Programmed death-1 targeting can promote allograft survival

Journal of Immunology

Volumn 169, Issue 11, 2002, Pages 6546-6553

  Özkaynak, Engin ^a,c   Wang, Liqing ^a,b   Goodearl, Andrew ^a   McDonald, Kevin ^a   Qin, Shixin ^a   O'Keefe, Theresa ^a   Duong, Thao ^a   Smith, Tammy ^a   Gutierrez Ramos, Jose Carlos ^a   Rottman, James B ^a   Coyle, Anthony J ^a   Hancock, Wayne W ^a,b,d  

^a MILLENNIUM PHARMACEUTICALS INC   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c TolerRx Inc   (United States)

^d CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; B7 ANTIGEN; CD28 ANTIGEN; CD40 LIGAND; CHEMOKINE; CYCLOSPORIN A; GAMMA INTERFERON; HYBRID PROTEIN; INTERLEUKIN 10; LIGAND; MAJOR HISTOCOMPATIBILITY ANTIGEN; MESSENGER RNA; MONOCLONAL ANTIBODY; PD L1 IMMUNOGLOBULIN; PD L2 IMMUNOGLOBULIN; PROTEIN PROGRAMMED DEATH 1; RAPAMYCIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; COMPLEMENTARY DNA; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; MEMBRANE ANTIGEN; MEMBRANE PROTEIN; PDCD1 PROTEIN, MOUSE; PDCD1LG1 PROTEIN, MOUSE; PDCD1LG2 PROTEIN, MOUSE; PEPTIDE; PLASMA PROTEIN;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; IN VIVO STUDY; ISOGRAFT; MALE; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; T LYMPHOCYTE; TISSUE DISTRIBUTION; TISSUE SPECIFICITY; ALLOTRANSPLANTATION; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; GENE EXPRESSION; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PATHOLOGY;

ANIMALS; ANTIGENS, CD28; ANTIGENS, CD80; ANTIGENS, SURFACE; APOPTOSIS REGULATORY PROTEINS; BASE SEQUENCE; BLOOD PROTEINS; CYCLOSPORINE; DNA, COMPLEMENTARY; GENE EXPRESSION; GRAFT REJECTION; GRAFT SURVIVAL; HEART TRANSPLANTATION; IMMUNOSUPPRESSIVE AGENTS; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, KNOCKOUT; PEPTIDES; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; SIROLIMUS; TISSUE DISTRIBUTION; TRANSPLANTATION, HOMOLOGOUS; TRANSPLANTATION, ISOGENEIC;

EID: 0036884356     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.11.6546     Document Type: Article

References (45)

