-
1
-
-
0034611791
-
Obesity as a medical problem
-
Kopelman PG: Obesity as a medical problem. Nature 404:635-643, 2000
-
(2000)
Nature
, vol.404
, pp. 635-643
-
-
Kopelman, P.G.1
-
2
-
-
0034972150
-
A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans
-
Esterbauer H, Schneitler C, Oberkofler H, Ebenbichler C, Paulweber B, Sandhofer F, Ladurner G, Hell E, Strosberg AD, Patsch JR, Krempler F, Patsch W: A common polymorphism in the promoter of UCP2 is associated with decreased risk of obesity in middle-aged humans. Nat Genet 28:178-183, 2001
-
(2001)
Nat Genet
, vol.28
, pp. 178-183
-
-
Esterbauer, H.1
Schneitler, C.2
Oberkofler, H.3
Ebenbichler, C.4
Paulweber, B.5
Sandhofer, F.6
Ladurner, G.7
Hell, E.8
Strosberg, A.D.9
Patsch, J.R.10
Krempler, F.11
Patsch, W.12
-
3
-
-
0034003392
-
Pax genes and the differentiation of hormone-producing endocrine cells in the pancreas
-
Dohrmann C, Gruss P, Lemaire L: Pax genes and the differentiation of hormone-producing endocrine cells in the pancreas. Mech Dev 92:47-54, 2000
-
(2000)
Mech Dev
, vol.92
, pp. 47-54
-
-
Dohrmann, C.1
Gruss, P.2
Lemaire, L.3
-
4
-
-
0026687778
-
Multiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells
-
Shelton KD, Franklin AJ, Khoor A, Beechem J, Magnuson MA: Multiple elements in the upstream glucokinase promoter contribute to transcription in insulinoma cells. Mol Cell Biol 12:4578-4589, 1992
-
(1992)
Mol Cell Biol
, vol.12
, pp. 4578-4589
-
-
Shelton, K.D.1
Franklin, A.J.2
Khoor, A.3
Beechem, J.4
Magnuson, M.A.5
-
5
-
-
0032718689
-
Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus
-
Hani EH, Stoffers DA, Chevre JC, Durand E, Stanojevic V, Dina C, Habener JF, Froguel P: Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus. J Clin Invest 104:R41-R48, 1999
-
(1999)
J Clin Invest
, vol.104
-
-
Hani, E.H.1
Stoffers, D.A.2
Chevre, J.C.3
Durand, E.4
Stanojevic, V.5
Dina, C.6
Habener, J.F.7
Froguel, P.8
-
6
-
-
0032742985
-
Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes
-
Macfarlane WM, Frayling TM, Ellard S, Evans JC, Allen LI, Bulman MP, Ayres S, Shepherd M, Clark P, Millward A, Demaine A, Wilkin T, Docherty K, Hattersley AT: Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes. J Clin Invest 104:R33-R39, 1999
-
(1999)
J Clin Invest
, vol.104
-
-
Macfarlane, W.M.1
Frayling, T.M.2
Ellard, S.3
Evans, J.C.4
Allen, L.I.5
Bulman, M.P.6
Ayres, S.7
Shepherd, M.8
Clark, P.9
Millward, A.10
Demaine, A.11
Wilkin, T.12
Docherty, K.13
Hattersley, A.T.14
-
7
-
-
0035875087
-
Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes
-
Zhang CY, Baffy G, Perret P, Krauss S, Peroni O, Gujic D, Hagen T, Vidal-Puig AJ, Boss O, Kim YB, Zheng XX, Wheeler MB, Shulman GI, Chan CB, Lowell BB: Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 105:745-755, 2001
-
(2001)
Cell
, vol.105
, pp. 745-755
-
-
Zhang, C.Y.1
Baffy, G.2
Perret, P.3
Krauss, S.4
Peroni, O.5
Gujic, D.6
Hagen, T.7
Vidal-Puig, A.J.8
Boss, O.9
Kim, Y.B.10
Zheng, X.X.11
Wheeler, M.B.12
Shulman, G.I.13
Chan, C.B.14
Lowell, B.B.15
-
8
-
-
0034990987
-
Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: Mechanism of action
-
Chan CB, De Leo D, Joseph JW, McQuaid TS, Ha XF, Xu F, Tsushima RG, Pennefather PS, Salapatek AM, Wheeler MB: Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion: Mechanism of action. Diabetes 50:1302-1310, 2001
-
(2001)
Diabetes
, vol.50
, pp. 1302-1310
-
-
Chan, C.B.1
De Leo, D.2
Joseph, J.W.3
McQuaid, T.S.4
Ha, X.F.5
Xu, F.6
Tsushima, R.G.7
Pennefather, P.S.8
Salapatek, A.M.9
Wheeler, M.B.10
-
9
-
-
0035078830
-
Uncoupling protein 2: A possible link between fatty acid excess and impaired glucose-induced insulin secretion?
