γ production. Nat. Immunol. 2:269-274.
14. Schwartz, J.C., X. Zhang, S.G. Nathenson, and S.C. Almo. 2002. Structural mechanisms of costimulation. Nat. Immunol. 3:427-434.
15. Williams, A.F., and A.N. Barclay. 1998. The immunoglobulin superfamily-domains for cell surface recognition. Annu. Rev. Immunol. 6:381-405.
16. Ostrov, D.A., W. Shi, J.C. Schwartz, S.C. Almo, and S.G. Nathenson. 2000. Structure of murine CTLA-4 and its role in modulating T cell responsiveness. Science. 290:816-819.
17. Metzler, W.J., J. Bajorath, W. Fenderson, S.Y. Shaw, K.L. Constantine, J. Naemura, G. Leytze, R.J. Peach, T.B. Lavoie, L. Mueller, and P.S. Linsley. 1997. Solution structure of human CD152 and delineation of a CD80/CD86 binding site conserved in CD28. Nat. Struct. Biol. 4:527-531.
18. Schwartz, J.C., X. Zhang, A.A. Federov, S.G. Nathenson, and S.C. Almo. 2001. Structural basis for co-stimulation by the human CTLA-4/B7-2 complex. Nature. 410:604-608.
19. Stamper, C.C., Y. Zhang,J.F. Tobin, D.V. Erbe, S. Ikemizu, S.J. Davis, M.L. Stahl, J. Seehra, W.S. Somers, and L. Mosyak. 2001. Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses. Nature. 410:608-611.
20. Ikemizu, S., R.J. Gilbert, J.A. Fennelly, A.V. Collins, K. Harlos, E.Y. Jones, D.I. Stuart, and S.J. Davis. 2000. Structure and dimerization of a soluble form of B7-1. Immunity. 12:51-60.
21. Bajorath, J., W.J. Metzler, and P.S. Linsley. 1997. Molecular modeling of CD28 and three-dimensional analysis of residue conservation in the CD28/CD152 family. J. Mol. Graph. Model. 15:135-139.
22. Wang, S., G. Zhu, K. Tamada, L. Chen, and J. Bajorath. 2002. Ligand binding sites of inducible costimulator and high avidity mutants with improved function. J. Exp. Med. 195: 1033-1041.
23. Tamura, H., H. Dong, G. Zhu, G.L. Sica, D.B. Flies, K. Tamada, and L. Chen. 2001. B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood. 97:1809-1816.
24. Ishida, M., Y. Iwai, Y. Tanaka, T. Okazaki, G.J. Freeman, N. Minato, and T. Honjo. 2002. Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues. Immunol. Lett. 84:57-62.
25. Ishida, Y., Y. Agata, K. Shibahara, and T. Honjo. 1992. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 11:3887-3895.
26. Agata, K., A. Kawasaki, H. Nishimura, Y. Ishida, T. Tsubata, H. Yagita, and T. Honjo. 1996. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol. 8:765-772.
27. Nishimura, H., M. Nose, H. Hiai, N. Minato, and T. Honjo. 1999. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity. 11:141-151.
28. Nishimura, H., T. Okazaki, Y. Tanaka, K. Nakatani, M. Hara, A. Matsumori, S. Sasayama, A. Mizoguchi, H. Hial, N. Minato, et al. 2001. Autoimmune dilated cardiomyopathy in PD-1 receptor deficient mice. Science. 291:319-322.
29. Dong, H., S.E. Strome, D.R. Salomao, H. Tamura, F. Hirano, D.B. Flies, P.C. Roche, G. Zhu, K. Tamada, V.A. Lennon, et al. 2002. Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion. Nat. Med. 8:793-800.
30. Nishimura, H., N. Minato, T. Nakano, and T. Honjo. 1998. Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int. Immunol. 10:1563-1572.
31. Levitt, M. 1992. Accurate modeling of protein conformation by automatic segment matching. J. Mol. Biol. 226:507-533.
32. Fechteler, T., U. Dengler, and D. Schomburg. 1995. Prediction of protein three-dimensional structures in insertion and deletion regions: a procedure for searching databases of representative protein fragments using geometric scoring criteria. J. Mol. Biol. 253:114-131.
33. Ponder, J.W., and F.M. Richards. 1987. Tertiary templates for proteins. Use of packing criteria in the enumeration of allowed sequences for different structure classes. J. Mol. Biol. 193:775-791.
34. Berman, H.M., J. Westbrook, Z. Feng, G. Gilliland, T.N. Bhat, H. Weissig, I.N. Shindyalov, and P.E. Bourne. 2000. The protein data bank. Nucleic Acid Res. 28:235-242.
35. Engh, R.A., and R. Huber. 1991. Accurate bond and angle parameters for X-ray protein structure refinement. Acta Crystallogr. A47:392-400.
36. Connolly, M.L. 1983. Analytical molecular surface calculations. J. Appl. Crystallogr. 16:548-558.