Structure and function of the human nuclear xenobiotic receptor PXR

Current Drug Metabolism

Volumn 6, Issue 4, 2005, Pages 357-367

  Carnahan, Virginia E ^a   Redinbo, Matthew R ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b University of North Carolina at Chapel Hill   (United States)

Author keywords

Cancer; Cholestasis; Drug interactions; Drug metabolism; Polymorphism; Promiscuity; Structural flexibility; Transcription

Indexed keywords

ALPHA TOCOPHEROL; BILE ACID; CHOLESTEROL; CISPLATIN; CLOTRIMAZOLE; CONSTITUTIVE ANDROSTANE RECEPTOR; COUMESTROL; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; CYTOCHROME P450 3A4; FARNOQUINONE; HYPERFORIN; HYPERICUM PERFORATUM EXTRACT; HYPOCHOLESTEROLEMIC AGENT; KETOCONAZOLE; LITHOCHOLIC ACID; MULTIDRUG RESISTANCE PROTEIN 1; NIFEDIPINE; NUCLEAR RECEPTOR COREPRESSOR; PACLITAXEL; PHENOBARBITAL; PREGNANE X RECEPTOR; RECEPTOR INTERACTING PROTEIN 140; RETINOID X RECEPTOR ALPHA; RIFAMPICIN; SR 12813; STEROID RECEPTOR COACTIVATOR 1; TAMOXIFEN; TRABECTEDIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

BILE ACID METABOLISM; BREAST TUMOR; CANCER RESISTANCE; CELLULAR DISTRIBUTION; CHOLESTEROL METABOLISM; COMPLEX FORMATION; DIMERIZATION; DNA RESPONSIVE ELEMENT; DRUG EFFICACY; DRUG METABOLISM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ENDOMETRIUM CANCER; GENE CONTROL; GENE EXPRESSION REGULATION; HUMAN; HYDROPHOBICITY; INTRAHEPATIC CHOLESTASIS; LIGAND BINDING; NONHUMAN; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; XENOBIOTIC METABOLISM;

DNA; DRUG INTERACTIONS; DRUG THERAPY; GENE EXPRESSION REGULATION; HUMANS; MODELS, MOLECULAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; XENOBIOTICS;

EID: 23144467497     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389200054633844     Document Type: Review

References (72)

