Uncoupling protein-2 overexpression inhibits mitochondrial death pathway in cardiomyocytes

Circulation Research

Volumn 93, Issue 3, 2003, Pages 192-200

  Teshima, Yasushi ^b   Akao, Masaharu ^b   Jones, Steven P ^b   Marbán, Eduardo ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b NONE

Author keywords

Calcium; Heart; Membrane potential; Mitochondria; Reactive oxygen species

Indexed keywords

ADENOVIRUS VECTOR; CASPASE 3; PHOSPHATIDYLSERINE; PROPIDIUM IODIDE; REACTIVE OXYGEN METABOLITE; UNCOUPLING PROTEIN 2;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL DEATH; CONTROLLED STUDY; HEART MUSCLE CELL; HEART PROTECTION; MEMBRANE POTENTIAL; MEMBRANE TRANSPORT; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NEWBORN; NICK END LABELING; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON TRANSPORT; RAT;

ADENOVIRIDAE; ANIMALS; ANIMALS, NEWBORN; CASPASE 3; CASPASES; CELL DEATH; CELLS, CULTURED; FLUORESCENT DYES; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; HUMANS; IN SITU NICK-END LABELING; ION CHANNELS; MEMBRANE POTENTIALS; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIA, HEART; MITOCHONDRIAL PROTEINS; MYOCYTES, CARDIAC; OXIDANTS; PHOSPHATIDYLSERINES; PROTEIN BIOSYNTHESIS; PROTEINS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

EID: 0042526012     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000085581.60197.4D     Document Type: Article

References (43)