-
Lameloise N, Muzzin P, Prentki M, Assimacopoulos-Jeannet F: Uncoupling protein 2: A possible link between fatty acid excess and impaired glucose-induced insulin secretion? Diabetes 50:803-809, 2001
-
(2001)
Diabetes
, vol.50
, pp. 803-809
-
-
Lameloise, N.1
Muzzin, P.2
Prentki, M.3
Assimacopoulos-Jeannet, F.4
-
10
-
-
0034663750
-
Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction
-
Wang H, Antinozzi PA, Hagenfeldt KA, Maechler P, Wollheim CB: Molecular targets of a human HNF1 alpha mutation responsible for pancreatic beta-cell dysfunction. EMBO J 19:4257-4264, 2000
-
(2000)
EMBO J
, vol.19
, pp. 4257-4264
-
-
Wang, H.1
Antinozzi, P.A.2
Hagenfeldt, K.A.3
Maechler, P.4
Wollheim, C.B.5
-
11
-
-
0034927069
-
Uncoupling protein 2: Adiposity angel and diabetes devil?
-
O'Rahilly S: Uncoupling protein 2: Adiposity angel and diabetes devil? Nature Med 7:770-772, 2001
-
(2001)
Nature Med
, vol.7
, pp. 770-772
-
-
O'Rahilly, S.1
-
12
-
-
0344731080
-
Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding
-
Xu HE, Rould MA, Xu W, Epstein JA, Maas RL, Pabo CO: Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding. Genes Dev 13:1263-1275, 1999
-
(1999)
Genes Dev
, vol.13
, pp. 1263-1275
-
-
Xu, H.E.1
Rould, M.A.2
Xu, W.3
Epstein, J.A.4
Maas, R.L.5
Pabo, C.O.6
-
13
-
-
0032947097
-
Expanding the TRANSFAC database towards an expert system of regulatory molecular mechanisms
-
Heinemeyer T, Chen X, Karas H, Kel AE, Kel OV, Liebich I, Meinhardt T, Reuter I, Schacherer F, Wingender E: Expanding the TRANSFAC database towards an expert system of regulatory molecular mechanisms. Nucleic Acids Res 27:318-322, 1999
-
(1999)
Nucleic Acids Res
, vol.27
, pp. 318-322
-
-
Heinemeyer, T.1
Chen, X.2
Karas, H.3
Kel, A.E.4
Kel, O.V.5
Liebich, I.6
Meinhardt, T.7
Reuter, I.8
Schacherer, F.9
Wingender, E.10
-
14
-
-
0028096639
-
Two independent and interactive DNA-binding subdomams of the Pax 6 paired domain are regulated by alternative splicing
-
Epstein JA, Glaser T, Cai J, Jepeal L, Walton DS, Maas RL: Two independent and interactive DNA-binding subdomams of the Pax6 paired domain are regulated by alternative splicing. Genes Dev 8:2022-2034, 1994
-
(1994)
Genes Dev
, vol.8
, pp. 2022-2034
-
-
Epstein, J.A.1
Glaser, T.2
Cai, J.3
Jepeal, L.4
Walton, D.S.5
Maas, R.L.6
-
15
-
-
0027375768
-
Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects: Evidence for a hyperbolic function
-
Kahn SE, Prigeon RL, McCulloch DK, Boyko EJ, Bergman RN, Schwartz MW, Neifing JL, Ward WK, Beard JC, Palmer JP: Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects: Evidence for a hyperbolic function. Diabetes 42:1663-1672, 1993
-
(1993)
Diabetes
, vol.42
, pp. 1663-1672
-
-
Kahn, S.E.1
Prigeon, R.L.2
McCulloch, D.K.3
Boyko, E.J.4
Bergman, R.N.5
Schwartz, M.W.6
Neifing, J.L.7
Ward, W.K.8
Beard, J.C.9
Palmer, J.P.10
-
16
-
-
0036318476
-
Accurate assessment of beta-cell function: The hyperbolic correction
-
Bergman RN, Ader M, Huecking K, Van Citters G: Accurate assessment of beta-cell function: The hyperbolic correction. Diabetes 51 (Suppl. 1):S212-S220, 2002
-
(2002)
Diabetes
, vol.51
, Issue.SUPPL. 1
-
-
Bergman, R.N.1
Ader, M.2
Huecking, K.3
Van Citters, G.4
-
17
-
-
0035960122
-
Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young