1. Kliewer, S.A.; Moore, J.T.; Wade, L.; Staudinger, J.L.; Watson, M.A.; Jones, S.A.; McKee, D.D.; Oliver, B.B.; Willson, T.M.; Zetterstrom, R.H.; Perlmann, T. and Lehmann, J.M. (1998) Cell, 92(1), 73-82.
2. Lehmann, J.M.; McKee, D.D.; Watson, M.A.; Willson, T.M.; Moore, J.T. and Kliewer, S.A. (1998) J. Clin. Invest., 102(5), 1016-1023.
3. Bertilsson, G.; Heidrich, J.; Svensson, K.; Asman, M.; Jendeberg, L.; Sydow-Backman, M.; Ohlsson, R.; Postlind, H.; Blomquist, P. and Berkenstam, A. (1998) Proc. Natl. Acad. Sci. USA, 95(21), 12208-12213.
4. Blumberg, B.; Sabbagh, W.; Juguilon, H.; Bolado, J.; van Meter, C.M.; Ono, E.S. and Evans, R.M. (1998) Genes Dev., 12(20), 3195-3205.
5. Kawana, K.; Ikuta, T.; Kobayashi, Y.; Gotoh, O.; Takeda, K. and Kawajiri, K. (2003) Mol. Pharmacol., 63(3), 524-531.
6. Gampe, R.T. Jr.; Montana, V.G.; Lambert, M.H.; Miller, A.B.; Bledsoe, R.K.; Milburn, M.V.; Kliewer, S.A.; Willson, T.M. and Xu, H.E. (2000) Mol. Cell, 5(3), 545-555.
7. Renaud, J.P.; Rochel, N.; Ruff, M.; Vivat, V.; Chambon, P.; Gronemeyer, H. and Moras, D. (1995) Nature, 378(6558), 681-689.
8. Xu, H.E.; Stanley, T.B.; Montana, V.G.; Lambert, M.H.; Shearer, B.G.; Cobb, J.E.; McKee, D.D.; Galardi, C.M.; Plunket, K.D.; Nolte, R.T.; Parks, D.J.; Moore, J.T.; Kliewer, S.A.; Willson, T.M. and Stimmel, J.B. (2002) Nature, 415(6873), 813-817.
9. Nolte, R.T.; Wisely, G.B.; Westin, S.; Cobb, J.E.; Lambert, M.H.; Kurokawa, R.; Rosenfeld, M.G.; Willson, T.M.; Glass, C.K. and Milburn, M.V. (1998) Nature, 395(6698), 137-143.
10. Zhang, J.; Kuehl, P.; Green, E.D.; Touchman, J.W.; Watkins, P.B.; Daly, A.; Hall, S.D.; Maurel, P.; Relling, M.; Brimer, C.; Yasuda, K.; Wrighton, S.A.; Hancock, M.; Kim, R.B.; Strom, S.; Thummel, K.; Russell, C.G.; Hudson, J.R.; Schuetz, E.G. and Boguski, M.S. (2001) Pharmacogenetics, 11(7), 555-572.
11. Hustert, E.; Zibat, A.; Presecan-Siedel, E.; Eiselt, R.; Mueller, R.; Fuss, C.; Brehm, I.; Brinkmann, U.; Eichelbaum, M.; Wojnowski, L. and Burk, O. (2001) Drug Metab. Dispos., 29(11), 1454-1459.
12. Koyano, S.; Kurose, K.; Ozawa, S.; Saeki, M.; Nakajima, Y.; Hasegawa, R.; Komamura, K.; Ueno, K.; Kamakura, S.; Nakajima, T.; Saito, H.; Kimura, H.; Goto, Y.; Saitoh, O.; Katoh, M.; Ohnuma, T.; Kawai, M.; Sugai, K.; Ohtsuki, T.; Suzuki, C.; Minami, N.; Saito, Y. and Sawada, J.I. (2002) Drug Metab. Pharmacokinet., 17(6), 561-565.
13. Rochette-Egly, C. (2003) Cell. Signall., 15(4), 355-366.
14. Blom, N.; Gammeltoft, S. and Brunak, S. (1999) J. Mol. Biol., 294(5), 1351-1362.
15. Ding, X.S. and Staudinger, J.L. (2005) J. Pharmacol. Exp. Ther., 312(2), 849-856.
16. Chrencik, J.E.; Orans, J.; Moore, L.B.; Xue, Y.; Peng, L.; Collins, J.L.; Wisely, G.B.; Lambert, M.H.; Kliewer, S.A. and Redinbo, M.R. (2005) Mol. Endocrinol., me.2004-0346.
17. Watkins, R.E.; Wisely, G.B.; Moore, L.B.; Collins, J.L.; Lambert, M.H.; Williams, S.P.; Willson, T.M.; Kliewer, S.A. and Redinbo, M.R. (2001) Science, 292(5525), 2329-2333.
18. Watkins, R.E.; Davis-Searles, P.R.; Lambert, M.H. and Redinbo, M.R. (2003) J. Mol. Biol., 331(4), 815-828.
19. Watkins, R.E.; Maglich, J.M.; Moore, L.B.; Wisely, G.B.; Noble, S.M.; Davis-Searles, P.R.; Lambert, M.H.; Kliewer, S.A. and Redinbo, M.R. (2003) Biochemistry, 42(6), 1430-1438.
20. Lipinski, C.A.; Lombardo, F.; Dominy, B.W. and Feeney, P.J. (2001) Adv. Drug Deliv. Rev., 46(1-3), 3-26.
