Role of uncoupling protein-2 up-regulation and triglyceride accumulation in impaired glucose-stimulated insulin secretion in a β-cell lipotoxicity model overexpressing sterol regulatory element-binding protein-1c

Endocrinology

Volumn 145, Issue 8, 2004, Pages 3566-3577

  Yamashita, Tokuyuki ^a,b   Eto, Kazuhiro ^a,b   Okazaki, Yukiko ^a,b   Yamashita, Shigeo ^a,e   Yamauchi, Toshimasa ^a   Sekine, Nobuo ^a   Nagai, Ryozo ^a   Noda, Mitsuhiko ^b,c,d,e   Kadowaki, Takashi ^a,b,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

^d INSTITUTE FOR ADULT DISEASES   (Japan)

^e TORANOMON HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ACETYL COENZYME A CARBOXYLASE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENOVIRUS VECTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUCOSE; INSULIN; SMALL INTERFERING RNA; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL LEVEL; CELL LINE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; HUMAN; HUMAN CELL; INSULIN RELEASE; LIPID STORAGE; LIPOGENESIS; LIPOTOXICITY; MEMBRANE POTENTIAL; METABOLIC DISORDER; MITOCHONDRIAL MEMBRANE; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; RAT; TRANSCRIPTION INITIATION; UPREGULATION;

ACETYL-COA CARBOXYLASE; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENOVIRIDAE; AMINOIMIDAZOLE CARBOXAMIDE; ANIMALS; CCAAT-ENHANCER-BINDING PROTEINS; CELLS, CULTURED; DNA-BINDING PROTEINS; FATTY ACIDS; GLUCOSE; INSULIN; ION CHANNELS; ISLETS OF LANGERHANS; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL PROTEINS; PHOSPHORYLATION; PROTEIN KINASES; RATS; RIBONUCLEOTIDES; RNA, SMALL INTERFERING; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION FACTORS; TRIGLYCERIDES; UP-REGULATION;

EID: 3843145012     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2003-1602     Document Type: Article

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