-
Fajans SS, Bell GI, Polonsky KS: Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N Engl J Med 345:971-980, 2001
-
(2001)
N Engl J Med
, vol.345
, pp. 971-980
-
-
Fajans, S.S.1
Bell, G.I.2
Polonsky, K.S.3
-
18
-
-
0031019249
-
Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia
-
Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levi-Meyrueis C, Bouillaud F, Seldin MF, Surwit RS, Ricquier D, Warden CH: Uncoupling protein-2: A novel gene linked to obesity and hyperinsulinemia. Nat Genet 15:269-272, 1997
-
(1997)
Nat Genet
, vol.15
, pp. 269-272
-
-
Fleury, C.1
Neverova, M.2
Collins, S.3
Raimbault, S.4
Champigny, O.5
Levi-Meyrueis, C.6
Bouillaud, F.7
Seldin, M.F.8
Surwit, R.S.9
Ricquier, D.10
Warden, C.H.11
-
19
-
-
0028153563
-
Interstitial insulin concentrations determine glucose uptake rates but not insulin resistance in lean and obese men
-
Castillo C, Bogardus C, Bergman R, Thuillez P, Lillioja S: Interstitial insulin concentrations determine glucose uptake rates but not insulin resistance in lean and obese men. J Clin Invest 93:10-16, 1994
-
(1994)
J Clin Invest
, vol.93
, pp. 10-16
-
-
Castillo, C.1
Bogardus, C.2
Bergman, R.3
Thuillez, P.4
Lillioja, S.5
-
20
-
-
0031737670
-
Biphasic insulin secretion during intravenous glucose tolerance test promotes optimal interstitial insulin profile
-
Getty L, Hamilton-Wessler M, Ader M, Dea MK, Bergman RN: Biphasic insulin secretion during intravenous glucose tolerance test promotes optimal interstitial insulin profile. Diabetes 47:1941-1947, 1998
-
(1998)
Diabetes
, vol.47
, pp. 1941-1947
-
-
Getty, L.1
Hamilton-Wessler, M.2
Ader, M.3
Dea, M.K.4
Bergman, R.N.5
-
21
-
-
0032929816
-
Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves β-cell function
-
Wang MY, Shimabukuro M, Lee Y, Trinh KY, Chen JL, Newgard CB, Unger RH: Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves β-cell function. Diabetes 48:1020-1025, 1999
-
(1999)
Diabetes
, vol.48
, pp. 1020-1025
-
-
Wang, M.Y.1
Shimabukuro, M.2
Lee, Y.3
Trinh, K.Y.4
Chen, J.L.5
Newgard, C.B.6
Unger, R.H.7
-
22
-
-
0033667705
-
Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production
-
Arsenijevic D, Onuma H, Pecqueur C, Raimbault S, Manning BS, Miroux B, Couplan E, Alves-Guerra MC, Goubern M, Surwit R, Bouillaud F, Richard D, Collins S, Ricquier D: Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. Nat Genet 26:435-439, 2000
-
(2000)
Nat Genet
, vol.26
, pp. 435-439
-
-
Arsenijevic, D.1
Onuma, H.2
Pecqueur, C.3
Raimbault, S.4
Manning, B.S.5
Miroux, B.6
Couplan, E.7
Alves-Guerra, M.C.8
Goubern, M.9
Surwit, R.10
Bouillaud, F.11
Richard, D.12
Collins, S.13
Ricquier, D.14
-
23
-
-
0036228574
-
Peroxisome proliferator-activated receptor-γ coactivator-1 gene locus: Associations with obesity indices in middle-aged women
-
Esterbauer H, Oberkofler H, Linnemayr V, Iglseder B, Hedegger M, Wolfsgruber P, Paulweber B, Fastner G, Krempler F, Patsch W: Peroxisome proliferator-activated receptor-γ coactivator-1 gene locus: Associations with obesity indices in middle-aged women. Diabetes 51:1281-1286, 2002
-
(2002)
Diabetes
, vol.51
, pp. 1281-1286
-
-
Esterbauer, H.1
Oberkofler, H.2
Linnemayr, V.3
Iglseder, B.4
Hedegger, M.5
Wolfsgruber, P.6
Paulweber, B.7
Fastner, G.8
Krempler, F.9
Patsch, W.10
|