21. Jones, S.A.; Moore, L.B.; Shenk, J.L.; Wisely, G.B.; Hamilton, G.A.; McKee, D.D.; Tomkinson, N.C.O.; LeCluyse, E.L.; Lambert, M.H.; Willson, T.M.; Kliewer, S.A. and Moore, J.T. (2000) Mol. Endocrinol., 14(1), 27-39.
22. Synold, T.W.; Dussault, I. and Forman, B.M. (2001) Nat. Med., 7(5), 584-590.
23. Takeshita, A.; Taguchi, M.; Koibuchi, N. and Ozawa, Y. (2002) J. Biol. Chem., 277(36), 32453-32458.
24. Tirona, R.G.; Leake, B.F.; Podust, L.M. and Kim, R.B. (2004) Mol. Pharmacol., 65(1), 36-44.
25. Krasowski, M.D.; Yasuda, K.; Hagey, L.R. and Schuetz, E.G. (2005) Mol. Endocrinol., me.2004-0427.
26. Sueyoshi, T. and Negishi, M. (2001) Annu. Rev. Pharmacol. Toxicol., 41(123-143.
27. Koyano, S.; Kurose, K.; Saito, Y.; Ozawa, S.; Hasegawa, R.; Komamura, K.; Ueno, K.; Kamakura, S.; Kitakaze, M.; Nakajima, T.; Matsumoto, K.; Akasawa, A.; Saito, H. and Sawada, J.I. (2004) Drug Metab. Dispos., 32(1), 149-154.
28. Squires, E.J.; Sueyoshi, T. and Negishi, M. (2004) J. Biol. Chem., 279(47), 49307-49314.
29. Mangelsdorf, D.J. and Evans, R.M. (1995) Cell, 83(6), 841-850.
30. Kast, H.R.; Goodwin, B.; Tarr, P.T.; Jones, S.A.; Anisfeld, A.M.; Stoltz, C.M.; Tontonoz, P.; Kliewer, S.; Willson, T.M. and Edwards, P.A. (2002) J. Biol. Chem., 277(4), 2908-2915.
31. Masuyama, H.; Hiramatsu, Y.; Kunitomi, M.; Kudo, T. and MacDonald, P.N. (2000) Mol. Endocrinol., 14(3), 421-428.
32. Masuyama, H.; Hiramatsu, Y.; Mizutani, Y.; Inoshita, H. and Kudo, T. (2001) Mol. Cell. Endocrinol., 172(1-2), 47-56.
33. Takeshita, A.; Koibuchi, N.; Oka, J.; Taguchi, M.; Shishiba, Y. and Ozawa, Y. (2001) Eur. J. Endocrinol., 145(4), 513-517.
34. Wentworth, J.M.; Agostini, M.; Love, J.; Schwabe, J.W. and Chatterjee, V.K.K. (2000) J. Endocrinol., 166(3), R11-R16.
35. Bhalla, S.; Ozalp, C.; Fang, S.S.; Xiang, L.J. and Kemper, K. (2004) J. Biol. Chem., 279(43), 45139-45147.
36. Suino, K.; Peng, L.; Reynolds, R.; Li, Y.; Cha, J.Y.; Repa, J.J.; Kliewer, S.A. and Xu, H.E. (2004) Mol. Cell, 16(6), 893-905.
37. Shan, L.; Vincent, J.; Brunzelle, J.S.; Dussault, I.; Lin, M.; Ianculescu, I.; Sherman, M.A.; Forman, B.M. and Fernandez, E.J. (2004) Mol. Cell, 16(6), 907-917.
38. Xu, R.X.; Lambert, M.H.; Wisely, B.B.; Warren, E.N.; Weinert, E.E.; Waitt, G.M.; Williams, J.D.; Collins, J.L.; Moore, L.B.; Willson, T.M. and Moore, J.T. (2004) Mol. Cell, 16(6), 919-928.
39. Moore, D.D. (2005) Cell Metab., 1(1), 6-8.
40. Ueda, A.; Matsui, K.; Yamamoto, Y.; Pedersen, L.C.; Sueyoshi, T. and Negishi, M. (2004) Biochem. J., Immediate publication, doi:10.1042/BJ20041572.
41. Zhou, C.C.; Tabb, M.M.; Sadatrafiei, A.; Grun, F. and Blumberg, B. (2004) Drug Metab. Dispos., 32(10), 1075-1082.
42. Masuyama, H.; Inoshita, H.; Hiramatsu, Y. and Kudo, T. (2002) Endocrinology, 143(1), 55-61.
43. Lamba, V.; Yasuda, K.; Lamba, J.K.; Assem, M.; Davila, J.; Strom, S. and Schuetz, E.G. (2004) Toxicol. Appl. Pharmacol., 199(3), 251-265.
44. Dotzlaw, H.; Leygue, E.; Watson, P. and Murphy, L.C. (1999) Clin. Cancer Res., 5(8), 2103-2107.
45. Masuyama, H.; Hiramatsu, Y.; Kodama, J.I. and Kudo, T. (2003) J. Clin. Endocrinol. Metab., 88(9), 4446-4454.
46. Masuyama, H.; Suwaki, N.; Tateishi, Y.; Nakatsukasa, H.; Segawa, T. and Hiramatsu, Y. (2005) Mol. Endocrinol., me.2004-0434.
47. Maglich, J.M.; Stoltz, C.M.; Goodwin, B.; Hawkins-Brown, D.; Moore, J.T. and Kliewer, S.A. (2002) Mol. Pharmacol., 62(3), 638-646.
48. Rosenfeld, J.M.; Vargas, R.; Xie, W. and Evans, R.M. (2003) Mol. Endocrinol., 17(7), 1268-1282.
