Activating ω-6 polyunsaturated fatty acids and inhibitory purine nucleotides are high affinity ligands for novel mitochondrial uncoupling proteins UCP2 and UCP3

Journal of Biological Chemistry

Volumn 278, Issue 23, 2003, Pages 20761-20769

  Žáčková, Markéta ^b   Škobisová, Eva ^b   Urbánková, Eva ^b   Ježek, Petr ^a  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ESCHERICHIA COLI; FATTY ACIDS; MUSCLE; PROTEINS; YEAST;

MITOCHONDRIA;

BIOCHEMISTRY;

5,8,11,14,17 ICOSAPENTAENOIC ACID; ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ARACHIDONIC ACID; CELL NUCLEUS RECEPTOR; DIHOMO GAMMA LINOLENIC ACID; FATTY ACID; GAMMA LINOLENIC ACID; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; LAURIC ACID; LIGAND; LIPOSOME; LONG CHAIN FATTY ACID; MITOCHONDRIAL PROTEIN; OMEGA 6 FATTY ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PURINE NUCLEOTIDE; TRITIUM; UBIQUINONE; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

ARTICLE; BINDING AFFINITY; BINDING KINETICS; BINDING SITE; CONTROLLED STUDY; ESCHERICHIA COLI; KIDNEY; LIVER MITOCHONDRION; LUNG; NONHUMAN; PARAMETER; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LIPID INTERACTION; PROTEIN PURIFICATION; PROTON TRANSPORT; REGULATORY MECHANISM; SKELETAL MUSCLE; TRANSCRIPTION INITIATION; YEAST;

ADENOSINE TRIPHOSPHATE; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; FATTY ACIDS, OMEGA-6; FATTY ACIDS, UNSATURATED; GUANOSINE TRIPHOSPHATE; HUMANS; ION CHANNELS; KINETICS; LAURIC ACIDS; LIGANDS; LIPOSOMES; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; PROTEINS; PROTONS; TRITIUM; UBIQUINONE; YEASTS;

ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0038419546     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M212850200     Document Type: Article

References (58)