1. Bretscher, P. A., and M. Cohn. 1970. A theory of self and non-self discrimination. Science 169:1042.
2. Harding, F. A., J. G. McArthur, J. A. Gross. D. H. Raulet, and J. P. Allison. 1992. CD28-mediated signalling costimulates murine T cells and prevents induction of anergy in T-cell clones. Nature 6370:607.
3. Lenschow, D. J., T. L. Walunas, and J. A. Bluestone. 1996. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14:233.
4. Foy, T. M., A. Aruffo, J. Bajorath, J. E. Buhlmann, and R. J. Noelle. 1996. Immune regulation by CD40 and its ligand gp39. Annu. Rev. Immunol. 14:591.
5. Grewal, I. S., and R. A. Flavell, 1998. CD40 and CD154 in cell-mediated immunity. Annu. Rev. Immunol. 16:111.
6. Locksley, R. M., N. Killeen. and M. J. Lenardo. 2001. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104:487.
7. Walunas, T. L., D. J. Lenschow, C. Y. Bakker, P. S. Linsley, G. J. Freeman, J. M. Green, C. B. Thompson, and J. A. Bluestone. 1994. CTLA-4 can function as a negative regulator of T cell activation. Immunity 1:405.
8. Coyle, A. J., and J. C. Gutierrez-Ramos, 2001. The expanding B7 superfamily: increasing complexity in costimulatory signals regulating T cell function. Nat. Immunol. 2:203.
9. Hutloff, A., A. M. Dittrich, K. C. Beier, B. Eljaschewitsch, R. Kraft, I. Anagnostopoulos, and R. A. Kroczek. 1999. ICOS is an inducible T-cell costimulator structurally and functionally related to CD28. Nature 397:263.
10. Coyle, A. J., S. Lehar, C. Lloyd, J. Tian, T. Delaney, S. Manning, T. Nguyen, T. Burwell, H. Schneider, J. A. Gonzalo, et al. 2000. The CD28-related molecule ICOS is required for effective T cell-dependent immune responses, Immunity 13:95.
11. Swallow, M. M., J. J. Wallin, and W. C. Sha. 1999. B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNF-α. Immunity 11:423.
12. Yoshinaga, S. K., J. S. Whoriskey, S. D. Khare, U. Sarmiento, J. Guo, T. Horan, G. Shih, M. Zhang, M. A. Coccia, T. Kohno, et al. 1999. T-cell co-stimulation through B7RP-1 and ICOS. Nature 402:827.
13. + T cells. J. Immunol. 164:265.
14. Özkaynak, E., W. Gao, N. Shemmeri, C. C. Wang, J. C. Gutierrez-Ramos, J. Amaral, S. Qin, J. B. Rottman, A. J. Coyle, and W. W. Hancock. 2001. Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection. Nat. Immunol. 2:591.
15. Ishida, Y., Y. Agata, K. Shibara, and T. Honjo. 1992. Induced expression of PD-1, a novel immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 11:3887.
16. Nishimura, H., Y. Agata, A. Kawasaki, M. Sato, S. Imamura, N. Minato, H. Yagita, T. Nakano, and T. Honjo. 1996. Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes. Int. Immunol. 8:73.
17. Shinohara, T., M. Taniwaki, Y. Ishida, M. Kawaichi, and T. Honjo. 1994. Structure and chromosomal localization of the human PD-I gene (PDCD1). Genomics 23:704.
18. Vivier, E., and M. Daeron. 1997. Immunoreceptor tyrosine-based inhibition motifs. Immunol. Today 18:286.
19. Nishimura, H., M. Nose, H. Hiai, N. Minato, and T. Honjo. 1999. Development of tupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor, Immunity 11:141.
20. Sinclair, N. R. 2000. Immunoreceptor tyrosine-based inhibitory motifs on activating molecules. Crit. Rev. Immunol. 20:89.
21. Nishimura, H., T. Okazaki, Y. Tanaka, K. Nakatani, M. Hara, A. Matsumori, S. Sasayama, A. Mizoguchi, H. Hiai, N. Minato, and T. Honjo. 2001. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science 291:319.
22. Dong, H., G. Zhu, K. Tamada, and L. Chen. 1999. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat. Med. 5:1365.
23. Freeman, G. J., A. J. Long, Y. Iwai, K. Bourque, T. Chemova, H. Nishimura, L. J. Fitz, N. Malenkovich, T. Okazaki, M. C. Byme, et al. 2000. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 192:1027.
24. Latchman, Y., C. R. Wood, T. Chemova, D. Chaudhary, M. Borde, I. Chemova, Y. Iwai, A. J. Long, J. A. Brown, R. Nunes, et al. 2001. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol. 2:261.
25. Tseng, S. Y., M. Otsuji, K. Gorski, X. Huang, J. E. Slansky, S. I. Pai, A. Shalabi, T. Shin, D. M. Pardoll, and H. Tsuchiya. 2001. B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J. Exp. Med. 193:839.
26. Rottman, J. B., A. J. Slavin, R. Silva, H. L. Weiner, C. G. Gerard, and W. W. Hancock. 2000. Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1-dependent. Eur. J. Immunol. 30:2372.
27. 10 thymocytes in vivo. Science 250:1720.
28. Gonzalo, J. A., J. Tian, T. Delaney, J. Corcoran, J. B. Rottman, J. Lora, A. Algarawi, R. Kroczek, J. C. Gutierrez-Ramos, and A. J. Coyle. 2001. ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses. Nat. Immunol. 2:597.
29. Hancock, W. W., R. Buelow, M. H. Sayegh, and L. A. Turka. 1998. Antibody-induced transplant arteriosclerosis is prevented by graft expression of anti-oxidant and anti-apoptotic genes. Nat. Med. 4:1392.
30. Hancock, W. W., M. H. Sayegh, X. G. Zheng, R. Peach, P. S. Linsley, and L. A. Turka. 1996. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. Proc. Natl. Acad. Sci. USA 93:13967.
31. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156.
32. Agata, Y., A. Kawasaki, H. Nishimura, Y. Ishida, T. Tsubata, H. Yagita, and T. Honjo. 1996. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol. 8:765.
33. Hancock, W. W., B. Lu, W. Gao, V. Csizmadia, K. L. Faia, J. A. King, S. T. Smiley, M. Ling, N. P. Gerard, and C. J. Gerard. 2000. Requirement of the chemokine receptor CXCR3 for acute allograft rejection. J. Exp. Med. 192:1515.
34. Gao, W., P. S. Topham, J. A. King, S. T. Smiley, V. Csizmadia, B. Lu, C. J. Gerard, and W. W. Hancock. 2000. Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejection. J. Clin. Invest. 105:35.
35. Hancock, W. W., W. Gao, K. L. Faia, and V. Csizmadia. 2000, Chemokines and their receptors in allograft rejection. Curr. Opin. Immunol. 12:511.
36. Gao, W., K. L. Faia, V. Csizmadia, S. T. Smiley, D. Soler, J. A. King, T. M. Danoff, and W. W. Hancock. 2001. Beneficial effects of targeting CCR5 in allograft recipients. Transplantation 72:1199.
37. Hancock, W. W., W. Gao, V. Csizmadia, K. L. Faia, N. Shemmeri, and A. D. Luster. 2001. Dohor-derived IP-10 initiates development of acute allograft rejection. J. Exp. Med. 193:975.
38. Tivol, E. A., F. Borriello, A. N. Schweitzer, W. P. Lynch, J. A. Bluestone. and A. H. Sharpe. 1995. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity 3:541.
39. Waterhouse, P., J. M. Penninger, E. Timms, A. Wakeham, A. Shahinian, K. P. Lee, C. B. Thompson, H. Griesser, and T. W. Mak. 1995. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 270:985.
40. + T cells and is overcome by IL-2. Eur. J. Immunol. 32:634.
41. Nishimura, H., and T. Honjo. 2001. PD-1: an inhibitory immunoreceptor involved in peripheral tolerance. Trends Immunol. 22:265.
42. Madrenas, J., R. H. Schwartz, and R. N. Germain. 1996. Interleukin 2 production, not the pattern of early T-cell antigen receptor-dependent tyrosine phosphorylation, controls early induction by both agonists and partial agonists. Proc. Natl. Acad. Sci. USA 93:9736.
43. Shimizu, K., U. Schonbeck, F. Mach, P. Libby, and R. N. Mitchell. 2000. Host CD40 ligand deficiency induces long-term allograft survival and donor-specific tolerance in mouse cardiac transplantation but does not prevent graft arteriosclerosis. J. Immunol. 165:3506.
44. + T cells contribute to the development of transplant arteriosclerosis despite CD 154 blockade. Transplantation 69:2609.
45. Nishimura, H., N. Minato, T. Nakano, and T. Honjo. 1998. Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses. Int. Immunol. 10:1563.