49. Maurel, P. (1996) In Cytochromes P450: Metabolic and Toxicological Aspects (Ioannides, C., ed), pp. 241-270, CRC Press, Inc., Boca Raton, FL.
50. Falkner, K.C.; Pinaire, J.A.; Xiao, G.H.; Geoghegan, T.E. and Prough, R.A. (2001) Mol. Pharmacol., 60(3), 611-619.
51. Runge-Morris, M.; Wu, W. and Kocharek, T.A. (1999) Mol. Pharmacol., 56(6), 1198-1206.
52. Dunn, R.T.; Gleason, B.A.; Hartley, D.P. and Klaassen, C.D. (1999) J. Pharmacol. Exp. Ther., 290(1), 319-324.
53. Geick, A.; Eichelbaum, M. and Burk, O. (2001) J. Biol. Chem., 276(18), 14581-14587.
54. Dussault, I.; Lin, M.; Hollister, K.; Wang, E.H.; Synold, T.W. and Forman, B.M. (2001) J. Biol. Chem., 276(36), 33309-33312.
55. Staudinger, J.L.; Goodwin, B.; Jones, S.A.; Hawkins-Brown, D.; MacKenzie, K.I.; Latour, A.; Liu, Y.P.; Klaassen, C.D.; Brown, K.K.; Reinhard, J.; Willson, T.N.; Koller, B.H. and Kliewer, S.A. (2001) Proc. Natl. Acad. Sci. USA, 98(6), 3369-3374.
56. Xie, W.; Radominska-Pandya, A.; Shi, Y.H.; Simon, C.M.; Nelson, M.C.; Ong, E.S.; Waxman, D.J. and Evans, R.M. (2001) Proc. Natl. Acad. Sci. USA, 98(6), 3375-3380.
57. Xie, W.; Yeuh, M.F.; Radominska-Pandya, A.; Saini, S.P.S.; Negishi, Y.; Bottroff, B.S.; Cabrera, G.Y.; Tukey, R.H. and Evans, R.M. (2003) Proc. Natl. Acad. Sci. USA, 100(7), 4150-4155.
58. Goodwin, B.; Gauthier, K.C.; Umetani, M.; Watson, M.A.; Lochansky, M.I.; Collins, J.L.; Leitersdorf, E.; Mangelsdorf, D.J.; Kliewer, S.A. and Repa, J.J. (2003) Proc. Natl. Acad. Sci. USA, 100(1), 223-228.
59. Dussault, I.; Yoo, H.D.; Lin, M.; Wang, E.; Fan, M.; Batta, A.K.; Salen, G.; Erickson, S.K. and Forman, B.M. (2003) Proc. Natl. Acad. Sci. USA, 100(3), 833-838.
60. Li, T.G. and Chiang, J.Y.L. (2005) Am. J. Physiol. Gastrointest. Liver Physiol., 288(1), G74-G84.
61. Piscitelli, S.C.; Burstein, A.H.; Chaitt, D.; Alfaro, R.M. and Falloon, J. (2000) Lancet, 355(9203), 547-548.
62. Ruschitzka, F.; Meier, P.J.; Turina, M.; Luscher, T.F. and Noll, G. (2000) Lancet, 355(9203), 548-549.
63. Moore, L.B.; Goodwin, B.; Jones, S.A.; Wisely, G.B.; Serabjit-Singh, C.J.; Willson, T.M.; Collins, J.L. and Kliewer, S.A. (2000) Proc. Natl. Acad. Sci. USA, 97(13), 7500-7502.
64. Landes, N.; Pfluger, P.; Kluth, D.; Birringer, M.; Ruhl, R.; Bol, G.F.; Glatt, H. and Brigelius-Flohe, R. (2003) Biochem. Pharmacol., 65(2), 269-273.
65. Tabb, M.M.; Sun, A.X.; Zhou, C.C.; Grun, F.; Errandi, J.; Romero, K.; Pham, H.; Inoue, S.; Mallick, S.; Lin, M.; Forman, B.M. and Blumberg, B. (2003) J. Biol. Chem., 278(45), 43919-43927.
66. Hariparsad, N.; Nallani, S.C.; Sane, R.S.; Buckley, D.J.; Buckley, A.R. and Desai, P.B. (2004) J. Clin. Pharmacol., 44(11), 1273-1281.
67. Gardner-Stephen, D.; Heydel, J.M.; Goyal, A.; Lu, Y.; Xie, W.; Lindblom, T.; Mackenzie, P. and Radominska-Pandya, A. (2004) Drug Metab. Dispos., 32(3), 340-347.
68. Sonoda, J.; Chong, L.W.; Downes, M.; Barish, G.D.; Coulter, S.; Liddle, C.; Lee, C.-H. and Evans, R.M. (2005) Proc. Natl. Acad. Sci. USA, 102(6), 2198-2203.
69. Bachs, L.; Pares, A.; Elena, M.; Piera, C. and Rodes, J. (1992) Gastroenterology, 102(6), 2077-2080.
70. Ozturk, Y.; Aydin, S.; Baser, K.H.C.; Kirimer, N. and Kurtarozturk, N. (1992) Phytother. Res., 6(1), 44-46.
71. Uppal, H.; Toma, D.; Saini, S.P.S.; Ren, S.R.; Jones, T.J. and Xie, W. (2005) Hepatology, 41(1), 168-176.
72. Song, X.L.; Xie, M.X.; Zhang, H.; Li, Y.X.; Sachdeva, K. and Yan, B.F. (2004) Drug Metab. Dispos., 32(1), 35-42.