1. Hanák, P., and Ježek, P. (2001) FEBS Lett. 495, 137-141
2. Ježek, P. (2002) Int. J. Biochem. & Cell Biol. 34, 1190-1206
3. Negre-Salvayre, A., Hirtz, C., Carrera, G., Cazenave, R., Troly, M., Salvayere, R., Penicaud, L., and Caisteila, L. (1997) FASEB J. 11, 809-815
4. Skulachev, V. P. (1998) Biochim. Biophys. Acta 1363, 100-124
5. Ricquier, D., and Bouillaud, F. (2000) Biochem. J. 345, 161-179
6. Gimeno, R. E., Dembski, M., Weng, X., Shyjan, A. W., Gimeno, C. J., Iris, F., Ellis, S. J., Deng, N., Woolf, E. A., and Tartaglia, L. A. (1997) Diabetes 46, 900-906
7. Fleury, C., Neverova, M. Collins, S. Raimbault, S. Champigny, O. Levi-Meyrueis, C. Bouillaud, F. Seldin, M. F. Surwit, R. S. Ricquier, D., and Warden, C. H. (1997) Nat. Genet. 15, 269-272
8. Gong, D.-W., He, Y., Karas, M., and Reitman, M. (1997) J. Biol. Chem. 272, 24129-24131
9. Faggioni, R., Shigenaga, J., Moser, A., Feingold, K. R., and Grunfeld, C. (1998) Biochem. Biophys. Res. Commun. 244, 75-78
10. Arsenijevic, D., Onuma, H., Pecqueur, C., Raimbault, S., Manning, B. S., Miroux, B., Couplan, E., Alves-Guerra, M. C., Goubern, M., Surwit, R., Bouillaud, F., Richard, D., Collins, S., and Ricquier, D. (2000) Nat. Genet. 26, 435-439
11. Clapham, J. C., Arch, J. R., Chapma, H., Haynes, A., Lister, C., Moore, G. B. T., Piercy, V., Carter, S. A., Lehner, I., Smith, S. A., Beeley, L. J., Godden, R. J., Herrity, N., Shekel, M., Changani, K. K., Hockings, P. D., Reid, D. G., Squires, S. M., Hatcher, J., Trail, B., Latchman, J., Rastan, S., Harper, A. J., Cadenas, S., Buckingham, J. A., Brand, M. D., and Abuin, A. (2000) Nature 406, 415-418
12. Cline, G. W., Vidal-Puig, A. J., Dufour, S., Cadman, K. S., Lowell, B. B., and Shulman, G. I. (2001) J. Biol. Chem. 276, 20240-20244
13. Estebauer, H., Schneitler, C., Oberkofler, H., Ebenbichler, C., Paulweber, B., Sandhofer, F., Ladurner, G., Hell, E., Strosberg, A. D., and Patch, J. R. (2001) Nat. Genet. 28, 178-183
14. Nagase, I., Yoshida, T., and Saito, M. (2001) FEBS Lett. 494, 175-180
15. Voehringer, D. W., Hirschberg, D. L., Xiao, J., Lu, Q., Roederer, M., Lock, C. B., Herzenberg, L. A., Steinman, L., and Herzenberg, L. A. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 2680-2685
16. Zhang, C.-Y., Baffy, G., Perret, P., Krauss, S., Peroni, O., Grujic, D., Hagen, T., Vidal-Puig, A. J., Boss, O., Kim, Y.-B., Zheng, X. X., Wheeler, M. B., Shulman, G. I., Chan, C. B., and Lowell, B. B. (2001) Cell 105, 745-755
17. Chevillotte, E., Rieusset, J., Roques, M., Desage, M., and Vidal H. (2001) J. Biol. Chem. 276, 10853-10860
18. Tsuboyama-Kasaoka, N., Takahashi, M., Kim, H., and Ezaki, O. (1999) Biochem. Biophys. Res. Commun. 257, 879-885
19. Pecqueur, C., Alves-Guerra M.-C., Gelly, C., Lévi-Meyrueis, C., Couplan, E., Collins, S., Ricquier, D., Bouillaud, F., and Miroux, B. (2001) J. Biol. Chem. 276, 8705-8712
20. Jabůrek, M., Vařecha, M., Gimeno, R. E., Dembski, M, Ježek, P., Zhang, M., Burn, P., Tartaglia, L. A., and Garlid, K. D. (1999) J. Biol. Chem. 274, 26003-26007
21. Echtay, K. S., Winkler, E., Frischmuth, K., and Klingenberg, M. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 1416-1421
22. Garlid, K. D., Orosz, D. E., Modrianský, M., Vassanelli, S., and Ježek, P. (1996) J. Biol. Chem. 271, 2615-2620
23. Jabůrek, M., Vařecha, M., Ježek, P., and Garlid, K. D. (2001) J. Biol. Chem. 276, 31897-31905
24. Ježek, P. (1999) J. Bioenerg. Biomembr. 31, 457-465