1. Ricquier D, Bouillaud F. The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP. Biochem J. 2000;345:161-179.
2. Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levi-Meyrueis C, Bouillaud F, Seldin MF, Surwit RS, Ricquier D, Warden CH. Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet. 1997;15:269-272.
3. Gimeno RE, Dembski M, Weng X, Deng N, Shyjan AW, Gimeno CJ, Iris F, Ellis SJ, Woolf EA, Tartaglia LA. Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. Diabetes. 1997;46:900-906.
4. Chan CB, MacDonald PE, Saleh MC, Johns DC, Marbán E, Wheeler MB. Overexpression of uncoupling protein 2 inhibits glucose-stimulated insulin secretion from rat islets. Diabetes. 1999;48:1482-1486.
5. Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Grujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, Lowell BB. Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, β cell dysfunction, and type 2 diabetes. Cell. 2001;105:745-755.
6. Joseph JW, Koshkin V, Zhang CY, Wang J, Lowell BB, Chan CB, Wheeler MB. Uncoupling protein 2 knockout mice have enhanced insulin secretory capacity after a high-fat diet. Diabetes. 2002;51:3211-3219.
7. Arsenijevic D, Onuma H, Pecqueur C, Raimbault S, Manning BS, Miroux B, Couplan E, Alves-Guerra MC, Goubern M, Surwit R, Bouillaud F, Richard D, Collins S, Ricquier D. Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet. 2000;26:435-439.
8. + channels: possible mechanism of cardioprotection. Circ Res. 1997;81:1072-1082.
9. Liu Y, Sato T, O'Rourke B, Marbán E. Mitochondrial ATP-dependent potassium channels: novel effectors of cardioprotection? Circulation. 1998;97:2463-2469.
10. Akao M, Ohler A, O'Rourke B, Marbán E. Mitochondrial ATP-sensitive potassium channels inhibit apoptosis induced by oxidative stress in cardiac cells. Circ Res. 2001;88:1267-1275.
11. 2+ overload during simulated ischemia and reperfusion: possible mechanism of cardioprotection. Circ Res. 2001;89:891-898.
12. 2+ overload in rat cardiac mitochondria. J Physiol. 1999;519:347-360.
13. Aronis A, Komarnitsky R, Shilo S, Tirosh O. Membrane depolarization of isolated rat liver mitochondria attenuates permeability transition pore opening and oxidant production. Antioxid Redox Signal. 2002;4:647-654.
14. Stoetzer OJ, Pogrebniak A, Pelka-Fleischer R, Hasmann M, Hiddemann W, Nuessler V. Modulation of apoptosis by mitochondrial uncouplers: apoptosis-delaying features despite intrinsic cytotoxicity. Biochem Pharmacol. 2002;63:471-483.
15. Minners J, van den Bos EJ, Yellon DM, Schwalb H, Opie LH, Sack MN. Dinitrophenol, cyclosporin A, and trimetazidine modulate preconditioning in the isolated rat heart: support for a mitochondrial role in cardioprotection. Cardiovasc Res. 2000;47:68-73.
16. Kizaki T, Suzuki K, Hitomi Y, Taniguchi N, Saitoh D, Watanabe K, Onoe K, Day NK, Good RA, Ohno H. Uncoupling protein 2 plays an important role in nitric oxide production of lipopolysaccharide-stimulated macrophages. Proc Natl Acad Sci USA. 2002;99:9392-9397.
17. Akao M, O'Rourke B, Teshima Y, Seharaseyon J, Marbán E. Mechanically distinct steps in the mitochondrial death pathway triggered by oxidative stress in cardiac myocytes. Circ Res. 2003;92:186-194.
18. Akao M, Teshima Y, Marbán E. Antiapoptotic effect of nicorandil mediated by mitochondrial ATP-sensitive potassium channels in cultured cardiac myocytes. J Am Coll Cardiol. 2002;40:803-810.
19. Thornberry NA, Lazebnik Y. Caspases: enemies within. Science. 1998;281:1312-1316.
20. Kroemer G, Dallaporta B, Resche-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol. 1998;60:619-642.
21. Akao M, O'Rourke B, Kusuoka H, Teshima Y, Jones SP, Marbán E. Differential actions of cardioprotective agents on the mitochondrial death pathway. Circ Res. 2003;92:195-202.
22. Davies KJ, Doroshow JH. Redox cycling of anthracyclines by cardiac mitochondria. I: anthracycline radical formation by NADH dehydrogenase. J Biol Chem. 1986;261:3060-3067.
23. Doroshow JH, Davies KJ. Redox cycling of anthracyclines by cardiac mitochondria, II: formation of superoxide anion, hydrogen peroxide, and hydroxyl radical. J Biol Chem. 1986;261:3068-3074.
24. Lefer DJ, Granger DN. Oxidative stress and cardiac disease. Am J Med. 2000;109:315-323.
25. Negre-Salvayre A, Hirtz C, Carrera G, Cazenave R, Troly M, Salvayre R, Penicaud L, Casteilla L. A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation. FASEB J. 1997;11:809-815.
26. Blanc J, Alves-Guerra MC, Esposito B, Rousset S, Gourdy P, Ricquier D, Tedgui A, Miroux B, Mallat Z. Protective role of uncoupling protein 2 in atherosclerosis. Circulation. 2003;107:388-390.
27. Echtay KS, Roussel D, St-Pierre J, Jekabsons MB, Cadenas S, Stuart JA, Harper JA, Roebuck SJ, Morrison A, Pickering S, Clapham JC, Brand MD. Superoxide activates mitochondrial uncoupling proteins. Nature. 2002;415:96-99.
28. Ogura R, Sugiyama M, Haramaki N, Hidaka T. Electron spin resonance studies on the mechanism of adriamycin-induced heart mitochondrial damages. Cancer Res. 1991;51:3555-3558.
29. Doroshow JH. Anthracycline antibiotic-stimulated superoxide, hydrogen peroxide, and hydroxyl radical production by NADH dehydrogenase. Cancer Res. 1983;43:4543-4551.
30. Echtay KS, Winkler E, Klingenberg M. Coenzyme Q is an obligatory cofactor for uncoupling protein function. Nature. 2000;408:609-613.
31. Waypa GB, Marks JD, Mack MM, Boriboun C, Mungai PT, Schumacker PT. Mitochondrial reactive oxygen species trigger calcium increases during hypoxia in pulmonary arterial myocytes. Circ Res. 2002;91:719-726.
32. Sharikabad MN, Hagelin EM, Hagberg IA, Lyberg T, Brors O. Effect of calcium on reactive oxygen species in isolated rat cardiomyocytes during hypoxia and reoxygenation. J Mol Cell Cardiol. 2000;32:441-452.
33. Tan S, Sagara Y, Liu Y, Maher P, Schubert, D. The regulation of reactive oxygen species production during programmed cell death. J Cell Biol. 1998;141:1423-1432.
34. Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem J. 1999;341:233-249.
35. 2+ release. Arch Biochem Biophys. 1979:195:468-477.
36. 2+-dependent pore activated by oxidative stress in heart mitochondria. Biochem J. 1987;245:915-918.
37. Mills EM, Xu D, Fergusson MM, Combs CA, Xu Y, Finkel T. Regulation of cellular oncosis by uncoupling protein 2. J Biol Chem. 2002;277:27385-27392.
38. Bienengraeber M, Ozcan C, Terzic A. Stable transfection of UCP1 confers resistance to hypoxia/reoxygenation in a heart-derived cell line. J Mol Cell Cardiol. 2003;35:861-865.
39. Bechmann I, Diano S, Warden CH, Bartfai T, Nitsch R, Horvath TL. Brain mitochondrial uncoupling protein 2 (UCP2): a protective stress signal in neuronal injury. Biochem Pharmacol. 2002;64:363-367.
40. Teshima Y, Saikawa T, Yonemochi H, Hidaka S, Yoshimatsu H, Sakata T. Alteration of heart uncoupling protein-2 mRNA regulated by sympathetic nerve and triiodothyronine during postnatal period in rats. Biochim Biophys Acta. 1999;1448:409-415.
41. Van Der Lee KA, Willemsen PH, Van Der Vusse GJ, Van Bilsen M. Effects of fatty acids on uncoupling protein-2 expression in the rat heart. FASEB J. 2000;14:495-502.
42. Murakami K, Mizushige K, Noma T, Tsuji T, Kimura S, Kohno M. Perindopril effect on uncoupling protein and energy metabolism in failing rat hearts. Hypertension. 2002;40:251-255.
43. Razeghi P, Young ME, Alcorn JL, Moravec CS, Frazier OH, Taegtmeyer H. Metabolic gene expression in fetal and failing human heart. Circulation. 2001;104:2923-2931.