25. Huang, S-G., Lin, Q-S., and Klingenberg, M. (1998) J. Biol. Chem. 273, 859-864
26. Echtay, K. S., Winkler, E., and Klingenberg, M. (2000) Nature 408, 609-613
27. Echtay, K. S., Roussel, D., St.-Pierre, J., Jekabson, M. B., Cadenas, S., Stuart, J. A., Harper, J. A., Roebuck, S. J., Morrison, A., Pickering, S., Clapham J. C., and Brand, M. D. (2002) Nature 415, 96-99
28. Jekabson, M. B., Echtay, K. S., and Brand, M. (2002) Biochem. J. 366, 565-571
29. Stuart, J. A., Harper, J. A., Brindle, K. M., Jekabson, M. B., and Brandt, M. D. (2001) J. Biol. Chem. 276, 18633-18639
30. Hinz, W., Grüninger, S., De Pover, A., and Chiesi, M. (1999) FEBS Lett. 462, 411-415
31. Zhang, C-Y., Hagen, T., Mootha, V. K., Slieker, L., and Lowell, B. B. (1999) FEBS Lett. 449, 129-134
32. Hagen, T., Zhang, C.-Y., Slieker, L. J., Chung, W. K., Leibel, R. L., and Lowell, B. B. (1999) FEBS Lett. 454, 201-206
33. Hagen, T., Zhang, C.-Y., Vianna, C. R., and Lowell, B. B. (2000) Biochemistry 39, 5845-5851
34. Hagen, T., and Lowell, B. B. (2000) Biochem. Biophys. Res. Commun. 276, 642-648
35. Heidkaemper, D., Winkler, E., Müller, V., Frischmuth, K., Liu, Q., Caskey, T., and Klingenberg, M. (2000) FEBS Lett. 480, 265-270
36. Rial, E., Gonzáles-Barroso, M., Fleury, C., Iturrizaga, S., Sanchis, D., Jimenéz-Jimenéz, J., Ricquier, D., Goubern, M., and Bouillaud, F. (1999) EMBO J., 15, 5827-5833
37. Ježek, P., Modrianský, M., and Garlid, K. D. (1997) FEBS Lett. 408, 166-170
38. Winkler, E., and Klingenberg, M. (1994) J. Biol. Chem. 269, 2508-2515
39. Žáćková, M., Krämer, R., and Ježek, P. (2000) Int. J. Biochem. & Cell Biol. 32, 499-508
40. Murdza-Inglis, D. L., Patel, H. V., Freeman, K. B., Ježek, P., Orosz, D. E., and Garlid, K. D. (1991) J. Biol. Chem. 260, 11871-11875
41. Ježek, P., Žáćková, M., Řeháková, Z., Růžička, M., Borecký, J., Škobisová, E., Brucknerová, J., Garlid, K. D., Gimeno, R. E., and Tartaglia L. A. (1999) FEBS Lett. 455, 79-82
42. Kaplan, R. S., and Pedersen, P. L. (1985) Anal. Biochem. 150, 97-104
43. Klingenberg, M., and Winkler, E. (1985) EMBO J. 4, 3087-3092
44. Klingenberg, M. (1988) Biochemistry 27, 781-791
45. Scatchard G. (1949) Ann. N. Y. Acad. Sci. 51, 660
46. Ježek, P., Modrianský, M., and Garlid, K. D. (1997) FEBS Lett. 408, 161-165
47. Ježek, P., Costa, A. D. T., and Vercesi, A. E. (1997) J. Biol. Chem. 272, 24272-24278
48. Brustovetski, N., and Klingenberg, M. (1994) J. Biol. Chem. 269, 27329-27336
49. Engstová, H., Žáčková, M., Růžička, M., Meinhardt, A., Hanuš, J., Krämer, R., and Ježek, P. (2001) J. Biol. Chem. 276, 4683-4691
50. Kleinfeld, A. M., Chu, P., and Romero, C. (1997) Biochemistry 36, 14146-14158
51. Huang, S.-G., and Klingenberg, M. (1995) Biochemistry 34, 349-360
52. Ježek, P., Houštěk, J., and Drahota, Z. (1988) J. Bioenerg. Biomembr. 20, 603-622
53. Feil, S., and Rafael, J. (1994) Eur. J. Biochem. 219, 681-690
54. Deiana, M., Aruoma, O. I., Rosa, A., Crobu, V., Casu, V., Piga, R., and Dessi, M. A. (2001) Toxicol. Lett. 123, 125-133
55. Johnson, M. M., Swan, D. D., Surette, M. E., Stegner, J., Chilton, T., Fonteh, A. N., Chilton, F. H. (1997) J. Nutr. 127, 1435-1444
56. Connor, W. E. (2000) Am. J. Clin. Nutr. 71 (suppl.) 171S-175S
57. Rosen, E. D., and Spiegelman, B. M. (2001) J. Biol. Chem. 276, 37731-37734
58. Echtay, K. S., Liu, Q., Caskey, T., Winkler, E., Frischmuth, K., Bienengräber, M., and Klingenberg, M. (1999) FEBS Lett. 450, 8-12